Risultati finali
Algorithms for wholeslide image compression The input of those algorithm is a multiresolution Gigapixel histopathology wholeslide image and the output is a compressed representation of the input in the form of a data volume rows columns features The amount of rows and column of the compressed representation will be much smaller than the original wholeslide image and the number of features will be in the order of 128 or 256 values Encoders will be implemented in the form of a webbased service in the EXA MODE web site which will allow to upload WSIs and download a compressed representation of it in the form of a data fileThe tool is tested in order to verify Milestone 8
Conceptual descriptive framework for multimodal knowledgeThis designed conceptual descriptive framework allows medical computer science experts to easily represent into a unified framework multimodal medical information reducing the effort to combine textual and imaging data for clinical decision support systems
2nd dissemination, communication and exploitation report & outline for the following yearThis report reviews all the dissemination exploitation and communication activities performed during the year and it draws the outlines for the following year divided per activity
Graph representation of the histopathology knowledgeThe histopathology visual knowledge graph represents the relationships between scale and color invariant content of the histopathology images It is described in a scientific publication and it is released to the other members of the consortium
Algorithms for whole-slide image classificationDeep neural networks for classification of histopathology wholeslide images Targets of trained networks will be released as a milestone during the project Classification algorithms will be implemented in a webbased platform available at Radboudumc namely CIRRUS Pathology Techniques addressing the problem of endtoend training of neural networks for WSI classification will be disseminated as scientific publicationsThe tool is tested in order to verify Milestone 8
Semantic knowledge extractor prototypeDescription This designed semantic knowledge extractor allows to represent textual descriptions of medical reports in terms of semantic networks extracting authoritative concepts and semantic relations out of text The released prototype benefits from the feedbacks of clinicians that supervised the quality of the resultsThe semantic knowledge extractor prototype includes the preliminary version of the visualisation tool prototype with basic functionalities targeting internal use in order to verify Milestone 7
Multimodal knowledge representation originating from imagesThe multimodal knowledge graphs includes paired histopathology visual and text information It is released to the other members of the consortium and it empowers WP 4 and WP5
Final dissemination, communication and exploitation reportThis report reviews all the dissemination exploitation and communication activities performed during the entire project It also provides a plan for continued dissemination activities subsequent to the project The deliverable includes the planned exploitation activities which are expected to take place upon the end of the project
Data and model parallel approaches for training ANNsEfficient scaling algorithms We focus on the large batch size learning challenge scaling behavior and hardware efficiency Techniques addressing the problem of scaling up the endtoend training of neural networks for WSI classification will be disseminated as scientific publications
1st dissemination, communication and exploitation report & outline for the following yearThis report reviews all the dissemination, exploitation and communication activities performed during the year and it draws the outlines for the following year, divided per activity.
Algorithms for semantic segmentation and detection in histopathology imagesDeep neural networks for detection and semantic segmentation of tissue regions in whole-slide images. Targets of trained networks will be released as a milestone during the project. Detection and segmentation algorithms will be implemented in a web-based platform available at Radboudumc, namely CIRRUS Pathology. Segmentation results will be produced in a format compatible with the in-house developed open-source platform ASAP [61], as well as CIRRUS Pathology, which will allow to inspect, modify and further process segmentation results as well as likelihood maps produced by neural networks. Novel techniques of weakly-supervised semantic in whole-slide images will be disseminated as scientific publications. The tool is tested in order to verify Milestone 8.
Automatic knowledge discovery system prototype and user study outcomeThis knowledge discovery system allows clinicians to automatically obtain connected relevant information in different combinations The returned types of information are report textual descriptions medical images authoritative concepts and semantic relations between them The released prototype take into account the different heterogeneous components of the systems and benefit from the feedbacks of expert users that tested the tool in the field The deliverable is shared among UNIPD and HESSO because they will strongly collaborate on the prototype
The final set of annotated whole slide images are made available to the consortium. Such data are selected from the AOEC data and must include at least 100 annotated whole slide images in the final annotated dataset. The annotation requirements are defined by AOEC and MICROSCOPEIT together before the data annotation begins and are made available on the private section of the EXA MODE web page. The data annotations are performed using a software based on previous works of the partners HES-SO and MICROSCOPEIT.
Final set of data curated and availableThe final set of whole slide images and medical report are made available to the consortium. Such data are selected from the 600’000 AOEC and Radboudumc data according to the consortium requirements.
First set of annotated digital pathology dataThe first set of annotated whole slide images are made available to the consortium. Such data are selected from the AOEC data and must include at least 100 annotated whole slide images in the final annotated dataset. The annotation requirements are defined by AOEC and MICROSCOPEIT together before the data annotation begins and are made available on the private section of the EXA MODE web page. The data annotations are performed using a software based on previous works of the partners HES-SO and MICROSCOPEIT.
First set of cured, publicly available multimodal and multimedia dataThe first set of cured publicly available data include respectively at least 500 and 5’000 histopathology images and related text extracted from scientific literature and the web. The images and the related text include content that is relevant for histopathology diagnostic purposes and that can be used to train machine learning based algorithms.
Set of publicly available algorithms to separate compound imagesThe algorithms to separate compound images and link them to related text are presented into a scientific publication and they are publicly released on the EXA MODE website.
Tools to extract homogeneous representations of heterogeneous colour visual informationThe algorithms and tools are presented into a scientific publication and they are publicly released on the EXA MODE websiteThe prototypes are tested in order to verify Milestone 6
Tools to extract multi-scale representations of visual informationThe algorithms and tools to extract multiscale representations of visual information are presented into a scientific publication and they are publicly released on the EXA MODE websiteThe prototypes are tested in order to verify Milestone 6
Final set of cured, publicly available multimodal and multimedia dataThe final set of cured publicly available data include respectively at least 500 and 5’000 histopathology images and related text extracted from scientific literature and the web. The images and the related text include content that is relevant for histopathology diagnostic purposes and that can be used to train machine learning based algorithms.
First set of data curated and availableThe first set of whole slide images and medical report are made available to the consortium. Such data are selected from the 600’000 AOEC and Radboudumc data according to the consortium requirements.
This visualization analytics prototype allows the interaction with the learning methods and allows the experts to understand intermediate learning states. The released prototype take into account the feedbacks of expert users that tested the tool in the field.
The web site contains the description of the project, a section with a list of publications (and also press releases and articles in the popular press) and a private section for the partners to exchange software, data and information. All public deliverables are available as pdf from the web page. The web site includes an RSS feeder with news on the project and it is updated regularly.
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Nature
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