Connecting digital mobility assessment to clinical outcomes for regulatory and clinical endorsement

Leistungen

Final version of study protocol as approved by first ethics committee; registration number of clinical study in an approved registry that also allows later posting of study results; approvals required for enrolment of first subject in at least one clinical centre

System performance analysis

This report will include the results of a detailed system performance analysis for the MobiliseD data management platform It will include a technical evaluation eg data transmission times access logs etc stakeholder feedback and an analysis of technical support logs

Risk assessment process and management procedure

Description of the methodology for project risk assessment and categorisation, including a risk management process

Detailed system requirements specification, including definition of data acquisition, transmission, integration, processing, analytics and governance requirements

This report will incorporate detailed system requirements specification for the data management platform. This will include definition of data acquisition, transmission, integration, processing, analytics and governance requirements

Ethical approval including all amendments

Ethical approval will be prepared during the first year and will include the experience of the WP 2 technical validation. The process will be finalized based on the results of WP2. Each site will submit the ethical protocol including the national requirments.

Report on publications, presentations, and event organisation (M12, with annual updates)

This deliverable is based on work carried out in Tasks 7.3 and 7.4, and details the publications, presentations and event organisations throughout the first year of the project, with subsequent annual updates. The report will be based on a database containing all outreach activities carried out by the consortium members.

Statistical description report on digital mobility outcomes, health outcomes and their relationships

We will study the statistical distribution of digital mobility outcomes, clinical outcomes and the shape of their relationships, using standard and hypothesis-free statistical analyses and existing cohort data

Data Management Plan V1

Inititial version of the data management plan

Data Management Plan V2

Mid project updated data management plan

Veröffentlichungen

Connecting real-world digital mobility assessment to clinical outcomes for regulatory and clinical endorsement–the Mobilise-D study protocol

Autoren: Mikolaizak, A. Stefanie; Rochester, Lynn; Maetzler, Walter; Sharrack, Basil; Demeyer, Heleen; Mazzà, Claudia; Caulfield, Brian; Garcia-Aymerich, Judith; Vereijken, Beatrix; Arnera, Valdo; Miller, Ram; Piraino, Paolo; Ammour, Nadir; Gordon, Mark Forrest; Troosters, Thierry; Yarnall, Alison J.; Alcock, Lisa; Gaßner, Heiko; Winkler, Jürgen; Klucken, Jochen; Schlenstedt, Christian; Watz, Henrik; Ki
Veröffentlicht in: Plos, Ausgabe 4, 2022, ISSN 1932-6203
Herausgeber: Public Library of Science
DOI: 10.1101/2022.05.25.22275598

Performance of a multi-sensor wearable system for validating gait assessment: preliminary results on patients and healthy

Autoren: F. Salis, T. Bonci, S. Bertuletti , M. Caruso , K. Scott , E. Buckley, L. Alcock , S. Del Din , L. Rochester , E. Gazit , J.M. Hausdorff , C. Hansen 7, W. Maetzler , L. Schwickert 8, C. Becker , C. Mazzà , A. Cereatti, on behalf of the Mobilise-D consortium
Veröffentlicht in: Gait & Posture, Ausgabe Volume 97, Supplement 2, October 2022, 2022, Seite(n) 13, ISSN 1879-2219
Herausgeber: Elsevier
DOI: 10.1016/j.gaitpost.2022.09.027

Mobility endpoints in marketing authorisation of drugs: what gets the European medicines agency moving?

Autoren: Jaeger, Simon U; Wohlrab, Martin; Schoene, Daniel; Tremmel, Roman; Chambers, Michael; Leocani, Letizia; Corriol-Rohou, Solange; Klenk, Jochen; Sharrack, Basil; Garcia-Aymerich, Judith; Rochester, Lynn; Maetzler, Walter; Puhan, Milo; Schwab, Matthias; Becker, Clemens
Veröffentlicht in: Age and Ageing, Ausgabe 5, 2022, ISSN 0002-0729
Herausgeber: Oxford University Press
DOI: 10.1093/ageing/afab242

Real-world speed estimation using single IMU: A conceptual framework

Autoren: Aminian, Kamiar; Soltani, Abolfazl Soltani; Paraschiv-Ionescu, Anisoara
Veröffentlicht in: A conceptual framework, 16th International Symposium of 3D-Analysis of Human Movement, Ames (USA), May 25-28, 2021., 2021, ISSN 2333-5432
Herausgeber: International Society of Biomechanics
DOI: 10.5281/zenodo.5561261

Computational modelling of the scoliotic spine: A literature review

Autoren: Samuele L Gould; Luca Cristofolini; Giorgio Davico; Marco Viceconti
Veröffentlicht in: International journal for Numerical Methods in Biomedical Engineering, Ausgabe 16, 2021, ISSN 2040-7947
Herausgeber: John Wiley & Sons Ltd
DOI: 10.1002/cnm.3503

A Quality Control Check to Ensure Comparability of Stereophotogrammetric Data between Sessions and Systems

Autoren: Kirsty Scott; Tecla Bonci; Lisa Alcock; Ellen Buckley; Clint Hansen; Eran Gazit; Lars Schwickert; Andrea Cereatti; Claudia Mazzà; on behalf of the Mobilise-D Consortium
Veröffentlicht in: Sensors; Volume 21; Ausgabe 24;, 2021, Seite(n) Pages: 8223, ISSN 1424-8220
Herausgeber: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s21248223

Inertial sensor-based gait parameters reflect patient-reported fatigue in multiple sclerosis

Autoren: Alzhraa A. Ibrahim, Arne Küderle, Heiko Gaßner, Jochen Klucken, Bjoern M. Eskofier, Felix Kluge
Veröffentlicht in: Journal of NeuroEngineering and Rehabilitation, Ausgabe 17/1, 2020, ISSN 1743-0003
Herausgeber: BioMed Central
DOI: 10.1186/s12984-020-00798-9

Gait Detection from a Wrist-Worn Sensor Using Machine Learning Methods: A Daily Living Study in Older Adults and People with Parkinson's Disease

Autoren: Yonatan E Brand, Dafna Schwartz, Eran Gazit, Aron S Buchman, Ran Gilad-Bachrach, Jeffrey M Hausdorff
Veröffentlicht in: Sensors, Ausgabe Sensors 2022, 22(18), 7094, 2022, ISSN 1424-8220
Herausgeber: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s22187094

uTUG: An unsupervised Timed Up and Go test for Parkinson’s disease

Autoren: João Elison da Rosa Tavares; Martin Ullrich; Nils Roth; Felix Kluge; Bjoern M. Eskofier; Heiko Gaßner; Jochen Klucken; Till Gladow; Franz Marxreiter; Cristiano André da Costa; Rodrigo da Rosa Righi; Jorge Luis Victória Barbosa
Veröffentlicht in: Biomedical Signal Processing and Control, Ausgabe Volume 81, March 2023, 104394, 2023, ISSN 1746-8094
Herausgeber: Elsevier BV
DOI: 10.1016/j.bspc.2022.104394

A deep learning model to discern indoor from outdoor environments based on data recorded by a tri-axial digital magnetic sensor

Autoren: Marcianò, V.; Bertuletti, S.; Bonci, T.; Mazzà, C.; Ireson, N.; Ciravegna, F.; Del Din, S.; Gazit, E.; Cereatti, A.
Veröffentlicht in: Gait and Posture, Ausgabe Volume 97, Supplement 2, October 2022,, 2022, Seite(n) 5, ISSN 0966-6362
Herausgeber: Elsevier BV
DOI: 10.1016/j.gaitpost.2022.09.015

Technologische innovationen in der Pneumonologie - Facetten aus Diagnostik und Therapie

Autoren: Randerath W, Dreher M, Gompelmann D, Held M, Koczulla R, Köhnlein T, Rohde G, Wälscher J, Watz H, Steinkamp G.
Veröffentlicht in: Pneumologie, Ausgabe 14.07.2020, 2020, ISSN 0934-8387
Herausgeber: Georg Thieme Verlag
DOI: 10.5281/zenodo.4468658

Wearable sensors can reliably quantify gait alterations associated with disability in people with progressive multiple sclerosis in a clinical setting

Autoren: Lorenza Angelini, William Hodgkinson, Craig Smith, Jessie Moorman Dodd, Basil Sharrack, Claudia Mazzà, David Paling
Veröffentlicht in: Journal of Neurology, Ausgabe 267/10, 2020, Seite(n) 2897-2909, ISSN 0340-5354
Herausgeber: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00415-020-09928-8

"It's not about the capture, it's about what we can learn"": a qualitative study of experts' opinions and experiences regarding the use of wearable sensors to measure gait and physical activity."

Autoren: Alison Keogh; Kristin Taraldsen; Brian Caulfield; Beatrix Vereijken
Veröffentlicht in: Journal of NeuroEngineering and Rehabilitation, 2021, ISSN 1743-0003
Herausgeber: BioMed Central
DOI: 10.1186/s12984-021-00874-8

Algorithms for Walking Speed Estimation Using a Lower-Back-Worn Inertial Sensor: A Cross-Validation on Speed Ranges

Autoren: Abolfazl Soltani; Kamiar Aminian; Claudia Mazzà; Andrea Cereatti; Luca Palmerini; Tecla Bonci; Anisoara Paraschiv-Ionescu
Veröffentlicht in:  IEEE TNSRE (2021), 2021, ISSN 1534-4320
Herausgeber: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tnsre.2021.3111681

Autoren: Ashley Marie Polhemus, Ronny Bergquist, Magda Bosch de Basea, Gavin Brittain, Sara Catherine Buttery, Nikolaos Chynkiamis, Gloria dalla Costa, Laura Delgado Ortiz, Heleen Demeyer, Kirsten Emmert, Judith Garcia Aymerich, Heiko Gassner, Clint Hansen, Nicholas Hopkinson, Jochen Klucken, Felix Kluge, Sarah Koch, Letizia Leocani, Walter Maetzler, M Encarna Micó-Amigo, A Stefanie Mikolaizak, Paolo Pira
Veröffentlicht in: BMJ Open, Ausgabe 10/7, 2020, Seite(n) e038704, ISSN 2044-6055
Herausgeber: BMJ Publishing Group
DOI: 10.1136/bmjopen-2020-038704

The value of walking: a systematic review on mobility and healthcare costs.

Autoren: Martin Wohlrab; Jochen Klenk; Laura Delgado-Ortiz; Michael Chambers; Lynn Rochester; Matthias Zuchowski; Matthias Schwab; Clemens Becker; Simon U. Jaeger
Veröffentlicht in: European Review of Aging and Physical Activity, Ausgabe 19, 2022, ISSN 1861-6909
Herausgeber: European Review of Aging and Physical Activity
DOI: 10.1186/s11556-022-00310-3

Analysis of the Accuracy of Ten Algorithms for Orientation Estimation Using Inertial and Magnetic Sensing under Optimal Conditions: One Size Does Not Fit All.

Autoren: M. Caruso; Angelo Maria Sabatini; Daniel Laidig; Thomas Seel; Marco Knaflitz; Ugo Della Croce; Andrea Cereatti
Veröffentlicht in: MDPI Sensors, Vol 21, Iss 2543, p 2543 (2021), Ausgabe 3, 2021, ISSN 1424-8220
Herausgeber: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s21072543

A wearable multi-sensor system for real world gait analysis

Autoren: F. Salis; S. Bertuletti; K. Scott; M. Caruso; T. Bonci; E. Buckley; U. Della Croce; C. Mazza; A. Cereatti
Veröffentlicht in: 2021 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), 2021, ISSN 2694-0604
Herausgeber: IEEE
DOI: 10.1109/embc46164.2021.9630392

Clinical Relevance of Standardized Mobile Gait Tests. Reliability Analysis Between Gait Recordings at Hospital and Home in Parkinson’s Disease: A Pilot Study

Autoren: Gaßner H, Sanders P, Dietrich A, Marxreiter F, Eskofier BM, Winkler J, Klucken J
Veröffentlicht in: Journal of Parkinson's Disease, Ausgabe 8/17/2020, 2020, ISSN 1877-7171
Herausgeber: IOS Press
DOI: 10.5281/zenodo.4468815

Classical Machine Learning Versus Deep Learning for the Older Adults Free-Living Activity Classification

Autoren: Muhammad Awais, Lorenzo Chiari, Espen A. F. Ihlen, Jorunn L. Helbostad, Luca Palmerini
Veröffentlicht in: Sensors, Ausgabe 21/14, 2021, Seite(n) 4669, ISSN 1424-8220
Herausgeber: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s21144669

The e-Science Central Study Data Platform

Autoren: Watson, Paul; Hiden, Hugo
Veröffentlicht in: 2022 IEEE 18th International Conference on e-Science (e-Science), Ausgabe 20, 2022, ISSN 2473-2001
Herausgeber: IEEE Xplore
DOI: 10.1109/escience55777.2022.00020

The Effects of an Individualized Smartphone-Based Exercise Program on Self-defined Motor Tasks in Parkinson Disease: Pilot Interventional Study

Autoren: Heiko Gaßner; Jana Friedrich; Alisa Masuch; Jelena Jukic; Sabine Stallforth; Martin Regensburger; Franz Marxreiter; Jürgen Winkler; Jochen Klucken
Veröffentlicht in: JMIR Rehabilitation and Assistive Technologies, Ausgabe Vol 9 , No 4 (2022) :Oct-Dec, 2022, ISSN 2369-2529
Herausgeber: JMIR Rehabilitation and Assistive Technologies
DOI: 10.2196/38994

Walking on common ground: a cross-disciplinary scoping review on the clinical utility of digital mobility outcomes.

Autoren: Ashley Polhemus; Laura Delgado Ortiz; Gavin Brittain; Nikolaos Chynkiamis; Francesca Salis; Heiko Gaßner; Michaela Gross; Cameron Kirk; Rachele Rossanigo; Kristin Taraldsen; Diletta Balta; Sofie Breuls; Sara Buttery; Gabriela Cardenas; Christoph Endress; Julia Gugenhan; Alison Keogh; Felix Kluge; Sarah Koch; M. Encarna Micó-Amigo; Corinna Nerz; Chloé Sieber; Parris J Williams; Ronny Bergquist;
Veröffentlicht in: npj Digital Medicine, 2021, ISSN 2398-6352
Herausgeber: npj Digital Medicine (npj Digit. Med.)
DOI: 10.1038/s41746-021-00513-5

Acceptability of wearable devices for measuring mobility remotely: Observations from the Mobilise-D technical validation study

Autoren: Alison Keogh, Lisa Alcock, Philip Brown, Ellen Buckley, Marina Brozgol, Eran Gazit, Clint Hansen, Kirsty Scott, Lars Schwickert, Clemens Becker, Jeffrey Hausdorff, Walter Maetzler, Lynn Rochester, Basil Sharrack, Ionnis Vogiatzis, Alison Yarnall, Claudia Mazza, Brian Caulfield.
Veröffentlicht in: Digital Health, Ausgabe DIGITAL HEALTH. 2023;9., 2023, ISSN 2158-2440
Herausgeber: SAGE Publications Inc.
DOI: 10.1177/20552076221150745

An Inertial Sensor-Based Gait Analysis Pipeline for the Assessment of Real-World Stair Ambulation Parameters.

Autoren: Nils Roth; Arne Küderle; Dominik Prossel; Heiko Gassner; Heiko Gassner; Bjoern M. Eskofier; Felix Kluge
Veröffentlicht in: MDPI Sensors (Basel, Switzerland), Ausgabe 2, 2021, ISSN 1424-8220
Herausgeber: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s21196559

Multidisciplinary Intensive Rehabilitation Program for People with Parkinson's Disease: Gaps between the Clinic and Real-World Mobility

Autoren: Moriya Cohen, Talia Herman, Natalie Ganz, Inbal Badichi, Tanya Gurevich , Jeffrey M Hausdorff
Veröffentlicht in: International Journal of Environmental Research and Public Health, Ausgabe IJERPH Volume 20 Ausgabe 5, 2023, ISSN 1660-4601
Herausgeber: International Journal of Environmental Research and Public Health
DOI: 10.3390/ijerph20053806

Assessing the usability of wearable devices to measure gait and physical activity in chronic conditions: a systematic review

Autoren: Alison Keogh; Rob Argent; Amy Anderson; Brian Caulfield; William Johnston
Veröffentlicht in: Journal of NeuroEngineering and Rehabilitation,, Ausgabe Vol 18, Iss 1,, 2021, Seite(n) Pp 1-17 (2021), ISSN 1743-0003
Herausgeber: BioMed Central
DOI: 10.1186/s12984-021-00931-2

Validation of a Sensor-Based Gait Analysis System with a Gold-Standard Motion Capture System in Patients with Parkinson’s Disease

Autoren: Verena Jakob, Arne Küderle, Felix Kluge, Jochen Klucken, Bjoern M. Eskofier, Jürgen Winkler, MartinWinterholler and Heiko Gassner
Veröffentlicht in: Sensors, Ausgabe Volume 22 Special Ausgabe Inertial Sensors for Clinically Relevant Mobility Outcome Measures, 2021, ISSN 1424-8220
Herausgeber: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s21227680

Orientation Estimation Through Magneto-Inertial Sensor Fusion: A Heuristic Approach for Suboptimal Parameters Tuning

Autoren: Caruso M, Sabatini M, Knaflitz M, Gazzoni M, Della Croce U, Cereatti A
Veröffentlicht in: IEEE Sensors Journal, Ausgabe 21.09.2020, 2020, ISSN 1530-437X
Herausgeber: Institute of Electrical and Electronics Engineers
DOI: 10.5281/zenodo.4457500

Consensus based framework for digital mobility monitoring

Autoren: Kluge, F., Del Din, S., Cereatti, A., Gaßner, H., Hansen, C., Helbostadt, J. L., Klucken, J., Küderle, A., Müller, A., Rochester, L., Ullrich, M., Eskofier, B. M., Mazzà, C., & Mobilise-D
Veröffentlicht in: PLoS ONE, 2021, ISSN 1932-6203
Herausgeber: Public Library of Science
DOI: 10.1371/journal.pone.0256541

Using musculoskeletal models to estimate in vivo total knee replacement kinematics and loads: effect of differences between models

Autoren: Curreli, Cristina; Di Puccio, Francesca; Davico, Giorgio; Modenese, Luca; Viceconti, Marco
Veröffentlicht in: Frontiers in Bioengineering and Biotechnology, Ausgabe Volume 9, 2021, Seite(n) 1-10, ISSN 2296-4185
Herausgeber: Frontiers Media
DOI: 10.3389/fbioe.2021.703508

A method for gait events detection based on low spatial resolution pressure insoles data

Autoren: F. Salis, S. Bertuletti, T. Bonci, U. Della Croce, C. Mazzà, A. Cereatti
Veröffentlicht in: Journal of Biomechanics, Ausgabe 127, 2021, Seite(n) 110687, ISSN 0021-9290
Herausgeber: Elsevier BV
DOI: 10.1016/j.jbiomech.2021.110687

Extension of the Rigid-Constraint Method for the Heuristic Suboptimal Parameter Tuning to Ten Sensor Fusion Algorithms Using Inertial and Magnetic Sensing

Autoren: Caruso, M.; Sabatini, A.M.; Knaflitz, M.; Della Croce, U.; Cereatti, A.
Veröffentlicht in: Sensors, Ausgabe 21(18) - Special Ausgabe Sensors and IoT in Modern Healthcare Delivery and Applications, 2021, ISSN 1424-8220
Herausgeber: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s21186307

Multi-level personalization of neuromusculoskeletal models to estimate physiologically plausible knee joint contact forces in children

Autoren: Claudio Pizzolato; Giorgio Davico; Bryce Killen; David Lloyd; Daniel Devaprakash; Christopher Carty
Veröffentlicht in: Biomechanics and Modeling in Mechanobiology, Ausgabe 21, 2022, ISSN 1617-7940
Herausgeber: Biomechanics and Modeling in Mechanobiology
DOI: 10.1007/s10237-022-01626-w

Design and validation of a multi-task, multi-context protocol for real-world gait simulation

Autoren: Scott, Kirsty; Bonci, Tecla; Alcock, Lisa; Buckley, Ellen; Gazit, Eran; Hansen, Clint; Schwickert, Lars; Aminian, Kamiar; Bertuletti, Stefano; Caruso, Marco; Chiari, Lorenzo; Sharrack, Basil; Maetzler, Walter; Becker, Clemens; Hausdorff, Jeffrey M.; Vogiatzis, Ioannis; Brown, Philipp; Del Din, Silvia; Eskofier, Björn; Paraschiv-Ionescu, Anisoara; Keogh, Alison; Kirk, Cameron; Kluge, Felix; Micó
Veröffentlicht in: Journal of NeuroEngineering and Rehabilitation, Ausgabe 19, Article number: 141 (2022), 2022, ISSN 1743-0003
Herausgeber: BioMed Central
DOI: 10.1186/s12984-022-01116-1

Investigating the Impact of Environment and Data Aggregation by Walking Bout Duration on Parkinson’s Disease Classification Using Machine Learning

Autoren: Rana Zia Ur Rehman, Yu Guan, Jian Qing Shi, Lisa Alcock, Alison J. Yarnall, Lynn Rochester and Silvia Del Din
Veröffentlicht in: Frontiers in Aging Neuroscience, Ausgabe Research topic: Activities of Daily Living and Everyday Functioning: From Normal Aging to Neurodegenerative Diseases, 2022, ISSN 1663-4365
Herausgeber: Frontiers Research Foundation
DOI: 10.3389/fnagi.2022.808518

A Proposal for a Linear Calculation of Gait Asymmetry

Autoren: Linda Maria Adriana van Gelder, Lorenza Angelini, Ellen E. Buckley, Claudia Mazzà
Veröffentlicht in: Symmetry, Ausgabe 13/9, 2021, Seite(n) 1560, ISSN 2073-8994
Herausgeber: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/sym13091560

Is a Wearable Sensor-Based Characterisation of Gait Robust Enough to Overcome Differences Between Measurement Protocols? A Multi-Centric Pragmatic Study in Patients with Multiple Sclerosis

Autoren: Lorenza Angelini, Ilaria Carpinella, Davide Cattaneo, Maurizio Ferrarin, Elisa Gervasoni, Basil Sharrack, David Paling, Krishnan Padmakumari Sivaraman Nair, Claudia Mazzà
Veröffentlicht in: Sensors, Ausgabe 20/1, 2020, Seite(n) 79, ISSN 1424-8220
Herausgeber: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s20010079

Accelerometry-Based Digital Gait Characteristics for Classification of Parkinson's Disease: What Counts?

Autoren: Rana Zia Ur Rehman, Christopher Buckley, Maria Encarna Mico-Amigo, Cameron Kirk, Michael Dunne-Willows, Claudia Mazza, Jian Qing Shi, Lisa Alcock, Lynn Rochester, Silvia Del Din
Veröffentlicht in: IEEE Open Journal of Engineering in Medicine and Biology, Ausgabe 1, 2020, Seite(n) 65-73, ISSN 2644-1276
Herausgeber: IEEE
DOI: 10.1109/ojemb.2020.2966295

Gait variability as digital biomarker of disease severity in Huntington’s disease

Autoren: Heiko Gaßner, Dennis Jensen, F. Marxreiter, Anja Kletsch, Stefan Bohlen, Robin Schubert, Lisa M. Muratori, Bjoern Eskofier, Jochen Klucken, Jürgen Winkler, Ralf Reilmann, Zacharias Kohl
Veröffentlicht in: Journal of Neurology, 2020, ISSN 0340-5354
Herausgeber: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00415-020-09725-3

Detection of Gait From Continuous Inertial Sensor Data Using Harmonic Frequencies

Autoren: Martin Ullrich, Arne Kuderle, Julius Hannink, Silvia Del Din, Heiko Gassner, Franz Marxreiter, Jochen Klucken, Bjoern Michael Eskofier, Felix Kluge
Veröffentlicht in: IEEE Journal of Biomedical and Health Informatics, 2020, Seite(n) 1-1, ISSN 2168-2194
Herausgeber: Institute of Electrical and Electronics Engineers Inc.
DOI: 10.1109/jbhi.2020.2975361

A wearable sensor identifies alterations in community ambulation in multiple sclerosis: contributors to real-world gait quality and physical activity

Autoren: Shirley Shema-Shiratzky, Inbar Hillel, Anat Mirelman, Keren Regev, Katherine L. Hsieh, Arnon Karni, Hannes Devos, Jacob J. Sosnoff, Jeffrey M. Hausdorff
Veröffentlicht in: Journal of Neurology, 2020, ISSN 0340-5354
Herausgeber: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00415-020-09759-7

Credibility of In Silico Trial Technologies—A Theoretical Framing

Autoren: Marco Viceconti, Miguel A. Juarez, Cristina Curreli, Marzio Pennisi, Giulia Russo, Francesco Pappalardo
Veröffentlicht in: IEEE Journal of Biomedical and Health Informatics, Ausgabe 24/1, 2020, Seite(n) 4-13, ISSN 2168-2194
Herausgeber: Institute of Electrical and Electronics Engineers Inc.
DOI: 10.1109/JBHI.2019.2949888

Long-term unsupervised mobility assessment in movement disorders

Autoren: Elke Warmerdam, Jeffrey M Hausdorff, Arash Atrsaei, Yuhan Zhou, Anat Mirelman, Kamiar Aminian, Alberto J Espay, Clint Hansen, Luc J W Evers, Andreas Keller, Claudine Lamoth, Andrea Pilotto, Lynn Rochester, Gerhard Schmidt, Bastiaan R Bloem, Walter Maetzler
Veröffentlicht in: The Lancet Neurology, Ausgabe 19/5, 2020, Seite(n) 462-470, ISSN 1474-4422
Herausgeber: The Lancet Publishing Group
DOI: 10.1016/s1474-4422(19)30397-7

Intra-operator Repeatability of Manual Segmentations of the Hip Muscles on Clinical Magnetic Resonance Images.

Autoren: Giorgio Davico; Francesca Bottin; Alberto Di Martino; Vanita Castafaro; Fabio Baruffaldi; Cesare Faldini; Marco Viceconti
Veröffentlicht in: Journal of Digital Imaging, Ausgabe Ausgabe 36, 2022, Seite(n) 143–152, ISSN 1618-727X
Herausgeber: Journal of Digital Imaging
DOI: 10.1007/s10278-022-00700-0

A Roadmap to Inform Development, Validation and Approval of Digital Mobility Outcomes: The Mobilise-D Approach

Autoren: Lynn Rochester, Claudia Mazzà, Arne Mueller, Brian Caulfield, Marie McCarthy, Clemens Becker, Ram Miller, Paolo Piraino, Marco Viceconti, Wilhelmus P. Dartee, Judith Garcia-Aymerich, Aida A. Aydemir, Beatrix Vereijken, Valdo Arnera, Nadir Ammour, Michael Jackson, Tilo Hache, Ronenn Roubenoff
Veröffentlicht in: Digital Biomarkers, Ausgabe 4/1, 2020, Seite(n) 13-27, ISSN 2504-110X
Herausgeber: S Karger AG
DOI: 10.1159/000512513

Sensor-Based and Patient-Based Assessment of Daily-Living Physical Activity in People with Parkinson’s Disease: Do Motor Subtypes Play a Role?

Autoren: Irina Galperin, Talia Herman, Mira Assad, Natalie Ganz, Anat Mirelman, Nir Giladi, Jeffrey M. Hausdorff
Veröffentlicht in: Sensors, Ausgabe 20/24, 2020, Seite(n) 7015, ISSN 1424-8220
Herausgeber: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s20247015

Technical validation of real-world monitoring of gait: a multicentric observational study.

Autoren: "Mazzà , Claudia; Alcock, Lisa; Aminian, Kamiar; Becker, Clemens; Bertuletti, Stefano; Bonci, Tecla; Brown, Philip; Brozgol, Marina; Buckley, Ellen; Carsin, Anne-Elie; Caruso, Marco; Caulfield, Brian; Cereatti, Andrea; Chiari, Lorenzo; Chynkiamis, Nikolaos; Ciravegna, Fabio; Del Din, Silvia; Eskofier, Bjö rn; Evers, Jordi; Garcia Aymerich, Judith; Gazit, Eran; Hansen, Clint; Hausdorff, Je"
Veröffentlicht in:  BMJ Open, Ausgabe Volume 11, Ausgabe 12, 2021, ISSN 2044-6055
Herausgeber: BMJ Publishing Group
DOI: 10.1136/bmjopen-2021-050785

Detection of unsupervised standardized gait tests from real-world inertial sensor data in Parkinson’s disease

Autoren: Martin Ullrich, Annika Mücke, Arne Küderle, Nils Roth, Till Gladow, Heiko Gaßner, Franz Marxreiter, Jochen Klucken, Bjoern M. Eskofier, and Felix Kluge
Veröffentlicht in: IEEE Transactions on Neural Systems and Rehabilitation Engineering, Ausgabe Volume 29:2103-2111, 2021, ISSN 1558-0210
Herausgeber: IEEE
DOI: 10.1109/tnsre.2021.3119390

Listening to the patients’ voice: a conceptual framework of the walking experience

Autoren: Laura Delgado-Ortiz; Ashley Polhemus; Alison Keogh; Norman Sutton; Werner Remmele; Clint Hansen; Felix Kluge; Basil Sharrack; Clemens Becker; Thierry Troosters; Walter Maetzler; Lynn Rochester; Anja Frei; Milo A Puhan; Judith Garcia-Aymerich
Veröffentlicht in: Age and Ageing, Ausgabe Volume 52, Ausgabe 1, January 2023, 2023, ISSN 1468-2834
Herausgeber: Oxford Academic
DOI: 10.1093/ageing/afac233

Feasibility and usability of a digital health technology system to monitor mobility and assess medication adherence in mild-to-moderate Parkinson’s disease

Autoren: Héloïse Debelle, Emma Packer, Esther Beales, Harry G B Bailey, Ríona Mc Ardle, Philip Brown, Heather Hunter, Fabio Ciravegna, Neil Ireson, Jordi Evers, Martijn Niessen, Jian Qing SHI, Alison J Yarnall, Lynn Rochester, Lisa Alcock, Silvia Del Din.
Veröffentlicht in: Frontiers in Neurology, Ausgabe Volume 14 - 2023, 2023, ISSN 1664-2295
Herausgeber: Frontiers Research Foundation
DOI: 10.3389/fneur.2023.1111260

On the use of wearable sensors as mobility biomarkers in the marketing authorization of new drugs: A regulatory perspective

Autoren: Viceconti, Marco; Tome, Maria; Dartee, Wilhelmus; Knezevic, Igor; Penna, Sabina Hernandez; Mazzà, Claudia; Caulfield, Brian; Garcia-Aymerich, Judith; Becker, Clemens; Maetzler, Walter; Troosters, Thierry; Sharrack, Basil; Davico, Giorgio; Corriol-Rohou, Solange; Rochester, Lynn; Mobilise-D Consortium
Veröffentlicht in: Frontiers in Medicine, Sec. Regulatory Science, Ausgabe 9, 2022, ISSN 2296-858X
Herausgeber: Frontiers in Medicine
DOI: 10.3389/fmed.2022.996903

Toward a Regulatory Qualification of Real-World Mobility Performance Biomarkers in Parkinson’s Patients Using Digital Mobility Outcomes

Autoren: Marco Viceconti, Sabina Hernandez Penna, Wilhelmus Dartee, Claudia Mazzà, Brian Caulfield, Clemens Becker, Walter Maetzler, Judith Garcia-Aymerich, Giorgio Davico, Lynn Rochester
Veröffentlicht in: Sensors, Ausgabe 20/20, 2020, Seite(n) 5920, ISSN 1424-8220
Herausgeber: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s20205920

An Objective Methodology for the Selection of a Device for Continuous Mobility Assessment

Autoren: Tecla Bonci, Alison Keogh, Silvia Del Din, Kirsty Scott, Claudia Mazzà
Veröffentlicht in: Sensors, Ausgabe 20/22, 2020, Seite(n) 6509, ISSN 1424-8220
Herausgeber: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s20226509

Mobility recorded by wearable devices and gold standards: the Mobilise-D procedure for data standardization

Autoren: Luca Palmerini; Luca Reggi; Tecla Bonci; Silvia Del Din; M. Encarna Micó-Amigo; Francesca Salis; Stefano Bertuletti; Marco Caruso; Andrea Cereatti; Eran Gazit; Anisoara Paraschiv-Ionescu; Abolfazl Soltani; Felix Kluge; Arne Küderle; Martin Ullrich; Cameron Kirk; Hugo Hiden; Ilaria D’Ascanio; Clint Hansen; Lynn Rochester; Claudia Mazzà; Lorenzo Chiari
Veröffentlicht in: Scientific Data, Ausgabe volume 10, Article number: 38 (2023), 2023, ISSN 2052-4463
Herausgeber: Sci data
DOI: 10.1038/s41597-023-01930-9

Body-Worn Sensors for Remote Monitoring of Parkinson’s Disease Motor Symptoms: Vision, State of the Art, and Challenges Ahead

Autoren: Silvia Del Din, Cameron Kirk, Alison J. Yarnall, Lynn Rochester, Jeffrey M. Hausdorff
Veröffentlicht in: Journal of Parkinson's Disease, 2021, Seite(n) 1-13, ISSN 1877-7171
Herausgeber: IOS Press
DOI: 10.3233/jpd-202471

Real-World Walking Speed Assessment Using a Mass-Market RTK-GNSS Receiver

Autoren: Reggi Luca, Palmerini Luca, Chiari Lorenzo, Mellone Sabato
Veröffentlicht in: Frontiers in Bioengineering and Biotechnology, 2022, ISSN 2296-4185
Herausgeber: Frontiers Media S.A.
DOI: 10.3389/fbioe.2022.873202

Machine learning-based distinction of left and right foot contacts in lower back inertial sensor gait data

Autoren: Ullrich, M., Küderle, A., Reggi, L., Cereatti, A., Eskofier, B.M., & Kluge, F. 
Veröffentlicht in: IEEE 2021 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), 2021, ISSN 2694-0604
Herausgeber: IEEE
DOI: 10.1109/embc46164.2021.9630653

A Multifactorial Model of Multiple Sclerosis Gait and its Changes Across Different Disability Levels

Autoren: Lorenza Angelini, Ellen Buckley, Tecla Bonci, Alexandra Radford, Basil Sharrack, David Paling, Krishnan Padmakumari Sivaraman Nair, Claudia Mazza
Veröffentlicht in: IEEE Transactions on Biomedical Engineering, Ausgabe 24.02.2021, 2021, Seite(n) 1-1, ISSN 0018-9294
Herausgeber: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tbme.2021.3061998

Fragmentation, circadian amplitude, and fractal pattern of daily-living physical activity in people with multiple sclerosis: Is there relevant information beyond the total amount of physical activity?

Autoren: Amit Salomon, Irina Galperin, David Buzaglo, Anat Mirelman, Keren Regev, Arnon Karni, Tanja Schmitz-Hübsch, Friedemann Paul, Hannes Devos, Jacob J Sosnoff, Eran Gazit, Raz Tamir, Nathaniel Shimoni, Jeffrey M Hausdorff
Veröffentlicht in: Multiple Sclerosis and Related Disorders, Ausgabe Volume 68, December 2022, 104108, 2022, ISSN 1879-3282
Herausgeber: Elsevier
DOI: 10.1016/j.msard.2022.104108

An Algorithm for Accurate Marker-Based Gait Event Detection in Healthy and Pathological Populations During Complex Motor Tasks

Autoren: Tecla Bonci; Francesca Salis; Kirsty Scott; Lisa Alcock; Clemens Becker; Stefano Bertuletti; Ellen Buckley; Marco Caruso; Andrea Cereatti; Silvia Del Din; Eran Gazit; Clint Hansen; Jeffrey M. Hausdorff; Walter Maetzler; Luca Palmerini; Lynn Rochester; Lars Schwickert; Basil Sharrack; Ioannis Vogiatzis; Claudia Mazzà
Veröffentlicht in: Frontiers in Bioengineering and Biotechnology, Sec. Biomechanics, Ausgabe Volume 10, 2022, ISSN 2296-4185
Herausgeber: Frontiers in Bioengineering and Biotechnology
DOI: 10.3389/fbioe.2022.868928

Mobilise-D: Evaluering av gange og mobilitet på en innovativ måte

Autoren: Kristin Taraldsen, Jorunn L Helbostad, Lars Gunnar Johnson, Ingvild Saltved, Beatrix Vereijken
Veröffentlicht in: Fysioterapeuten, Ausgabe 4.21, 2021, Seite(n) 70-72, ISSN 0807-9277
Herausgeber: Norsk Fysioterapeutforbund
DOI: 10.5281/zenodo.6832443

Next-generation digital tools for mobility in research & health

Autoren: Vereijken, Beatrix; Rochester, Lynn
Veröffentlicht in: Open Access Government, 2021
Herausgeber: Open Access Government
DOI: 10.5281/zenodo.6531977

Multi-sensor integration and data fusion for enriching gait assessment In and Out of the laboratory

Autoren: Cereatti, A.; Bertuletti, S.; Caruso, M.; Salis, F.
Veröffentlicht in: International Society of Biomechanics (ISB), Ausgabe 1, 2019
Herausgeber: ISB2019
DOI: 10.5281/zenodo.4469142

Accuracy of a multi-sensor system in stride parameters estimation: comparison of straight and curvilinear portions.

Autoren: F. Salis, S. Bertuletti, K. Scott, M. Caruso, T. Bonci, E. Buckley, U. Della Croce, C. Mazzà and A. Cereatti
Veröffentlicht in: Proceedings XXI Congresso SIAMOC 2021, 2021, Seite(n) 95, ISSN 2038-7954
Herausgeber: AMS Acta
DOI: 10.6092/unibo/amsacta/6846

Continuous mobility monitoring: what is currently missing for a widespread deployment in clinical and research settings?

Autoren: Bonci, Tecla; Keogh, Alisson; Del Din, Silvia; Scott, Kirsty; Mazzà, Claudia
Veröffentlicht in: International Conference on the Virtual Physiological Human (VPH), Ausgabe 5, 2020
Herausgeber: VPH2020
DOI: 10.5281/zenodo.4463250

Accuracy of the Orientation Estimate Obtained Using Four Sensor Fusion Filters Applied to Recordings of Magneto-Inertial Sensors Moving at Three Rotation Rates

Autoren: M. Caruso, A. M. Sabatini, M. Knaflitz, M. Gazzoni, U. Della Croce, A. Cereatti
Veröffentlicht in: 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2019, Seite(n) 2053-2058, ISBN 978-1-5386-1311-5
Herausgeber: IEEE
DOI: 10.1109/embc.2019.8857655

Towards an automatic parameter setting for MIMU sensor fusion algorithms

Autoren: M. Caruso; R. Rossanigo; A.M. Sabatini; M. Knaflitz; M. Gazzoni; U. Della Croce; A. Cereatti
Veröffentlicht in: Gait & Posture, Ausgabe 5, 2019
Herausgeber: Elsevier
DOI: 10.5281/zenodo.4461502

Real-world speed estimation using single trunk IMU: methodological challenges for impaired gait patterns *

Autoren: Anisoara Paraschiv-Ionescu, Abolfazl Soltani, Kamiar Aminian
Veröffentlicht in: 2020 42nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), 2020, Seite(n) 4596-4599, ISBN 978-1-7281-1990-8
Herausgeber: IEEE
DOI: 10.1109/embc44109.2020.9176281

Multi-sensor integration and data fusion for enhancing gait assessment in and out of the laboratory

Autoren: F. Salis; S. Bertuletti; M. Caruso; U. Della Croce; C. Mazzà; A. Cereatti
Veröffentlicht in: Gait & Posture 74 34, Ausgabe 4, 2019
Herausgeber: ISM2019
DOI: 10.5281/zenodo.4471297

Effects of pharmacological and non-pharmacological interventions on physical activity outcomes in chronic respiratory diseases: a systematic review and meta-analysis

Autoren: D Megaritis, E Hume, N Chynkiamis, C Buckley, AM Polhemus, H Watz, T Troosters, I Vogiatzis
Veröffentlicht in: Thorax, Ausgabe 77, 2022, Seite(n) A215, ISSN 1468-3296
Herausgeber: BMJ
DOI: 10.1136/thorax-2022-btsabstracts.305

Gait in real world: validated algorithms for gait periods and speed estimation using a single wearable sensor

Autoren: Soltani, Abolfazl
Veröffentlicht in: 2020
Herausgeber: Lausanne, EPFL
DOI: 10.5075/epfl-thesis-8099

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