Periodic Reporting for period 3 - LymphMap (Navigating lymphatic formation and function in health and disease)
Berichtszeitraum: 2022-02-01 bis 2023-07-31
As a whole, when this work is completed, we expect to have a major scientific impact on the way lymphatic vessels are perceived, no longer as a passive system, but rather as active players in tissue morphogenesis, disease and regeneration.
Since our studies are among the first to analyse organ-specific lymphatic vessels in adult zebrafish, we invested extensive efforts in the establishing the required platforms.
2. Our recent publication in Cell Reports (Jerafi-Vider et.al. 2021), which has recently been highlighted by the Israeli news (https://wis-wander.weizmann.ac.il/life-sciences/blocking-distraction-how-growing-blood-vessels-do-it-all describes the involvement of cell cycle progression in growth and differentiation of lymphatic endothelial cells. Our findings raise new questions regarding the use of cell-cycle inhibitors (for instance, during cancer treatments), as they may in fact promote blood vessel growth.