Description du projet
Modèles in vitro avancés des troubles neurologiques
La prévalence croissante et les déficiences à long terme causées par les troubles neurologiques tels que les maladies de Parkinson et d’Alzheimer nécessitent de nouveaux traitements. Toutefois, la recherche dans ce domaine n’a connu qu’un succès limité en raison de l’absence de modèles de maladie appropriés. La mission du projet ASCTN-Training, financé par l’UE, est de former de jeunes chercheurs à la construction de modèles in vitro robustes pour étudier les mécanismes des troubles neurologiques. Les activités de recherche comprennent la conception et l’optimisation d’organoïdes 3D à base de cellules souches et de technologies de cerveau sur puce qui reproduisent les circuits cérébraux in vitro. Ces travaux contribueront à une meilleure compréhension des troubles neurologiques et devraient accélérer les efforts de découverte de médicaments.
Objectif
Neuronal disorders (NDs) are associated with behavioural and cognitive impairments and have a high prevalence. As such they are a high emotional, financial and social burden on the patients and their social network.
To reduce the impact of NDs new scientific technologies and disease models must be developed, and specialized professionals are needed.
The primary aim of ASCTN-Training is to provide the appropriate training for the participating ESRs, so that each individual ESR will complete a PhD degree based on their research work, while at the same time equipping them with the necessary tools to collaborate and develop innovative technologies for the modeling of NDs and the development of novel therapies
ASCTN-Training consists of six closely interlinked Work Packages (WPs), the central theme – techniques for modeling neuronal disorders - will be executed through scientific WPs 1-3 – biotechnology, molecular neurobiology and preclinical studies - where individual ESRs will be trained together across multiple scientific disciplines. Training will be achieved using the different didactic methods in WP4 – education and training - to enable efficient work on each ESR project as well as in joint efforts with other ESRs both within and across WPs1-3.
Each ESR project is directly or indirectly linked to other ESR projects and contributes various parts to the different scientific WPs, which in turn will make a large contribution to the completion of the scientific deliverables.
The education, training and industrial secondments will provide ESRs with training in both individual scientific disciplines and inter-disciplinary fields. This approach will provide ESRs with the transferrable inter-sectorial skills and tools that will prepare them for innovative thinking and true inter-disciplinary work.
Communication, dissemination and exploitation of the results that are obtained will be achieved through WP5 while ASCTN-Training as a whole will be managed through WP6.
Champ scientifique
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MSCA-ITN - Marie Skłodowska-Curie Innovative Training Networks (ITN)Coordinateur
08007 Barcelona
Espagne