Descripción del proyecto
Modelos avanzados «in vitro» de trastornos neurológicos
La creciente prevalencia y el deterioro a largo plazo de los trastornos neurológicos, como las enfermedades de Parkinson y Alzheimer, requieren tratamientos novedosos. Sin embargo, esto ha tenido un éxito limitado debido a la falta de modelos de enfermedad apropiados. El objetivo del proyecto ASCTN-Training, financiado con fondos europeos, es formar a jóvenes investigadores en la construcción de modelos robustos «in vitro» para estudiar los mecanismos de los trastornos neurológicos. Las actividades de investigación incluyen el diseño y la optimización de organoides tridimensionales basados en células madre y tecnologías de cerebro en un chip que reproducen circuitos encefálicos «in vitro». El trabajo contribuirá a una mejor comprensión de los trastornos neurológicos y se espera que acelere los trabajos de descubrimiento de fármacos.
Objetivo
Neuronal disorders (NDs) are associated with behavioural and cognitive impairments and have a high prevalence. As such they are a high emotional, financial and social burden on the patients and their social network.
To reduce the impact of NDs new scientific technologies and disease models must be developed, and specialized professionals are needed.
The primary aim of ASCTN-Training is to provide the appropriate training for the participating ESRs, so that each individual ESR will complete a PhD degree based on their research work, while at the same time equipping them with the necessary tools to collaborate and develop innovative technologies for the modeling of NDs and the development of novel therapies
ASCTN-Training consists of six closely interlinked Work Packages (WPs), the central theme – techniques for modeling neuronal disorders - will be executed through scientific WPs 1-3 – biotechnology, molecular neurobiology and preclinical studies - where individual ESRs will be trained together across multiple scientific disciplines. Training will be achieved using the different didactic methods in WP4 – education and training - to enable efficient work on each ESR project as well as in joint efforts with other ESRs both within and across WPs1-3.
Each ESR project is directly or indirectly linked to other ESR projects and contributes various parts to the different scientific WPs, which in turn will make a large contribution to the completion of the scientific deliverables.
The education, training and industrial secondments will provide ESRs with training in both individual scientific disciplines and inter-disciplinary fields. This approach will provide ESRs with the transferrable inter-sectorial skills and tools that will prepare them for innovative thinking and true inter-disciplinary work.
Communication, dissemination and exploitation of the results that are obtained will be achieved through WP5 while ASCTN-Training as a whole will be managed through WP6.
Ámbito científico
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Régimen de financiación
MSCA-ITN - Marie Skłodowska-Curie Innovative Training Networks (ITN)Coordinador
08007 Barcelona
España