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Infinite Protein Self-Assembly in Health and Disease

Project description

The impact of mutations in protein assembly

Understanding how mutations disrupt protein structure and function is central for comprehending diseases. The working hypothesis of the EU-funded Agglomerates project is that mutations can have another impact; they can change a protein’s surface chemistry and alter its supramolecular self-assembly, leading to the generation of large polymeric structures. Researchers will study this phenomenon, known as protein agglomeration, using yeast as a model system. They will also predict polymorphisms that trigger agglomeration and further investigate the potential of translating this effect in drug design. Project results will provide important insight into the implication of agglomeration in cell physiology.

Host institution

WEIZMANN INSTITUTE OF SCIENCE
Net EU contribution
€ 2 574 819,00
Address
Herzl Street 234
7610001 Rehovot
Israel

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Activity type
Higher or Secondary Education Establishments
Other funding
€ 2 574 819,00

Beneficiaries (1)

WEIZMANN INSTITUTE OF SCIENCE
Israel
Net EU contribution
€ 2 574 819,00
Address
Herzl Street 234
7610001 Rehovot

See on map

Activity type
Higher or Secondary Education Establishments
Other funding
€ 2 574 819,00