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A bio-identical and non-animal replacement for the quality control reagent of pyrogen testing in the medical and pharmaceutical industries.

Project description

Towards more sustainable endotoxin testing

Bacteria produce lipopolysaccharides, which may induce strong immune reactions including fever and shock. This is why all pharmaceutical products undergo rigorous endotoxin or pyrogen testing. The gold standard method involves the reagent Limulus amoebocyte lysate (LAL), which is extracted from the horseshoe crab, Limulus polyphemus. The aim of the EU-funded LimuleX project is to address the growing demand for LAL in a sustainable manner. Using proprietary cell technology, researchers have succeeded in producing a bio-identical LAL reagent in an animal-free manner. Moreover, the LimuleX LAL reagent constitutes a better-quality product and is in line with the animal replacement, reduction and refinement principles.

Call for proposal


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Net EU contribution
€ 50 000,00
Buckley Kiely Heritage Business Park Mahon Industr Estate
T12 P1HX Blackrock Cork

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Ireland Southern South-West
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 21 429,00