Infinite Protein Self-Assembly in Health and Disease

Project Information

Agglomerates

Grant agreement ID: 819318

DOI

10.3030/819318

Project closed

EC signature date 25 February 2019

Start date 1 April 2019

End date 31 March 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 574 819,00

EU contribution

€ 2 574 819,00

Coordinated by

UNIVERSITE DE GENEVE
Switzerland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (24)

Uncovering the mechanism for polar sequestration of the major bacterial sugar regulator by high-throughput screens and 3D interaction modeling

Author(s): Nitsan Albocher-Kedem, Meta Heidenreich, Amir Fadel, Elizabeta Sirotkin, Omer Goldberger, Anat Nussbaum-Shochat, Emmanuel D. Levy, Ora Schueler-Furman, Maya Schuldiner, Orna Amster-Choder
Published in: Cell Reports, Issue 44, 2026, Page(s) 115436, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2025.115436

How gene duplication diversifies the landscape of protein oligomeric state and function

Author(s): Saurav Mallik, Dan S Tawfik, Emmanuel D Levy
Published in: Current Opinion in Genetics & Development, Issue 76, 2025, Page(s) 101966, ISSN 0959-437X
Publisher: Elsevier BV
DOI: 10.1016/j.gde.2022.101966

Protein Abundance Biases the Amino Acid Composition of Disordered Regions to Minimize Non-functional Interactions

Author(s): Benjamin Dubreuil, Or Matalon, Emmanuel D. Levy
Published in: Journal of Molecular Biology, Issue 431/24, 2019, Page(s) 4978-4992, ISSN 0022-2836
Publisher: Academic Press
DOI: 10.1016/j.jmb.2019.08.008

Mutational biases favor complexity increases in protein interaction networks after gene duplication

Author(s): Angel F Cisneros, Lou Nielly-Thibault, Saurav Mallik, Emmanuel D Levy, Christian R Landry
Published in: Molecular Systems Biology, Issue 20, 2026, Page(s) 549-572, ISSN 1744-4292
Publisher: Nature Publishing Group
DOI: 10.1038/s44320-024-00030-z

Mutant libraries reveal negative design shielding proteins from supramolecular self-assembly and relocalization in cells

Author(s): Hector Garcia Seisdedos, Tal Levin, Gal Shapira, Saskia Freud, Emmanuel D. Levy
Published in: Proceedings of the National Academy of Sciences, Issue 119, 2022, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2101117119

Proteomic analysis reveals the direct recruitment of intrinsically disordered regions to stress granules in S. cerevisiae.

Author(s): Mang Zhu; Erich R. Kuechler; Joyce Zhang; Or Matalon; Benjamin Dubreuil; Analise Hofmann; Christopher J. R. Loewen; Emmanuel D. Levy; Joerg Gsponer; Thibault Mayor
Published in: Journal of Cell Science, Issue 1, 2020, ISSN 0021-9533
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/jcs.244657

Mapping interactions between disordered regions reveals promiscuity in biomolecular condensate formation

Author(s): Atar Gilat, Alexander I. Alexandrov, Benjamin Dubreuil, Emmanuel D. Levy
Published in: Nature Communications, Issue 17, 2026, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-026-73800-y

Rapid and sensitive protein complex alignment with Foldseek-Multimer

Author(s): Woosub Kim, Milot Mirdita, Eli Levy Karin, Cameron L. M. Gilchrist, Hugo Schweke, Johannes Söding, Emmanuel D. Levy, Martin Steinegger
Published in: Nature Methods, Issue 22, 2025, Page(s) 469-472, ISSN 1548-7091
Publisher: Nature Publishing Group
DOI: 10.1038/s41592-025-02593-7

Designer protein assemblies with tunable phase diagrams in living cells

Author(s): Meta Heidenreich, Joseph M. Georgeson, Emanuele Locatelli, Lorenzo Rovigatti, Saroj Kumar Nandi, Avital Steinberg, Yotam Nadav, Eyal Shimoni, Samuel A. Safran, Jonathan P. K. Doye, Emmanuel D. Levy
Published in: Nature Chemical Biology, 2020, ISSN 1552-4450
Publisher: Nature Publishing Group
DOI: 10.1038/s41589-020-0576-z

An atlas of protein homo-oligomerization across domains of life

Author(s): Hugo Schweke, Tal Levin, Martin Pacesa, Casper A. Goverde, Prasun Kumar, Yoan Duhoo, Lars J. Dornfeld, Benjamin Dubreuil, Sandrine Georgeon, Sergey Ovchinnikov, Derek N. Woolfson, Bruno E. Correia, Su
Published in: Cell, 2024, ISSN 1097-4172
Publisher: elsevier
DOI: 10.1101/2023.06.09.544317

QSalignWeb: A Server to Predict and Analyze Protein Quaternary Structure

Author(s): Sucharita Dey, Jaime Prilusky, Emmanuel D. Levy
Published in: Frontiers in Molecular Biosciences, Issue 8, 2022, ISSN 2296-889X
Publisher: Frontiers Media SA
DOI: 10.3389/fmolb.2021.787510

<scp>CC⁺</scp>: A searchable database of validated coiled coils in <scp>PDB</scp> structures and <scp>AlphaFold2</scp> models

Author(s): Prasun Kumar; Rokas Petrenas; William M. Dawson; Hugo Schweke; Emmanuel D. Levy; Derek N. Woolfson
Published in: Crossref, Issue 5, 2023, ISSN 0961-8368
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1002/pro.4789

Discriminating physiological from non‐physiological interfaces in structures of protein complexes: A community‐wide study

Author(s): Hugo Schweke; Qifang Xu; Gerardo Tauriello; Lorenzo Pantolini; Torsten Schwede; Frédéric Cazals; Alix Lhéritier; Juan Fernandez‐Recio; Luis Angel Rodríguez‐Lumbreras; Ora Schueler‐Furman; Julia K. Varga; Brian Jiménez‐García; Manon F. Réau; Alexandre M. J. J. Bonvin; Castrense Savojardo; Pier‐Luigi Martelli; Rita Casadio; Jérôme Tubiana; Haim J. Wolfson; Romina Oliva; Didier Bar
Published in: Crossref, Issue 5, 2023, ISSN 1615-9853
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/pmic.202200323

Principles of cotranslational mitochondrial protein import

Author(s): Zikun Zhu, Saurav Mallik, Taylor A. Stevens, Riming Huang, Emmanuel D. Levy, Shu-ou Shan
Published in: Cell, Issue 188, 2026, Page(s) 5605-5617.e14, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2025.07.021

Molecular and environmental determinants of biomolecular condensate formation

Author(s): José A. Villegas, Meta Heidenreich, Emmanuel D. Levy
Published in: Nature Chem. Bio., 2022, ISSN 1552-4450
Publisher: Nature Publishing Group
DOI: 10.1038/s41589-022-01175-4

PDB-wide identification of physiological hetero-oligomeric assemblies based on conserved quaternary structure geometry

Author(s): Sucharita Dey, Emmanuel D. Levy
Published in: Structure, Issue 29/11, 2021, Page(s) 1303-1311.e3, ISSN 0969-2126
Publisher: Cell Press
DOI: 10.1016/j.str.2021.07.012

<scp>CC⁺</scp>: A searchable database of validated coiled coils in <scp>PDB</scp> structures and <scp>AlphaFold2</scp> models

Author(s): Prasun Kumar; Rokas Petrenas; William M. Dawson; Hugo Schweke; Emmanuel D. Levy; Derek N. Woolfson
Published in: Protein Science, Issue 12, 2023, ISSN 0961-8368
Publisher: Cold Spring Harbor Laboratory Press

Affinity and Valence Impact the Extent and Symmetry of Phase Separation of Multivalent Proteins

Author(s): Saroj Kumar Nandi; Daniel Österle; Meta Heidenreich; Emmanuel D. Levy; Samuel A. Safran
Published in: Crossref, Issue 2, 2022, ISSN 0031-9007
Publisher: American Physical Society
DOI: 10.1103/physrevlett.129.128102

Structural determinants of co-translational protein complex assembly

Author(s): Saurav Mallik, Johannes Venezian, Arseniy Lobov, Meta Heidenreich, Hector Garcia-Seisdedos, Todd O. Yeates, Ayala Shiber, Emmanuel D. Levy
Published in: Cell, 2026, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1101/2024.01.20.576408

PDBe-KB: collaboratively defining the biological context of structural data

Author(s): Mihaly Varadi; Stephen Anyango; David R. Armstrong; John M. Berrisford; Preeti Choudhary; Mandar Deshpande; Nurul Nadzirin; Sreenath Nair; Lukáš Pravda; Ahsan Tanweer; Bissan Al-Lazikani; Claudia Andreini; Geoffrey J. Barton; David Bednar; Karel Berka; Tom L. Blundell; Kelly P Brock; José María Carazo; Jiri Damborsky; Alessia David; Sucharita Dey; Roland L. Dunbrack; Juan Fernandez Recio; Fran
Published in: D534-D542, Issue 2, 2021, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkab988

A unified statistical potential reveals that amino acid stickiness governs nonspecific recruitment of client proteins into condensates

Author(s): José A. Villegas; Emmanuel D. Levy
Published in: Crossref, Issue 1, 2022, ISSN 0961-8368
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1002/pro.4361

Abundance Imparts Evolutionary Constraints of Similar Magnitude on the Buried, Surface, and Disordered Regions of Proteins

Author(s): Benjamin Dubreuil, Emmanuel D. Levy
Published in: Frontiers in Molecular Biosciences, Issue 8, 2021, ISSN 2296-889X
Publisher: Frontiers
DOI: 10.3389/fmolb.2021.626729

A pharmacological modality to sequester homomeric proteins

Author(s): Ella Livnah, Ohad Suss, Adi Rogel, Atar Gilat, Yuval Abdan, Jose D Villegas, Barr Tivon, Shira Albeck, Tamar Unger, Ofra Golani, Inna Goliand, David Margulies, Emmanuel D Levy, Nir London
Published in: Nature chemical biology, 2026, ISSN 1552-4450
Publisher: Nature Publishing Group
DOI: 10.1101/2025.03.05.641597

Mutation-induced filaments of folded proteins are inert and non-toxic in a cellular system

Author(s): Tal Levin, Hector Garcia-Seisdedos, Arseniy Lobov, Matthias Wojtynek, Alexander Alexandrov, Ghil Jona, Dikla Levi, Ohad Medalia, Emmanuel D Levy
Published in: Molecular Systems Biology, Issue 21, 2026, Page(s) 1306-1324, ISSN 1744-4292
Publisher: Nature Publishing Group
DOI: 10.1038/s44320-025-00144-y

Other (1)

The phase separation landscape of genome-wide genetic perturbations

Author(s): Meta Heidenreich, Saurabh Mathur, Tong Shu, Ying Xie, David Sriker, Benjamin Dubreuil, Liam Holt, Emmanuel D. Levy
Published in: 2026
Publisher: openRxiv
DOI: 10.1101/2024.10.25.620319