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CORDIS - Resultados de investigaciones de la UE
CORDIS

Synaptic Dysfunction in Neuropsychiatric Disorders

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Characterization of the synaptic and neural correlates of spatial memory deficits in a glycine receptor knock-out model of ASD (se abrirá en una nueva ventana)

Presentation of scientific data in peerreviewed manuscript

PhD Theses (WP2) (se abrirá en una nueva ventana)

Five PhD Theses

Report on network school 1 (NS1) (se abrirá en una nueva ventana)

Report will be produced after the network school 1, indicating the activities and summaries of the different lectures/laboratory activities.

Characterization of cortical excitation/inhibition imbalance in vivo in models of synaptic dysfunction using mesoscopic methods (se abrirá en una nueva ventana)

Presentation of scientific data in peerreviewed manuscript

PhD Theses (WP1) (se abrirá en una nueva ventana)

Three PhD Theses

Identification of the role of the excitation/inhibition (E/I) imbalance in the cortico-thalamic system in the development of neuropsychiatric disorders (se abrirá en una nueva ventana)

Presentation of scientific data in peerreviewed manuscript

Report on network school 2 (NS2) (se abrirá en una nueva ventana)

Report will be produced after the network school 2 indicating the activities and summaries of the different lectureslaboratory activities

Identification of presynaptic defects and alterations in glutamate receptor dynamics in Fragile X syndrome (se abrirá en una nueva ventana)

Presentation of scientific data in peerreviewed manuscript

Oral/ Poster presentations in international scientific meetings (WP3) (se abrirá en una nueva ventana)

Presentation of scientific data in a scientific meetings as oral communications b scientific meetings as poster presentations

Identification of circuit deficits associated with ASD (se abrirá en una nueva ventana)

Presentation of scientific data in peerreviewed manuscript

Development and characterization of human-derived neurons and brain organoids as models of neurodevelopmental disorders (se abrirá en una nueva ventana)

Presentation of scientific data in peerreviewed manuscript

Establishment of the impact of the corticotropic releasing hormone system on schizophrenia- and ASD-related endophenotype (se abrirá en una nueva ventana)

Presentation of scientific data in peerreviewed manuscript

Oral/ Poster presentations in international scientific meetings (WP2) (se abrirá en una nueva ventana)

Presentation of scientific data in a scientific meetings as oral communications b scientific meetings as poster presentations

Identification of the role of specific mitochondrial genes for the development of psychopathologies (se abrirá en una nueva ventana)

Presentation of scientific data in peerreviewed manuscript

Depiction of synapses and functional networks in a new paradigm to model Down syndrome (human iPSC-derived neurons from DS donors transplanted in the mouse brain) (se abrirá en una nueva ventana)

Presentation of scientific data in peerreviewed manuscript

Report on network school 3 (NS3) (se abrirá en una nueva ventana)

Report will be produced after the network school 3 indicating the activities and summaries of the different lectureslaboratory activities

Public media dissemination (se abrirá en una nueva ventana)

We expect that several deliverables will be produced based on press reports focusing on particular aspects of the Syn2Psy research programme. We expect that media outlets will pick up the press releases and perform media articles, including interviews with involved scientists and ESRs.

Definition of the therapeutic potential of the endocannabinoid system in an ASD model (se abrirá en una nueva ventana)

Presentation of scientific data in peerreviewed manuscript

Report on outreach & public engagement (se abrirá en una nueva ventana)

A final outreach report containing a description of all outreach initiatives with feedback from the public appropriate metrics photos and adicional videos will be prepared by month 48

Report on network school 4 (NS4) (se abrirá en una nueva ventana)

Report will be produced after the network school 4 indicating the activities and summaries of the different lectureslaboratory activities

Identification of defects in single NMDA receptor dynamics in psychosis (se abrirá en una nueva ventana)

Presentation of scientific data in peerreviewed manuscript

Oral/ Poster presentations in international scientific meetings (WP1) (se abrirá en una nueva ventana)

Presentation of scientific data in a scientific meetings as oral communications b scientific meetings as poster presentations

Establishment of the role of stargazin in psychiatric disorders; development of targeted therapies (se abrirá en una nueva ventana)

Presentation of scientific data in a peerreviewed manuscript

Identification of aberrant synaptic mRNA translation as a point of convergence for multiple genetic causes of ASD/ID (se abrirá en una nueva ventana)

Presentation of scientific data in peerreviewed manuscript

PhD Theses (WP3) (se abrirá en una nueva ventana)

Five PhD Theses

Theatre (se abrirá en una nueva ventana)

Theatre play written and interpreted by the ESRs in collaboration with the Marionet theatre company.

Final Conference (se abrirá en una nueva ventana)

Final project conference.

Syn2Psy public website (se abrirá en una nueva ventana)

A public website will be prepared, open to the general public and demonstrating the general activities of the consortium, plus scientific data originating from the programme, biographies from the involved reserachers, important links, etc.

Publicaciones

Gating small conductance calcium‐activated potassium channels in the thalamic reticular nucleus (se abrirá en una nueva ventana)

Autores: Ágata Silván, Kristi Anne Kohlmeier, Kjartan Frisch Herrik, Charlotte Hougaard
Publicado en: Synapse, 2023, ISSN 1098-2396
Editor: Wiley Periodicals, LLC.
DOI: 10.1002/syn.22283

Generation and Characterization of Novel iPSC Lines from a Portuguese Family Bearing Heterozygous and Homozygous GRN Mutations (se abrirá en una nueva ventana)

Autores: Ana Rafaela Oliveira, Solange Martins, Giuseppe Cammarata, Mariana Martins, Ana Maria Cardoso, Maria Rosário Almeida, Maria do Carmo Macário, Isabel Santana, João Peça and Ana Luísa Cardoso.
Publicado en: Biomedicines, 2022, ISSN 2227-9059
Editor: MDPI
DOI: 10.3390/biomedicines10081905

Autoimmunity and NMDA receptor in brain disorders: Where do we stand? (se abrirá en una nueva ventana)

Autores: Daniel Hunter, Zoe Jamet, Laurent Groc
Publicado en: Neurobiology of Disease, Edición 147, 2021, Página(s) 105161, ISSN 0969-9961
Editor: Academic Press
DOI: 10.1016/j.nbd.2020.105161

The role of post-translational modifications in synaptic AMPA receptor activity (se abrirá en una nueva ventana)

Autores: Elisa Corti, Carlos B. Duarte.
Publicado en: Biochemical Society Transactions, 2023, ISSN 1470-8752
Editor: Portland Press, Ltd.
DOI: 10.1042/bst20220827

Mitofusin-2 in nucleus accumbens D2-MSNs regulates social dominance and neuronal function (se abrirá en una nueva ventana)

Autores: Sriparna Ghosal, Elias Gebara, Eva Ramos-Fernández, Alessandro Chioino, Jocelyn Grosse , Isabelle Guillot de Suduiraut, Olivia Zanoletti, Bernard Schneider, Antonio Zorzano, Simone Astori, Carmen Sandi.
Publicado en: Cell Reports, 2023, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2023.112776

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