Infinite Protein Self-Assembly in Health and Disease

Project Information

Agglomerates

Grant agreement ID: 819318

DOI 10.3030/819318

EC signature date 25 February 2019

Start date 1 April 2019

End date 30 September 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 574 819,00

EU contribution € 2 574 819,00

Coordinated by

UNIVERSITE DE GENEVE
Switzerland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (11)

Protein Abundance Biases the Amino Acid Composition of Disordered Regions to Minimize Non-functional Interactions

Author(s): Benjamin Dubreuil, Or Matalon, Emmanuel D. Levy
Published in: Journal of Molecular Biology, Issue 431/24, 2019, Page(s) 4978-4992, ISSN 0022-2836
Publisher: Academic Press
DOI: 10.1016/j.jmb.2019.08.008

Proteomic analysis reveals the direct recruitment of intrinsically disordered regions to stress granules in S. cerevisiae.

Author(s): Mang Zhu; Erich R. Kuechler; Joyce Zhang; Or Matalon; Benjamin Dubreuil; Analise Hofmann; Christopher J. R. Loewen; Emmanuel D. Levy; Joerg Gsponer; Thibault Mayor
Published in: Journal of Cell Science, Issue 1, 2020, ISSN 0021-9533
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/jcs.244657

Designer protein assemblies with tunable phase diagrams in living cells

Author(s): Meta Heidenreich, Joseph M. Georgeson, Emanuele Locatelli, Lorenzo Rovigatti, Saroj Kumar Nandi, Avital Steinberg, Yotam Nadav, Eyal Shimoni, Samuel A. Safran, Jonathan P. K. Doye, Emmanuel D. Levy
Published in: Nature Chemical Biology, 2020, ISSN 1552-4450
Publisher: Nature Publishing Group
DOI: 10.1038/s41589-020-0576-z

<scp>CC⁺</scp>: A searchable database of validated coiled coils in <scp>PDB</scp> structures and <scp>AlphaFold2</scp> models

Author(s): Prasun Kumar; Rokas Petrenas; William M. Dawson; Hugo Schweke; Emmanuel D. Levy; Derek N. Woolfson
Published in: Crossref, Issue 5, 2023, ISSN 0961-8368
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1002/pro.4789

Discriminating physiological from non‐physiological interfaces in structures of protein complexes: A community‐wide study

Author(s): Hugo Schweke; Qifang Xu; Gerardo Tauriello; Lorenzo Pantolini; Torsten Schwede; Frédéric Cazals; Alix Lhéritier; Juan Fernandez‐Recio; Luis Angel Rodríguez‐Lumbreras; Ora Schueler‐Furman; Julia K. Varga; Brian Jiménez‐García; Manon F. Réau; Alexandre M. J. J. Bonvin; Castrense Savojardo; Pier‐Luigi Martelli; Rita Casadio; Jérôme Tubiana; Haim J. Wolfson; Romina Oliva; Didier Bar
Published in: Crossref, Issue 5, 2023, ISSN 1615-9853
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/pmic.202200323

Molecular and environmental determinants of biomolecular condensate formation

Author(s): José A. Villegas, Meta Heidenreich, Emmanuel D. Levy
Published in: Nature Chem. Bio., 2022, ISSN 1552-4450
Publisher: Nature Publishing Group
DOI: 10.1038/s41589-022-01175-4

PDB-wide identification of physiological hetero-oligomeric assemblies based on conserved quaternary structure geometry

Author(s): Sucharita Dey, Emmanuel D. Levy
Published in: Structure, Issue 29/11, 2021, Page(s) 1303-1311.e3, ISSN 0969-2126
Publisher: Cell Press
DOI: 10.1016/j.str.2021.07.012

Affinity and Valence Impact the Extent and Symmetry of Phase Separation of Multivalent Proteins

Author(s): Saroj Kumar Nandi; Daniel Österle; Meta Heidenreich; Emmanuel D. Levy; Samuel A. Safran
Published in: Crossref, Issue 2, 2022, ISSN 0031-9007
Publisher: American Physical Society
DOI: 10.1103/physrevlett.129.128102

PDBe-KB: collaboratively defining the biological context of structural data

Author(s): Mihaly Varadi; Stephen Anyango; David R. Armstrong; John M. Berrisford; Preeti Choudhary; Mandar Deshpande; Nurul Nadzirin; Sreenath Nair; Lukáš Pravda; Ahsan Tanweer; Bissan Al-Lazikani; Claudia Andreini; Geoffrey J. Barton; David Bednar; Karel Berka; Tom L. Blundell; Kelly P Brock; José María Carazo; Jiri Damborsky; Alessia David; Sucharita Dey; Roland L. Dunbrack; Juan Fernandez Recio; Fran
Published in: D534-D542, Issue 2, 2021, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkab988

A unified statistical potential reveals that amino acid stickiness governs nonspecific recruitment of client proteins into condensates

Author(s): José A. Villegas; Emmanuel D. Levy
Published in: Crossref, Issue 1, 2022, ISSN 0961-8368
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1002/pro.4361

Abundance Imparts Evolutionary Constraints of Similar Magnitude on the Buried, Surface, and Disordered Regions of Proteins

Author(s): Benjamin Dubreuil, Emmanuel D. Levy
Published in: Frontiers in Molecular Biosciences, Issue 8, 2021, ISSN 2296-889X
Publisher: Frontiers
DOI: 10.3389/fmolb.2021.626729