METABOL is a deep-tech company specialized in the development of novel biomarker-based diagnostic solutions for complex diseases. The company has developed an effective pipeline to firstly identify diagnostic biomarker panels and then translate these panels into clinical assays ready for application in the clinical laboratory.
This pipeline combines the biomarker multiplexing capabilities of Mass Spectrometry (LC-MSMS), a powerful analytical technology, with the company’s own informatics and statistics solutions to deliver diagnostic innovation. This is reflected in METABOL’ strong and versatile IP portfolio of technical innovations and biomarkers.
We use LC-MSMS to evaluate multiple biomarker candidates in one run, leveraging the multiplexing capabilities of LC-MSMS platforms. Thus facilitating translation to novel IVD suited for risk screening in the clinical laboratory.
Our technology combines the biomarker multiplexing capabilities of Mass Spectrometry with the company’s own informatics and statistics solutions to deliver diagnostic innovation.
METABOL vision is to develop a portfolio of diagnostic solutions for pregnancy risk for the “great obstetrical syndromes”. These are complications of pregnancy that arise when the complex and highly concerted interactions formed in pregnancy between mother, baby and the environment are disturbed in some way. This can lead to pregnancy complications like preeclampsia, gestational diabetes, preterm birth, and in-uterine growth restriction, which all have the potential to severely impact on the well-being of mother and child.
In collaboration with leading clinical researchers worldwide, METABOL’ team have used mass spectrometry based workflows to analyse 1000’s of pregnancy samples, which allows us to verify a panel of biomarkers relevant for the prediction of preeclampsia risk. Our team is already working on similar solutions for some of the other great obstetrical syndromes.
IPOG supported METABOL in its journey to become a world leader in innovative pregnancy diagnostics by supporting the development of METABOL's first product PrePsia™ . Pregnancy care globally has not benefited from recent significant advances in technology, IPOG has supported METABOL to change that. The accelerated commercialisation of PrePsia™ through the support of Horizon2020 will save the lives of mothers and babies and generate cost savings for health services globally.
PrePsia is a prototype screening test, which identifies in early pregnancy, those women at increased risk of developing preeclampsia later in their pregnancies
One of the most significant complications which can occur during pregnancy is preeclampsia, affecting up to 8% of all pregnancies. Unfortunately, the disease is complex and remains hidden in early pregnancy. When clinical symptoms do eventually appear, preeclampsia can have serious health implications: the condition is responsible for the deaths of more than 70,000 mothers and half a million babies each year. In addition to the human cost, dealing with preeclampsia puts significant pressure on healthcare systems worldwide. Identifying in early pregnancy, those mothers at risk of developing preeclampsia is difficult. The current gold standard in prenatal care does not detect the disease early enough, thus limiting the opportunity for medical interventions. If clinicians could easily identify early in pregnancy those at risk of the condition, there is clinical intervention available which can have a dramatic impact, saving the lives of mothers and babies.
PrePsia™ will revolutionise prenatal care globally by enabling healthcare providers to customize pregnancy care to a woman’s personal risk profile.
PrePsia™ is a simple blood test that will run in clinical laboratories on Liquid Chromatography Mass Spectrometer platforms (LC/MSMS) which has been shown to be a cost-effective solution in the clinical laboratory.
