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European Training Network to Diagnose, Understand and Treat Stargardt Disease, a Frequent Inherited Blinding Disorder

Objective

StarT will create an interdisciplinary and intersectorial European training network focusing on different aspects of autosomal recessive Stargardt disease (STGD1), a frequent inherited blinding disorder that affects an estimated 925,000 persons worldwide. StarT research aims to uncover the regulation of its disease gene ABCA4 and its missing heritability, in order to develop novel treatments. StarT training will give young researchers unparalleled training opportunities in outstanding vision research groups with unique expertise in omics technologies, bio-informatics, stem cell biology, animal models of disease, and therapeutics, providing each ESR with the necessary competences in state-of-the-art academic and industrial research.
STGD1 is due to ABCA4 mutations, however up to 35% of STGD1 cases carries one or no ABCA4 coding mutation. New unconventional classes of ABCA4 mutations were recently discovered by us, the significance of which largely remains elusive. In order to understand the mechanisms triggered by these missing ABCA4 mutations and to design new therapies for STGD1 cases, challenging research questions will be addressed by the integration of unique skills from this network.
Early-Stage Researchers will perform cutting edge research using innovative and interdisciplinary approaches: (functional) genomics and transcriptomics, bio-informatics, CRISPR/Cas9 genome editing, generation of stem cell and animal disease models and design of new treatments. The training objectives will be met through academic and industrial training-by-research via individual research projects, secondments, and network-wide training sessions.

Field of science

  • /natural sciences/biological sciences/cell biology
  • /medical and health sciences/medical biotechnology/cells technologies/stem cells
  • /natural sciences/biological sciences/genetics and heredity/mutation
  • /natural sciences/biological sciences/genetics and heredity/genome

Call for proposal

H2020-MSCA-ITN-2018
See other projects for this call

Funding Scheme

MSCA-ITN-ETN - European Training Networks

Coordinator

UNIVERSITEIT GENT
Address
Sint Pietersnieuwstraat 25
9000 Gent
Belgium
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 768 960

Participants (9)

STICHTING KATHOLIEKE UNIVERSITEIT
Netherlands
EU contribution
€ 531 239,76
Address
Geert Grooteplein Noord 9
6525 EZ Nijmegen
Activity type
Higher or Secondary Education Establishments
EBERHARD KARLS UNIVERSITAET TUEBINGEN
Germany
EU contribution
€ 252 788,40
Address
Geschwister-scholl-platz
72074 Tuebingen
Activity type
Higher or Secondary Education Establishments
FONDAZIONE TELETHON
Italy
EU contribution
€ 522 999,36
Address
Via Varese 16/B
00185 Roma
Activity type
Research Organisations
UNIVERSITY OF LEEDS
United Kingdom
EU contribution
€ 303 172,56
Address
Woodhouse Lane
LS2 9JT Leeds
Activity type
Higher or Secondary Education Establishments
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS
Spain
EU contribution
€ 250 904,88
Address
Calle Serrano 117
28006 Madrid
Activity type
Research Organisations
THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
Ireland
EU contribution
€ 274 684,32
Address
College Green
2 Dublin
Activity type
Higher or Secondary Education Establishments
UNIVERSITY COLLEGE LONDON
United Kingdom
EU contribution
€ 303 172,56
Address
Gower Street
WC1E 6BT London
Activity type
Higher or Secondary Education Establishments
NEWCELLS BIOTECH LIMITED
United Kingdom
EU contribution
€ 303 172,56
Address
1 Times Square Scotswood Road
NE1 4EP Newcastle Upon Tyne
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
PROQR THERAPEUTICS NV
Netherlands
EU contribution
€ 265 619,88
Address
Zernikedreef 9
2333 CK Leiden
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)

Partners (5)

EUROPEAN VISION INSTITUTE - EEIG
Belgium
Address
Rue Du Trône, 98
1050 Bruxelles
Activity type
Research Organisations
F. HOFFMANN-LA ROCHE AG
Switzerland
Address
Grenzacherstrasse 124
4070 Basel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
20MED THERAPEUTICS BV
Netherlands
Address
Drienerlolaan 5 Kamer Zh252
7522 NB Enschede
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Fighting Blindness
Ireland
Address
3Rd Floor, Ely Place
D02 Dublin
Activity type
Other
INTERNATIONAL RETINITIS PIGMENTOSA ASSOCIATION
Switzerland
Address
Ausstellungsstrasse 36
8005 Zurich
Activity type
Other