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Artificial Cells with Distributed Cores to Decipher Protein Function

Objective

We envision a future where ‘chemical apps’ on mobile devices produce on demand valuable compounds for health and performance as well as apps for bioagent threat detection and disease. To take concrete and defined steps toward this future vision, we will exploit the miniaturization provided by lab on a chip technology and construct responsive architectures and metabolism based on living cells and tissues. We will build programmable and re-configurable, (bio)chemical processes, with precision, order, and as hierarchical cellular constructs, in the same way as living systems. We will enable microscale, liquid-based, chemical compartmentalisation (cores), and inter-compartmental (core-core) communication, just as one finds in organelles, cells and tissues. ACDC will focus on developing this next generation technology through a detailed workplan that heavily involves the nontrivial tasks of integrating diverse state of the art technologies including microfluidics, microwave resonators, DNA-based supramolecular assembly, in vitro gene expression and the integration of membrane channels into a functional platform. In a future embodiment of this project, artificial cell technology will be used as programmable and reconfigurable matter for specific applications, including theranostics and personalized medicine as well as sensing and actuation in the environments for bioremediation.
As the first steps towards that future vision, we aim to produce an artificial technological construct and process that recapitulates some aspects of living systems on the microscale, and therefore this project will produce exemplars of secondary living technologies concentrating on the wetware class [1] but also a multi-level mathematical framework. We have assembled an international, interdisciplinary team from academia, industry and public engagement. Our outreach and engagement programme will define the impact in both the public and economic sectors with ethical dimensions considered. Further, building upon 55 years of collective start-up enterprise experience, we will explore the translation of new intellectual property generated into commercial advantage and job creation for the European Union.

Call for proposal

H2020-FETPROACT-2018-01
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

UNIVERSITA DEGLI STUDI DI TRENTO
Address
Via Calepina 14
38122 Trento
Italy
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 198 437,50

Participants (5)

CARDIFF UNIVERSITY
United Kingdom
EU contribution
€ 1 144 596,25
Address
Newport Road 30-36
CF24 ODE Cardiff
Activity type
Higher or Secondary Education Establishments
ZURCHER HOCHSCHULE FUR ANGEWANDTE WISSENSCHAFTEN
Switzerland
EU contribution
€ 630 550
Address
Gertrudstrasse 15
8401 Winterthur
Activity type
Higher or Secondary Education Establishments
EXPLORA SRL
Italy
EU contribution
€ 729 500
Address
Via Giacomo Peroni 386
00131 Roma
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ELVESYS
France
EU contribution
€ 512 125
Address
172 Rue De Charonne B2 2 Eme Etage
75011 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
MUSEO DELLE SCIENZE
Italy
EU contribution
€ 161 086,25
Address
Corso Del Lavoro E Della Scienza 3
38123 Trento
Activity type
Other