Objective
StarT will create an interdisciplinary and intersectorial European training network focusing on different aspects of autosomal recessive Stargardt disease (STGD1), a frequent inherited blinding disorder that affects an estimated 925,000 persons worldwide. StarT research aims to uncover the regulation of its disease gene ABCA4 and its missing heritability, in order to develop novel treatments. StarT training will give young researchers unparalleled training opportunities in outstanding vision research groups with unique expertise in omics technologies, bio-informatics, stem cell biology, animal models of disease, and therapeutics, providing each ESR with the necessary competences in state-of-the-art academic and industrial research.
STGD1 is due to ABCA4 mutations, however up to 35% of STGD1 cases carries one or no ABCA4 coding mutation. New unconventional classes of ABCA4 mutations were recently discovered by us, the significance of which largely remains elusive. In order to understand the mechanisms triggered by these missing ABCA4 mutations and to design new therapies for STGD1 cases, challenging research questions will be addressed by the integration of unique skills from this network.
Early-Stage Researchers will perform cutting edge research using innovative and interdisciplinary approaches: (functional) genomics and transcriptomics, bio-informatics, CRISPR/Cas9 genome editing, generation of stem cell and animal disease models and design of new treatments. The training objectives will be met through academic and industrial training-by-research via individual research projects, secondments, and network-wide training sessions.
Fields of science
Programme(s)
Funding Scheme
MSCA-ITN-ETN - European Training NetworksCoordinator
9000 Gent
Belgium
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Participants (10)
Participation ended
6525 XZ Nijmegen
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72074 Tuebingen
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00185 Roma
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LS2 9JT Leeds
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28006 Madrid
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D02 CX56 Dublin 2
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WC1E 6BT London
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NE1 4EP Newcastle Upon Tyne
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
2333 CK Leiden
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
6525 GA Nijmegen
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Partners (5)
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
1050 Bruxelles
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
4070 Basel
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
7522 NB Enschede
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
D02 Dublin
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
8005 Zurich
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