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HEalth data LInkage for ClinicAL benefit

Description du projet

Former les chercheurs à l’analyse de données à grande échelle

Les chercheurs européens ont contribué de manière significative aux vastes ensembles de données génomiques, transcriptomiques et cliniques recueillis auprès de patients atteints de maladies chroniques. Les progrès réalisés en science de l’information offrent des possibilités d’utilisation accrue de ces ensembles de données. Cependant, peu de chercheurs possèdent les compétences informatiques requises et connaissent les derniers principes de protection des données. Le projet HELICAL, financé par l’UE, développera un programme de formation interdisciplinaire pour 15 étudiants en doctorat. Il utilisera la vascularite auto‑immune comme paradigme pour dispenser une formation à l’analyse des données. Ce programme de formation de 36 mois sera axé sur l’application de l’informatique à ces ensembles de données afin d’acquérir de nouvelles connaissances biologiques, ainsi que sur la traduction des résultats biologiques en résultats cliniques pratiques. Il vise également à développer des stratégies pour gérer les contraintes éthiques imposées à de telles études.

Objectif

European researchers have made leading contributions to the large genomic, transcriptomic and clinical datasets from patients with chronic diseases. Advances in information science provide unprecedented opportunities for using these datasets to elucidate the complex biology of these disorders, its influence by environmental triggers, and to personalise their management. Currently, exploitation of these opportunities is limited by a shortage of researchers with the required informatics skills and knowledge of requisite data protection principles. HELICAL addresses this unmet need by developing a trans-sectoral and interdisciplinary training programme that builds on the expertise and existing collaborations of its partners. It provides 15 early stage researchers with training in analysis of large datasets, using autoimmune vasculitis as a paradigm as it is scalable, and as comprehensive biological and clinical datasets are already available. The HELICAL training program focuses on three complementary areas: application of informatics to such datasets to gain new biological insights; translation of these into practical clinical outputs and management of ethical constraints imposed on such studies. The programme will be delivered through a multidisciplinary, trans-sectoral partnership of Academic and Industry researchers with expertise in basic biomedical research, epidemiology, statistics, machine learning, health data governance and ethics. Therefore, HELICAL exploits recent advances in data science to link research datasets with longitudinal healthcare records, based on the robust ethical foundation required for linkage studies using near-patient data, to address key experimental questions. The results will have obvious potential for transforming healthcare in the field of autoimmune disease. The training provided addresses a key skills gap in the European workforce and should make the ESR eminently employable in academic, industrial and clinical sectors.

Mots‑clés

Coordinateur

THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
Contribution nette de l'UE
€ 675 090,51
Adresse
COLLEGE GREEN TRINITY COLLEGE
D02 CX56 DUBLIN 2
Irlande

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Région
Ireland Eastern and Midland Dublin
Type d’activité
Higher or Secondary Education Establishments
Liens
Coût total
€ 675 090,51

Participants (14)

Partenaires (10)