HEalth data LInkage for ClinicAL benefit

Informations projet

HELICAL

N° de convention de subvention: 813545

DOI 10.3030/813545

Projet clôturé

Date de signature de la CE 31 Août 2018

Date de début 1 Janvier 2019

Date de fin 30 Juin 2023

Financé au titre de

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coût total € 4 050 338,34

Contribution de l’UE € 4 050 338,34

Coordonné par

THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
Ireland

Livrables

Documents, reports (26)

Plan for Exploitation and Dissemination of Results

To guide WP 7 activity

Report on protein composition of EV

ESR 11

Statistical Software Package and Code

ESR 3

Governance framework for research in rare diseases

ESR 15

WP 3 Summary report

Report on WP 3 outputs

Report on suitability of EV as disease marker in AAV

ESR 11

Data Management Plan (DMP)

ESR 15

Report on the analysis of the molecular mechanisms in the context of a human interaction network

ESR 9

WP1 Summary Report

Report on WP1 outputs

Validated / endorsed ethical and governance framework

Report on WP4 outputs

Report describing vasculitis flare prodome

ESR1

Report on development of a multivariate assay for the diagnosis of different forms of vasculitis

ESR 14

Final Report

Final summary of achievements of consortium along with plans for sustainability

Report on clinical evaluation of automated descriptor reading in tissue morphometry

ESR 12

Report summarising key pathways activated in tissue from patients with GCA

ESR 10

Dissemination/Exploitation 2

Report to be the basis of the periodic report

Communication/Public Engagement 2

Report to be the basis of the periodic report

Report on identification of new genetic associations

ESR 8

Dissemination/Exploitation 1

Report to be the basis of the periodic report

WP 2 Report Summary

Report on WP 2 outputs

Report on genetic/epigenetic markers of GCA & related vasculitides

ESR 78

Report on minimal biomarker set for diagnosis of active vasculitis

ESR 14

Report on the role of environment in AAV onset

ESR45

Report on the analysis of the vasculitis associated autoantibody repertoire

KTH

Helical IG policies

ESR 15

Communication/Public Engagement 1

Report to be the basis of the periodic report

Open Research Data Pilot (1)

Open Data research Pilot

ORDP

Publications

Non-peer reviewed articles (1)

COVID-19 Pandemic Sets New Clues on the Transmission Pathways in Kawasaki Disease

Auteurs: Xavier Rodó, Alejandro Fontal
Publié dans: JAMA Network Open, Numéro 4/4, 2021, Page(s) e214624, ISSN 2574-3805
Éditeur: JAMA Network
DOI: 10.1001/jamanetworkopen.2021.4624

Peer reviewed articles (21)

Climatic signatures in the different COVID-19 pandemic waves across both hemispheres

Auteurs: Alejandro Fontal, Menno J. Bouma, Adrià San-José, Leonardo López, Mercedes Pascual & Xavier Rodó
Publié dans: Nature Computational Science, 2021, ISSN 2662-8457
Éditeur: Springer Nature
DOI: 10.1038/s43588-021-00136-6

DECODE: a computational pipeline to discover T cell receptor binding rules

Auteurs: Iliana Papadopoulou, An-Phi Nguyen, Anna Weber, María Rodríguez Martínez
Publié dans: Bioinformatics, Numéro 38, 2022, ISSN 1367-4803
Éditeur: Oxford University Press
DOI: 10.1093/bioinformatics/btac257

ANCA-associated vasculitis in Ireland: a multi-centre national cohort study

Auteurs: Jennifer Scott, Eithne Nic an Ríogh , Shamma Al Nokhatha1, Cliona Cowhig, Alyssa Verrelli, Ted Fitzgerald, Arthur White, Cathal Walsh, Louis Aslett, Declan DeFreitas, Michael R. Clarkson, John Holian, Matthew D. Griffin, Niall Conlon , Yvonne O’Meara, Liam Casserly, Eamonn Molloy, Julie Power, Sarah M. Moran, Mark A. Little
Publié dans: HRB Open Res, 2022, ISSN 2515-4826
Éditeur: Research Limited
DOI: 10.12688/hrbopenres.13651.1

Isolation of Small Extracellular Vesicles from Human Sera

Auteurs: Małgorzata S. Małys, Christof Aigner, Stefan M. Schulz, Helga Schachner, Andrew J. Rees, Renate Kain
Publié dans: International Journal of Molecular Sciences, Numéro 22/9, 2021, Page(s) 4653, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22094653

Persisting Salivary IgG Against SARS-CoV-2 at 9 Months After Mild COVID-19: A Complementary Approach to Population Surveys

Auteurs: Hassan Alkharaan, Shaghayegh Bayati, Cecilia Hellström, Soo Aleman, Annika Olsson, Karin Lindahl, Gordana Bogdanovic, Katie Healy, Georgios Tsilingaridis, Patricia De Palma, Sophia Hober, Anna Månberg, Peter Nilsson, Elisa Pin, Margaret Sällberg Chen
Publié dans: The Journal of Infectious Diseases, Numéro 224/3, 2021, Page(s) 407-414, ISSN 0022-1899
Éditeur: University of Chicago Press
DOI: 10.1093/infdis/jiab256

Benchmarking solutions to the T-cell receptor epitope prediction problem: IMMREP22 workshop report

Auteurs: Pieter Meysman, Justin Barton, Barbara Bravi, Liel Cohen-Lavi, Vadim Karnaukhov, Elias Lilleskov, Alessandro Montemurro, Morten Nielsen, Thierry Mora, Paul Pereira, Anna Postovskaya, María Rodríguez Martínez, Jorge Fernandez-de-Cossio-Diaz, Alexandra Vujkovic, Aleksandra M. Walczak, Anna Weber, Rose Yin, Anne Eugster, Virag Sharma
Publié dans: ImmunoInformatics, Numéro Vol 9, 2023, ISSN 2667-1190
Éditeur: Elsevier
DOI: 10.1016/j.immuno.2023.100024

Evaluating the usability of a semantic environmental health data framework: Approach and study

Auteurs: Albert Navarro-Gallinad, Fabrizio Orlandi, Jennifer Scott, Mark Little, Declan O'Sullivan
Publié dans: Semantic Web, Numéro Pre-press, 2022, ISSN 1570-0844
Éditeur: IOS Press
DOI: 10.3233/sw-223212

Identification of new risk loci shared across systemic vasculitides points towards potential target genes for drug repurposing.

Auteurs: Lourdes Ortiz-Fernández; Elio G Carmona; Martin Kerick; Paul Lyons; Francisco David Carmona; Raquel López Mejías; Chiea Chuen Khor; Peter C Grayson; Enrico Tombetti; Lindi Jiang; Haner Direskeneli; Guher Saruhan-Direskeneli; José-Luis Callejas-Rubio; Augusto Vaglio; Carlo Salvarani; Jose Hernández-Rodríguez; Maria Cinta Cid; Ann W Morgan; Peter A Merkel; David Burgner; Kenneth GC Smith; Migu
Publié dans: Annals of Rheumatic Disease, Numéro 1, 2022, ISSN 0003-4967
Éditeur: BMJ Publishing Group
DOI: 10.1136/ard-2022-223697

On the interpretation of the atmospheric mechanism transporting the environmental trigger of Kawasaki Disease

Auteurs: Joan Ballester, Sílvia Borràs, Roger Curcoll, Albert Navarro-Gallinad, Sofya Pozdniakova, Lidia Cañas, Jane C. Burns, Xavier Rodó
Publié dans: PLOS ONE, Numéro 14/12, 2019, Page(s) e0226402, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0226402

The end of social confinement and COVID-19 re-emergence risk.

Auteurs: López, Leonardo; Rodó, Xavier
Publié dans: Nature Human Behaviour, Numéro 2, 2020, ISSN 2397-3374
Éditeur: Springer Nature Limited
DOI: 10.1038/s41562-020-0908-8

Blocking GM-CSF receptor α with mavrilimumab reduces infiltrating cells, pro-inflammatory markers and neoangiogenesis in ex vivo cultured arteries from patients with giant cell arteritis

Auteurs: Marc Corbera-Bellalta, Roser Alba-Rovira, Sujatha Muralidharan, Georgina Espígol-Frigolé, Roberto Ríos-Garcés, Javier Marco-Hernández, Amanda Denuc, Farah Kamberovic, Patricia Pérez-Galán, Alexandra Joseph, Annalisa D’Andrea, Kent Bondensgaard, Maria C Cid, John F Paolini
Publié dans: Annals of the Rheumatic Diseases, Numéro 81/4, 2022, ISSN 0003-4967
Éditeur: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2021-220873

Methylome and transcriptome profiling of giant cell arteritis monocytes reveals novel pathways involved in disease pathogenesis and molecular response to glucocorticoids

Auteurs: Elkyn Estupiñán-Moreno, Lourdes Ortiz-Fernández, Tianlu Li, Jose Hernández-Rodríguez, Laura Ciudad, Eduardo Andrés-León, Laura Carmen Terron-Camero, Sergio Prieto-González, Georgina Espígol-Frigolé, Maria Cinta Cid, Ana Márquez, Esteban Ballestar, Javier Martín
Publié dans: Annals of the Rheumatic Diseases, Numéro 81/9, 2022, ISSN 0003-4967
Éditeur: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2022-222156

IDENTIFICATION OF NEW RISK LOCI AND PATHWAYS INVOLVED IN GCA PATHOGENESIS BY A GENOME-WIDE STUDY

Auteurs: G. Borrego-Yaniz, L. Ortiz-Fernández, M. Kerick, A. Madrid-Paredes, A. Vaglio, J. Hernández-Rodríguez, S. Mackie, S. Castañeda, R. Solans-Laqué, J. Mestre, B. Dasgupta, R. Watts, N. Khalidi, C. Langford, S. R. Ytterberg, L. Beretta, M. Govoni, G. Emmi, M. A. Cimmino, T. Witte, T. Neumann, J. Holle, V. Schönau, G. Pugnet, T. Papo, J. Haroche, A. Mahr, L. Mouthon, Ø. Molberg, A. Diamantopoulo
Publié dans: Annals of the Rheumatic Diseases, Numéro volume 82, supplement 1, year 2023, 2023, Page(s) page 68, ISSN 0003-4967
Éditeur: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2023-eular.673

Incidence of giant cell arteritis in six districts of Paris, France (2015–2017)

Auteurs: Solange Gonzalez Chiappe; Sarah Lechtman; Carla Soledad Maldini; Arsène Mekinian; Thomas Papo; Thomas Sené; Alfred Daniel Mahr
Publié dans: Rheumatology International, Numéro 42, 2022, ISSN 1437-160X
Éditeur: Springer
DOI: 10.1007/s00296-022-05167-4

Environmental risk factors associated with ANCA associated vasculitis: A systematic mapping review

Auteurs: Jennifer Scott, Jack Hartnett, David Mockler, Mark A. Little
Publié dans: Autoimmunity Reviews, Numéro 19/11, 2020, Page(s) 102660, ISSN 1568-9972
Éditeur: Elsevier BV
DOI: 10.1016/j.autrev.2020.102660

Small extracellular vesicles are released ex vivo from platelets into serum and from residual blood cells into stored plasma

Auteurs: Małgorzata S. Małys, Maximilian C. Köller, Kristin Papp, Christof Aigner, Daffodil Dioso, Patrick Mucher, Helga Schachner, Michael Bonelli, Helmuth Haslacher, Andrew J. Rees, Renate Kain
Publié dans: Journal of Extracellular Biology, Numéro Vol.2/5, 2023, ISSN 2001-3078
Éditeur: Wiley in pqrtnership with ISEV
DOI: 10.1002/jex2.88

A Literature Review on the GDPR, COVID-19 and the Ethical Considerations of Data Protection During a Time of Crisis

Auteurs: Maria Christofidou, Nathan Lea, Pascal Coorevits
Publié dans: Yearbook of Medical Informatics, Numéro 30/01, 2021, Page(s) 226-232, ISSN 0943-4747
Éditeur: Pubmed
DOI: 10.1055/s-0041-1726512

Somatostatin Receptor PET/MR Imaging of Inflammation in Patients With Large Vessel Vasculitis and Atherosclerosis

Auteurs: Andrej Corovic, Christopher Wall, Meritxell Nus, Deepa Gopalan, Yuan Huang, Maria Imaz, Michal Zulcinski, Marta Peverelli, Anna Uryga, Jordi Lambert, Dario Bressan, Robert T. Maughan, Charis Pericleous, Suraiya Dubash, Natasha Jordan, David R. Jayne, Stephen P. Hoole, Patrick A. Calvert, Andrew F. Dean, Doris Rassl, Tara Barwick, Mark Iles, Mattia Frontini, Greg Hannon, Roido Manavaki, Tim D. Fr
Publié dans: Journal of the American College of Cardiology, Numéro Vol. 81 No. 4, 2023, ISSN 0735-1097
Éditeur: Elsevier BV
DOI: 10.1016/j.jacc.2022.10.034

TITAN: T Cell Receptor Specificity Prediction with Bimodal Attention Networks

Auteurs: Weber, Anna; Born, Jannis; Martínez, María Rodríguez
Publié dans: Bioinformatics, Numéro 10, 2021, ISSN 1367-4803
Éditeur: Oxford University Press
DOI: 10.48550/arxiv.2105.03323

Sub-weekly signatures relate ultrafine aerosols enriched in metals from intensive farming and urban pollution to Kawasaki disease

Auteurs: Xavier Rodó, Albert Navarro-Gallinad, Tomoko Kojima, Josep-Anton Morguí, Silvia Borràs and Alejandro Fontal
Publié dans: Environmental Research Letters, Numéro Vol.18, n.7, 2023, ISSN 1748-9326
Éditeur: Institute of Physics Publishing
DOI: 10.1088/1748-9326/acd798

The association between ambient UVB dose and ANCA-associated vasculitis relapse and onset

Auteurs: Scott, J; Havyarimana, E; Navarro-Gallinad, A; White, A; Wyse, J; van Geffen, J; van Weele, M; Buettner, A; Wanigasekera, T; Walsh, C; Aslett, LJM; Kelleher, JD; Power, J; Ng, J; O’Sullivan, D; Hederman, L; Basu, N; Little, MA; Zgaga, L; , RKD and UKIVAS groups
Publié dans: Arthritis Research & Therapy, 2022, Vol.24(1), pp.147 [Peer Reviewed Journal], Numéro 13, 2022, ISSN 1478-6362
Éditeur: Springer Nature
DOI: 10.1186/s13075-022-02834-6

Conference proceedings (3)

Enhancing Rare Disease Research with Semantic Integration of Environmental and Health Data

Auteurs: Albert Navarro-Gallinad, Fabrizio Orlandi, Declan O'Sullivan
Publié dans: IJCKG'21, Numéro 10, 2022, Page(s) 19-27
Éditeur: Association for Computing Machinery
DOI: 10.1145/3502223.3502226

The Semantic Combining for Exploration of Environmental and Disease Data Dashboard for Clinician Researchers

Auteurs: Albert Navarro-Gallinad, Alan Meehan, and Declan O’Sullivan
Publié dans: VOILA! 2020 Visualization and Interaction for Ontologies and Linked Data 5th International Workshop co-located with ISWC 2020, November 2nd 2020, Virtual Conference, Numéro Annual, 2020
Éditeur: http://ceur-ws.org/

Proceedings of the 20th International Vasculitis and ANCA workshop 3-6th April 2022

Auteurs: Michael Clarkson; Allyson Egan; Mark A Little
Publié dans: Proceedings of the 20th International Vasculitis and ANCA workshop 3-6th April 2022, Numéro 8, 2022
Éditeur: Zenodo
DOI: 10.5281/zenodo.6454077

Thesis and dissertations (3)

A Usable Knowledge Graph Framework for Linking Health Events with Environmental Data

Auteurs: Navarro Gallinad, Albert
Publié dans: 2023
Éditeur: Trinity College Dublin

Estudio de las causas moleculares de la arteritis de células gigantes mediante una aproximación sistémica

Auteurs: Estupiñán Moreno, Elkyn Fabián
Publié dans: 2023
Éditeur: University of Granada

Autoantibody profiling in autoimmune diseases

Auteurs: Shaghayegh Bayati
Publié dans: 2023
Éditeur: KTH

Other (1)

HELICAL Open Research Guidelines

Auteurs: Christofidou, Maria; Navarro-Gallinad, Albert
Publié dans: Numéro 3, 2022
Éditeur: Zenodo
DOI: 10.5281/zenodo.7214802