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CORDIS - Risultati della ricerca dell’UE
CORDIS

Synaptic Dysfunction in Neuropsychiatric Disorders

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Characterization of the synaptic and neural correlates of spatial memory deficits in a glycine receptor knock-out model of ASD (si apre in una nuova finestra)

Presentation of scientific data in peerreviewed manuscript

PhD Theses (WP2) (si apre in una nuova finestra)

Five PhD Theses

Report on network school 1 (NS1) (si apre in una nuova finestra)

Report will be produced after the network school 1, indicating the activities and summaries of the different lectures/laboratory activities.

Characterization of cortical excitation/inhibition imbalance in vivo in models of synaptic dysfunction using mesoscopic methods (si apre in una nuova finestra)

Presentation of scientific data in peerreviewed manuscript

PhD Theses (WP1) (si apre in una nuova finestra)

Three PhD Theses

Identification of the role of the excitation/inhibition (E/I) imbalance in the cortico-thalamic system in the development of neuropsychiatric disorders (si apre in una nuova finestra)

Presentation of scientific data in peerreviewed manuscript

Report on network school 2 (NS2) (si apre in una nuova finestra)

Report will be produced after the network school 2 indicating the activities and summaries of the different lectureslaboratory activities

Identification of presynaptic defects and alterations in glutamate receptor dynamics in Fragile X syndrome (si apre in una nuova finestra)

Presentation of scientific data in peerreviewed manuscript

Oral/ Poster presentations in international scientific meetings (WP3) (si apre in una nuova finestra)

Presentation of scientific data in a scientific meetings as oral communications b scientific meetings as poster presentations

Identification of circuit deficits associated with ASD (si apre in una nuova finestra)

Presentation of scientific data in peerreviewed manuscript

Development and characterization of human-derived neurons and brain organoids as models of neurodevelopmental disorders (si apre in una nuova finestra)

Presentation of scientific data in peerreviewed manuscript

Establishment of the impact of the corticotropic releasing hormone system on schizophrenia- and ASD-related endophenotype (si apre in una nuova finestra)

Presentation of scientific data in peerreviewed manuscript

Oral/ Poster presentations in international scientific meetings (WP2) (si apre in una nuova finestra)

Presentation of scientific data in a scientific meetings as oral communications b scientific meetings as poster presentations

Identification of the role of specific mitochondrial genes for the development of psychopathologies (si apre in una nuova finestra)

Presentation of scientific data in peerreviewed manuscript

Depiction of synapses and functional networks in a new paradigm to model Down syndrome (human iPSC-derived neurons from DS donors transplanted in the mouse brain) (si apre in una nuova finestra)

Presentation of scientific data in peerreviewed manuscript

Report on network school 3 (NS3) (si apre in una nuova finestra)

Report will be produced after the network school 3 indicating the activities and summaries of the different lectureslaboratory activities

Public media dissemination (si apre in una nuova finestra)

We expect that several deliverables will be produced based on press reports focusing on particular aspects of the Syn2Psy research programme. We expect that media outlets will pick up the press releases and perform media articles, including interviews with involved scientists and ESRs.

Definition of the therapeutic potential of the endocannabinoid system in an ASD model (si apre in una nuova finestra)

Presentation of scientific data in peerreviewed manuscript

Report on outreach & public engagement (si apre in una nuova finestra)

A final outreach report containing a description of all outreach initiatives with feedback from the public appropriate metrics photos and adicional videos will be prepared by month 48

Report on network school 4 (NS4) (si apre in una nuova finestra)

Report will be produced after the network school 4 indicating the activities and summaries of the different lectureslaboratory activities

Identification of defects in single NMDA receptor dynamics in psychosis (si apre in una nuova finestra)

Presentation of scientific data in peerreviewed manuscript

Oral/ Poster presentations in international scientific meetings (WP1) (si apre in una nuova finestra)

Presentation of scientific data in a scientific meetings as oral communications b scientific meetings as poster presentations

Establishment of the role of stargazin in psychiatric disorders; development of targeted therapies (si apre in una nuova finestra)

Presentation of scientific data in a peerreviewed manuscript

Identification of aberrant synaptic mRNA translation as a point of convergence for multiple genetic causes of ASD/ID (si apre in una nuova finestra)

Presentation of scientific data in peerreviewed manuscript

PhD Theses (WP3) (si apre in una nuova finestra)

Five PhD Theses

Theatre (si apre in una nuova finestra)

Theatre play written and interpreted by the ESRs in collaboration with the Marionet theatre company.

Final Conference (si apre in una nuova finestra)

Final project conference.

Syn2Psy public website (si apre in una nuova finestra)

A public website will be prepared, open to the general public and demonstrating the general activities of the consortium, plus scientific data originating from the programme, biographies from the involved reserachers, important links, etc.

Pubblicazioni

Gating small conductance calcium‐activated potassium channels in the thalamic reticular nucleus (si apre in una nuova finestra)

Autori: Ágata Silván, Kristi Anne Kohlmeier, Kjartan Frisch Herrik, Charlotte Hougaard
Pubblicato in: Synapse, 2023, ISSN 1098-2396
Editore: Wiley Periodicals, LLC.
DOI: 10.1002/syn.22283

Generation and Characterization of Novel iPSC Lines from a Portuguese Family Bearing Heterozygous and Homozygous GRN Mutations (si apre in una nuova finestra)

Autori: Ana Rafaela Oliveira, Solange Martins, Giuseppe Cammarata, Mariana Martins, Ana Maria Cardoso, Maria Rosário Almeida, Maria do Carmo Macário, Isabel Santana, João Peça and Ana Luísa Cardoso.
Pubblicato in: Biomedicines, 2022, ISSN 2227-9059
Editore: MDPI
DOI: 10.3390/biomedicines10081905

Autoimmunity and NMDA receptor in brain disorders: Where do we stand? (si apre in una nuova finestra)

Autori: Daniel Hunter, Zoe Jamet, Laurent Groc
Pubblicato in: Neurobiology of Disease, Numero 147, 2021, Pagina/e 105161, ISSN 0969-9961
Editore: Academic Press
DOI: 10.1016/j.nbd.2020.105161

The role of post-translational modifications in synaptic AMPA receptor activity (si apre in una nuova finestra)

Autori: Elisa Corti, Carlos B. Duarte.
Pubblicato in: Biochemical Society Transactions, 2023, ISSN 1470-8752
Editore: Portland Press, Ltd.
DOI: 10.1042/bst20220827

Mitofusin-2 in nucleus accumbens D2-MSNs regulates social dominance and neuronal function (si apre in una nuova finestra)

Autori: Sriparna Ghosal, Elias Gebara, Eva Ramos-Fernández, Alessandro Chioino, Jocelyn Grosse , Isabelle Guillot de Suduiraut, Olivia Zanoletti, Bernard Schneider, Antonio Zorzano, Simone Astori, Carmen Sandi.
Pubblicato in: Cell Reports, 2023, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2023.112776

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