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Infinite Protein Self-Assembly in Health and Disease

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Publications

Protein Abundance Biases the Amino Acid Composition of Disordered Regions to Minimize Non-functional Interactions

Author(s): Benjamin Dubreuil, Or Matalon, Emmanuel D. Levy
Published in: Journal of Molecular Biology, 431/24, 2019, Page(s) 4978-4992, ISSN 0022-2836
Publisher: Academic Press
DOI: 10.1016/j.jmb.2019.08.008

Proteomic analysis reveals the direct recruitment of intrinsically disordered regions to stress granules in S. cerevisiae.

Author(s): Mang Zhu; Erich R. Kuechler; Joyce Zhang; Or Matalon; Benjamin Dubreuil; Analise Hofmann; Christopher J. R. Loewen; Emmanuel D. Levy; Joerg Gsponer; Thibault Mayor
Published in: Journal of Cell Science, 1, 2020, ISSN 0021-9533
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/jcs.244657

Designer protein assemblies with tunable phase diagrams in living cells

Author(s): Meta Heidenreich, Joseph M. Georgeson, Emanuele Locatelli, Lorenzo Rovigatti, Saroj Kumar Nandi, Avital Steinberg, Yotam Nadav, Eyal Shimoni, Samuel A. Safran, Jonathan P. K. Doye, Emmanuel D. Levy
Published in: Nature Chemical Biology, 2020, ISSN 1552-4450
Publisher: Nature Publishing Group
DOI: 10.1038/s41589-020-0576-z

PDB-wide identification of physiological hetero-oligomeric assemblies based on conserved quaternary structure geometry

Author(s): Sucharita Dey, Emmanuel D. Levy
Published in: Structure, 29/11, 2021, Page(s) 1303-1311.e3, ISSN 0969-2126
Publisher: Cell Press
DOI: 10.1016/j.str.2021.07.012

Abundance Imparts Evolutionary Constraints of Similar Magnitude on the Buried, Surface, and Disordered Regions of Proteins

Author(s): Benjamin Dubreuil, Emmanuel D. Levy
Published in: Frontiers in Molecular Biosciences, 8, 2021, ISSN 2296-889X
Publisher: Frontiers
DOI: 10.3389/fmolb.2021.626729