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CORDIS - Forschungsergebnisse der EU
CORDIS

Synaptic Dysfunction in Neuropsychiatric Disorders

CORDIS bietet Links zu öffentlichen Ergebnissen und Veröffentlichungen von HORIZONT-Projekten.

Links zu Ergebnissen und Veröffentlichungen von RP7-Projekten sowie Links zu einigen Typen spezifischer Ergebnisse wie Datensätzen und Software werden dynamisch von OpenAIRE abgerufen.

Leistungen

Characterization of the synaptic and neural correlates of spatial memory deficits in a glycine receptor knock-out model of ASD (öffnet in neuem Fenster)

Presentation of scientific data in peerreviewed manuscript

PhD Theses (WP2) (öffnet in neuem Fenster)

Five PhD Theses

Report on network school 1 (NS1) (öffnet in neuem Fenster)

Report will be produced after the network school 1, indicating the activities and summaries of the different lectures/laboratory activities.

Characterization of cortical excitation/inhibition imbalance in vivo in models of synaptic dysfunction using mesoscopic methods (öffnet in neuem Fenster)

Presentation of scientific data in peerreviewed manuscript

PhD Theses (WP1) (öffnet in neuem Fenster)

Three PhD Theses

Identification of the role of the excitation/inhibition (E/I) imbalance in the cortico-thalamic system in the development of neuropsychiatric disorders (öffnet in neuem Fenster)

Presentation of scientific data in peerreviewed manuscript

Report on network school 2 (NS2) (öffnet in neuem Fenster)

Report will be produced after the network school 2 indicating the activities and summaries of the different lectureslaboratory activities

Identification of presynaptic defects and alterations in glutamate receptor dynamics in Fragile X syndrome (öffnet in neuem Fenster)

Presentation of scientific data in peerreviewed manuscript

Oral/ Poster presentations in international scientific meetings (WP3) (öffnet in neuem Fenster)

Presentation of scientific data in a scientific meetings as oral communications b scientific meetings as poster presentations

Identification of circuit deficits associated with ASD (öffnet in neuem Fenster)

Presentation of scientific data in peerreviewed manuscript

Development and characterization of human-derived neurons and brain organoids as models of neurodevelopmental disorders (öffnet in neuem Fenster)

Presentation of scientific data in peerreviewed manuscript

Establishment of the impact of the corticotropic releasing hormone system on schizophrenia- and ASD-related endophenotype (öffnet in neuem Fenster)

Presentation of scientific data in peerreviewed manuscript

Oral/ Poster presentations in international scientific meetings (WP2) (öffnet in neuem Fenster)

Presentation of scientific data in a scientific meetings as oral communications b scientific meetings as poster presentations

Identification of the role of specific mitochondrial genes for the development of psychopathologies (öffnet in neuem Fenster)

Presentation of scientific data in peerreviewed manuscript

Depiction of synapses and functional networks in a new paradigm to model Down syndrome (human iPSC-derived neurons from DS donors transplanted in the mouse brain) (öffnet in neuem Fenster)

Presentation of scientific data in peerreviewed manuscript

Report on network school 3 (NS3) (öffnet in neuem Fenster)

Report will be produced after the network school 3 indicating the activities and summaries of the different lectureslaboratory activities

Public media dissemination (öffnet in neuem Fenster)

We expect that several deliverables will be produced based on press reports focusing on particular aspects of the Syn2Psy research programme. We expect that media outlets will pick up the press releases and perform media articles, including interviews with involved scientists and ESRs.

Definition of the therapeutic potential of the endocannabinoid system in an ASD model (öffnet in neuem Fenster)

Presentation of scientific data in peerreviewed manuscript

Report on outreach & public engagement (öffnet in neuem Fenster)

A final outreach report containing a description of all outreach initiatives with feedback from the public appropriate metrics photos and adicional videos will be prepared by month 48

Report on network school 4 (NS4) (öffnet in neuem Fenster)

Report will be produced after the network school 4 indicating the activities and summaries of the different lectureslaboratory activities

Identification of defects in single NMDA receptor dynamics in psychosis (öffnet in neuem Fenster)

Presentation of scientific data in peerreviewed manuscript

Oral/ Poster presentations in international scientific meetings (WP1) (öffnet in neuem Fenster)

Presentation of scientific data in a scientific meetings as oral communications b scientific meetings as poster presentations

Establishment of the role of stargazin in psychiatric disorders; development of targeted therapies (öffnet in neuem Fenster)

Presentation of scientific data in a peerreviewed manuscript

Identification of aberrant synaptic mRNA translation as a point of convergence for multiple genetic causes of ASD/ID (öffnet in neuem Fenster)

Presentation of scientific data in peerreviewed manuscript

PhD Theses (WP3) (öffnet in neuem Fenster)

Five PhD Theses

Theatre (öffnet in neuem Fenster)

Theatre play written and interpreted by the ESRs in collaboration with the Marionet theatre company.

Final Conference (öffnet in neuem Fenster)

Final project conference.

Syn2Psy public website (öffnet in neuem Fenster)

A public website will be prepared, open to the general public and demonstrating the general activities of the consortium, plus scientific data originating from the programme, biographies from the involved reserachers, important links, etc.

Veröffentlichungen

Gating small conductance calcium‐activated potassium channels in the thalamic reticular nucleus (öffnet in neuem Fenster)

Autoren: Ágata Silván, Kristi Anne Kohlmeier, Kjartan Frisch Herrik, Charlotte Hougaard
Veröffentlicht in: Synapse, 2023, ISSN 1098-2396
Herausgeber: Wiley Periodicals, LLC.
DOI: 10.1002/syn.22283

Generation and Characterization of Novel iPSC Lines from a Portuguese Family Bearing Heterozygous and Homozygous GRN Mutations (öffnet in neuem Fenster)

Autoren: Ana Rafaela Oliveira, Solange Martins, Giuseppe Cammarata, Mariana Martins, Ana Maria Cardoso, Maria Rosário Almeida, Maria do Carmo Macário, Isabel Santana, João Peça and Ana Luísa Cardoso.
Veröffentlicht in: Biomedicines, 2022, ISSN 2227-9059
Herausgeber: MDPI
DOI: 10.3390/biomedicines10081905

Autoimmunity and NMDA receptor in brain disorders: Where do we stand? (öffnet in neuem Fenster)

Autoren: Daniel Hunter, Zoe Jamet, Laurent Groc
Veröffentlicht in: Neurobiology of Disease, Ausgabe 147, 2021, Seite(n) 105161, ISSN 0969-9961
Herausgeber: Academic Press
DOI: 10.1016/j.nbd.2020.105161

The role of post-translational modifications in synaptic AMPA receptor activity (öffnet in neuem Fenster)

Autoren: Elisa Corti, Carlos B. Duarte.
Veröffentlicht in: Biochemical Society Transactions, 2023, ISSN 1470-8752
Herausgeber: Portland Press, Ltd.
DOI: 10.1042/bst20220827

Mitofusin-2 in nucleus accumbens D2-MSNs regulates social dominance and neuronal function (öffnet in neuem Fenster)

Autoren: Sriparna Ghosal, Elias Gebara, Eva Ramos-Fernández, Alessandro Chioino, Jocelyn Grosse , Isabelle Guillot de Suduiraut, Olivia Zanoletti, Bernard Schneider, Antonio Zorzano, Simone Astori, Carmen Sandi.
Veröffentlicht in: Cell Reports, 2023, ISSN 2211-1247
Herausgeber: Cell Press
DOI: 10.1016/j.celrep.2023.112776

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