Establishing a Nanotechnology Risk Governance Framework

Risultati finali

Report on the verification of the models
Detailed text modules outlining initiative on how the RGF and NRGC can function in relation to the international stakeholders' requirements.

Detailed text modules outlining initiative on how the RGF and NRGC can function in relation to the international stakeholders requirements

Development of an Organisational Form for Nanotechnology Risk Governance (NRGOF) in the context of present policy goals (joint deliverable G4N-D5.5 –T5.3)

Development of an Organisational Form for Nanotechnology Risk Governance NRGOF in the context of present policy goals joint deliverable G4ND55 T53

Evaluation of the identified governance tools for their inclusion in the RGF
Publication on economic benefits from implementing the RGF, based on case studies.

Publication on economic benefits from implementing the RGF based on case studies

1st. virtual Conference and proceedings

1st virtual Conference and proceedings

Report: Case study on TiO2

Report Case study on TiO2

Options for the harmonization of existing international standards and guidelines with for integrating new risk governance tools
Mandate, composition and structure of NRGC

Mandate composition and structure of NRGC

Inventory of effective organizational forms in support of CSS.

Inventory of effective organizational forms in support of CSS

Integrative prospective on user / stakeholder needs

Integrative prospective on user stakeholder needs

Report: Case study on the impact of the RGF in Dutch industries

Report Case study on the impact of the RGF in Dutch industries

Detailed list of how the RGF has contributed to ongoing international activities, including. Brochures, webinares targeted the global audience

Detailed list of how the RGF has contributed to ongoing international activities including Brochures webinares targeted the global audience

List of contributions to EU, EU-US, ISO/CEN and OECD on TG and standardization.

List of contributions to EU EUUS ISOCEN and OECD on TG and standardization

Report on how to integrate views and needs from insurers and expectations from stakeholders regarding role from insurance
Report on multidisciplinary and multi-stakeholder dialogue

Report of the integration of NRGC with social sciences and humanities

Potential mandate, composition and structure of NRGC
Report: Case study on setting up a workplace

Report Case study on setting up a workplace

The NANORIGO database
Report: Case study on risk management

Report Case study on risk management

Report outlining the compliance of the performance and RGF tools with legislation
Training materials for students, early stage researchers and experts

Training materials for students early stage researchers and experts

Final report on dissemination and engagement activities.

Final report on dissemination and engagement activities

Report: Case study on training

Report Case study on training

Virtual NRGC workshop no.2 and proceedings

Webinar for NRGC workshop for Global Partners

Virtual NRGC workshop no.1 and proceedings

Intermediate report on all case studies, produced as a video combined with factsheets

Intermediate report on all case studies produced as a video combined with factsheets

Multimedia presentation on results of the case studies

Website and social media presence.

Pubblicazioni

Defining Quality Criteria for Nanoplastic Hazard Evaluation: The Case of Polystyrene Nanoplastics and Aquatic Invertebrate Daphnia spp.

Autori: Jemec Kokalj, Anita; Heinlaan, Margit; Novak, Sara; Drobne, Damjana; Kühnel, Dana
Pubblicato in: Nanomaterials, Numero 1, 2023, ISSN 2079-4991
Editore: Basel MDPI AG 2011-
DOI: 10.3390/nano13030536

The Impact of Nanoparticles on Innate Immune Activation by Live Bacteria.

Autori: Benjamin J, Swartzwelter; Alexandra C, Fux; Litty, Johnson; Elmer, Swart; Sabine, Hofer; Norbert, Hofstätter; Mark, Geppert; Paola, Italiani; Diana, Boraschi; Albert, Duschl; Martin, Himly
Pubblicato in: International Journal of Molecular Sciences, Vol 21, Iss 9695, p 9695 (2020), 2020, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21249695

Children’s Privilege in COVID-19: The Protective Role of the Juvenile Lung Morphometry and Ventilatory Pattern on Airborne SARS-CoV-2 Transmission to Respiratory Epithelial Barriers and Disease Severity

Autori: Hofstätter Norbert, Sabine Hofer, Albert Duschl, and Martin Himly
Pubblicato in: Biomedicines, Numero 2021-10-08, 9, 1414, 2021, ISSN 2227-9059
Editore: MDPI
DOI: 10.3390/biomedicines9101414

Plastic pollution – A case study with Enchytraeus crypticus – From micro-to nanoplastics

Autori: M.J.B. Amorim, J.J. Scott-fordsmand
Pubblicato in: Environmental Pollution -Elsevier, 2021, Pagina/e 116363, ISSN 0269-7491
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.envpol.2020.116363

SARS-CoV-2-Laden Respiratory Aerosol Deposition in the Lung Alveolar-Interstitial Region Is a Potential Risk Factor for Severe Disease: A Modeling Study

Autori: Hofer, S.; Hofstätter, N.; Duschl, A.; Himly Martin,
Pubblicato in: Journal of Personalized Medicine, 2021, Pagina/e 2021-05-19, 11,431, ISSN 2075-4426
Editore: MDPI
DOI: 10.3390/jpm11050431

Iron Oxide Nanoparticles in Bioimaging – An Immune Perspective

Autori: Mark Gppert and Martin Himly
Pubblicato in: Frontiers in Immunology, 2021, ISSN 1664-3224
Editore: Lausanne Frontiers Media S.A. 2010-
DOI: 10.3389/fimmu.2021.688927

Alternative test methods for (nano)materials hazards assessment: Challenges and recommendations for regulatory preparedness

Autori: Susana I.L.Gomes, Janeck J.Scott-Fordsmand , Monica J.B.Amorima
Pubblicato in: Elsevier, 2021, ISSN 1748-0132
Editore: Elsevier BV
DOI: 10.1016/j.nantod.2021.101242

Tyre wear nanoparticles as test for a nano risk governance framework.

Autori: van Broekhuizen P., Säämänen A., Schuurbiers D., Isigonis P., Jensen K.A., Kühnel D. and Le Blansch K.
Pubblicato in: Frontiers in Environmental Sciences, Numero 12 December 2022, vol 10, 2022, ISSN 2296-665X
Editore: Frontiers
DOI: 10.3389/fenvs.2022.1045246

Metadata stewardship in nanosafety research: Community-driven organisation of metadata schemas to support FAIR nanoscience data

Autori: """Anastasios G Papadiamantis, Frederick C Klaessig, Thomas E Exner, Sabine Hofer, Norbert Hofstaetter, Martin Himly, Marc A Williams, Philip Doganis, Mark D Hoover, Antreas Afantitis, Georgia Melagraki, Tracy S Nolan, John Rumble, Dieter Maier, Iseult Lynch"""
Pubblicato in: Nanomaterials, 2020, ISSN 2079-4991
Editore: MDPI
DOI: 10.3390/nano10102033

Ecotoxicological and Regulatory Aspects of Environmental Sustainability of Nanopesticides

Autori: R. Grillo, L.F. Fraceto, M.J.B. Amorim, J.J. Scott-Fordsmand, R. Schoonjans, Q. Chaudhry
Pubblicato in: Journal of Hazardous Materials, 2021, Pagina/e 124148, ISSN 1873-3336
Editore: Elsevier
DOI: 10.1016/j.jhazmat.2020.124148

Microbial Population Dynamics in Model Sewage Treatment Plants and the Fate and Effect of Gold Nanoparticles

Autori: Schlich, K.; Díaz, C.; Gomez Pizarro, B.; Knopf, B.; Schlinkert, R.; Wege, F.F.; Jurack, A.; Hund-Rinke, K.
Pubblicato in: Toxics, 2021, Pagina/e 2021-3-10; 9, 54, ISSN 2305-6304
Editore: MDPI
DOI: 10.3390/toxics9030054

"""Immunotoxicity of nanomaterials in health and disease: Current challenges and emerging approaches for identifying immune modifiers in susceptible populations"""

Autori: Sabine Hofer, Norbert Hofstätter, Benjamin Punz, Ingrid Hasenkopf, Litty Johnson, Martin Himly
Pubblicato in: WIREs Nanomedicine and Nanobiotechnology, 2022, ISSN 1939-0041
Editore: John Wiley & Sons Inc.
DOI: 10.1002/wnan.1804

When Would Immunologists Consider a Nanomaterial to be Safe? Recommendations for Planning Studies on Nanosafety

Autori: Martin Himly, Mark Geppert, Sabine Hofer, Norbert Hofstätter, Jutta Horejs‐Höck, Albert Duschl
Pubblicato in: Small, Numero 16/21, 2020, Pagina/e 1907483, ISSN 1613-6810
Editore: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.201907483

In vitro-based human toxicity effect factors: challenges and opportunities for nanomaterial impact assessment

Autori: D. Romeo, R. Hischier, B. Nowack, O. Jolliet, P. Fantke, P. Wick
Pubblicato in: Environmental Science: nano, 2022, Pagina/e 1913-1925, ISSN 2051-8161
Editore: Royal Society of Chemistry
DOI: 10.1039/d1en01014j

Systems toxicology to advance human and environmental hazard assessment : A roadmap for advanced materials

Autori: Amorim, M. J.B.; Peijnenburg, W.; Greco, D.; Saarimäki, L. A.; Dumit, V. I.; Bahl, A.; Haase, A.; Tran, L.; Hackermüller, J.; Canzler, S.; Scott-Fordsmand, J. J.
Pubblicato in: Nano Today, Numero 1, 2023, ISSN 1878-044X
Editore: Science Direct
DOI: 10.1016/j.nantod.2022.101735

Molecular mechanisms of zinc toxicity in the potworm Enchytraeus crypticus, analysed by high-throughput gene expression profiling

Autori: S.I.L. Gomes, T.E. de Boer, C.A.M. van Gestel, N.M. van Straalen, A.M.V.M. Soares, D. Roelofs, M.J.B. Amorim,
Pubblicato in: Science of the Total Environment, 2022, Pagina/e 153875, ISSN 0048-9697
Editore: Elsevier BV
DOI: 10.1016/j.scitotenv.2022.153975

Reliable Surface Analysis Data of Nanomaterials in Support of Risk Assessment Based on Minimum Information Requirements.

Autori: Jörg Radnik; Reinhard Kersting; Birgit Hagenhoff; Francesca Bennet; Dmitri Ciornii; Penny Nymark; Roland C. Grafström; Vasile-Dan Hodoroaba
Pubblicato in: Nanomaterials, Vol 11, Iss 639, p 639 (2021), Numero 1, 2021, ISSN 2079-4991
Editore: Basel MDPI AG 2011-
DOI: 10.3390/nano11030639

Environmental hazard testing of nanobiomaterials

Autori: M. J. B. Amorim, M. L. Fernández-Cruz, K. Hund-Rinke, J. J. Scott-Fordsmand
Pubblicato in: Environmental Sciences Europe, Numero 32/1, 2020, ISSN 2190-4707
Editore: Springer Verlag
DOI: 10.1186/s12302-020-00369-8

High-throughput transcriptomics reveals the mechanisms of nanopesticides – nanoformulation, commercial formulation, active ingredient – finding safe and sustainable-by-design (SSbD) options for the environment

Autori: Susana I. L. Gomes; Estefânia V. R. Campos; Leonardo F. Fraceto; Renato Grillo; Janeck J. Scott-Fordsmand; Mónica J. B. Amorim
Pubblicato in: Environmental Science: Nano, 2022, ISSN 2051-8161
Editore: Royal Society of Chemistry
DOI: 10.1039/d1en00735a

Annelid genomes: Enchytraeus crypticus, a soil model for the innate (and primed) immune system

Autori: M.J.B. Amorim, Y. Gansemans, S.I.L. Gomes, F. Van Nieuwerburgh, J.J. Scott-Fordsmand,
Pubblicato in: Lab Animal, 2021, Pagina/e 285–294., ISSN 1548-4475
Editore: Nature
DOI: 10.1038/s41684-021-00831-x

Impacts of Longer-Term Exposure to AuNPs on Two Soil Ecotoxicological Model Species

Autori: B. Guimarães, S.I.L. Gomes, J.J. Scott-fordsmand, M.J.B. Amorim
Pubblicato in: Toxics, 2022, ISSN 2305-6304
Editore: MDPI
DOI: 10.3390/toxics10040153

An integrated pathway based on in vitro data for the human hazard assessment of nanomaterials

Autori: Daina Romeo, Beatrice Salieri, Roland Hischier, Bernd Nowack, Peter Wick
Pubblicato in: Environment International, Numero 137, 2020, Pagina/e 105505, ISSN 0160-4120
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2020.105505

Approach toward In Vitro-Based Human Toxicity Effect Factors for the Life Cycle Impact Assessment of Inhaled Low-Solubility Particles

Autori: D. Romeo, R. Hischier, B. Nowack, P. Wick
Pubblicato in: Environmental Science & Technology, 2022, ISSN 0013-936X
Editore: American Chemical Society
DOI: 10.1021/acs.est.2c01816

Combined in vitro-in vivo dosimetry enables the extrapolation of in vitro doses to human exposure levels: A proof of concept based on a meta-analysis of in vitro and in vivo titanium dioxide toxicity data

Autori: Daina Romeo, Bernd Nowack, Peter Wick
Pubblicato in: Elsevier, 2022, ISSN 2452-0748
Editore: Elsevier
DOI: 10.1016/j.impact.2021.100376

Current status and future challenges of genotoxicity OECD Test Guidelines for nanomaterials: a workshop report

Autori: Shareen H Doak; Cristina Andreoli; Michael J Burgum; Qasim Chaudhry; Eric A J Bleeker; Cecilia Bossa; Josefa Domenech; Damjana Drobne; Valérie Fessard; Nina Jeliazkova; Eleonora Longhin; Elise Rundén-Pran; Maciej Stępnik; Naouale El Yamani; Julia Catalán; Maria Dusinska
Pubblicato in: "Mutagenesis, 2023, pp.1-9. ⟨10.1093/mutage/gead017⟩", Numero 1, 2023, ISSN 1464-3804
Editore: Oxford University Press
DOI: 10.1093/mutage/gead017

Toxicokinetics of Ag (nano)materials in the soil model Enchytraeus crypticus (Oligochaeta) – impact of aging and concentration

Autori: F.C.F. Santos, P.S. Tourinho, J.J. Scott-Fordsmand, C.A.M. van Gestel, M.J.B. Amorim, T , Environ. Sci. Nano.
Pubblicato in: Environmental Science: nano, 2021, ISSN 1473-7604
Editore: Royal Society of Chemistry
DOI: 10.1039/d1en00338k

Reactive Oxygen Species Detection Using Fluorescence in Enchytraeus crypticus—Method Implementation through Ag NM300K Case Study

Autori: Gomes, S.I.L.; Neves, A.B.; Scott-Fordsmand, J.J.; Amorim, M.J.B
Pubblicato in: Toxics, 2021, Pagina/e 1-12, ISSN 2305-6304
Editore: MDPI
DOI: 10.3390/toxics9100232

Attachment Efficiency of Nanomaterials to Algae as an Important Criterion for Ecotoxicity and Grouping.

Autori: Kerstin, Hund-Rinke; Tim, Sinram; Karsten, Schlich; Carmen, Nickel; Hanna Paula, Dickehut; Matthias, Schmidt; Dana, Kühnel
Pubblicato in: Nanomaterials, 2020, ISSN 2079-4991
Editore: Basel MDPI AG 2011-
DOI: 10.3390/nano10061021

Environmental hazards of nanopesticides to non-target soil species - commercial nanoformulation versus its active substance (Karate Zeon® and lambda-cyhalothrin)

Autori: Susana I.L. Gomes; Sekerani B. Chidiamassamba; Janeck J. Scott-Fordsmand; Mónica J.B. Amorim
Pubblicato in: Science of The Total Environment, 2023, ISSN 1879-1026
Editore: Science Direct
DOI: 10.1016/j.scitotenv.2023.164664

Machine learning and materials modelling interpretation of in vivo toxicological response to TiO2 nanoparticles library (UV and non-UV exposure)

Autori: Susana I. L. Gomes, Mónica J. B. Amorim, Suman Pokhrel, Lutz Mädler, Matteo Fasano, Eliodoro Chiavazzo, Pietro Asinari, Jaak Jänes, Kaido Tämm, Jaanus Burkf and Janeck J. Scott-Fordsmand
Pubblicato in: Royal Society of Chemistry, 2021, Pagina/e 13, ISSN 2040-3372
Editore: Royal Society of Chemistry
DOI: 10.1039/d1nr03231c

(Re)Conceptualizing decision-making tools in a risk governance framework for emerging technologies—the case of nanomaterials

Autori: Martin Mullins, Martin Himly, Isabel Rodríguez Llopis, Irini Furxhi, Sabine Hofer, Norbert Hofstätter, Peter Wick, Daina Romeo, Dana Küehnel, Kirsi Siivola, Julia Catalán, Kerstin Hund-Rinke, Ioannis Xiarchos, Shona Linehan, Daan Schuurbiers, Amaia García Bilbao, Leire Barruetabeña & Damjana Drobne
Pubblicato in: Environment Systems and Decisions, 2022, ISSN 2194-5411
Editore: Springer
DOI: 10.1007/s10669-022-09870-2

Precaution as a Risk in Data Gaps and Sustainable Nanotechnology Decision Support Systems: a Case Study of Nano-Enabled Textiles Production

Autori: Irini Furxhi; Finbarr Murphy; Craig A. Poland; Martin Cunneen; Martin Mullins
Pubblicato in: NanoEthics, 2021, ISSN 1871-4765
Editore: Springer
DOI: 10.1007/s11569-021-00400-z

Toxicity of fungicides to terrestrial non-target fauna – Formulated products versus active ingredients (azoxystrobin, cyproconazole, prothioconazole, tebuconazole) – A case study with Enchytraeus crypticus (Oligochaeta)

Autori: Susana I.L. Gomes, Anna Ammendola, Silvia Casini, Mónica J.B. Amorim
Pubblicato in: Science of The Total Environment, Numero 754, 2021, Pagina/e 142098, ISSN 0048-9697
Editore: Elsevier BV
DOI: 10.1016/j.scitotenv.2020.142098

Embryotoxicity of silver nanomaterials (Ag NM300k) in the soil invertebrate Enchytraeus crypticus – Functional assay detects Ca channels shutdown

Autori: R.C. Bicho, A.M.R. Faustino, F. Carvalho, A.M.V.M. Soares, J.J. Scott-Fordsmand, M.J.B. Amorim
Pubblicato in: Nanoimpact, 2021, ISSN 2452-0748
Editore: Elsevier
DOI: 10.1016/j.impact.2021.100300

Nano-pesticides: the lunch-box principle—deadly goodies (semio-chemical functionalised nanoparticles that deliver pesticide only to target species)

Autori: J.J. Scott-Fordsmand, L.F. Fraceto, M.J.B. Amorim
Pubblicato in: Journal of Nanobiotechnology, 2022, ISSN 1477-3155
Editore: BioMed Central
DOI: 10.1186/s12951-021-01216-5

Avoidance Behaviour of Six Collembolan Species Shows Species-Specific Sensitivity—Impact of Ag NM300K

Autori: Janeck Scott-Fordsmand; Mónica Amorim; Marija Kovačević; Branimir Hackenberger
Pubblicato in: Nanomaterials, 2022, ISSN 2079-4991
Editore: Basel MDPI AG 2011-
DOI: 10.3390/nano12193276

Nanopharmaceuticals (Au-NPs) after use: Experiences with a complex higher tier test design simulating environmental fate and effect

Autori: Kerstin Hund-Rinke, Cecilia Diaz, Anne Jurack, Judith Klein, Burkhard Knopf, Karsten Schlich, María Luisa Fernández-Cruz, David Hernández-Moreno, Nicolas Manier, Pascal Pandard, Bruno Guimarães, Susana I.L. Gomes, Janeck Scott-Fordsmand, Mónica J.B. Amorim.
Pubblicato in: Elsevier, 2021, Pagina/e 14, ISSN 0147-6513
Editore: Academic Press
DOI: 10.1016/j.ecoenv.2021.112949

Proceedings of the NANORIGO Special Scientific Coordination Meeting

Autori: Reuther, Rudolf & Tobin, Lesley
Pubblicato in: 2023
Editore: Zenodo

Integrating societal considerations in nanotechnology risk governance

Autori: D. Schuurbiers
Pubblicato in: 2020
Editore: Zenodo OpenAIRE
DOI: 10.5281/zenodo.4277549

Risk assessment with social dimension: how does risk governance differ from risk assessment or management?

Autori: Martin Himly; Sabine Hofer; Norbert Hofstaetter; Dmitri Ciornii; Daan Schuurbiers
Pubblicato in: Zenodo OpenAIRE, 2021
Editore: Zenodo
DOI: 10.5281/zenodo.5057543

From Principles to Reality. FAIR Implementation in the Nanosafety Community

Autori: Dumit, Verónica I.; Ammar, Ammar; Bakker, Martine; Bañares, Miguel A.; Bossa, Cecilia; Costa, Anna; Cowie, Hilary; Drobne, Damjana; Exner, Thomas E.; Farcal, Lucian; Friedrichs, Steffi; Furxhi, Irini; Grafström, Roland; Haase, Andrea; Himly, Martin; Jeliazkova, Nina; Lynch, Iseult; Maier, Dieter; Noorlander, Cornelle W.; Shin, Hyun Kil; Soler-Illia, Galo J.A.A.; Suarez-Merino, Blanca; Willighag
Pubblicato in: Numero 1, 2023
Editore: OpenAIRE
DOI: 10.5281/zenodo.7614989

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