Connecting digital mobility assessment to clinical outcomes for regulatory and clinical endorsement

Resultado final

Final version of study protocol as approved by first ethics committee; registration number of clinical study in an approved registry that also allows later posting of study results; approvals required for enrolment of first subject in at least one clinical centre

System performance analysis

This report will include the results of a detailed system performance analysis for the MobiliseD data management platform It will include a technical evaluation eg data transmission times access logs etc stakeholder feedback and an analysis of technical support logs

Risk assessment process and management procedure

Description of the methodology for project risk assessment and categorisation, including a risk management process

Detailed system requirements specification, including definition of data acquisition, transmission, integration, processing, analytics and governance requirements

This report will incorporate detailed system requirements specification for the data management platform. This will include definition of data acquisition, transmission, integration, processing, analytics and governance requirements

Ethical approval including all amendments

Ethical approval will be prepared during the first year and will include the experience of the WP 2 technical validation. The process will be finalized based on the results of WP2. Each site will submit the ethical protocol including the national requirments.

Report on publications, presentations, and event organisation (M12, with annual updates)

This deliverable is based on work carried out in Tasks 7.3 and 7.4, and details the publications, presentations and event organisations throughout the first year of the project, with subsequent annual updates. The report will be based on a database containing all outreach activities carried out by the consortium members.

Statistical description report on digital mobility outcomes, health outcomes and their relationships

We will study the statistical distribution of digital mobility outcomes, clinical outcomes and the shape of their relationships, using standard and hypothesis-free statistical analyses and existing cohort data

Data Management Plan V1

Inititial version of the data management plan

Data Management Plan V2

Mid project updated data management plan

Publicaciones

Connecting real-world digital mobility assessment to clinical outcomes for regulatory and clinical endorsement–the Mobilise-D study protocol

Autores: Mikolaizak, A. Stefanie; Rochester, Lynn; Maetzler, Walter; Sharrack, Basil; Demeyer, Heleen; Mazzà, Claudia; Caulfield, Brian; Garcia-Aymerich, Judith; Vereijken, Beatrix; Arnera, Valdo; Miller, Ram; Piraino, Paolo; Ammour, Nadir; Gordon, Mark Forrest; Troosters, Thierry; Yarnall, Alison J.; Alcock, Lisa; Gaßner, Heiko; Winkler, Jürgen; Klucken, Jochen; Schlenstedt, Christian; Watz, Henrik; Ki
Publicado en: Plos, Edición 4, 2022, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1101/2022.05.25.22275598

Performance of a multi-sensor wearable system for validating gait assessment: preliminary results on patients and healthy

Autores: F. Salis, T. Bonci, S. Bertuletti , M. Caruso , K. Scott , E. Buckley, L. Alcock , S. Del Din , L. Rochester , E. Gazit , J.M. Hausdorff , C. Hansen 7, W. Maetzler , L. Schwickert 8, C. Becker , C. Mazzà , A. Cereatti, on behalf of the Mobilise-D consortium
Publicado en: Gait & Posture, Edición Volume 97, Supplement 2, October 2022, 2022, Página(s) 13, ISSN 1879-2219
Editor: Elsevier
DOI: 10.1016/j.gaitpost.2022.09.027

Mobility endpoints in marketing authorisation of drugs: what gets the European medicines agency moving?

Autores: Jaeger, Simon U; Wohlrab, Martin; Schoene, Daniel; Tremmel, Roman; Chambers, Michael; Leocani, Letizia; Corriol-Rohou, Solange; Klenk, Jochen; Sharrack, Basil; Garcia-Aymerich, Judith; Rochester, Lynn; Maetzler, Walter; Puhan, Milo; Schwab, Matthias; Becker, Clemens
Publicado en: Age and Ageing, Edición 5, 2022, ISSN 0002-0729
Editor: Oxford University Press
DOI: 10.1093/ageing/afab242

Real-world speed estimation using single IMU: A conceptual framework

Autores: Aminian, Kamiar; Soltani, Abolfazl Soltani; Paraschiv-Ionescu, Anisoara
Publicado en: A conceptual framework, 16th International Symposium of 3D-Analysis of Human Movement, Ames (USA), May 25-28, 2021., 2021, ISSN 2333-5432
Editor: International Society of Biomechanics
DOI: 10.5281/zenodo.5561261

Computational modelling of the scoliotic spine: A literature review

Autores: Samuele L Gould; Luca Cristofolini; Giorgio Davico; Marco Viceconti
Publicado en: International journal for Numerical Methods in Biomedical Engineering, Edición 16, 2021, ISSN 2040-7947
Editor: John Wiley & Sons Ltd
DOI: 10.1002/cnm.3503

A Quality Control Check to Ensure Comparability of Stereophotogrammetric Data between Sessions and Systems

Autores: Kirsty Scott; Tecla Bonci; Lisa Alcock; Ellen Buckley; Clint Hansen; Eran Gazit; Lars Schwickert; Andrea Cereatti; Claudia Mazzà; on behalf of the Mobilise-D Consortium
Publicado en: Sensors; Volume 21; Edición 24;, 2021, Página(s) Pages: 8223, ISSN 1424-8220
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s21248223

Inertial sensor-based gait parameters reflect patient-reported fatigue in multiple sclerosis

Autores: Alzhraa A. Ibrahim, Arne Küderle, Heiko Gaßner, Jochen Klucken, Bjoern M. Eskofier, Felix Kluge
Publicado en: Journal of NeuroEngineering and Rehabilitation, Edición 17/1, 2020, ISSN 1743-0003
Editor: BioMed Central
DOI: 10.1186/s12984-020-00798-9

Gait Detection from a Wrist-Worn Sensor Using Machine Learning Methods: A Daily Living Study in Older Adults and People with Parkinson's Disease

Autores: Yonatan E Brand, Dafna Schwartz, Eran Gazit, Aron S Buchman, Ran Gilad-Bachrach, Jeffrey M Hausdorff
Publicado en: Sensors, Edición Sensors 2022, 22(18), 7094, 2022, ISSN 1424-8220
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s22187094

uTUG: An unsupervised Timed Up and Go test for Parkinson’s disease

Autores: João Elison da Rosa Tavares; Martin Ullrich; Nils Roth; Felix Kluge; Bjoern M. Eskofier; Heiko Gaßner; Jochen Klucken; Till Gladow; Franz Marxreiter; Cristiano André da Costa; Rodrigo da Rosa Righi; Jorge Luis Victória Barbosa
Publicado en: Biomedical Signal Processing and Control, Edición Volume 81, March 2023, 104394, 2023, ISSN 1746-8094
Editor: Elsevier BV
DOI: 10.1016/j.bspc.2022.104394

A deep learning model to discern indoor from outdoor environments based on data recorded by a tri-axial digital magnetic sensor

Autores: Marcianò, V.; Bertuletti, S.; Bonci, T.; Mazzà, C.; Ireson, N.; Ciravegna, F.; Del Din, S.; Gazit, E.; Cereatti, A.
Publicado en: Gait and Posture, Edición Volume 97, Supplement 2, October 2022,, 2022, Página(s) 5, ISSN 0966-6362
Editor: Elsevier BV
DOI: 10.1016/j.gaitpost.2022.09.015

Technologische innovationen in der Pneumonologie - Facetten aus Diagnostik und Therapie

Autores: Randerath W, Dreher M, Gompelmann D, Held M, Koczulla R, Köhnlein T, Rohde G, Wälscher J, Watz H, Steinkamp G.
Publicado en: Pneumologie, Edición 14.07.2020, 2020, ISSN 0934-8387
Editor: Georg Thieme Verlag
DOI: 10.5281/zenodo.4468658

Wearable sensors can reliably quantify gait alterations associated with disability in people with progressive multiple sclerosis in a clinical setting

Autores: Lorenza Angelini, William Hodgkinson, Craig Smith, Jessie Moorman Dodd, Basil Sharrack, Claudia Mazzà, David Paling
Publicado en: Journal of Neurology, Edición 267/10, 2020, Página(s) 2897-2909, ISSN 0340-5354
Editor: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00415-020-09928-8

"It's not about the capture, it's about what we can learn"": a qualitative study of experts' opinions and experiences regarding the use of wearable sensors to measure gait and physical activity."

Autores: Alison Keogh; Kristin Taraldsen; Brian Caulfield; Beatrix Vereijken
Publicado en: Journal of NeuroEngineering and Rehabilitation, 2021, ISSN 1743-0003
Editor: BioMed Central
DOI: 10.1186/s12984-021-00874-8

Algorithms for Walking Speed Estimation Using a Lower-Back-Worn Inertial Sensor: A Cross-Validation on Speed Ranges

Autores: Abolfazl Soltani; Kamiar Aminian; Claudia Mazzà; Andrea Cereatti; Luca Palmerini; Tecla Bonci; Anisoara Paraschiv-Ionescu
Publicado en:  IEEE TNSRE (2021), 2021, ISSN 1534-4320
Editor: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tnsre.2021.3111681

Autores: Ashley Marie Polhemus, Ronny Bergquist, Magda Bosch de Basea, Gavin Brittain, Sara Catherine Buttery, Nikolaos Chynkiamis, Gloria dalla Costa, Laura Delgado Ortiz, Heleen Demeyer, Kirsten Emmert, Judith Garcia Aymerich, Heiko Gassner, Clint Hansen, Nicholas Hopkinson, Jochen Klucken, Felix Kluge, Sarah Koch, Letizia Leocani, Walter Maetzler, M Encarna Micó-Amigo, A Stefanie Mikolaizak, Paolo Pira
Publicado en: BMJ Open, Edición 10/7, 2020, Página(s) e038704, ISSN 2044-6055
Editor: BMJ Publishing Group
DOI: 10.1136/bmjopen-2020-038704

The value of walking: a systematic review on mobility and healthcare costs.

Autores: Martin Wohlrab; Jochen Klenk; Laura Delgado-Ortiz; Michael Chambers; Lynn Rochester; Matthias Zuchowski; Matthias Schwab; Clemens Becker; Simon U. Jaeger
Publicado en: European Review of Aging and Physical Activity, Edición 19, 2022, ISSN 1861-6909
Editor: European Review of Aging and Physical Activity
DOI: 10.1186/s11556-022-00310-3

Analysis of the Accuracy of Ten Algorithms for Orientation Estimation Using Inertial and Magnetic Sensing under Optimal Conditions: One Size Does Not Fit All.

Autores: M. Caruso; Angelo Maria Sabatini; Daniel Laidig; Thomas Seel; Marco Knaflitz; Ugo Della Croce; Andrea Cereatti
Publicado en: MDPI Sensors, Vol 21, Iss 2543, p 2543 (2021), Edición 3, 2021, ISSN 1424-8220
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s21072543

A wearable multi-sensor system for real world gait analysis

Autores: F. Salis; S. Bertuletti; K. Scott; M. Caruso; T. Bonci; E. Buckley; U. Della Croce; C. Mazza; A. Cereatti
Publicado en: 2021 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), 2021, ISSN 2694-0604
Editor: IEEE
DOI: 10.1109/embc46164.2021.9630392

Clinical Relevance of Standardized Mobile Gait Tests. Reliability Analysis Between Gait Recordings at Hospital and Home in Parkinson’s Disease: A Pilot Study

Autores: Gaßner H, Sanders P, Dietrich A, Marxreiter F, Eskofier BM, Winkler J, Klucken J
Publicado en: Journal of Parkinson's Disease, Edición 8/17/2020, 2020, ISSN 1877-7171
Editor: IOS Press
DOI: 10.5281/zenodo.4468815

Classical Machine Learning Versus Deep Learning for the Older Adults Free-Living Activity Classification

Autores: Muhammad Awais, Lorenzo Chiari, Espen A. F. Ihlen, Jorunn L. Helbostad, Luca Palmerini
Publicado en: Sensors, Edición 21/14, 2021, Página(s) 4669, ISSN 1424-8220
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s21144669

The e-Science Central Study Data Platform

Autores: Watson, Paul; Hiden, Hugo
Publicado en: 2022 IEEE 18th International Conference on e-Science (e-Science), Edición 20, 2022, ISSN 2473-2001
Editor: IEEE Xplore
DOI: 10.1109/escience55777.2022.00020

The Effects of an Individualized Smartphone-Based Exercise Program on Self-defined Motor Tasks in Parkinson Disease: Pilot Interventional Study

Autores: Heiko Gaßner; Jana Friedrich; Alisa Masuch; Jelena Jukic; Sabine Stallforth; Martin Regensburger; Franz Marxreiter; Jürgen Winkler; Jochen Klucken
Publicado en: JMIR Rehabilitation and Assistive Technologies, Edición Vol 9 , No 4 (2022) :Oct-Dec, 2022, ISSN 2369-2529
Editor: JMIR Rehabilitation and Assistive Technologies
DOI: 10.2196/38994

Walking on common ground: a cross-disciplinary scoping review on the clinical utility of digital mobility outcomes.

Autores: Ashley Polhemus; Laura Delgado Ortiz; Gavin Brittain; Nikolaos Chynkiamis; Francesca Salis; Heiko Gaßner; Michaela Gross; Cameron Kirk; Rachele Rossanigo; Kristin Taraldsen; Diletta Balta; Sofie Breuls; Sara Buttery; Gabriela Cardenas; Christoph Endress; Julia Gugenhan; Alison Keogh; Felix Kluge; Sarah Koch; M. Encarna Micó-Amigo; Corinna Nerz; Chloé Sieber; Parris J Williams; Ronny Bergquist;
Publicado en: npj Digital Medicine, 2021, ISSN 2398-6352
Editor: npj Digital Medicine (npj Digit. Med.)
DOI: 10.1038/s41746-021-00513-5

Acceptability of wearable devices for measuring mobility remotely: Observations from the Mobilise-D technical validation study

Autores: Alison Keogh, Lisa Alcock, Philip Brown, Ellen Buckley, Marina Brozgol, Eran Gazit, Clint Hansen, Kirsty Scott, Lars Schwickert, Clemens Becker, Jeffrey Hausdorff, Walter Maetzler, Lynn Rochester, Basil Sharrack, Ionnis Vogiatzis, Alison Yarnall, Claudia Mazza, Brian Caulfield.
Publicado en: Digital Health, Edición DIGITAL HEALTH. 2023;9., 2023, ISSN 2158-2440
Editor: SAGE Publications Inc.
DOI: 10.1177/20552076221150745

An Inertial Sensor-Based Gait Analysis Pipeline for the Assessment of Real-World Stair Ambulation Parameters.

Autores: Nils Roth; Arne Küderle; Dominik Prossel; Heiko Gassner; Heiko Gassner; Bjoern M. Eskofier; Felix Kluge
Publicado en: MDPI Sensors (Basel, Switzerland), Edición 2, 2021, ISSN 1424-8220
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s21196559

Multidisciplinary Intensive Rehabilitation Program for People with Parkinson's Disease: Gaps between the Clinic and Real-World Mobility

Autores: Moriya Cohen, Talia Herman, Natalie Ganz, Inbal Badichi, Tanya Gurevich , Jeffrey M Hausdorff
Publicado en: International Journal of Environmental Research and Public Health, Edición IJERPH Volume 20 Edición 5, 2023, ISSN 1660-4601
Editor: International Journal of Environmental Research and Public Health
DOI: 10.3390/ijerph20053806

Assessing the usability of wearable devices to measure gait and physical activity in chronic conditions: a systematic review

Autores: Alison Keogh; Rob Argent; Amy Anderson; Brian Caulfield; William Johnston
Publicado en: Journal of NeuroEngineering and Rehabilitation,, Edición Vol 18, Iss 1,, 2021, Página(s) Pp 1-17 (2021), ISSN 1743-0003
Editor: BioMed Central
DOI: 10.1186/s12984-021-00931-2

Validation of a Sensor-Based Gait Analysis System with a Gold-Standard Motion Capture System in Patients with Parkinson’s Disease

Autores: Verena Jakob, Arne Küderle, Felix Kluge, Jochen Klucken, Bjoern M. Eskofier, Jürgen Winkler, MartinWinterholler and Heiko Gassner
Publicado en: Sensors, Edición Volume 22 Special Edición Inertial Sensors for Clinically Relevant Mobility Outcome Measures, 2021, ISSN 1424-8220
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s21227680

Orientation Estimation Through Magneto-Inertial Sensor Fusion: A Heuristic Approach for Suboptimal Parameters Tuning

Autores: Caruso M, Sabatini M, Knaflitz M, Gazzoni M, Della Croce U, Cereatti A
Publicado en: IEEE Sensors Journal, Edición 21.09.2020, 2020, ISSN 1530-437X
Editor: Institute of Electrical and Electronics Engineers
DOI: 10.5281/zenodo.4457500

Consensus based framework for digital mobility monitoring

Autores: Kluge, F., Del Din, S., Cereatti, A., Gaßner, H., Hansen, C., Helbostadt, J. L., Klucken, J., Küderle, A., Müller, A., Rochester, L., Ullrich, M., Eskofier, B. M., Mazzà, C., & Mobilise-D
Publicado en: PLoS ONE, 2021, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0256541

Using musculoskeletal models to estimate in vivo total knee replacement kinematics and loads: effect of differences between models

Autores: Curreli, Cristina; Di Puccio, Francesca; Davico, Giorgio; Modenese, Luca; Viceconti, Marco
Publicado en: Frontiers in Bioengineering and Biotechnology, Edición Volume 9, 2021, Página(s) 1-10, ISSN 2296-4185
Editor: Frontiers Media
DOI: 10.3389/fbioe.2021.703508

A method for gait events detection based on low spatial resolution pressure insoles data

Autores: F. Salis, S. Bertuletti, T. Bonci, U. Della Croce, C. Mazzà, A. Cereatti
Publicado en: Journal of Biomechanics, Edición 127, 2021, Página(s) 110687, ISSN 0021-9290
Editor: Elsevier BV
DOI: 10.1016/j.jbiomech.2021.110687

Extension of the Rigid-Constraint Method for the Heuristic Suboptimal Parameter Tuning to Ten Sensor Fusion Algorithms Using Inertial and Magnetic Sensing

Autores: Caruso, M.; Sabatini, A.M.; Knaflitz, M.; Della Croce, U.; Cereatti, A.
Publicado en: Sensors, Edición 21(18) - Special Edición Sensors and IoT in Modern Healthcare Delivery and Applications, 2021, ISSN 1424-8220
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s21186307

Multi-level personalization of neuromusculoskeletal models to estimate physiologically plausible knee joint contact forces in children

Autores: Claudio Pizzolato; Giorgio Davico; Bryce Killen; David Lloyd; Daniel Devaprakash; Christopher Carty
Publicado en: Biomechanics and Modeling in Mechanobiology, Edición 21, 2022, ISSN 1617-7940
Editor: Biomechanics and Modeling in Mechanobiology
DOI: 10.1007/s10237-022-01626-w

Design and validation of a multi-task, multi-context protocol for real-world gait simulation

Autores: Scott, Kirsty; Bonci, Tecla; Alcock, Lisa; Buckley, Ellen; Gazit, Eran; Hansen, Clint; Schwickert, Lars; Aminian, Kamiar; Bertuletti, Stefano; Caruso, Marco; Chiari, Lorenzo; Sharrack, Basil; Maetzler, Walter; Becker, Clemens; Hausdorff, Jeffrey M.; Vogiatzis, Ioannis; Brown, Philipp; Del Din, Silvia; Eskofier, Björn; Paraschiv-Ionescu, Anisoara; Keogh, Alison; Kirk, Cameron; Kluge, Felix; Micó
Publicado en: Journal of NeuroEngineering and Rehabilitation, Edición 19, Article number: 141 (2022), 2022, ISSN 1743-0003
Editor: BioMed Central
DOI: 10.1186/s12984-022-01116-1

Investigating the Impact of Environment and Data Aggregation by Walking Bout Duration on Parkinson’s Disease Classification Using Machine Learning

Autores: Rana Zia Ur Rehman, Yu Guan, Jian Qing Shi, Lisa Alcock, Alison J. Yarnall, Lynn Rochester and Silvia Del Din
Publicado en: Frontiers in Aging Neuroscience, Edición Research topic: Activities of Daily Living and Everyday Functioning: From Normal Aging to Neurodegenerative Diseases, 2022, ISSN 1663-4365
Editor: Frontiers Research Foundation
DOI: 10.3389/fnagi.2022.808518

A Proposal for a Linear Calculation of Gait Asymmetry

Autores: Linda Maria Adriana van Gelder, Lorenza Angelini, Ellen E. Buckley, Claudia Mazzà
Publicado en: Symmetry, Edición 13/9, 2021, Página(s) 1560, ISSN 2073-8994
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/sym13091560

Is a Wearable Sensor-Based Characterisation of Gait Robust Enough to Overcome Differences Between Measurement Protocols? A Multi-Centric Pragmatic Study in Patients with Multiple Sclerosis

Autores: Lorenza Angelini, Ilaria Carpinella, Davide Cattaneo, Maurizio Ferrarin, Elisa Gervasoni, Basil Sharrack, David Paling, Krishnan Padmakumari Sivaraman Nair, Claudia Mazzà
Publicado en: Sensors, Edición 20/1, 2020, Página(s) 79, ISSN 1424-8220
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s20010079

Accelerometry-Based Digital Gait Characteristics for Classification of Parkinson's Disease: What Counts?

Autores: Rana Zia Ur Rehman, Christopher Buckley, Maria Encarna Mico-Amigo, Cameron Kirk, Michael Dunne-Willows, Claudia Mazza, Jian Qing Shi, Lisa Alcock, Lynn Rochester, Silvia Del Din
Publicado en: IEEE Open Journal of Engineering in Medicine and Biology, Edición 1, 2020, Página(s) 65-73, ISSN 2644-1276
Editor: IEEE
DOI: 10.1109/ojemb.2020.2966295

Gait variability as digital biomarker of disease severity in Huntington’s disease

Autores: Heiko Gaßner, Dennis Jensen, F. Marxreiter, Anja Kletsch, Stefan Bohlen, Robin Schubert, Lisa M. Muratori, Bjoern Eskofier, Jochen Klucken, Jürgen Winkler, Ralf Reilmann, Zacharias Kohl
Publicado en: Journal of Neurology, 2020, ISSN 0340-5354
Editor: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00415-020-09725-3

Detection of Gait From Continuous Inertial Sensor Data Using Harmonic Frequencies

Autores: Martin Ullrich, Arne Kuderle, Julius Hannink, Silvia Del Din, Heiko Gassner, Franz Marxreiter, Jochen Klucken, Bjoern Michael Eskofier, Felix Kluge
Publicado en: IEEE Journal of Biomedical and Health Informatics, 2020, Página(s) 1-1, ISSN 2168-2194
Editor: Institute of Electrical and Electronics Engineers Inc.
DOI: 10.1109/jbhi.2020.2975361

A wearable sensor identifies alterations in community ambulation in multiple sclerosis: contributors to real-world gait quality and physical activity

Autores: Shirley Shema-Shiratzky, Inbar Hillel, Anat Mirelman, Keren Regev, Katherine L. Hsieh, Arnon Karni, Hannes Devos, Jacob J. Sosnoff, Jeffrey M. Hausdorff
Publicado en: Journal of Neurology, 2020, ISSN 0340-5354
Editor: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00415-020-09759-7

Credibility of In Silico Trial Technologies—A Theoretical Framing

Autores: Marco Viceconti, Miguel A. Juarez, Cristina Curreli, Marzio Pennisi, Giulia Russo, Francesco Pappalardo
Publicado en: IEEE Journal of Biomedical and Health Informatics, Edición 24/1, 2020, Página(s) 4-13, ISSN 2168-2194
Editor: Institute of Electrical and Electronics Engineers Inc.
DOI: 10.1109/JBHI.2019.2949888

Long-term unsupervised mobility assessment in movement disorders

Autores: Elke Warmerdam, Jeffrey M Hausdorff, Arash Atrsaei, Yuhan Zhou, Anat Mirelman, Kamiar Aminian, Alberto J Espay, Clint Hansen, Luc J W Evers, Andreas Keller, Claudine Lamoth, Andrea Pilotto, Lynn Rochester, Gerhard Schmidt, Bastiaan R Bloem, Walter Maetzler
Publicado en: The Lancet Neurology, Edición 19/5, 2020, Página(s) 462-470, ISSN 1474-4422
Editor: The Lancet Publishing Group
DOI: 10.1016/s1474-4422(19)30397-7

Intra-operator Repeatability of Manual Segmentations of the Hip Muscles on Clinical Magnetic Resonance Images.

Autores: Giorgio Davico; Francesca Bottin; Alberto Di Martino; Vanita Castafaro; Fabio Baruffaldi; Cesare Faldini; Marco Viceconti
Publicado en: Journal of Digital Imaging, Edición Edición 36, 2022, Página(s) 143–152, ISSN 1618-727X
Editor: Journal of Digital Imaging
DOI: 10.1007/s10278-022-00700-0

A Roadmap to Inform Development, Validation and Approval of Digital Mobility Outcomes: The Mobilise-D Approach

Autores: Lynn Rochester, Claudia Mazzà, Arne Mueller, Brian Caulfield, Marie McCarthy, Clemens Becker, Ram Miller, Paolo Piraino, Marco Viceconti, Wilhelmus P. Dartee, Judith Garcia-Aymerich, Aida A. Aydemir, Beatrix Vereijken, Valdo Arnera, Nadir Ammour, Michael Jackson, Tilo Hache, Ronenn Roubenoff
Publicado en: Digital Biomarkers, Edición 4/1, 2020, Página(s) 13-27, ISSN 2504-110X
Editor: S Karger AG
DOI: 10.1159/000512513

Sensor-Based and Patient-Based Assessment of Daily-Living Physical Activity in People with Parkinson’s Disease: Do Motor Subtypes Play a Role?

Autores: Irina Galperin, Talia Herman, Mira Assad, Natalie Ganz, Anat Mirelman, Nir Giladi, Jeffrey M. Hausdorff
Publicado en: Sensors, Edición 20/24, 2020, Página(s) 7015, ISSN 1424-8220
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s20247015

Technical validation of real-world monitoring of gait: a multicentric observational study.

Autores: "Mazzà , Claudia; Alcock, Lisa; Aminian, Kamiar; Becker, Clemens; Bertuletti, Stefano; Bonci, Tecla; Brown, Philip; Brozgol, Marina; Buckley, Ellen; Carsin, Anne-Elie; Caruso, Marco; Caulfield, Brian; Cereatti, Andrea; Chiari, Lorenzo; Chynkiamis, Nikolaos; Ciravegna, Fabio; Del Din, Silvia; Eskofier, Bjö rn; Evers, Jordi; Garcia Aymerich, Judith; Gazit, Eran; Hansen, Clint; Hausdorff, Je"
Publicado en:  BMJ Open, Edición Volume 11, Edición 12, 2021, ISSN 2044-6055
Editor: BMJ Publishing Group
DOI: 10.1136/bmjopen-2021-050785

Detection of unsupervised standardized gait tests from real-world inertial sensor data in Parkinson’s disease

Autores: Martin Ullrich, Annika Mücke, Arne Küderle, Nils Roth, Till Gladow, Heiko Gaßner, Franz Marxreiter, Jochen Klucken, Bjoern M. Eskofier, and Felix Kluge
Publicado en: IEEE Transactions on Neural Systems and Rehabilitation Engineering, Edición Volume 29:2103-2111, 2021, ISSN 1558-0210
Editor: IEEE
DOI: 10.1109/tnsre.2021.3119390

Listening to the patients’ voice: a conceptual framework of the walking experience

Autores: Laura Delgado-Ortiz; Ashley Polhemus; Alison Keogh; Norman Sutton; Werner Remmele; Clint Hansen; Felix Kluge; Basil Sharrack; Clemens Becker; Thierry Troosters; Walter Maetzler; Lynn Rochester; Anja Frei; Milo A Puhan; Judith Garcia-Aymerich
Publicado en: Age and Ageing, Edición Volume 52, Edición 1, January 2023, 2023, ISSN 1468-2834
Editor: Oxford Academic
DOI: 10.1093/ageing/afac233

Feasibility and usability of a digital health technology system to monitor mobility and assess medication adherence in mild-to-moderate Parkinson’s disease

Autores: Héloïse Debelle, Emma Packer, Esther Beales, Harry G B Bailey, Ríona Mc Ardle, Philip Brown, Heather Hunter, Fabio Ciravegna, Neil Ireson, Jordi Evers, Martijn Niessen, Jian Qing SHI, Alison J Yarnall, Lynn Rochester, Lisa Alcock, Silvia Del Din.
Publicado en: Frontiers in Neurology, Edición Volume 14 - 2023, 2023, ISSN 1664-2295
Editor: Frontiers Research Foundation
DOI: 10.3389/fneur.2023.1111260

On the use of wearable sensors as mobility biomarkers in the marketing authorization of new drugs: A regulatory perspective

Autores: Viceconti, Marco; Tome, Maria; Dartee, Wilhelmus; Knezevic, Igor; Penna, Sabina Hernandez; Mazzà, Claudia; Caulfield, Brian; Garcia-Aymerich, Judith; Becker, Clemens; Maetzler, Walter; Troosters, Thierry; Sharrack, Basil; Davico, Giorgio; Corriol-Rohou, Solange; Rochester, Lynn; Mobilise-D Consortium
Publicado en: Frontiers in Medicine, Sec. Regulatory Science, Edición 9, 2022, ISSN 2296-858X
Editor: Frontiers in Medicine
DOI: 10.3389/fmed.2022.996903

Toward a Regulatory Qualification of Real-World Mobility Performance Biomarkers in Parkinson’s Patients Using Digital Mobility Outcomes

Autores: Marco Viceconti, Sabina Hernandez Penna, Wilhelmus Dartee, Claudia Mazzà, Brian Caulfield, Clemens Becker, Walter Maetzler, Judith Garcia-Aymerich, Giorgio Davico, Lynn Rochester
Publicado en: Sensors, Edición 20/20, 2020, Página(s) 5920, ISSN 1424-8220
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s20205920

An Objective Methodology for the Selection of a Device for Continuous Mobility Assessment

Autores: Tecla Bonci, Alison Keogh, Silvia Del Din, Kirsty Scott, Claudia Mazzà
Publicado en: Sensors, Edición 20/22, 2020, Página(s) 6509, ISSN 1424-8220
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s20226509

Mobility recorded by wearable devices and gold standards: the Mobilise-D procedure for data standardization

Autores: Luca Palmerini; Luca Reggi; Tecla Bonci; Silvia Del Din; M. Encarna Micó-Amigo; Francesca Salis; Stefano Bertuletti; Marco Caruso; Andrea Cereatti; Eran Gazit; Anisoara Paraschiv-Ionescu; Abolfazl Soltani; Felix Kluge; Arne Küderle; Martin Ullrich; Cameron Kirk; Hugo Hiden; Ilaria D’Ascanio; Clint Hansen; Lynn Rochester; Claudia Mazzà; Lorenzo Chiari
Publicado en: Scientific Data, Edición volume 10, Article number: 38 (2023), 2023, ISSN 2052-4463
Editor: Sci data
DOI: 10.1038/s41597-023-01930-9

Body-Worn Sensors for Remote Monitoring of Parkinson’s Disease Motor Symptoms: Vision, State of the Art, and Challenges Ahead

Autores: Silvia Del Din, Cameron Kirk, Alison J. Yarnall, Lynn Rochester, Jeffrey M. Hausdorff
Publicado en: Journal of Parkinson's Disease, 2021, Página(s) 1-13, ISSN 1877-7171
Editor: IOS Press
DOI: 10.3233/jpd-202471

Real-World Walking Speed Assessment Using a Mass-Market RTK-GNSS Receiver

Autores: Reggi Luca, Palmerini Luca, Chiari Lorenzo, Mellone Sabato
Publicado en: Frontiers in Bioengineering and Biotechnology, 2022, ISSN 2296-4185
Editor: Frontiers Media S.A.
DOI: 10.3389/fbioe.2022.873202

Machine learning-based distinction of left and right foot contacts in lower back inertial sensor gait data

Autores: Ullrich, M., Küderle, A., Reggi, L., Cereatti, A., Eskofier, B.M., & Kluge, F. 
Publicado en: IEEE 2021 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), 2021, ISSN 2694-0604
Editor: IEEE
DOI: 10.1109/embc46164.2021.9630653

A Multifactorial Model of Multiple Sclerosis Gait and its Changes Across Different Disability Levels

Autores: Lorenza Angelini, Ellen Buckley, Tecla Bonci, Alexandra Radford, Basil Sharrack, David Paling, Krishnan Padmakumari Sivaraman Nair, Claudia Mazza
Publicado en: IEEE Transactions on Biomedical Engineering, Edición 24.02.2021, 2021, Página(s) 1-1, ISSN 0018-9294
Editor: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tbme.2021.3061998

Fragmentation, circadian amplitude, and fractal pattern of daily-living physical activity in people with multiple sclerosis: Is there relevant information beyond the total amount of physical activity?

Autores: Amit Salomon, Irina Galperin, David Buzaglo, Anat Mirelman, Keren Regev, Arnon Karni, Tanja Schmitz-Hübsch, Friedemann Paul, Hannes Devos, Jacob J Sosnoff, Eran Gazit, Raz Tamir, Nathaniel Shimoni, Jeffrey M Hausdorff
Publicado en: Multiple Sclerosis and Related Disorders, Edición Volume 68, December 2022, 104108, 2022, ISSN 1879-3282
Editor: Elsevier
DOI: 10.1016/j.msard.2022.104108

An Algorithm for Accurate Marker-Based Gait Event Detection in Healthy and Pathological Populations During Complex Motor Tasks

Autores: Tecla Bonci; Francesca Salis; Kirsty Scott; Lisa Alcock; Clemens Becker; Stefano Bertuletti; Ellen Buckley; Marco Caruso; Andrea Cereatti; Silvia Del Din; Eran Gazit; Clint Hansen; Jeffrey M. Hausdorff; Walter Maetzler; Luca Palmerini; Lynn Rochester; Lars Schwickert; Basil Sharrack; Ioannis Vogiatzis; Claudia Mazzà
Publicado en: Frontiers in Bioengineering and Biotechnology, Sec. Biomechanics, Edición Volume 10, 2022, ISSN 2296-4185
Editor: Frontiers in Bioengineering and Biotechnology
DOI: 10.3389/fbioe.2022.868928

Mobilise-D: Evaluering av gange og mobilitet på en innovativ måte

Autores: Kristin Taraldsen, Jorunn L Helbostad, Lars Gunnar Johnson, Ingvild Saltved, Beatrix Vereijken
Publicado en: Fysioterapeuten, Edición 4.21, 2021, Página(s) 70-72, ISSN 0807-9277
Editor: Norsk Fysioterapeutforbund
DOI: 10.5281/zenodo.6832443

Next-generation digital tools for mobility in research & health

Autores: Vereijken, Beatrix; Rochester, Lynn
Publicado en: Open Access Government, 2021
Editor: Open Access Government
DOI: 10.5281/zenodo.6531977

Multi-sensor integration and data fusion for enriching gait assessment In and Out of the laboratory

Autores: Cereatti, A.; Bertuletti, S.; Caruso, M.; Salis, F.
Publicado en: International Society of Biomechanics (ISB), Edición 1, 2019
Editor: ISB2019
DOI: 10.5281/zenodo.4469142

Accuracy of a multi-sensor system in stride parameters estimation: comparison of straight and curvilinear portions.

Autores: F. Salis, S. Bertuletti, K. Scott, M. Caruso, T. Bonci, E. Buckley, U. Della Croce, C. Mazzà and A. Cereatti
Publicado en: Proceedings XXI Congresso SIAMOC 2021, 2021, Página(s) 95, ISSN 2038-7954
Editor: AMS Acta
DOI: 10.6092/unibo/amsacta/6846

Continuous mobility monitoring: what is currently missing for a widespread deployment in clinical and research settings?

Autores: Bonci, Tecla; Keogh, Alisson; Del Din, Silvia; Scott, Kirsty; Mazzà, Claudia
Publicado en: International Conference on the Virtual Physiological Human (VPH), Edición 5, 2020
Editor: VPH2020
DOI: 10.5281/zenodo.4463250

Accuracy of the Orientation Estimate Obtained Using Four Sensor Fusion Filters Applied to Recordings of Magneto-Inertial Sensors Moving at Three Rotation Rates

Autores: M. Caruso, A. M. Sabatini, M. Knaflitz, M. Gazzoni, U. Della Croce, A. Cereatti
Publicado en: 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2019, Página(s) 2053-2058, ISBN 978-1-5386-1311-5
Editor: IEEE
DOI: 10.1109/embc.2019.8857655

Towards an automatic parameter setting for MIMU sensor fusion algorithms

Autores: M. Caruso; R. Rossanigo; A.M. Sabatini; M. Knaflitz; M. Gazzoni; U. Della Croce; A. Cereatti
Publicado en: Gait & Posture, Edición 5, 2019
Editor: Elsevier
DOI: 10.5281/zenodo.4461502

Real-world speed estimation using single trunk IMU: methodological challenges for impaired gait patterns *

Autores: Anisoara Paraschiv-Ionescu, Abolfazl Soltani, Kamiar Aminian
Publicado en: 2020 42nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), 2020, Página(s) 4596-4599, ISBN 978-1-7281-1990-8
Editor: IEEE
DOI: 10.1109/embc44109.2020.9176281

Multi-sensor integration and data fusion for enhancing gait assessment in and out of the laboratory

Autores: F. Salis; S. Bertuletti; M. Caruso; U. Della Croce; C. Mazzà; A. Cereatti
Publicado en: Gait & Posture 74 34, Edición 4, 2019
Editor: ISM2019
DOI: 10.5281/zenodo.4471297

Effects of pharmacological and non-pharmacological interventions on physical activity outcomes in chronic respiratory diseases: a systematic review and meta-analysis

Autores: D Megaritis, E Hume, N Chynkiamis, C Buckley, AM Polhemus, H Watz, T Troosters, I Vogiatzis
Publicado en: Thorax, Edición 77, 2022, Página(s) A215, ISSN 1468-3296
Editor: BMJ
DOI: 10.1136/thorax-2022-btsabstracts.305

Gait in real world: validated algorithms for gait periods and speed estimation using a single wearable sensor

Autores: Soltani, Abolfazl
Publicado en: 2020
Editor: Lausanne, EPFL
DOI: 10.5075/epfl-thesis-8099

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