Ocular Research By Integrated Training And Learning

Informations projet

ORBITAL

N° de convention de subvention: 813440

DOI

10.3030/813440

Projet clôturé

Date de signature de la CE 9 Avril 2019

Date de début 1 Septembre 2019

Date de fin 31 Août 2023

Financé au titre de

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coût total

€ 4 066 231,32

Contribution de l’UE

€ 4 066 231,32

Coordonné par

SOUTH EAST TECHNOLOGICAL UNIVERSITY
Ireland

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Websites, patent fillings, videos etc. (1)

Launch of ORBITAL website and social media

ORBITALs website and social media presence will be launched at an early a stage as possible to ensure awareness as well as a platform for engagement with the scientific and lay communities

Publications

Peer reviewed articles (34)

Validation of a Rapid and Easy-to-Apply Method to Simultaneously Quantify Co-Loaded Dexamethasone and Melatonin PLGA Microspheres by HPLC-UV: Encapsulation Efficiency and In Vitro Release

Auteurs: Marco Brugnera; Marta Vicario-de-la-Torre; Vanessa Andrés-Guerrero; Irene Bravo-Osuna; Irene Teresa Molina-Martínez; Rocío Herrero-Vanrell
Publié dans: Pharmaceutics; Volume 14; Numéro 2; Pages: 288, Numéro 5, 2022, ISSN 1999-4923
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics14020288

Phosphorylcholine-Based Contact Lenses for Sustained Release of Resveratrol: Design, Antioxidant and Antimicrobial Performances, and In Vivo Behavior

Auteurs: Maria Vivero-Lopez, Ana F. Pereira-da-Mota, Gonzalo Carracedo, Fernando Huete-Toral, Ana Parga, Ana Otero, Angel Concheiro, and Carmen Alvarez-Lorenzo
Publié dans: ACS Appl. Mater. Interfaces, Numéro 14, 2022, Page(s) 55431–55446, ISSN 1944-8244
Éditeur: American Chemical Society
DOI: 10.1021/acsami.2c18217

Oxidative Stress in the Anterior Ocular Diseases: Diagnostic and Treatment

Auteurs: Azza Dammak; Cristina Pastrana; Alba Martin-Gil; Carlos Carpena-Torres; Assumpta Peral Cerda; Mirjam Simovart; Pilar Alarma; Fernando Huete-Toral; Gonzalo Carracedo
Publié dans: instname:, Numéro 4, 2023, ISSN 2227-9059
Éditeur: MDPI
DOI: 10.3390/biomedicines11020292

Ocular application of electrospun materials for drug delivery and cellular therapies

Auteurs: Deepakkumar Mishra; Shilpkala Gade; Varun Pathak; Lalitkumar K Vora; Kiran Mcloughlin; Reinhold Medina; Ryan F Donnelly; Thakur Raghu Raj Singh
Publié dans: Mishra , D , Gade , S , Pathak , V , Vora , L K , Mcloughlin , K , Medina , R , Donnelly , R F & Raghu Raj Singh , T 2023 , ' Ocular application of electrospun materials for drug delivery and cellular therapies ' , Drug Discovery Today , vol. 28 , no. 9 , 103676 . https://doi.org/10.1016/j.drudis.2023.103676, Numéro 1, 2023, ISSN 1359-6446
Éditeur: Elsevier BV
DOI: 10.1016/j.drudis.2023.103676

Melatonin-Eluting Contact Lenses Effect on Tear Volume: In Vitro and In Vivo Experiments

Auteurs: María Serramito, Ana F. Pereira-da-Mota, Carlos Carpena-Torres, Fernando Huete-Toral, Carmen Alvarez-Lorenzo, and Gonzalo Carracedo
Publié dans: Pharmaceutics, Numéro 1019, 2022, ISSN 1999-4923
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics14051019

Epidemiologie okulärer Manifestationen bei Autoimmunkrankheiten

Auteurs: Katie Glover; Deepakkumar Mishra; Thakur Raghu Raj Singh
Publié dans: Kompass Ophthalmologie, Numéro Volume 8, Numéro 1, 2022, Page(s) 2-17, ISSN 2297-0118
Éditeur: KARGER
DOI: 10.1159/000521961

Ocular Disorders and Associated Drug Development Challenges: The Current Scenario

Auteurs: Mishra, Deepakkumar; Gade, Shilpkala; Singh, Thakur Raghu Raj
Publié dans: EC Ophthalmology, Numéro 11.6, 2020, Page(s) 92-101, ISSN 2453-188X
Éditeur: Queens University Belfast

Diabetic eye: associated diseases, drugs in clinic, and role of self-assembled carriers in topical treatment

Auteurs: Axel Kattar, Angel Concheiro, Carmen Alvarez-Lorenzo
Publié dans: Expert Opinion on Drug Delivery, 2021, Page(s) 1-19, ISSN 1742-5247
Éditeur: Ashley Publications Ltd.
DOI: 10.1080/17425247.2021.1953466

How patient/public involvement impacts the research journey – an overview of the visual impairment research field

Auteurs: Tess Ames; Evan Matthews; Alison Reynolds; Laurence Fitzhenry; Ann Logan; Martina Gooney; Helena Prior Filipe
Publié dans: Open Research Europe, Numéro 2, 2023, ISSN 2732-5121
Éditeur: Open Research Europe
DOI: 10.12688/openreseurope.16057.1

In vitro–in vivo correlation of drug release profiles from medicated contact lenses using an in vitro eye blink model.

Auteurs: Ana F. Pereira-da-Mota, Maria Vivero-Lopez, Piyush Garg, Chau-Minh Phan, Angel Concheiro, Lyndon Jones & Carmen Alvarez-Lorenzo
Publié dans: Drug Delivery and Translational Research, Numéro 13, 2023, Page(s) 1116–1127, ISSN 2190-3948
Éditeur: Springer Nature
DOI: 10.1007/s13346-022-01276-6

Testing drug release from medicated contact lenses: the missing link to predict in vivo performance

Auteurs: Ana F. Pereira-da-Mota, Chau-Minh Phan, Angel Concheiro, Lyndon Jones, Carmen Alvarez-Lorenzo
Publié dans: Journal of Controlled Release, Numéro 343, 2022, Page(s) 672-702, ISSN 0168-3659
Éditeur: Elsevier BV
DOI: 10.1016/j.jconrel.2022.02.014

New Biomarker Combination Related to Oxidative Stress and Inflammation in Primary Open-Angle Glaucoma

Auteurs: Azza Dammak; Juan Sanchez Naves; Fernando Huete-Toral; Gonzalo Carracedo
Publié dans: Life; Volume 13; Numéro 7; Pages: 1455, Numéro 2, 2023, Page(s) 13/7:1455, ISSN 2075-1729
Éditeur: MDPI
DOI: 10.3390/life13071455

Atorvastatin-Eluting Contact Lenses: Effects of Molecular Imprinting and Sterilization on Drug Loading and Release

Auteurs: Ana F. Pereira-da-Mota, María Vivero-Lopez, Ana Topete, Ana Paula Serro, Angel Concheiro, Carmen Alvarez-Lorenzo
Publié dans: Pharmaceutics, Numéro 13/5, 2021, Page(s) 606, ISSN 1999-4923
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13050606

Novel electrospun implants of Sunitinib can depress ex-vivo ocular neovascularization

Auteurs: Deepakkumar Mishra; Hákon Hrafn Sigurðsson; Ana Paula Serro; Giedrius Kalesnykas; Ryan F Donnelly; Raghu Raj Singh Thakur
Publié dans: Mishra , D , Sigurðsson , H H , Serro , A P , Kalesnykas , G , Donnelly , R & Singh , T R R 2022 , ' Novel electrospun implants of Sunitinib can depress ex-vivo ocular neovascularization ' , British Journal of Pharmacy , vol. 7 , no. 2 . https://doi.org/10.5920/bjpharm.1174, Numéro 1, 2022, ISSN 2058-8356
Éditeur: British Journal of Pharmacy
DOI: 10.5920/bjpharm.1174

Nanostructured Lipid Carriers for Enhanced Transscleral Delivery of Dexamethasone Acetate: Development, Ex Vivo Characterization and Multiphoton Microscopy Studies

Auteurs: González-Fernández, Felipe M; Delledonne, Andrea; Nicoli, Sara; Gasco, Paolo; Padula, Cristina; Santi, Patrizia; Sissa, Cristina; Pescina, Silvia
Publié dans: Pharmaceutics, Volume 15, Numéro 2 (February 2023), Numéro 3, 2023, Page(s) 407, ISSN 1999-4923
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics15020407

Niosomes-based gene delivery systems for effective transfection of human mesenchymal stem cells

Auteurs: Natalia Carballo-Pedrares, Axel Kattar, Angel Concheiro, Carmen Alvarez-Lorenzo, Ana Rey-Rico
Publié dans: Materials Science and Engineering: C, Numéro 128, 2021, Page(s) 112307, ISSN 0928-4931
Éditeur: Elsevier BV
DOI: 10.1016/j.msec.2021.112307

Injectable depot forming thermoresponsive hydrogel for sustained intrascleral delivery of sunitinib using hollow microneedles

Auteurs: Gade, Shilpkala Shankar; Pentlavalli, Sreekanth; Mishra, Deepakkumar; Vora, Lalitkumar K.; Waite, David; Alvarez-Lorenzo, Carmen Isabel; Herrero Vanrell, Maria Roccio; Laverty, Garry; Larrañeta, Eneko; Donnelly, Ryan F.; Singh Thakur, Raghu Raj
Publié dans: ournal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, Numéro 38(6), 2022, Page(s) 433-448, ISSN 1557-7732
Éditeur: Mary Ann Liebert, Inc
DOI: 10.1089/jop.2022.0016

From Oxidative Stress to Inflammation in the Posterior Ocular Diseases: Diagnosis and Treatment.

Auteurs: Azza Dammak; Fernando Huete-Toral; Carlos Carpena-Torres; Alba Martin-Gil; Cristina Pastrana; Gonzalo Carracedo
Publié dans: Pharmaceutics, Numéro 13, 2021, Page(s) 1376, ISSN 1999-4923
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13091376

Therapeutic Ophthalmic Lenses: A Review

Auteurs: Nadia Toffoletto, Benilde Saramago, Ana Paula Serro
Publié dans: Pharmaceutics, Numéro 13/1, 2021, Page(s) 36, ISSN 1999-4923
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13010036

Neuroprotective Nanoparticles Targeting the Retina: A Polymeric Platform for Ocular Drug Delivery Applications

Auteurs: Patrizia Colucci; Martina Giannaccini; Matteo Baggiani; Breandán N. Kennedy; Luciana Dente; Vittoria Raffa; Chiara Gabellini
Publié dans: Pharmaceutics; Volume 15; Numéro 4; Pages: 1096, Numéro 2, 2023, ISSN 1999-4923
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics15041096

Development and characterization of injectable depot forming thermoresponsive hydrogel for the sustained intrascleral delivery of Sunitinib

Auteurs: Shilpkala Gade; Eneko Larrañeta; Ryan F Donnelly; Rocio Herrero Vanrell; Carmen Isabel Alvarez Lorenzo; Raghu Raj Singh Thakur
Publié dans: British Journal of Pharmacy, Numéro Volume 7, Numéro 2, 2022, ISSN 2058-8356
Éditeur: University of Huddersfield Press
DOI: 10.5920/bjpharm.1175

A physiology-based mathematical model to understand drug delivery from contact lenses to the back of the eye

Auteurs: N. Toffoletto, B. Saramago, A.P. Serro, A. Chauhan
Publié dans: Pharmaceutical Research, 2023, Page(s) 40(8) 1939–1951, ISSN 0724-8741
Éditeur: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s11095-023-03560-7

Dexamethasone phosphate and penetratin co-eluting contact lenses: a strategy to enhance ocular drug permeability

Auteurs: N. Toffoletto, M. Salema-Oom, S. Nicoli, S. Pescina, F.M. González-Fernández C.A. Pinto, J.A. Saraiva, A.P.A. Matos, M. Vivero-Lopez; F. Huete-Toral, G. Carracedo, B. Saramago, A.P. Serro
Publié dans: International Journal of Pharmaceutics, 2024, Page(s) 650 (2024)123685, ISSN 0378-5173
Éditeur: Elsevier BV
DOI: 10.1016/j.ijpharm.2023.123685

Formulation and Characterization of Epalrestat-Loaded Polysorbate 60 Cationic Niosomes for Ocular Delivery

Auteurs: Axel Kattar; Ana Quelle-Regaldie; Laura Sánchez; Angel Concheiro; Carmen Alvarez-Lorenzo
Publié dans: reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela, Numéro 1, 2023, ISSN 1999-4923
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics15041247

Penetration Enhancers for Topical Drug Delivery to the Ocular Posterior Segment—A Systematic Review

Auteurs: Abhinav Thareja, Helen Hughes, Carmen Alvarez-Lorenzo, Jenni J. Hakkarainen, Zubair Ahmed
Publié dans: Pharmaceutics, Numéro 13/2, 2021, Page(s) 276, ISSN 1999-4923
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13020276

Mucoadhesive gellan gum-based and carboxymethyl cellulose -based hydrogels containing gemcitabine and papain for bladder cancer treatment

Auteurs: Caroline S.A. de Lima; M. Isabel Rial-Hermida; Lucas Freitas de Freitas; Ana F. Pereira-da-Mota; Maria Vivero-Lopez; Aryel Heitor Ferreira; Sławomir Kadłubowski; Gustavo H.C. Varca; Ademar B. Lugão; Carmen Alvarez-Lorenzo
Publié dans: Crossref, Numéro 2, 2023, ISSN 0141-8130
Éditeur: Elsevier BV
DOI: 10.1016/j.ijbiomac.2023.124957

Contact lenses for pravastatin delivery to eye segments: Design and in vitro-in vivo correlations

Auteurs: Ana F.Pereira-da-Mota, Maria Vivero-Lopez, Maria Serramito, Luis Diaz-Gomez, Ana Paula Serro, Gonzalo Carracedo, Fernando Huete-Toral, Angel Concheiro, Carmen Alvarez-Lorenzo
Publié dans: Journal of Controlled Release, Numéro 348, 2022, Page(s) 431-443, ISSN 0168-3659
Éditeur: Elsevier BV
DOI: 10.1016/j.jconrel.2022.06.001

Asymmetry in Drug Permeability through the Cornea

Auteurs: Nadia Toffoletto, Anuj Chauhan, Carmen Alvarez-Lorenzo, Benilde Saramago, Ana Paula Serro
Publié dans: Pharmaceutics, Numéro 13/5, 2021, Page(s) 694, ISSN 1999-4923
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13050694

Posterior Segment Ophthalmic Drug Delivery: Role of Muco-Adhesion with a Special Focus on Chitosan

Auteurs: Ayah Mohammad Burhan; Butsabarat Klahan; Wayne Cummins; Vanessa Andrés-Guerrero; Mark E. Byrne; Niall J. O’Reilly; Anuj Chauhan; Laurence Fitzhenry; Helen Hughes
Publié dans: Pharmaceutics, Numéro 13, 2021, ISSN 1999-4923
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13101685

Epidemiology of Ocular Manifestations in Autoimmune Disease

Auteurs: Katie Glover; Deepakkumar Mishra; Thakur Raghu Raj Singh
Publié dans: Frontiers in Immunology, Numéro 2, 2021, ISSN 1664-3224
Éditeur: Frontiers
DOI: 10.3389/fimmu.2021.744396

Penetration enhancers for topical drug delivery to the ocular posterior segment: a systematic Review

Auteurs: Thareja, Abhinav; Hughes, Helen; Álvarez Lorenzo, Carmen Isabel; Hakkarainen, Jenni J.; Ahmed, Zubair
Publié dans: reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela, Numéro 1, 2021, ISSN 1999-4923
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13020276

Drug-Loaded Hydrogels for Intraocular Lenses with Prophylactic Action against Pseudophakic Cystoid Macular Edema

Auteurs: Nadia Toffoletto, Madalena Salema-Oom, Soledad Anguiano Igea, Carmen Alvarez-Lorenzo, Benilde Saramago, Ana Paula Serro
Publié dans: Pharmaceutics, Numéro 13/7, 2021, Page(s) 976, ISSN 1999-4923
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13070976

Langmuir monolayer studies of non-ionic surfactants and DOTMA for the design of ophthalmic niosomes

Auteurs: Axel Kattar Emílio V. Lage Matilde Casas Angel Concheiro Carmen Alvarez-Lorenzo
Publié dans: Heliyon, 2024, ISSN 2405-8440
Éditeur: Elsevier
DOI: 10.1016/j.heliyon.2024.e25887

Lipid-Based Nanocarriers for Ophthalmic Administration: Towards Experimental Design Implementation

Auteurs: Felipe M. González-Fernández, Annalisa Bianchera, Paolo Gasco, Sara Nicoli, Silvia Pescina
Publié dans: Pharmaceutics, Numéro 13/4, 2021, Page(s) 447, ISSN 1999-4923
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13040447

Conference proceedings (1)

Development of 3D-printed devices for the study of transscleral drug delivery on freshly excised whole porcine eyes

Auteurs: Felipe M. González-Fernández, Daniele A. Cauzzi, Sara Nicoli, Paolo Gasco, Silvia Pescina
Publié dans: Volume 100, Numéro S275 Special Numéro:Abstracts from the 2022 European Association for Vision and Eye Research Festival, 13‐15 October 2022, Valencia, 2022
Éditeur: Wiley
DOI: 10.1111/j.1755-3768.2022.15545