Descrizione del progetto
La fluorurazione strategica potrebbe sbloccare un enorme potenziale chimico
I composti organofluorinici, molecole organiche contenenti legami carbonio-fluoro, vengono ampiamente utilizzati per creare prodotti farmaceutici ad alto impatto, agenti di imaging, prodotti chimici per l’agricoltura e diversi altri materiali. Numerosi prodotti farmaceutici vengono fluorurati per conferire maggiore stabilità metabolica e ossidativa, lipofilia e permeabilità di membrana. Abbiamo tuttavia probabilmente visto solo la punta dell’iceberg per quanto riguarda il potenziale dei composti organofluorinici. L’ostacolo è derivato dalle limitazioni nel controllo dei siti di fluorurazione e dalla risultante architettura molecolare 2D e 3D. RECON sta lavorando per sbloccare il potenziale dei complessi composti fluorurati con una progettazione razionale della struttura per una funzione altamente specifica e unica. Ancora meglio, questi metodi si basano su materie prime a base di fluoruri economiche e commercialmente disponibili.
Obiettivo
Despite the abundance of organic compounds in Nature, only 12 contain fluorine. In contrast, fluorinated organic materials account for over 40% of all pharmaceuticals and agrochemicals. Closer inspection of the fluorination patterns in these functional molecules reveals striking extremes towards perfluorination (in both 2D and 3D scaffolds) or single site fluorination predominantly in aryl substituents. Consequently, most fluorinated moieties in functional materials lack stereochemical information and are thus achiral. This disparity between the paucity of naturally occurring organofluorine compounds and their venerable history in functional molecule design confirms the enormous potential of fluorinated materials in the discovery of novel properties. That progress has largely been confined to 3 dimensional achiral and 2 dimensional achiral architectures reflects the synthetic challenges associated with preparing stereochemical defined multiply fluorinated systems. A major limitation in the construction of C(sp3)-F units remains the need for substrate pre-functionalisation via oxidation and the competing substitution/elimination scenario that compromises efficiency in the deoxyfluorination. This problem is magnified in the synthesis of optically active fluorides where the deoxyfluorination can compromise the enantiopurity of the starting materials. The principle aim of RECON is to facilitate exploration of 3D, chiral space by providing access to multiply fluorinated, stereochemically complex organofluorine materials from simple feedstock using inexpensive, commercially available fluoride sources. In providing a modular platform to rationally place function on a structural basis, exploration of uncharted chemical space will accelerate the discovery of next generation materials for medicinal and agrochemistry, material sciences and bio-medicine.
Campo scientifico
Parole chiave
Programma(i)
Argomento(i)
Meccanismo di finanziamento
ERC-COG - Consolidator GrantIstituzione ospitante
48149 MUENSTER
Germania