HEalth data LInkage for ClinicAL benefit

Informazioni relative al progetto

HELICAL

ID dell’accordo di sovvenzione: 813545

DOI 10.3030/813545

Progetto chiuso

Data della firma CE 31 Agosto 2018

Data di avvio 1 Gennaio 2019

Data di completamento 30 Giugno 2023

Finanziato da

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Costo totale € 4 050 338,34

Contributo UE € 4 050 338,34

Coordinato da

THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
Ireland

Risultati finali

Documents, reports (26)

Plan for Exploitation and Dissemination of Results

To guide WP 7 activity

Report on protein composition of EV

ESR 11

Statistical Software Package and Code

ESR 3

Governance framework for research in rare diseases

ESR 15

WP 3 Summary report

Report on WP 3 outputs

Report on suitability of EV as disease marker in AAV

ESR 11

Data Management Plan (DMP)

ESR 15

Report on the analysis of the molecular mechanisms in the context of a human interaction network

ESR 9

WP1 Summary Report

Report on WP1 outputs

Validated / endorsed ethical and governance framework

Report on WP4 outputs

Report describing vasculitis flare prodome

ESR1

Report on development of a multivariate assay for the diagnosis of different forms of vasculitis

ESR 14

Final Report

Final summary of achievements of consortium along with plans for sustainability

Report on clinical evaluation of automated descriptor reading in tissue morphometry

ESR 12

Report summarising key pathways activated in tissue from patients with GCA

ESR 10

Dissemination/Exploitation 2

Report to be the basis of the periodic report

Communication/Public Engagement 2

Report to be the basis of the periodic report

Report on identification of new genetic associations

ESR 8

Dissemination/Exploitation 1

Report to be the basis of the periodic report

WP 2 Report Summary

Report on WP 2 outputs

Report on genetic/epigenetic markers of GCA & related vasculitides

ESR 78

Report on minimal biomarker set for diagnosis of active vasculitis

ESR 14

Report on the role of environment in AAV onset

ESR45

Report on the analysis of the vasculitis associated autoantibody repertoire

KTH

Helical IG policies

ESR 15

Communication/Public Engagement 1

Report to be the basis of the periodic report

Open Research Data Pilot (1)

Open Data research Pilot

ORDP

Pubblicazioni

Non-peer reviewed articles (1)

COVID-19 Pandemic Sets New Clues on the Transmission Pathways in Kawasaki Disease

Autori: Xavier Rodó, Alejandro Fontal
Pubblicato in: JAMA Network Open, Numero 4/4, 2021, Pagina/e e214624, ISSN 2574-3805
Editore: JAMA Network
DOI: 10.1001/jamanetworkopen.2021.4624

Peer reviewed articles (21)

Climatic signatures in the different COVID-19 pandemic waves across both hemispheres

Autori: Alejandro Fontal, Menno J. Bouma, Adrià San-José, Leonardo López, Mercedes Pascual & Xavier Rodó
Pubblicato in: Nature Computational Science, 2021, ISSN 2662-8457
Editore: Springer Nature
DOI: 10.1038/s43588-021-00136-6

DECODE: a computational pipeline to discover T cell receptor binding rules

Autori: Iliana Papadopoulou, An-Phi Nguyen, Anna Weber, María Rodríguez Martínez
Pubblicato in: Bioinformatics, Numero 38, 2022, ISSN 1367-4803
Editore: Oxford University Press
DOI: 10.1093/bioinformatics/btac257

ANCA-associated vasculitis in Ireland: a multi-centre national cohort study

Autori: Jennifer Scott, Eithne Nic an Ríogh , Shamma Al Nokhatha1, Cliona Cowhig, Alyssa Verrelli, Ted Fitzgerald, Arthur White, Cathal Walsh, Louis Aslett, Declan DeFreitas, Michael R. Clarkson, John Holian, Matthew D. Griffin, Niall Conlon , Yvonne O’Meara, Liam Casserly, Eamonn Molloy, Julie Power, Sarah M. Moran, Mark A. Little
Pubblicato in: HRB Open Res, 2022, ISSN 2515-4826
Editore: Research Limited
DOI: 10.12688/hrbopenres.13651.1

Isolation of Small Extracellular Vesicles from Human Sera

Autori: Małgorzata S. Małys, Christof Aigner, Stefan M. Schulz, Helga Schachner, Andrew J. Rees, Renate Kain
Pubblicato in: International Journal of Molecular Sciences, Numero 22/9, 2021, Pagina/e 4653, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22094653

Persisting Salivary IgG Against SARS-CoV-2 at 9 Months After Mild COVID-19: A Complementary Approach to Population Surveys

Autori: Hassan Alkharaan, Shaghayegh Bayati, Cecilia Hellström, Soo Aleman, Annika Olsson, Karin Lindahl, Gordana Bogdanovic, Katie Healy, Georgios Tsilingaridis, Patricia De Palma, Sophia Hober, Anna Månberg, Peter Nilsson, Elisa Pin, Margaret Sällberg Chen
Pubblicato in: The Journal of Infectious Diseases, Numero 224/3, 2021, Pagina/e 407-414, ISSN 0022-1899
Editore: University of Chicago Press
DOI: 10.1093/infdis/jiab256

Benchmarking solutions to the T-cell receptor epitope prediction problem: IMMREP22 workshop report

Autori: Pieter Meysman, Justin Barton, Barbara Bravi, Liel Cohen-Lavi, Vadim Karnaukhov, Elias Lilleskov, Alessandro Montemurro, Morten Nielsen, Thierry Mora, Paul Pereira, Anna Postovskaya, María Rodríguez Martínez, Jorge Fernandez-de-Cossio-Diaz, Alexandra Vujkovic, Aleksandra M. Walczak, Anna Weber, Rose Yin, Anne Eugster, Virag Sharma
Pubblicato in: ImmunoInformatics, Numero Vol 9, 2023, ISSN 2667-1190
Editore: Elsevier
DOI: 10.1016/j.immuno.2023.100024

Evaluating the usability of a semantic environmental health data framework: Approach and study

Autori: Albert Navarro-Gallinad, Fabrizio Orlandi, Jennifer Scott, Mark Little, Declan O'Sullivan
Pubblicato in: Semantic Web, Numero Pre-press, 2022, ISSN 1570-0844
Editore: IOS Press
DOI: 10.3233/sw-223212

Identification of new risk loci shared across systemic vasculitides points towards potential target genes for drug repurposing.

Autori: Lourdes Ortiz-Fernández; Elio G Carmona; Martin Kerick; Paul Lyons; Francisco David Carmona; Raquel López Mejías; Chiea Chuen Khor; Peter C Grayson; Enrico Tombetti; Lindi Jiang; Haner Direskeneli; Guher Saruhan-Direskeneli; José-Luis Callejas-Rubio; Augusto Vaglio; Carlo Salvarani; Jose Hernández-Rodríguez; Maria Cinta Cid; Ann W Morgan; Peter A Merkel; David Burgner; Kenneth GC Smith; Migu
Pubblicato in: Annals of Rheumatic Disease, Numero 1, 2022, ISSN 0003-4967
Editore: BMJ Publishing Group
DOI: 10.1136/ard-2022-223697

On the interpretation of the atmospheric mechanism transporting the environmental trigger of Kawasaki Disease

Autori: Joan Ballester, Sílvia Borràs, Roger Curcoll, Albert Navarro-Gallinad, Sofya Pozdniakova, Lidia Cañas, Jane C. Burns, Xavier Rodó
Pubblicato in: PLOS ONE, Numero 14/12, 2019, Pagina/e e0226402, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0226402

The end of social confinement and COVID-19 re-emergence risk.

Autori: López, Leonardo; Rodó, Xavier
Pubblicato in: Nature Human Behaviour, Numero 2, 2020, ISSN 2397-3374
Editore: Springer Nature Limited
DOI: 10.1038/s41562-020-0908-8

Blocking GM-CSF receptor α with mavrilimumab reduces infiltrating cells, pro-inflammatory markers and neoangiogenesis in ex vivo cultured arteries from patients with giant cell arteritis

Autori: Marc Corbera-Bellalta, Roser Alba-Rovira, Sujatha Muralidharan, Georgina Espígol-Frigolé, Roberto Ríos-Garcés, Javier Marco-Hernández, Amanda Denuc, Farah Kamberovic, Patricia Pérez-Galán, Alexandra Joseph, Annalisa D’Andrea, Kent Bondensgaard, Maria C Cid, John F Paolini
Pubblicato in: Annals of the Rheumatic Diseases, Numero 81/4, 2022, ISSN 0003-4967
Editore: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2021-220873

Methylome and transcriptome profiling of giant cell arteritis monocytes reveals novel pathways involved in disease pathogenesis and molecular response to glucocorticoids

Autori: Elkyn Estupiñán-Moreno, Lourdes Ortiz-Fernández, Tianlu Li, Jose Hernández-Rodríguez, Laura Ciudad, Eduardo Andrés-León, Laura Carmen Terron-Camero, Sergio Prieto-González, Georgina Espígol-Frigolé, Maria Cinta Cid, Ana Márquez, Esteban Ballestar, Javier Martín
Pubblicato in: Annals of the Rheumatic Diseases, Numero 81/9, 2022, ISSN 0003-4967
Editore: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2022-222156

IDENTIFICATION OF NEW RISK LOCI AND PATHWAYS INVOLVED IN GCA PATHOGENESIS BY A GENOME-WIDE STUDY

Autori: G. Borrego-Yaniz, L. Ortiz-Fernández, M. Kerick, A. Madrid-Paredes, A. Vaglio, J. Hernández-Rodríguez, S. Mackie, S. Castañeda, R. Solans-Laqué, J. Mestre, B. Dasgupta, R. Watts, N. Khalidi, C. Langford, S. R. Ytterberg, L. Beretta, M. Govoni, G. Emmi, M. A. Cimmino, T. Witte, T. Neumann, J. Holle, V. Schönau, G. Pugnet, T. Papo, J. Haroche, A. Mahr, L. Mouthon, Ø. Molberg, A. Diamantopoulo
Pubblicato in: Annals of the Rheumatic Diseases, Numero volume 82, supplement 1, year 2023, 2023, Pagina/e page 68, ISSN 0003-4967
Editore: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2023-eular.673

Incidence of giant cell arteritis in six districts of Paris, France (2015–2017)

Autori: Solange Gonzalez Chiappe; Sarah Lechtman; Carla Soledad Maldini; Arsène Mekinian; Thomas Papo; Thomas Sené; Alfred Daniel Mahr
Pubblicato in: Rheumatology International, Numero 42, 2022, ISSN 1437-160X
Editore: Springer
DOI: 10.1007/s00296-022-05167-4

Environmental risk factors associated with ANCA associated vasculitis: A systematic mapping review

Autori: Jennifer Scott, Jack Hartnett, David Mockler, Mark A. Little
Pubblicato in: Autoimmunity Reviews, Numero 19/11, 2020, Pagina/e 102660, ISSN 1568-9972
Editore: Elsevier BV
DOI: 10.1016/j.autrev.2020.102660

Small extracellular vesicles are released ex vivo from platelets into serum and from residual blood cells into stored plasma

Autori: Małgorzata S. Małys, Maximilian C. Köller, Kristin Papp, Christof Aigner, Daffodil Dioso, Patrick Mucher, Helga Schachner, Michael Bonelli, Helmuth Haslacher, Andrew J. Rees, Renate Kain
Pubblicato in: Journal of Extracellular Biology, Numero Vol.2/5, 2023, ISSN 2001-3078
Editore: Wiley in pqrtnership with ISEV
DOI: 10.1002/jex2.88

A Literature Review on the GDPR, COVID-19 and the Ethical Considerations of Data Protection During a Time of Crisis

Autori: Maria Christofidou, Nathan Lea, Pascal Coorevits
Pubblicato in: Yearbook of Medical Informatics, Numero 30/01, 2021, Pagina/e 226-232, ISSN 0943-4747
Editore: Pubmed
DOI: 10.1055/s-0041-1726512

Somatostatin Receptor PET/MR Imaging of Inflammation in Patients With Large Vessel Vasculitis and Atherosclerosis

Autori: Andrej Corovic, Christopher Wall, Meritxell Nus, Deepa Gopalan, Yuan Huang, Maria Imaz, Michal Zulcinski, Marta Peverelli, Anna Uryga, Jordi Lambert, Dario Bressan, Robert T. Maughan, Charis Pericleous, Suraiya Dubash, Natasha Jordan, David R. Jayne, Stephen P. Hoole, Patrick A. Calvert, Andrew F. Dean, Doris Rassl, Tara Barwick, Mark Iles, Mattia Frontini, Greg Hannon, Roido Manavaki, Tim D. Fr
Pubblicato in: Journal of the American College of Cardiology, Numero Vol. 81 No. 4, 2023, ISSN 0735-1097
Editore: Elsevier BV
DOI: 10.1016/j.jacc.2022.10.034

TITAN: T Cell Receptor Specificity Prediction with Bimodal Attention Networks

Autori: Weber, Anna; Born, Jannis; Martínez, María Rodríguez
Pubblicato in: Bioinformatics, Numero 10, 2021, ISSN 1367-4803
Editore: Oxford University Press
DOI: 10.48550/arxiv.2105.03323

Sub-weekly signatures relate ultrafine aerosols enriched in metals from intensive farming and urban pollution to Kawasaki disease

Autori: Xavier Rodó, Albert Navarro-Gallinad, Tomoko Kojima, Josep-Anton Morguí, Silvia Borràs and Alejandro Fontal
Pubblicato in: Environmental Research Letters, Numero Vol.18, n.7, 2023, ISSN 1748-9326
Editore: Institute of Physics Publishing
DOI: 10.1088/1748-9326/acd798

The association between ambient UVB dose and ANCA-associated vasculitis relapse and onset

Autori: Scott, J; Havyarimana, E; Navarro-Gallinad, A; White, A; Wyse, J; van Geffen, J; van Weele, M; Buettner, A; Wanigasekera, T; Walsh, C; Aslett, LJM; Kelleher, JD; Power, J; Ng, J; O’Sullivan, D; Hederman, L; Basu, N; Little, MA; Zgaga, L; , RKD and UKIVAS groups
Pubblicato in: Arthritis Research & Therapy, 2022, Vol.24(1), pp.147 [Peer Reviewed Journal], Numero 13, 2022, ISSN 1478-6362
Editore: Springer Nature
DOI: 10.1186/s13075-022-02834-6

Conference proceedings (3)

Enhancing Rare Disease Research with Semantic Integration of Environmental and Health Data

Autori: Albert Navarro-Gallinad, Fabrizio Orlandi, Declan O'Sullivan
Pubblicato in: IJCKG'21, Numero 10, 2022, Pagina/e 19-27
Editore: Association for Computing Machinery
DOI: 10.1145/3502223.3502226

The Semantic Combining for Exploration of Environmental and Disease Data Dashboard for Clinician Researchers

Autori: Albert Navarro-Gallinad, Alan Meehan, and Declan O’Sullivan
Pubblicato in: VOILA! 2020 Visualization and Interaction for Ontologies and Linked Data 5th International Workshop co-located with ISWC 2020, November 2nd 2020, Virtual Conference, Numero Annual, 2020
Editore: http://ceur-ws.org/

Proceedings of the 20th International Vasculitis and ANCA workshop 3-6th April 2022

Autori: Michael Clarkson; Allyson Egan; Mark A Little
Pubblicato in: Proceedings of the 20th International Vasculitis and ANCA workshop 3-6th April 2022, Numero 8, 2022
Editore: Zenodo
DOI: 10.5281/zenodo.6454077

Thesis and dissertations (3)

A Usable Knowledge Graph Framework for Linking Health Events with Environmental Data

Autori: Navarro Gallinad, Albert
Pubblicato in: 2023
Editore: Trinity College Dublin

Estudio de las causas moleculares de la arteritis de células gigantes mediante una aproximación sistémica

Autori: Estupiñán Moreno, Elkyn Fabián
Pubblicato in: 2023
Editore: University of Granada

Autoantibody profiling in autoimmune diseases

Autori: Shaghayegh Bayati
Pubblicato in: 2023
Editore: KTH

Other (1)

HELICAL Open Research Guidelines

Autori: Christofidou, Maria; Navarro-Gallinad, Albert
Pubblicato in: Numero 3, 2022
Editore: Zenodo
DOI: 10.5281/zenodo.7214802