BestTreat – Building a Gut Microbiome Engineering Toolbox for In-Situ Therapeutic Treatments for Non-alcoholic Fatty Liver Disease

Informazioni relative al progetto

BestTreat

ID dell’accordo di sovvenzione: 813781

DOI

10.3030/813781

Progetto chiuso

Data della firma CE 21 Agosto 2018

Data di avvio 1 Settembre 2018

Data di completamento 31 Agosto 2022

Finanziato da

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Costo totale

€ 4 134 155,76

Contributo UE

€ 4 134 155,76

Coordinato da

LEIBNIZ-INSTITUT FUR NATURSTOFF-FORSCHUNG UND INFEKTIONSBIOLOGIE EV HANS-KNOLL-INSTITUT
Germany

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (2)

Public dissemination of project results after protection (supported on a dissemination strategy)

The due date of this deliverable is throughout the project

Scientific papers published in high-impact journals with results from WP2-WP5

"All beneficiaries are responsible for the deliverable ""Scientific papers published in high-impact journals with results from WP2-WP5"", and this deliverable is linked to all WPs."

Other (3)

Conference organization on Human Host-Microbiome Symbiotic Interactions - photos and materials

Conference organization on Human Host-Microbiome Symbiotic Interactions – photos and materials

Student public engagement presentations
Awards of doctoral degrees

The due date of this deliverable depends on the duration of the PhD degree in each country and it can be extended to 54 months. All Beneficiaries are Lead Beneficiaries for the deliverable.

Websites, patent fillings, videos etc. (3)

Project website
Project social media profiles created and first content published
Development of MOOC on Microbiome Systems Biology - videos and study material

Development of MOOC on Microbiome Systems Biology – videos and study material

Open Research Data Pilot (1)

BestTreat Data Management Plan

Pubblicazioni

Peer reviewed articles (16)

Recent advances in diabetes and microbiota.

Autori: Jia W, Panagiotou G
Pubblicato in: Science Bulletin, Numero 67(17), 2022, Pagina/e 1720-1723, ISSN 2095-9273
Editore: Elsevier
DOI: 10.1016/j.scib.2022.07.027

Decreased Abundance of Akkermansia muciniphila Leads to the Impairment of Insulin Secretion and Glucose Homeostasis in Lean Type 2 Diabetes

Autori: Jing Zhang, Yueqiong Ni, Lingling Qian, Qichen Fang, Tingting Zheng, Mingliang Zhang, Qiongmei Gao, Ying Zhang, Jiacheng Ni, Xuhong Hou, Yuqian Bao, Petia Kovatcheva‐Datchary, Aimin Xu, Huating Li, Gianni Panagiotou, Weiping Jia
Pubblicato in: Advanced Science, 2021, Pagina/e 2100536, ISSN 2198-3844
Editore: Wiley-VCH
DOI: 10.1002/advs.202100536

Identification and Distribution of Sterols, Bile Acids, and Acylcarnitines by LC–MS/MS in Humans, Mice, and Pigs—A Qualitative Analysis.

Autori: Identification and Distribution of Sterols, Bile Acids, and Acylcarnitines by LC–MS/MS in Humans, Mice, and Pigs—A Qualitative Analysis
Pubblicato in: Metabolites, Numero 12(1), 2022, Pagina/e 49, ISSN 2218-1989
Editore: MDPI
DOI: 10.3390/metabo12010049

Role of microbiota and related metabolites in gastrointestinal tract barrier function in NAFLD

Autori: Maria Victoria Fernandez-Cantos, Diego Garcia-Morena, Valeria Iannone, Hani El-Nezami, Marjukka Kolehmainen, Oscar P. Kuipers
Pubblicato in: Tissue Barriers, 2021, Pagina/e 1879719, ISSN 2168-8370
Editore: Tissue Barriers
DOI: 10.1080/21688370.2021.1879719

Tissue-wide metabolomics reveals wide impact of gut microbiota on mice metabolite composition.

Autori: Zarei I, Koistinen V.M, Kokla M, Klåvus A, Babu A.F, Lehtonen M, Auriola S, and Hanhineva K
Pubblicato in: Sci Rep, Numero 12, 2022, Pagina/e 15018, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-022-19327-w

Effects of exercise on NAFLD using non-targeted metabolomics in adipose tissue, plasma, urine, and stool

Autori: Babu AF, Csader S, Männistö V, Tauriainen MM, Pentikäinen H, Savonen K, Klåvus A, Koistinen V, Hanhineva K, Schwab U
Pubblicato in: Sci Rep, Numero 12(1), 2022, Pagina/e 6485, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-022-10481-9

hysical Activity and Dietary Composition Relate to Differences in Gut Microbial Patterns in a Multi-Ethnic Cohort—The HELIUS Study.

Autori: Houttu V, Boulund U, Nicolaou M, Holleboom AG, Grefhorst A, Galenkamp H, van den Born B-J, Zwinderman K, Nieuwdorp M.
Pubblicato in: Metabolies, Numero 11, 2021, Pagina/e 858, ISSN 2218-1989
Editore: MDPI
DOI: 10.3390/metabo11120858

Evaluation of Caco-2 and human intestinal epithelial cells as in vitro models of colonic and small intestinal integrity

Autori: Silvia Lopez-Escalera; Anja Wellejus
Pubblicato in: Biochemistry and Biophysics Reports, Numero 31, 2022, Pagina/e 101314, ISSN 2405-5808
Editore: Elsevier
DOI: 10.1016/j.bbrep.2022.101314

Risk assessment with gut microbiome and metabolite markers in NAFLD development.

Autori: Leung H, Long X, Ni Y, Qian L, Nychas E, Leal Siliceo S, Pohl D, Hanhineva K, Liu Y, Xu A, Nielsen HB, Belda E, Clément K, Loomba R, Li H, Jia W, Panagiotou G
Pubblicato in: Sci Transl Med., Numero 14(648), 2022, Pagina/e eabk0855, ISSN 1946-6234
Editore: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.abk0855

Does aerobic exercise reduce NASH and liver fibrosis in patients with non-alcoholic fatty liver disease? A systematic literature review and meta-analysis.

Autori: Houttu V, Bouts J, Vali Y, Daams J, Grefhorst A, Nieuwdorp M, Holleboom A.G
Pubblicato in: Front. Endocrinol., 2022, ISSN 1664-2392
Editore: Frontiers Media
DOI: 10.3389/fendo.2022.1032164

The role of the gut microbiome and exercise in non-alcoholic fatty liver disease

Autori: Veera Houttu, Ulrika Boulund, Aldo Grefhorst, Maarten R. Soeters, Sara-Joan Pinto-Sietsma, Max Nieuwdorp, Adriaan G. Holleboom
Pubblicato in: Therapeutic Advances in Gastroenterology, Numero 13, 2020, Pagina/e 175628482094174, ISSN 1756-2848
Editore: Therapeutic Advances in Gastroenterology
DOI: 10.1177/1756284820941745

Gut Microbiome Fermentation Determines the Efficacy of Exercise for Diabetes Prevention

Autori: Yan Liu, Yao Wang, Yueqiong Ni, Cynthia K.Y. Cheung, Karen S.L. Lam, Yu Wang, Zhengyuan Xia, Dewei Ye, Jiao Guo, Michael Andrew Tse, Gianni Panagiotou, Aimin Xu
Pubblicato in: Cell Metabolism, Numero 31/1, 2020, Pagina/e 77-91.e5, ISSN 1550-4131
Editore: Cell Press
DOI: 10.1016/j.cmet.2019.11.001

Mining, analyzing, and integrating viral signals from metagenomic data

Autori: Tingting Zheng, Jun Li, Yueqiong Ni, Kang Kang, Maria-Anna Misiakou, Lejla Imamovic, Billy K. C. Chow, Anne A. Rode, Peter Bytzer, Morten Sommer, Gianni Panagiotou
Pubblicato in: Microbiome, Numero 7/1, 2019, ISSN 2049-2618
Editore: Springer Nature
DOI: 10.1186/s40168-019-0657-y

Effects of broad-spectrum antibiotics on the colonisation of probiotic yeast Saccharomyces boulardii in the murine gastrointestinal tract.

Autori: Hedin KA, Rees VE, Zhang H, Vibeke Kruse, Vazquez-Uribe R, Sommer M
Pubblicato in: Sci Rep, Numero 12(1), 2022, Pagina/e 6485, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-022-12806-0

Dietary Interventions in Patients With Non-alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis

Autori: Houttu Veera, Csader Susanne, Nieuwdorp Max, Holleboom Adriaan G., Schwab Ursula
Pubblicato in: Frontiers in Nutrition, 2021, ISSN 2296-861X
Editore: Frontiers
DOI: 10.3389/fnut.2021.716783

Positive Effects of Exercise Intervention without Weight Loss and Dietary Changes in NAFLD-Related Clinical Parameters: A Systematic Review and Meta-Analysis

Autori: Ambrin Farizah Babu, Susanne Csader, Johnson Lok, Carlos Gómez-Gallego, Kati Hanhineva, Hani El-Nezami, Ursula Schwab
Pubblicato in: Nutrients, Numero 13/9, 2021, Pagina/e 3135, ISSN 2072-6643
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu13093135

Other (1)

Can microbiota modulation prevent the development of fatty liver disease?

Autori: Garcia-Morena D, Lok J, Lopez-Escalera S, Fernandez-Cantos M.V, Babu A, Aranzamendi C, El Aidy S, Hanhineva K, El-Nezamy H, Kuipers O.P, and Wellejus A
Pubblicato in: Project Repository Journal, Numero 14, 2022, Pagina/e 66-69, ISSN 2632-4067
Editore: EDMA
DOI: 10.54050/prj1419178