MICROBiome-based biomarkers to PREDICT decompensation of liver cirrhosis and treatment response

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Go-online of the public project website
Second patient and layman event
Project brochure and professional templates
Dissemination activity at IHMC congress in Barcelona 2020

Dissemination activity at IHMC congress in Barcelona 2020.

First patient and layman event

Final version of study protocol to be approved by ethics committee(s)
Report on Acquire proteomics data
Report on lipidomics and bile acids data
Brochure to inform in brief about MICROB-PREDICT for participants involved in the clinical study

Brochure to inform in brief about MICROB-PREDICT for participants involved in the clinical study.

Codes of conduct applicable and research integrity policy including publications in journals
Registration number of clinical study in a WHO- or ICMJE- approved registry
First written draft of a model describing typical treatment paths in decompensated cirrhosis
Information and Informed consent template for participation of human beings (patients/healthy volunteers), for using biological samples of human origin in research and for the use of personal data (including genetic data) in research
Policy for integrating the 6 agendas (ethics, gender equality, public engagement, governance, scientific education and open access) of responsible research and innovation
Checklist for participants to assure informed consent / other mechanisms for those unable to give a written consent
Report on histological data of gut barrier
Report on metabolomics data
Public engagement strategy to design MICROB-PREDICT along with the need of patients

Multi-omic data analysis software public release
Implementation of model in a software package

Publications

The Specific NLRP3 Antagonist IFM-514 Decreases Fibrosis and Inflammation in Experimental Murine Non-Alcoholic Steatohepatitis

Author(s): Torres Sandra, Brol Maximilian J, Magdaleno Fernando, Schierwagen Robert, Uschner Frank E., Klein Sabine, Ortiz Cristina, Tyc Olaf, Bachtler Nadine, Stunden James, Bertheloot Damien, Kitanovic Ana, Sanchez Brian, Schrum Jacob, Roush William R., Franchi Luigi, Byth Kate, Latz Eicke, Trebicka Jonel
Published in: Frontiers in Molecular Biosciences, Issue Volume 8, 2021, ISSN 2296-889X
Publisher: Frontiers Media
DOI: 10.3389/fmolb.2021.715765

Prognostic Value of the CLIF-C AD Score in Patients With Implantation of Transjugular Intrahepatic Portosystemic Shunt

Author(s): Sturm, L., Praktiknjo, M., Bettinger, D., Huber, J.P., Volkwein, L., Schmidt, A.R., Kaeser, R., Chang, J., Jansen, C., Meyer, C.H., Thomas, D.K., Thimme, R., Trebicka, J., & Schultheiss, M
Published in: Hepatology Communications, Issue Volume 5, 2021, Page(s) 650-660, ISSN 2471-254X
Publisher: AASLD
DOI: 10.1002/hep4.1654

Bile Acids, Liver Cirrhosis, and Extrahepatic Vascular Dysfunction

Author(s): Tilman Sauerbruch, Martin Hennenberg, Jonel Trebicka and Ulrich Beuers
Published in: Frontiers in Physiology, Issue 29.07.2021, 2021, ISSN 2296-858X
Publisher: Frontiers of Medicine
DOI: 10.3389/fphys.2021.718783

The Development and Outcome of Acute‐on‐Chronic Liver Failure After Surgical Interventions

Author(s): Leah Maria Klein, Johannes Chang, Wenyi Gu, Steffen Manekeller, Christian Jansen, Philipp Lingohr, Michael Praktiknjo, Jörg C. Kalf, Martin Schulz, Ulrich Spengler, Christian Strassburg, Andrés Cárdenas, Vicente Arroyo, Jonel Trebicka
Published in: Liver Transplantation, Issue 26/2, 2019, Page(s) 227-237, ISSN 1527-6465
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/lt.25675

Epidemiology of liver transplantation and post-LT complications in Germany: nationwide study (2005-2018).

Author(s): Gu, W., Schaaf, L., Hortlik, H., Zeleke, Y., Brol, M. J., Schnitzbauer, A. A., Bechstein, W. O., Zeuzem, S., Queck, A., Peiffer, K. H., Tischendorf, M., Pascher, A., Laleman, W., Praktiknjo, M., Schulz, M. S., Uschner, F. E., Rennebaum, F., & Trebicka, J.
Published in: European journal of gastroenterology & hepatology, 2023, ISSN 1473-5687
Publisher: Wolters Kluwer
DOI: 10.1097/meg.0000000000002640

Total area of spontaneous portosystemic shunts independently predicts hepatic encephalopathy and mortality in liver cirrhosis

Author(s): Michael Praktiknjo, Macarena Simón-Talero, Julia Römer, Davide Roccarina, Javier Martínez, Katharina Lampichler, Anna Baiges, Gavin Low, Elba Llop, Martin H. Maurer, Alexander Zipprich, Michela Triolo, Geert Maleux, Annette Dam Fialla, Claus Dam, Judit Vidal-González, Avik Majumdar, Carmen Picón, Daniel Toth, Anna Darnell, Juan G. Abraldes, Marta López, Christian Jansen, Johannes Chang, Robe
Published in: Journal of Hepatology, Issue 72/6, 2020, Page(s) 1140-1150, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/j.jhep.2019.12.021

The Role of Macrophage-Inducible C-Type Lectin in Different Stages of Chronic Liver Disease

Author(s): Robert Schierwagen, Frank E. Uschner, Cristina Ortiz, Sandra Torres, Max J. Brol, Olaf Tyc, Wenyi Gu, Christian Grimm, Stefan Zeuzem, Andreas Plamper, Philipp Pfeifer, Sebastian Zimmer, Christoph Welsch, Liliana Schaefer, Karl P. Rheinwalt, Joan Clària, Vicente Arroyo, Jonel Trebicka, Sabine Klein
Published in: Frontiers in Immunology, Issue 11, 2020, ISSN 1664-3224
Publisher: Frontiers Media SA
DOI: 10.3389/fimmu.2020.01352

Liver Transplantation as a Cornerstone Treatment for Acute-On-Chronic Liver Failure.

Author(s): Schulz, M. S., Gu, W., Schnitzbauer, A. A., & Trebicka, J.
Published in: Transplant international : official journal of the European Society for Organ Transplantation, 2022, ISSN 1432-2277
Publisher: Frontiers Media
DOI: 10.3389/ti.2022.10108

Beta-blockers in patients with liver cirrhosis: Pragmatism or perfection?.

Author(s): Sauerbruch, T., Hennenberg, M., Trebicka, J., & Schierwagen, R.
Published in: Frontiers in medicine, 2023, ISSN 2296-858X
Publisher: Frontiers media
DOI: 10.3389/fmed.2022.1100966

Baseline Presence of NAFLD Predicts Weight Loss after Gastric Bypass Surgery for Morbid Obesity

Author(s): Karl P. Rheinwalt; Uta Drebber; orcid Robert Schierwagen; Sabine D. Klein; Ulf P. Neumann; Tom Florian Ulmer; Andreas Plamper;orcid bw Andreas Kroh; Sandra Schipper; Margarete Odenthal; Frank Erhard Uschner; Philipp Lingohr; Jonel Trebicka; Maximilian J. Brol;
Published in: Journal of Clinical Medicine, Issue Volume 9, Issue 11, 2020, ISSN 2077-0383
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm9113430

Controlled underdilation using novel VIATORR® controlled expansion stents improves survival after transjugular intrahepatic portosystemic shunt implantation

Author(s): Michael Praktiknjo, Jasmin Abu-Omar, Johannes Chang, Daniel Thomas, Christian Jansen, Patrick Kupczyk, Filippo Schepis, Juan Carlos Garcia-Pagan, Manuela Merli, Carsten Meyer, Christian P. Strassburg, Claus C. Pieper, Jonel Trebicka
Published in: JHEP, Issue Volume 3, Issue 3, 2021, ISSN 0346-251X
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.jhepr.2021.100264

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction-associated fatty liver disease

Author(s): López-Vicario, C., Sebastián, D., Casulleras, M., Duran-Güell, M., Flores-Costa, R., Aguilar, F., Lozano, J. J., Zhang, I. W., Titos, E., Kang, J. X., Zorzano, A., Arita, M., & Clària, J.
Published in: Hepatology, 2023, ISSN 1527-3350
Publisher: Wiley
DOI: 10.1002/hep.32647

Deep Visual Proteomics maps proteotoxicity in a genetic liver disease

Author(s): Florian A. Rosenberger, Sophia C. Mädler, Katrine Holtz Thorhauge, Sophia Steigerwald, Malin Fromme, Mikhail Lebedev, Caroline A. M. Weiss, Marc Oeller, Maria Wahle, Andreas Metousis, Maximilian Zwiebel, Niklas A. Schmacke, Sönke Detlefsen, Peter Boor, Ondřej Fabián, Soňa Fraňková, Aleksander Krag, Pavel Strnad, Matthias Mann
Published in: Nature, 2025, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-025-08885-4

Dynamic human liver proteome atlas reveals functional insights into disease pathways.

Author(s): Niu L, Geyer PE, Gupta R, Santos A, Meier F, Doll S, Wewer Albrechtsen NJ, Klein S, Ortiz C, Uschner FE, Schierwagen R, Trebicka J, Mann M
Published in: Mol Syst Biol., 2022, ISSN 1744-4292
Publisher: Nature Publishing Group
DOI: 10.15252/msb.202210947

Mitochondrial Dysfunction in Advanced Liver Disease: Emerging Concepts

Author(s): Ingrid W. Zhang; Ingrid W. Zhang; Cristina López-Vicario; Cristina López-Vicario; Cristina López-Vicario; Marta Duran-Güell; Marta Duran-Güell; Joan Clària; Joan Clària; Joan Clària; Joan Clària
Published in: instname:Universidad de Barcelona, Issue 3, 2021, ISSN 2296-889X
Publisher: Frontiers
DOI: 10.3389/fmolb.2021.772174

Extrahepatic Surgery in Cirrhosis Significantly Increases Portal Pressure in Preclinical Animal Models

Author(s): Chang Johannes, Meinke Jonathan, Geck Moritz, Hebest Marc, Böhling Nina, Dolscheid-Pommerich Ramona, Stoffel-Wagner Birgit, Kristiansen Glen, Overhaus Marcus, Peyman Leon O., Klein Sabine, Uschner Frank E., Brol Maximilian J., Vilz Tim O., Lingohr Philipp, Kalff Jörg C., Jansen Christian, Strassburg Christian P., Wehner Sven, Trebicka Jonel, Praktiknjo Michael
Published in: Frontiers in Physiology, Issue Volume 12, 2021, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2021.720898

Author(s): Xiaojie Yu, Natalia Elfimova, Marion Müller, Daniel Bachurski, Ulrike Koitzsch, Uta Drebber, Esther Mahabir, Hinrich P Hansen, Scott L Friedman, Sabine Klein, Hans Peter Dienes, Marianna Hösel, Reinhard Buettner, Jonel Trebicka, Vangelis Kondylis, Inge Mannaerts, Margarete Odenthal
Published in: cmgh, Issue Volume 13, Issue 6, 2022, Page(s) 1701- 1716, ISSN 2352-345X
Publisher: Elsevier Inc.
DOI: 10.1016/j.jcmgh.2022.02.013

Acute-On-Chronic Liver Failure: Current Interventional Treatment Options and Future Challenges.

Author(s): Kimmann, M., & Trebicka, J.
Published in: Journal of personalized medicine, 2023, ISSN 2075-4426
Publisher: MDPI
DOI: 10.3390/jpm13071052

Use and outcome of TIPS in hospitalized patients in Germany: A Nationwide study (2007-2018)

Author(s): Gu, W., Zeleke, Y., Hortlik, H., Schaaf, L., Uschner, F. E., Schulz, M., Tischendorf, M., Peiffer, K. H., Brol, M. J., Kimmann, M., Vogl, T., Köhler, M., Meyer, C., Gerbes, A., Rössle, M., Laleman, W., Zipprich, A., Steib, C., Praktiknjo, M., Trebicka, J., …German TIPS Working Group
Published in: Hepatology communications, 2023, ISSN 2471-254X
Publisher: Wolters Kluwer Health, Inc.
DOI: 10.1097/hc9.0000000000000237

Serological response and breakthrough infection after COVID-19 vaccination in patients with cirrhosis and post-liver transplant

Author(s): Gautam Mehta, Antonio Riva, Maria Pilar Ballester, Eva Uson, Montserrat Pujadas, Ângela Carvalho-Gomes, Ivan Sahuco, Ariadna Bono, Federico D’Amico, Raffaela Viganò, Elena Diago, Beatriz Tormo Lanseros, Elvira Inglese, Dani Martinez Vazquez, Rajni Sharma, Hio Lam Phoebe Tsou, Nicola Harris, Annelotte Broekhoven, Marjolein Kikkert, Shessy P. Torres Morales, Sebenzile K. Myeni, Mar Riveiro-Barci
Published in: Hepatology Communications, Issue 7, 2024, ISSN 2471-254X
Publisher: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1097/hc9.0000000000000273

Harnessing Bioluminescent Bacteria to Develop an Enzymatic-free Enzyme-linked immunosorbent assay for the Detection of Clinically Relevant Biomarkers

Author(s): Liming Hu, Marianna Rossetti, José Francisco Bergua, Claudio Parolo, Ruslan Álvarez-Diduk, Lourdes Rivas, Andrea Idili, Arben Merkoçi
Published in: ACS Applied Materials & Interfaces, Issue 16, 2024, Page(s) 30636-30647, ISSN 1944-8244
Publisher: American Chemical Society
DOI: 10.1021/acsami.4c01744

Nanodiagnostics to Face SARS-CoV‑2 and Future Pandemics: From an Idea to the Market and Beyond

Author(s): Rosati G., Idili A., Parolo C., Fuentes-Chust C., Calucho E., Hu L., De Carvalho Castro Silva C., Rivas L., Nguyen E., Bergua J., Alvarez-Diduk R., Muñoz J., Junot C., Penon O., Monferrer D., Delamarche, E. Merkoçi A.
Published in: ACS Nano, Issue Volume 15, Issue 11, 2021, Page(s) 17137–17149, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.1c06839

Follistatin-controlled activin-HNF4α-coagulation factor axis in liver progenitor cells determines outcome of acute liver failure

Author(s): Tao Lin, Shanshan Wang, Stefan Munker, Kyounghwa Jung, Ricardo U. Macías-Rodríguez, Astrid Ruiz-Margáin, Robert Schierwagen, Hui Liu, Chen Shao, Chunlei Fan, Rilu Feng, Xiaodong Yuan, Sai Wang, Franziska Wandrer, Christoph Meyer, Ralf Wimmer, Roman Liebe, Jens Kroll, Long Zhang, Tobias Schiergens, Peter ten Dijke, Andreas Teufel, Alexander Marx, Peter R. Mertens, Hua Wang, Matthias P.A. Ebert,
Published in: Hepatology, Issue Volume 75, Issue 2, 2021, Page(s) 322-337, ISSN 2471-254X
Publisher: AASLD
DOI: 10.1002/hep.32119

Trends and the course of liver cirrhosis and its complications in Germany: Nationwide population-based study (2005 to 2018)

Author(s): Wenyi Gu, Hannah Hortlik, Hans-Peter Erasmus, Louisa Schaaf, Yasmin Zeleke, Frank E. Uschner, Philip Ferstl, Martin Schulz, Kai-Henrik Peiffer, Alexander Queck, Tilman Sauerbruch, Maximilian Joseph Brol, Gernot Rohde, Cristina Sanchez, Richard Moreau, Vicente Arroyo, Stefan Zeuzem, Christoph Welsch, Jonel Trebicka
Published in: The Lancet Regional Health - Europe, Issue Volume 12, 2022, ISSN 2666-7762
Publisher: Elsevier Ltd.
DOI: 10.1016/j.lanepe.2021.100240

Assessment of portal hypertension severity using machine learning models in patients with compensated cirrhosis

Author(s): Reiniš, J., Petrenko, O., Simbrunner, B., Hofer, B. S., Schepis, F., Scoppettuolo, M., Saltini, D., Indulti, F., Guasconi, T., Albillos, A., Téllez, L., Villanueva, C., Brujats, A., Garcia-Pagan, J. C., Perez-Campuzano, V., Hernández-Gea, V., Rautou, P. E., Moga, L., Vanwolleghem, T., Kwanten, W. J., … Reiberger, T.
Published in: Journal of hepatology, 2023, ISSN 1600-0641
Publisher: Elsevier Open Access
DOI: 10.1016/j.jhep.2022.09.012

Trust is good, control is better: technical considerations in blood microbiome analysis

Author(s): Robert Schierwagen, Camila Alvarez-Silva, Florence Servant, Jonel Trebicka, Benjamin Lelouvier, Manimozhiyan Arumugam
Published in: Gut, Issue 69/7, 2020, Page(s) 1362-1363, ISSN 0017-5749
Publisher: BMJ Publishing Group
DOI: 10.1136/gutjnl-2019-319123

Precipitants of Acute‐on‐Chronic Liver Failure: An Opportunity for Preventative Measures to Improve Outcomes

Author(s): Giuseppe Cullaro, Rajani Sharma, Jonel Trebicka, Andrés Cárdenas, Elizabeth C. Verna
Published in: Liver Transplantation, Issue 26/2, 2019, Page(s) 283-293, ISSN 1527-6465
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/lt.25678

Essential role for albumin in preserving liver cells from TNFα-induced mitochondrial injury.

Author(s): Duran-Güell, M., Garrabou, G., Flores-Costa, R., Casulleras, M., López-Vicario, C., Zhang, I. W., Cantó-Santos, J., Contreras, B. J., Sánchez-Rodríguez, M. B., Romero-Grimaldo, B., Horrillo, R., Costa, M., Arroyo, V., & Clària, J.
Published in: FASEB, 2023, ISSN 1530-6860
Publisher: Wiley
DOI: 10.1096/fj.202201526r

The Role of Decorin and Biglycan Signaling in Tumorigenesis

Author(s): Diehl Valentina, Huber Lisa Sophie, Trebicka Jonel, Wygrecka Malgorzata, Iozzo Renato V., Schaefer Liliana
Published in: Frontiers in Oncology, Issue Volume 11, 2021, ISSN 2234-943X
Publisher: Frontiers Media S. A.
DOI: 10.3389/fonc.2021.801801

Sex specificity of kidney markers to assess prognosis in cirrhotic patients with TIPS

Author(s): Maria Torner, Adjmal Mangal, Hubert Scharnagl, Christian Jansen, Michael Praktiknjo, Alexander Queck, Wenyi Gu, Robert Schierwagen, Jennifer Lehmann, Frank E. Uschner, Christiana Graf, Christian P. Strassburg, Javier Fernandez, Tatjana Stojakovic, Rainer Woitas, Jonel Trebicka
Published in: Liver International, Issue 40/1, 2019, Page(s) 186-193, ISSN 1478-3223
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/liv.14230

Plasma Proteomes Can Be Reidentifiable and Potentially Contain Personally Sensitive and Incidental Findings

Author(s): Geyer PE, Mann SP, Treit PV, Mann M. Plasma
Published in: Molecula & Cellular Proteomics, Issue 20, 2021, ISSN 1535-9476
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/mcp.ra120.002359

Definition, diagnosis and epidemiology of acute‐on‐chronic liver failure

Author(s): Ruben Hernaez; Hai Li; Richard Moreau; Minneke J. Coenraad
Published in: Crossref, Issue 2, 2023, ISSN 1478-3223
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/liv.15670

Leveraging omics to understand the molecular basis of acute-on-chronic liver failure

Author(s): Joan Clària
Published in: instname:Universidad de Barcelona, Issue 2, 2021, ISSN 2628-491X
Publisher: De Gruyter
DOI: 10.1515/almed-2021-0023

Janus kinase 2 inhibition by pacritinib as potential therapeutic target for liver fibrosis.

Author(s): orres, S., Ortiz, C., Bachtler, N., Gu, W., Grünewald, L. D., Kraus, N., Schierwagen, R., Hieber, C., Meier, C., Tyc, O., Joseph Brol, M., Uschner, F. E., Nijmeijer, B., Welsch, C., Berres, M. L., Garcia-Ruiz, C., Fernandez-Checa, J. C., Trautwein, C., Vogl, T. J., Zeuzem, S., … Klein, S.
Published in: Hepatology, 2023, ISSN 0270-9139
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/hep.32746

Variation in Bile Microbiome by the Etiology of Cholestatic Liver Disease

Author(s): Olaf Tyc, Christian Jansen, Robert Schierwagen, Frank Erhard Uschner, Mads Israelsen, Sabine Klein, Cristina Ortiz, Christian P. Strassburg, Stefan Zeuzem, Wenyi Gu, Sandra Torres, Michael Praktiknjo, Stephan Kersting, Melanie Langheinrich, Jacob Nattermann, Florence Servant, Manimozhiyan Arumugam, Aleksander Krag, Benjamin Lelouvier, Tobias J. Weismüller, Jonel Trebicka
Published in: Liver Transplantation, 2020, ISSN 1527-6465
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/lt.25882

Ethical Principles, Constraints, and Opportunities in Clinical Proteomics

Author(s): Sebastian Porsdam Mann, Peter V.Treit, Philipp E.Geyer, Gilbert S.Omenn, MatthiasMann
Published in: MCP, Issue Volume20, 2021, ISSN 1535-9476
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.mcpro.2021.100046

Restoration of the gut microbiota is associated with a decreased risk of hepatic encephalopathy after TIPS

Author(s): Menghao Li, Kai Li, Shihao Tang, Yong Lv, Qiuhe Wang, Zhengyu Wang, Bohan Luo, Jing Niu, Ying Zhu, Wengang Guo, Wei Bai, Enxin Wang, Dongdong Xia, Zhexuan Wang, Xiaomei Li, Jie Yuan, Zhanxin Yin, Jonel Trebicka, Guohong Han
Published in: JHEP Reports, Issue Volume 4, Issue 5, 2022, ISSN 2589-5559
Publisher: Elsevier BV
DOI: 10.1016/j.jhepr.2022.100448

Genetic variation in TERT modifies the risk of hepatocellular carcinoma in alcohol-related cirrhosis: results from a genome-wide case-control study.

Author(s): Buch, S., Innes, H., Lutz, P. L., Nischalke, H. D., Marquardt, J. U., Fischer, J., Weiss, K. H., Rosendahl, J., Marot, A., Krawczyk, M., Casper, M., Lammert, F., Eyer, F., Vogel, A., Marhenke, S., von Felden, J., Sharma, R., Atkinson, S. R., McQuillin, A., Nattermann, J., … Stickel, F.
Published in: Gut, 2023, ISSN 1468-3288
Publisher: BMJ Group
DOI: 10.1136/gutjnl-2022-327196

Stratifying the risk of NAFLD in patients with HIV under combination antiretroviral therapy (cART)

Author(s): Jenny Bischoff, Wenyi Gu, Carolynne Schwarze-Zander, Christoph Boesecke, Jan-Christian Wasmuth, Kathrin van Bremen, Leona Dold, Jürgen K Rockstroh, Jonel Trebicka
Published in: EClinicalMedicine, Issue Volume 40, 2021, ISSN 2589-5370
Publisher: Elsevier
DOI: 10.1016/j.eclinm.2021.101116

Granulocyte-colony stimulating factor (G-CSF) to treat acute-on-chronic liver failure: A multicenter randomized trial (GRAFT study)

Author(s): Cornelius Engelmann, Adam Herber, Annegret Franke, Tony Bruns, Philipp Reuken, Ingolf Schiefke, Alexander Zipprich, Stefan Zeuzem, Tobias Goeser, Ali Canbay, Christoph Berg, Jonel Trebicka, Frank E. Uschner, Johannes Chang, Tobias Mueller, Niklas Aehling, Moritz Schmelzle, Katrin Splith, Frank Lammert, Christian M. Lange, Christoph Sarrazin, Christian Trautwein, Michael Manns, Dieter Häussinger,
Published in: Journal of Hepatology, Issue Volume 75, Issue 6, 2021, Page(s) 1346-1354, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/j.jhep.2021.07.033

Role of circulating angiogenin levels in portal hypertension and TIPS

Author(s): Alexander Queck, Frank E Uschner, Philip G Ferstl, Martin Schulz, Maximilian J Brol, Michael Praktiknjo, Robert Schierwagen, Sabine Klein, Christian P Strassburg, Carsten Meyer, Christian Jansen, Marie-Luise Berres, Jonel Trebicka
Published in: PLoS One, Issue Volume 16, Issue 8, 2021, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0256473

To TIPS or Not to TIPS in High Risk of Variceal Rebleeding and Acute-on-Chronic Liver Failure.

Author(s): Gu, W., Kimmann, M., Laleman, W., Praktiknjo, M., & Trebicka, J.
Published in: Seminars in liver disease, 2023, ISSN 1098-8971
Publisher: Georg Thieme Verlag
DOI: 10.1055/a-2107-0576

The rs429358 Locus in Apolipoprotein E Is Associated With Hepatocellular Carcinoma in Patients With Cirrhosis

Author(s): Innes H, Nischalke HD, Guha IN, Weiss KH, Irving W, Gotthardt D, Barnes E, Fischer J, Ansari MA, Rosendahl J, Lin SK, Marot A, Pedergnana V, Casper M, Benselin J, Lammert F, McLauchlan J, Lutz PL, Hamill V, Mueller S, Morling JR, Semmler G, Eyer F, von Felden J, Link A, Vogel A, Marquardt JU, Sulk S, Trebicka J, Valenti L, Datz C, Reiberger T, Schafmayer C, Berg T, Deltenre P, Hampe J, Stickel F,
Published in: Hepatology Communications, Issue Volume6, Issue 5, 2022, Page(s) 1213-1226, ISSN 2471-254X
Publisher: AASLD
DOI: 10.1002/hep4.1886

Roles of systemic inflammatory and metabolic responses in the pathophysiology of acute-on-chronic liver failure

Author(s): Clària, J., Arroyo, V., & Moreau, R.
Published in: JHEP reports : innovation in hepatology, 2023, ISSN 1744-4292
Publisher: Nature Publishing Group

Systemic MCP-1 Levels Derive Mainly From Injured Liver and Are Associated With Complications in Cirrhosis

Author(s): Alexander Queck, Hannah Bode, Frank E. Uschner, Maximilian J. Brol, Christiana Graf, Martin Schulz, Christian Jansen, Michael Praktiknjo, Robert Schierwagen, Sabine Klein, Christian Trautwein, Hermann E. Wasmuth, Marie-Luise Berres, Jonel Trebicka, Jennifer Lehmann
Published in: Frontiers in Immunology, Issue 11, 2020, ISSN 1664-3224
Publisher: Frontiers Media SA
DOI: 10.3389/fimmu.2020.00354

The proteome landscape of the kingdoms of life

Author(s): Johannes B. Müller, Philipp E. Geyer, Ana R. Colaço, Peter V. Treit, Maximilian T. Strauss, Mario Oroshi, Sophia Doll, Sebastian Virreira Winter, Jakob M. Bader, Niklas Köhler, Fabian Theis, Alberto Santos, Matthias Mann
Published in: Nature, Issue 582/7813, 2020, Page(s) 592-596, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-020-2402-x

Sympathetic nervous activation, mitochondrial dysfunction and outcome in acutely decompensated cirrhosis: the metabolomic prognostic models (CLIF-C MET)

Author(s): Weiss, E., de la Peña-Ramirez, C., Aguilar, F., Lozano, J. J., Sánchez-Garrido, C., Sierra, P., Martin, P. I., Diaz, J. M., Fenaille, F., Castelli, F. A., Gustot, T., Laleman, W., Albillos, A., Alessandria, C., Domenicali, M., Caraceni, P., Piano, S., Saliba, F., Zeuzem, S., Gerbes, A. L., … Arroyo, V.
Published in: Gut, 2023, ISSN 0017-5749
Publisher: BMJ Publishing Group
DOI: 10.1136/gutjnl

Differential inflammasome activation predisposes to acute-on-chronic liver failure in human and experimental cirrhosis with and without previous decompensation

Author(s): Sofia Monteiro, Josephine Grandt, Frank Erhard Uschner, Nina Kimer, Jan Lysgård Madsen, Robert Schierwagen, Sabine Klein, Christoph Welsch, Liliana Schäfer, Christian Jansen, Joan Claria, José Alcaraz-Quiles, Vicente Arroyo, Richard Moreau, Javier Fernandez, Flemming Bendtsen, Gautam Mehta, Lise Lotte Gluud, Søren Møller, Michael Praktiknjo, Jonel Trebicka
Published in: Gut, 2020, Page(s) gutjnl-2019-320170, ISSN 0017-5749
Publisher: BMJ Publishing Group
DOI: 10.1136/gutjnl-2019-320170

Communications via the Small Leucine-rich Proteoglycans: Molecular Specificity in Inflammation and Autoimmune Diseases

Author(s): Jinyang Zeng-Brouwers, Sony Pandey, Jonel Trebicka, Malgorzata Wygrecka, Liliana Schaefer
Published in: Journal of Histochemistry & Cytochemistry, 2020, Page(s) 002215542093030, ISSN 0022-1554
Publisher: Histochemical Society
DOI: 10.1369/0022155420930303

Pathophysiological role of prostanoids in coagulation of the portal venous system in liver cirrhosis

Author(s): Alexander Queck, Dominique Thomas, Christian Jansen, Yannick Schreiber, Sabrina Rüschenbaum, Michael Praktiknjo, Katharina Maria Schwarzkopf, Marcus Maximilian Mücke, Robert Schierwagen, Frank Erhard Uschner, Carsten Meyer, Joan Clària, Stefan Zeuzem, Gerd Geisslinger, Jonel Trebicka, Christian Markus Lange
Published in: PLOS ONE, Issue 14/10, 2019, Page(s) e0222840, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0222840

Freiburg index of post-TIPS survival (FIPS) identifies patients at risk of further decompensation and ACLF after TIPS

Author(s): Lukas Sturm, Michael Schultheiss, Fabian Stöhr, Christian Labenz, Benjamin Maasoumy, Anja Tiede, Michael Praktiknjo, Leon Louis Seifert, Timo Alexander Auer, Uli Fehrenbach, Felix Piecha, Aenne Harberts, Johannes Kluwe, Tony Bruns, Maike Rebecca Pollmanns, Johannes Chang, Jakub Grobelski, Christian Jansen, Carsten Meyer, Marlene Reincke, Charlotte Rohrer, Sina Rastin Philipp Arbabi, Markus Kimman
Published in: Journal of Hepatology, 2025, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/j.jhep.2025.01.030

Role of portal venous platelet activation in patients with decompensated cirrhosis and TIPS

Author(s): Alexander Queck, Roberto Carnevale, Frank Erhard Uschner, Robert Schierwagen, Sabine Klein, Christian Jansen, Carsten Meyer, Michael Praktiknjo, Daniel Thomas, Christian Strassburg, Stefan Zeuzem, Francesco Violi, Jonel Trebicka
Published in: Gut, Issue 69/8, 2020, Page(s) 1535-1536, ISSN 0017-5749
Publisher: BMJ Publishing Group
DOI: 10.1136/gutjnl-2019-319044

Effect of sarcopenia on survival in patients with cirrhosis: A meta-analysis

Author(s): Xinxing Tantai, Yi Liu, Yee Hui Yeo, Michael Praktiknjo, Ezequiel Mauro, Yuhei Hamaguchi, Cornelius Engelmann, Peng Zhang, Jae Yoon Jeong, Jeroen Laurens Ad van Vugt, Huijuan Xiao, Huan Deng, Xu Gao, Qing Ye, Jiayuan Zhang, Longbao Yang, Yaqin Cai, Yixin Liu, Na Liu, Zongfang Li, Tao Han, Toshimi Kaido, Joo Hyun Sohn, Christian Strassburg, Thomas Berg, Jonel Trebicka, Yao-Chun Hsu, Jan Nicolaas Ma
Published in: Journal of Hepatology, Issue Volume 76, Issue 3, 2021, Page(s) 588-599, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/j.jhep.2021.11.006

Two-dimensional shear wave elastography predicts survival in advanced chronic liver disease

Author(s): Trebicka J, Gu W, de Ledinghen V, Aubé C, Krag A, Praktiknjo M, Castera L, Dumortier J, Bauer DJM, Friedrich-Rust M, Pol S, Grgurevic I, Zheng R, Francque S, Gottfriedovà H, Mustapic S, Sporea I, Berzigotti A, Uschner FE, Simbrunner B, Ronot M, Cassinotto C, Kjaergaard M, Andrade F, Schulz M, Semmler G, Drinkovic IT, Chang J, Brol MJ, Rautou PE, Vanwolleghem T, Strassburg CP, Boursier J, Ferstl
Published in: GUT, Issue Volume 71, Issue 3, 2022, ISSN 0017-5749
Publisher: BMJ Publishing Group
DOI: 10.1136/gutjnl-2020-323419

Acute Decompensation and Acute-on-Chronic Liver Failure

Author(s): Dr. med. Philip Ferstl, Dr. med. Jonel Trebicka
Published in: Clinics in Liver Disease, Issue Volume 25, Issue 2, May 2021, 2022, Page(s) 419 -430, ISSN 1089-3261
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.cld.2021.01.009

β-Arrestin2 is increased in liver fibrosis in humans and rodents

Author(s): Robert Schierwagen, Peter Dietrich, Sabine Klein, Frank Erhard Uschner, Cristina Ortiz, Olaf Tyc, Sandra Torres, Claus Hellerbrand, Tilman Sauerbruch, Jonel Trebicka
Published in: PNAS, Issue Volume 117, No. 44, 2020, Page(s) 27082-27084, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2014337117

Sarcopenia Is Associated With Development of Acute-on-Chronic Liver Failure in Decompensated Liver Cirrhosis Receiving Transjugular Intrahepatic Portosystemic Shunt

Author(s): Michael Praktiknjo, Caroline Clees, Alessandra Pigliacelli, Stefan Fischer, Christian Jansen, Jennifer Lehmann, Alessandra Pohlmann, Barbara Lattanzi, Viktoria Katharina Krabbe, Christian P. Strassburg, Vicente Arroyo, Manuela Merli, Carsten Meyer, Jonel Trebicka
Published in: Clinical and Translational Gastroenterology, Issue 10/4, 2019, Page(s) e00025, ISSN 2155-384X
Publisher: Nature Publishing Group
DOI: 10.14309/ctg.0000000000000025

The Role of Hypoxia-Inducible Factor 1 Alpha in Acute-on-Chronic Liver Failure

Author(s): Marcus M. Mücke, Nihad El Bali, Katharina M. Schwarzkopf, Frank Erhard Uschner, Nico Kraus, Larissa Eberle, Victoria Therese Mücke, Julia Bein, Sandra Beyer, Peter J. Wild, Robert Schierwagen, Sabine Klein, Stefan Zeuzem, Christoph Welsch, Jonel Trebicka, Angela Brieger
Published in: International Journal of Molecular Sciences, Issue 25, 2025, Page(s) 1542, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms25031542

Targeting the gut-liver-immune axis to treat cirrhosis

Author(s): Thomas Henry Tranah, Lindsey A Edwards, Bernd Schnabl, Debbie Lindsay Shawcross
Published in: Gut, 2020, Page(s) gutjnl-2020-320786, ISSN 0017-5749
Publisher: BMJ Publishing Group
DOI: 10.1136/gutjnl-2020-320786

Hyperammonemia induces programmed liver cell death

Author(s): Annarein J. C. Kerbert, Cornelius Engelmann, Abeba Habtesion, Pavitra Kumar, Mohsin Hassan, Tingting Qi, Ines Volkert, Tobias Otto, Andrew Hall, Varun U. Khetan, Steven Olde Damink, Ferran Aguilar, Céline Chollet, Ludovic Brunet, Joan Clària, Richard Moreau, Vicente Arroyo, Minneke J. Coenraad, Gautam Mehta, Florence Castelli, Christian Trautwein, François Fenaille, Fausto Andreola, Rajiv Jalan
Published in: Science Advances, Issue 11, 2025, ISSN 2375-2548
Publisher: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/sciadv.ado1648

Reduced Plasma Extracellular Vesicle CD5L Content in Patients With Acute-On-Chronic Liver Failure: Interplay With Specialized Pro-Resolving Lipid Mediators

Author(s): Sánchez-Rodríguez, M. B., Téllez, É., Casulleras, M., Borràs, F. E., Arroyo, V., Clària, J., & Sarrias, M. R.
Published in: Frontiers in immunology, 2022, ISSN 1664-3224
Publisher: Frontiers Media
DOI: 10.3389/fimmu.2022.842996

Low-cost inkjet-printed nanostructured biosensor based on CRISPR/Cas12a system for pathogen detection

Author(s): Angela Gilda Carota, Andrea Bonini, Massimo Urban, Noemi Poma, Federico Maria Vivaldi, Arianna Tavanti, Marianna Rossetti, Giulio Rosati, Arben Merkoçi, Fabio Di Francesco
Published in: Biosensors and Bioelectronics, Issue 258, 2024, Page(s) 116340, ISSN 0956-5663
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.bios.2024.116340

Using liver stiffness to predict and monitor the risk of decompensation and mortality in patients with alcohol-related liver disease

Author(s): Katrine Holtz Thorhauge, Georg Semmler, Stine Johansen, Katrine Prier Lindvig, Maria Kjærgaard, Johanne Kragh Hansen, Nikolaj Torp, Camilla Dalby Hansen, Peter Andersen, Benedikt Silvester Hofer, Wenyi Gu, Mads Israelsen, Mattias Mandorfer, Thomas Reiberger, Jonel Trebicka, Maja Thiele, Aleksander Krag
Published in: Journal of Hepatology, Issue 81, 2024, Page(s) 23-32, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/j.jhep.2024.02.019

Neprilysin-dependent neuropeptide Y cleavage in the liver promotes fibrosis by blocking NPY-receptor 1.

Author(s): Ortiz, C., Klein, S., Reul, W. H., Magdaleno, F., Gröschl, S., Dietrich, P., Schierwagen, R., Uschner, F. E., Torres, S., Hieber, C., Meier, C., Kraus, N., Tyc, O., Brol, M., Zeuzem, S., Welsch, C., Poglitsch, M., Hellerbrand, C., Alfonso-Prieto, M., Mira, F., … Trebicka, J.
Published in: Cell reports, 2023, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2023.112059

Mechanisms of immunity in acutely decompensated cirrhosis and acute-on-chronic liver failure

Author(s): Engelmann, C., Zhang, I. W., & Clària, J.
Published in: Liver International, 2023, ISSN 1478-3231
Publisher: Wiley

Editorial: Portal Hypertension in Cirrhosis: From Pathogenesis to Novel Treatments

Author(s): Chandana B. Herath, Peter W. Angus and Jonel Trebicka
Published in: Frontiers in Physiology, Issue Volume 13, 2022, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2022.864083

Rectal colonization by resistant bacteria increases the risk of infection by the colonizing strain in critically ill patients with cirrhosis

Author(s): Verónica Prado, María Hernández-Tejero, Marcus M. Mücke, Francesc Marco, Wenyi Gu, Alex Amoros, David Toapanta, Enric Reverter, Carlos de la Peña-Ramirez, Laura Altenpeter, Octavi Bassegoda, Gabriel Mezzano, Fátima Aziz, Adria Juanola, Sergio Rodríguez-Tajes, Vanessa Chamorro, David López, Marta Reyes, Michael Hogardt, Volkhard A.J. Kempf, Philip G. Ferstl, Stefan Zeuzem, José Antonio Mar
Published in: Journal of Hepatology, Issue Volume 76, Issue 5, 2022, Page(s) 1079-1089, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/j.jhep.2021.12.042

Acute-on-chronic liver failure: a global disease

Author(s): Martin Schulz, Jonel Trebicka
Published in: Gut BMJ, Issue Volume 71, Issue 1, 2021, Page(s) 5-6, ISSN 0017-5749
Publisher: BMJ Publishing Group
DOI: 10.1136/gutjnl-2020-323973

Liver Transplantation for Acute‐on‐Chronic Liver Failure: Science or Fiction?

Author(s): Jonel Trebicka, Vinay Sundaram, Richard Moreau, Rajiv Jalan, Vicente Arroyo
Published in: Liver Transplantation, Issue 26/7, 2020, Page(s) 906-915, ISSN 1527-6465
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/lt.25788

Gene score to quantify systemic inflammation in patients with acutely decompensated cirrhosis

Author(s): Jonel Trebicka, Ferran Aguilar, Alberto Queiroz Farias, Juan-José Lozano, Cristina Sánchez-Garrido, Eva Usón-Raposo, Carlos de la Peña-Ramirez, Julia Sidorova, Anna Curto-Vilalta, Patricia Sierra-Casas, Patricia Momoyo Zitelli, Maria Papp, Gustavo Pereira, Paolo Caraceni, Luciana L Goncalves, Carlo Alessandria, Aldo Torre, Wim Laleman, Adrián Gadano, Salvatore Piano, Angelo Z Mattos, Wenyi Gu
Published in: Gut, Issue Feb 2025, 2025, Page(s) gutjnl-2024-333876, ISSN 0017-5749
Publisher: BMJ Publishing Group
DOI: 10.1136/gutjnl-2024-333876

Serum levels of bone sialoprotein correlate with portal pressure in patients with liver cirrhosis

Author(s): Fabian Benz, Andreas Bogen, Michael Praktiknjo, Christian Jansen, Carsten Meyer, Alexander Wree, Muenevver Demir, Sven Loosen, Mihael Vucur, Robert Schierwagen, Frank Tacke, Jonel Trebicka, Christoph Roderburg
Published in: PLOS ONE, Issue 15/4, 2020, Page(s) e0231701, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0231701

Untargeted lipidomics uncovers lipid signatures that distinguish severe from moderate forms of acutely decompensated cirrhosis

Author(s): Clària, J., Curto, A., Moreau, R., Colsch, B., López-Vicario, C., Lozano, J. J., Aguilar, F., Castelli, F. A., Fenaille, F., Junot, C., Zhang, I., Vinaixa, M., Yanes, O., Caraceni, P., Trebicka, J., Fernández, J., Angeli, P., Jalan, R., & Arroyo, V.
Published in: Journal of Hepatology, Issue Volume 75, Issue 5, 2021, Page(s) 1116-1127, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/j.jhep.2021.06.043

Rebleeding and mortality risk are increased by ACLF but reduced by pre-emptive TIPS

Author(s): Jonel Trebicka; Wenyi Gu; Wenyi Gu; Luis Ibáñez-Samaniego; Virginia Hernández-Gea; Carla Pitarch; Elisabet Garcia; Bogdan Procopet; Álvaro Giráldez; Lucio Amitrano; Càndid Villanueva; Dominique Thabut; Gilberto Silva-Junior; Javier Martínez; Joan Genescà; C. Bureau; Elba Llop; Wim Laleman; José María Palazón; José Castellote; Susanag Rodrigues; L.L. Gluud; Carlos Noronha Ferreira; Rafa
Published in: ISSNe: 01688278, Issue 3, 2020, ISSN 1600-0641
Publisher: Elsevier
DOI: 10.1016/j.jhep.2020.04.024

Combination of Fat-Free Muscle Index and Total Spontaneous Portosystemic Shunt Area Identifies High-Risk Cirrhosis Patients.

Author(s): Faron, A., Abu-Omar, J., Chang, J., Böhling, N., Sprinkart, A. M., Attenberger, U., Rockstroh, J. K., Luu, A. M., Jansen, C., Strassburg, C. P., Trebicka, J., Luetkens, J., & Praktiknjo, M.
Published in: Frontiers in medicine, 2022, ISSN 2296-858X
Publisher: Frontiers Media
DOI: 10.3389/fmed.2022.831005

Selection and characterisation of bioreceptors to develop nanoparticle-based lateral-flow immunoassays in the context of the SARS-CoV-2 outbreak

Author(s): Liming Hu; Enric Calucho; Celia Fuentes-Chust; Claudio Parolo; Andrea Idili; Ruslan Álvarez-Diduk; Lourdes Rivas; Arben Merkoçi
Published in: instname:Universitat Autònoma de Barcelona, Issue 1, 2022, ISSN 1473-0197
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2lc00486k

Sympathetic nervous activation, mitochondrial dysfunction and outcome in acutely decompensated cirrhosis: the metabolomic prognostic models (CLIF-C MET)

Author(s): Emmanuel Weiss; Carlos de la Peña-Ramirez; Ferran Aguilar; Juan-Jose Lozano; Cristina Sánchez-Garrido; Patricia Sierra; Pedro Izquierdo-Bueno Martin; Juan Manuel Diaz; François Fenaille; Florence A Castelli; Thierry Gustot; Wim Laleman; Agustín Albillos; Carlo Alessandria; Marco Domenicali; Paolo Caraceni; Salvatore Piano; Faouzi Saliba; Stefan Zeuzem; Alexander L Gerbes; Julia A Wendon; Chris
Published in: Crossref, Issue 3, 2023, ISSN 0017-5749
Publisher: BMJ Publishing Group
DOI: 10.1136/gutjnl-2022-328708

Recent Advances in Practical Methods for Liver Cell Biology: A Short Overview

Author(s): Sandra Torres, Zeinab Abdullah, Maximilian J Brol, Claus Hellerbrand, Mercedes Fernandez, Romina Fiorotto, Sabine Klein, Philipp Königshofer, Christian Liedtke, Sophie Lotersztajn, Yulia A. Nevzorova, Robert Schierwagen, Thomas Reiberger, Frank Erhard Uschner, Frank Tacke, Ralf Weiskirchen, Jonel Trebicka
Published in: International Journal of Molecular Sciences, Issue 21/6, 2020, Page(s) 2027, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21062027

Pathogenetic mechanisms and therapeutic approaches of acute-to-chronic liver failure.

Author(s): Schierwagen, R., Gu, W., Brieger, A., Brüne, B., Ciesek, S., Đikić, I., Dimmeler, S., Geisslinger, G., Greten, F. R., Hermann, E., Hildt, E., Kempf, V. A. J., Klein, S., Koch, I., Mühl, H., Müller, V., Peiffer, K. H., Kestner, R. I., Piiper, A., Rohde, G., … Trebicka, J.
Published in: American journal of physiology. Cell physiology, 2023, ISSN 1522-1563
Publisher: American Physiological Society
DOI: 10.1152/ajpcell.00101.2023

The microbiota in cirrhosis and its role in hepatic decompensation

Author(s): Trebicka J, MacNaughtan J, Schnabl B, Shawcross DL and Bajaj JS.
Published in: Journal of Hepatology, Issue Vol 75 Suppl 1, 2021, Page(s) 67-81, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/j.jhep.2020.11.013

Myostatin is associated with the presence and development of acute-on-chronic liver failure

Author(s): Ruiz-Margáin, A., Pohlmann, A., Lanzerath, S., Langheinrich, M., Campos-Murguía, A., Román-Calleja, B. M., Schierwagen, R., Klein, S., Uschner, F. E., Brol, M. J., Torre-Delgadillo, A., Flores-García, N. C., Praktiknjo, M., Macías Rodríguez, R. U., & Trebicka, J.
Published in: JHEP reports, 2023, ISSN 2589-5559
Publisher: Elsevier
DOI: 10.1016/j.jhepr.2023.100761

Distinct immunometabolic signatures in circulating immune cells define disease outcome in acute-on-chronic liver failure

Author(s): Rita Feio-Azevedo, Markus Boesch, Silvia Radenkovic, Lukas van Melkebeke, Lena Smets, Marie Wallays, Bram Boeckx, Gino Philips, Janaíne Prata de Oliveira, Mohammad Ghorbani, Wim Laleman, Philippe Meersseman, Alexander Wilmer, David Cassiman, Hannah van Malenstein, Evangelos Triantafyllou, Cristina Sánchez, Ferran Aguilar, Frederik Nevens, Jef Verbeek, Richard Moreau, Vicente Arroyo, Alexandre De
Published in: Hepatology, Issue 81, 2025, Page(s) 509-522, ISSN 0270-9139
Publisher: John Wiley & Sons Inc.
DOI: 10.1097/hep.0000000000000907

Circulating levels of endotrophin and cross-linked type III collagen reflect liver fibrosis in people with HIV.

Author(s): Dold, L., Nielsen, M. J., Praktiknjo, M., Schwarze-Zander, C., Boesecke, C., Wasmuth, J. C., Bischoff, J., Rockstroh, J. K., Karsdal, M. A., Spengler, U., Trebicka, J., Strassburg, C. P., Leeming, D. J., & Langhans, B.
Published in: BMC infectious diseases, 2023, ISSN 1471-2334
Publisher: BioMed Central
DOI: 10.1186/s12879-023-08000-w

Short-Term Western Diet Aggravates Non-Alcoholic Fatty Liver Disease (NAFLD) With Portal Hypertension in TGR(mREN2)27 Rats

Author(s): Carla Cremonese, Robert Schierwagen, Frank Erhard Uschner, Sandra Torres, Olaf Tyc, Cristina Ortiz, Martin Schulz, Alexander Queck, Glen Kristiansen, Michael Bader, Tilman Sauerbruch, Ralf Weiskirchen, Thomas Walther, Jonel Trebicka, Sabine Klein
Published in: International Journal of Molecular Sciences, Issue 21/9, 2020, Page(s) 3308, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21093308

The non-selective Rho-kinase inhibitors Y-27632 and Y-33075 decrease contraction but increase migration in murine and human hepatic stellate cells.

Author(s): Bachtler, N., Torres, S., Ortiz, C., Schierwagen, R., Tyc, O., Hieber, C., Berres, M. L., Meier, C., Kraus, N., Zeuzem, S., Nijmeijer, B., Pronk, S., Trebicka, J., & Klein, S.
Published in: PloS one, 2023, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0270288

Activation of the Alternate Renin-Angiotensin System Correlates with the Clinical Status in Human Cirrhosis and Corrects Post Liver Transplantation

Author(s): Stephen Casey, Robert Schierwagen, Kai Mak, Sabine Klein, Frank Uschner, Christian Jansen, Michael Praktiknjo, Carsten Meyer, Daniel Thomas, Chandana Herath, Robert Jones, Jonel Trebicka, Peter Angus
Published in: Journal of Clinical Medicine, Issue 8/4, 2019, Page(s) 419, ISSN 2077-0383
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm8040419

Baveno VII - Renewing consensus in portal hypertension

Author(s): Abraldes JG, Albillos A, Baiges A, Bajaj J, Bañares R, Barrufet M, Benajiba L, Berzigotti A, Bureau C, Calvaruso V, Cardenas A, D'Amico G, De Gottardi A, Dell'Era A, Escorsell A, Fallowfield J, Ferral H, Francque S, Gaba R, Garcia-Pagàn JC, Genescà J, Rodrigues SG, Gracia-Sancho J, Han G, Hernandez-Gea V, Jia J, Kiladjian JJ, Krag A, Laleman W, La Mura V, Lens S, Luo X, Mandorfer M, Murad SD, P
Published in: Journal of Hepatology, Issue Volume 76, Issue 4, 2021, Page(s) 959-974, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/j.jhep.2021.12.022

Elective Surgery but not Transjugular Intrahepatic Portosystemic Shunt Precipitates Acute-On-Chronic Liver Failure

Author(s): Johannes Chang, Avend Bamarni, Nina Böhling, Xin Zhou, Leah-Marie Klein, Jonathan Meinke, Georg Daniel Duerr, Philipp Lingohr, Sven Wehner, Maximilian J. Brol, Jürgen K. Rockstroh, Jörg C. Kalff, Steffen Manekeller, Carsten Meyer, Ulrich Spengler, Christian Jansen, Vicente Arroyo, Christian P. Strassburg, Jonel Trebicka, Michael Praktiknjo
Published in: Hepatology Communications, Issue Volume 5, Issue 7, 2021, Page(s) 1265-1277, ISSN 2471-254X
Publisher: AASLD
DOI: 10.1002/hep4.1712

Early transplantation maximizes survival in severe acute-on-chronic liver failure: Results of a Markov decision process model

Author(s): SuyanpengZhang, Sze-Chuan Suen, Cynthia L.Gong, JessicaPham, JonelTrebicka, ChristopheDuvoux, Andrew S.Klein, TiffanyWu, RajivJalan, VinaySundaram
Published in: JHEP Reports, Issue Volume 3, Issue 6, 2021, ISSN 2589-5559
Publisher: Elsevier
DOI: 10.1016/j.jhepr.2021.100367

Preoperative TIPS prevents the development of postoperative acute-on-chronic liver failure in patients with high CLIF-C AD score

Author(s): Johannes Chang, Pauline Höfer, Nina Böhling, Philipp Lingohr, Steffen Manekeller, Jörg C. Kalff, Jonas Dohmen, Dominik J. Kaczmarek, Christian Jansen, Carsten Meyer, Christian P. Strassburg, Jonel Trebicka, Michael Praktiknjo
Published in: JHEP Reports, Issue Volume 4, Issue 3, 2022, ISSN 2589-5559
Publisher: Elsevier
DOI: 10.1016/j.jhepr.2022.100442

Proteome profiling in cerebrospinal fluid reveals novel biomarkers of Alzheimer's disease

Author(s): Jakob M Bader, Philipp E Geyer, Johannes B Müller, Maximilian T Strauss, Manja Koch, Frank Leypoldt, Peter Koertvelyessy, Daniel Bittner, Carola G Schipke, Enise I Incesoy, Oliver Peters, Nikolaus Deigendesch, Mikael Simons, Majken K Jensen, Henrik Zetterberg, Matthias Mann
Published in: Molecular Systems Biology, Issue 16/6, 2020, ISSN 1744-4292
Publisher: Nature Publishing Group
DOI: 10.15252/msb.20199356

Editorial: Acute-on-chronic liver failure: systemic inflammation and immunosuppression.

Author(s): Tyc, O., Shi, Y., Fan, Y. C., Trebicka, J., & Xiang, X.
Published in: Frontiers in immunology, 2023, ISSN 1664-3224
Publisher: Frontiers Media
DOI: 10.3389/fimmu.2023.1260749

Letter: improve survival! Place early pre-emptive TIPSS in high-risk variceal bleeders

Author(s): Juan Carlos García-Pagán, Jaume Bosch, Jonel Trebicka, Juan G Abraldes, Agustín Albillos, Henning Grønbaek, Álvaro Giráldez, Alexander Zipprich, Christophe Bureau, Virginia Hernández-Gea
Published in: Alimentary Pharmacology & Therapeutics, Issue 52/5, 2020, Page(s) 927-928, ISSN 0269-2813
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/apt.15926

Portal hypertension in cirrhosis: Pathophysiological mechanisms and therapy

Author(s): Yasuko Iwakiri, Jonel Trebicka
Published in: JHEP Reports, Issue Volume 3, Issue 4, 2021, ISSN 2589-5559
Publisher: Elsevier
DOI: 10.1016/j.jhepr.2021.100316

Profiling circulating microRNAs in patients with cirrhosis and acute-on-chronic liver failure

Author(s): Delia Blaya, Elisa Pose, Mar Coll, Juan José Lozano, Isabel Graupera, Robert Schierwagen, Christian Jansen, Pedro Castro, Sara Fernandez, Julia Sidorova, Mariuca Vasa-Nicotera, Elsa Solà, Joan Caballería, Jonel Trebicka, Pere Ginès, Pau Sancho-Bru
Published in: JHEP Reports, Issue Volume 3, Issue 2, 2021, ISSN 2589-5559
Publisher: Elsevier
DOI: 10.1016/j.jhepr.2021.100233

Controversies regarding albumin therapy in cirrhosis

Author(s): Jonel Trebicka, Guadalupe Garcia-Tsao
Published in: Hepatology, Issue 81, 2025, Page(s) 288-303, ISSN 0270-9139
Publisher: John Wiley & Sons Inc.
DOI: 10.1097/hep.0000000000000521

OS-041-YI A spatiotemporal map of the hepatocyte proteome in alpha-1 antitrypsin deficiency by single-cell and visual proteomics

Author(s): Florian Rosenberger, Katrine Thorhauge, Sophia Mädler, Malin Fromme, Caroline Weiss, Marc Oeller, Sophia Steigerwald, Marvin Thielert, Thierry Nordmann, Sönke Detlefsen, Peter Boor, Ondřej Fabián, Soňa Fraňková, Aleksander Krag, Pavel Strnad, Matthias Mann
Published in: Journal of Hepatology, Issue 80, 2024, Page(s) S32, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/s0168-8278(24)00482-3

MICROB-PREDICT: 15 millió eurós költségvetéssel induló mikrobiom kutatási vizsgálat az Európai Unióban

Author(s): Coenraad, M., Papp, M., Trebica, J., De Lecuona, I., Klein, S., Junot, C., Mann, M., Krag, A., Bork, P., Arumugam, M.
Published in: Central European Journal of Gastroenterology and Hepatology, Issue June/2019, Volume 5, Issue 2, 2019, 2019, Page(s) 40-42, ISSN 2415-9107
Publisher: Promenade Publishing House

Imaging-based diagnosis of sarcopenia for transplant-free survival in primary sclerosing cholangitis

Author(s): Pedram Keshoofi, Philipp Schindler, Florian Rennebaum, Friederike Cordes, Haluk Morgul, Moritz Wildgruber, Hauke S. Heinzow, Andreas Pascher, Hartmut H. Schmidt, Anna Hüsing-Kabar, Michael Praktiknjo, Jonel Trebicka, Leon Louis Seifert
Published in: BMC Gastroenterology, Issue 24, 2024, ISSN 1471-230X
Publisher: BioMed Central
DOI: 10.1186/s12876-024-03232-9

Alcohol-associated hepatitis: a neutrophile disease?

Author(s): Maximilian Joseph Brol, Ali Canbay, Jonel Trebicka
Published in: Gut, Issue 74, 2024, Page(s) 6-8, ISSN 0017-5749
Publisher: BMJ Publishing Group
DOI: 10.1136/gutjnl-2024-333222

Atorvastatin for patients with cirrhosis. A randomized, placebo-controlled trial

Author(s): Thit M. Kronborg, Robert Schierwagen, Kajetan Trošt, Qian Gao, Thomas Moritz, Flemming Bendtsen, Rasmus H. Gantzel, Mette L. Andersen, Ane S. Teisner, Henning Grønbæk, Lise Hobolth, Søren Møller, Jonel Trebicka, Nina Kimer
Published in: Hepatology Communications, Issue 7, 2024, Page(s) 2023 Dec 1;7(12):e0332., ISSN 2471-254X
Publisher: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1097/hc9.0000000000000332

Palmitoylcarnitine impairs immunity in decompensated cirrhosis

Author(s): Ingrid Wei Zhang, María Belén Sánchez-Rodríguez, Cristina López-Vicario, Mireia Casulleras, Marta Duran-Güell, Roger Flores-Costa, Ferran Aguilar, Michael Rothe, Paula Segalés, Carmen García-Ruiz, José C. Fernández-Checa, Jonel Trebicka, Vicente Arroyo, Joan Clària
Published in: JHEP Reports, Issue 6, 2024, Page(s) 101187, ISSN 2589-5559
Publisher: Elsevier BV
DOI: 10.1016/j.jhepr.2024.101187

Noninvasive assessment of hepatic decompensation

Author(s): Maja Thiele, Stine Johansen, Mads Israelsen, Jonel Trebicka, Juan G. Abraldes, Pere Gines, Aleksander Krag
Published in: Hepatology, Issue 81, 2025, Page(s) 1019-1037, ISSN 0270-9139
Publisher: John Wiley & Sons Inc.
DOI: 10.1097/hep.0000000000000618

Terlipressin therapy is associated with increased risk of colonisation with multidrug‐resistant bacteria in patients with decompensated cirrhosis

Author(s): Marcus M. Mücke, María Hernández‐Tejero, Wenyi Gu, Michael Kuhn, Malte Janz, Marisa I. Keller, Anthony Fullam, Laura Altepeter, Victoria T. Mücke, Fabian Finkelmeier, Katharina M. Schwarzkopf, Carla Cremonese, Peter‐Merton Hunyady, Myriam W. Heilani, Frank Erhard Uschner, Robert Schierwagen, Maximilian J. Brol, Julia Fischer, Sabine Klein, Kai‐Henrik Peiffer, Michael Hogardt, Saeed Shoai
Published in: Alimentary Pharmacology & Therapeutics, Issue 59, 2024, Page(s) 877-888, ISSN 0269-2813
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/apt.17899

Association between endotoxemia and blood no in the portal circulation of cirrhotic patients: results of a pilot study

Author(s): Simona Bartimoccia, Michael Praktiknjo, Cristina Nocella, Robert Schierwagen, Vittoria Cammisotto, Christian Jansen, Luca Cristiano, Valentina Castellani, Johannes Chang, Roberto Carnevale, Sofia Maiucci, Frank Erhard Uschner, Pasquale Pignatelli, Maximilian Joseph Brol, Jonel Trebicka, Francesco Violi
Published in: Internal and Emergency Medicine, Issue 19, 2024, Page(s) 713-720, ISSN 1828-0447
Publisher: CEPI-AIM Group
DOI: 10.1007/s11739-024-03534-6

Novel prognostic biomarkers in decompensated cirrhosis: a systematic review and meta-analysis

Author(s): Adrià Juanola, Ann Thu Ma, Koos de Wit, Kohilan Gananandan, Olivier Roux, Giacomo Zaccherini, César Jiménez, Marta Tonon, Cristina Solé, Clara Villaseca, Frank E Uschner, Isabel Graupera, Elisa Pose, Maria José Moreta, Daniela Campion, Ulrich Beuers, Rajeshawar P Mookerjee, Claire Francoz, Francois Durand, Victor Vargas, Salvatore Piano, Sonia Alonso, Jonel Trebicka, Wim Laleman, Sumeet K Asr
Published in: Gut, Issue 73, 2024, Page(s) 156-165, ISSN 0017-5749
Publisher: BMJ Publishing Group
DOI: 10.1136/gutjnl-2023-329923

Utilizing the gut microbiome in decompensated cirrhosis and acute-on-chronic liver failure.

Author(s): Trebicka J., Bork P., Krag A., Arumugam M.
Published in: Nature Reviews Gastroenterology & Hepatology, Issue Volume 18, Issue 3, 2021, Page(s) 167-180, ISSN 1759-5045
Publisher: Nature Publishing Group
DOI: 10.1038/s41575-020-00376-3

The Microbiome Meets Nanotechnology: Opportunities and Challenges in Developing New Diagnostic Devices

Author(s): Fuentes-Chust C., Parolo C., Rosati G., Rivas L., Perez-Toralla K., Simon S., de Lecuona I., Junot C., Trebicka J., Merkoçi A.
Published in: Advanced Materials, Issue Volume 33, Issue 18, 2021, Page(s) 1-18, ISSN 0935-9648
Publisher: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202006104

Fecal microbial load is a major determinant of gut microbiome variation and a confounder for disease associations

Author(s): Suguru Nishijima, Evelina Stankevic, Oliver Aasmets, Thomas S.B. Schmidt, Naoyoshi Nagata, Marisa Isabell Keller, Pamela Ferretti, Helene Bæk Juel, Anthony Fullam, Shahriyar Mahdi Robbani, Christian Schudoma, Johanne Kragh Hansen, Louise Aas Holm, Mads Israelsen, Robert Schierwagen, Nikolaj Torp, Anja Telzerow, Rajna Hercog, Stefanie Kandels, Diënty H.M. Hazenbrink, Manimozhiyan Arumugam, Flemmi
Published in: Cell, Issue 188, 2025, Page(s) 222-236.e15, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2024.10.022

Endoscopic procedures in hepatology: Current trends and new developments

Author(s): Wim Laleman, Emma Vanderschueren, Zain Seyad Mehdi, Reiner Wiest, Andres Cardenas, Jonel Trebicka
Published in: Journal of Hepatology, Issue 80, 2024, Page(s) 124-139, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/j.jhep.2023.08.032

Albumin reprograms the B cell transcriptional landscape and improves neutrophil antimicrobial function in patients with decompensated cirrhosis

Author(s): Joan Clària, Ferran Aguilar, Juan-José Lozano, Laura Jiménez-Gracia, Juan C. Nieto, Berta Romero-Grimaldo, Xavi Marcos-Fa, Emma Giarracco, Emmanuel Weiss, Jonel Trebicka, Inmaculada Hernàndez, Javier Fernandez, Mireia Casulleras, Cristina López-Vicario, Sinan Muldur, Alex Hopke, Alexandru Vlagea, Ana M. Aransay, Domenica Marchese, Mauro Bernardi, Rajiv Jalan, Paolo Angeli, Giuliana Magri, And
Published in: JHEP Reports, Issue 6, 2024, Page(s) 101184, ISSN 2589-5559
Publisher: Elsevier BV
DOI: 10.1016/j.jhepr.2024.101184

WED-111 Plasma proteomics uncovers progression markers of acute-onchronic liver failure

Author(s): Florian Rosenberger, Peter Treit, Vincent Albrecht, Maximilian Zwiebel, Johannes Müller-Reif, Robert Schierwagen, Wenyi Gu, David Tornai, Frank Erhard Uschner, Debbie L. Shawcross, Minneke Coenraad, Rajiv Jalan, Joan Clària, Maria Papp, Wim Laleman, Jonel Trebicka, Matthias Mann
Published in: Journal of Hepatology, Issue 80, 2024, Page(s) S193, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/s0168-8278(24)00816-x

Role of endoscopy in hepatology

Author(s): Wim Laleman, Kai-Henrik Peiffer, Michael Tischendorf, Hans-Joerg Ullerich, Michael Praktiknjo, Jonel Trebicka
Published in: Digestive and Liver Disease, Issue 56, 2024, Page(s) 1185-1195, ISSN 1590-8658
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.dld.2023.11.032

Hepatocellular Cancer Surveillance in Patients with Advanced Chronic Liver Disease

Author(s): Wenyi Gu, Victor de Lédinghen, Christophe Aubé, Aleksander Krag, Christian Strassburg, Laurent Castéra, Jérôme Dumortier, Mireen Friedrich-Rust, Stanislas Pol, Ivica Grgurevic, Yasmin Zeleke, Michael Praktiknjo, Robert Schierwagen, Sabine Klein, Sven Francque, Halima Gottfriedová, Ioan Sporea, Philipp Schindler, Florian Rennebaum, Maximilian Joseph Brol, Martin Schulz, Frank Erhard Uschner,
Published in: NEJM Evidence, Issue 3, 2025, Page(s) EVIDoa2400062, ISSN 2766-5526
Publisher: Massachusetts Medical Society
DOI: 10.1056/evidoa2400062

Operating under pressure: Is there a place for preoperative TIPS?

Author(s): Michael Praktiknjo, Jonel Trebicka
Published in: JHEP Reports, Issue 6, 2024, Page(s) 101034, ISSN 2589-5559
Publisher: Elsevier BV
DOI: 10.1016/j.jhepr.2024.101034

Personalised human albumin in patients with cirrhosis and ascites: design and rationale for the ALB-TRIAL - a randomised clinical biomarker validation trial

Author(s): Nikolaj Torp, Mads Israelsen, Minneke Coenraad, Maria Papp, Debbie Shawcross, Marko Korenjak, Paolo Angeli, Wim Laleman, Adria Juanola, Pere Gines, Jonel Trebicka, Aleksander Krag
Published in: BMJ Open, Issue 14, 2024, Page(s) e079309, ISSN 2044-6055
Publisher: BMJ Publishing Group
DOI: 10.1136/bmjopen-2023-079309

Metabolomics for personalized medicine: the input of analytical chemistry from biomarker discovery to point-of-care tests

Author(s): Castelli F.A., Rosati G., Moguet C., Fuentes C., Marrugo-Rmírez J.,Lefebvre T.,Volland H., Merkoçi A., Junot C.
Published in: Analytical and Bioanalytical Chemistry, Issue Volume 414, Issue 2, 2021, Page(s) 759-789, ISSN 1618-2650
Publisher: Springer Link
DOI: 10.1007/s00216-021-03586-z

Stage of fibrosis is not a predictive determinant of weight loss in patients undergoing bariatric surgery

Author(s): Maximilian Joseph Brol, Uta Drebber, Xiaojie Yu, Robert Schierwagen, Wenyi Gu, Andreas Plamper, Sabine Klein, Margarete Odenthal, Frank Erhard Uschner, Michael Praktiknjo, Jonel Trebicka, Karl Peter Rheinwalt
Published in: Surgery for Obesity and Related Diseases, Issue 20, 2024, Page(s) 759-766, ISSN 1550-7289
Publisher: Elsevier BV
DOI: 10.1016/j.soard.2024.02.006

Diversity within species: interpreting strains in microbiomes

Author(s): Thea Van Rossum, Pamela Ferretti, Oleksandr M. Maistrenko, Peer Bork
Published in: Nature Reviews Microbiology, Issue 18/9, 2020, Page(s) 491-506, ISSN 1740-1526
Publisher: Nature Publishing Group
DOI: 10.1038/s41579-020-0368-1

Acute and non‐acute decompensation of liver cirrhosis (47/130)

Author(s): Martin S. Schulz, Paolo Angeli, Jonel Trebicka
Published in: Liver International, Issue 45, 2025, Page(s) Liver International, ISSN 1478-3223
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/liv.15861

Targeted lipidomics reveals extensive changes in circulating lipid mediators in patients with acutely decompensated cirrhosis

Author(s): Cristina López-Vicario, Antonio Checa, Arantxa Urdangarin, Ferran Aguilar, José Alcaraz-Quiles, Paolo Caraceni, Alex Amorós, Marco Pavesi, David Gómez-Cabrero, Jonel Trebicka, Karl Oettl, Richard Moreau, Núria Planell, Vicente Arroyo, Craig E. Wheelock, Joan Clària
Published in: Journal of Hepatology, Issue 73/4, 2020, Page(s) 817-828, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/j.jhep.2020.03.046

Decompensated MASH-Cirrhosis Model by Acute and Toxic Effects of Phenobarbital

Author(s): Nico Kraus, Frank Erhard Uschner, Magnus Moeslein, Robert Schierwagen, Wenyi Gu, Maximilian Joseph Brol, Eike Fürst, Inga Grünewald, Sophie Lotersztajn, Pierre-Emmanuel Rautou, Marta Duran-Güell, Roger Flores Costa, Joan Clària, Jonel Trebicka, Sabine Klein
Published in: Cells, Issue 13, 2025, Page(s) 1707, ISSN 2073-4409
Publisher: MDPI AG
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A plug, print & play inkjet printing and impedance-based biosensing technology operating through a smartphone for clinical diagnostics

Author(s): Rosati G., Urban M., Zhao L., Yang Q., De Carvalho Castro e Silva C., Bonaldo S., Parolo C., Nguyen E., Ortega G., Fornasiero P., Paccagnella A., Merkoci A.
Published in: Biosensors and Bioelectronics, Issue 196, 113737, 29 October 2021, 2021, Page(s) 1 –10, ISSN 0956-5663
Publisher: Pergamon Press Ltd.
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Recent advances in the prevention and treatment of decompensated cirrhosis and acute-on-chronic liver failure (ACLF) and the role of biomarkers

Author(s): Jonel Trebicka, Ruben Hernaez, Debbie Lindsay Shawcross, Alexander L Gerbes
Published in: Gut, Issue 73, 2024, Page(s) 1015-1024, ISSN 0017-5749
Publisher: BMJ Publishing Group
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Electrochromism: An emerging and promising approach in (bio)sensing technology

Author(s): Mohammad Amin Farahmand Nejad; Mohammad Amin Farahmand Nejad; Saba Ranjbar; Claudio Parolo; Emily P. Nguyen; Ruslan Álvarez-Diduk; Mohammad Reza Hormozi-Nezhad; Arben Merkoçi; Arben Merkoçi
Published in: Materials Today, Issue 1, 2021, ISSN 1872-6291
Publisher: Science Direct
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A robust clustering strategy for stratification unveils unique patient subgroups in acutely decompensated cirrhosis

Author(s): Palomino-Echeverria S, Huergo E, Ortega-Legarreta A, Uson Raposo EM, Aguilar F, de la Peña-Ramirez C, López-Vicario C, Alessandria C, Laleman W, Farias AQ, Moreau R, Fernandez J, Arroyo V, Caraceni P, Lagani V, Sánchez-Garrido C, Clària J, Tegner J, Trebicka J, Kiani NA, Planell N, Rautou PE, Gomez-Cabrero D
Published in: J Tranl Med., Issue 2024 Jun 27;22(1):599., 2024, Page(s) 599, ISSN 1479-5876
Publisher: BioMed Central
DOI: 10.1186/s12967-024-05386-2

Opportunities and barriers in omics-based biomarker discovery for steatotic liver diseases

Author(s): Maja Thiele, Ida Falk Villesen, Lili Niu, Stine Johansen, Karolina Sulek, Suguru Nishijima, Lore Van Espen, Marisa Keller, Mads Israelsen, Tommi Suvitaival, Andressa de Zawadzki, Helene Bæk Juel, Maximilian Joseph Brol, Sara Elizabeth Stinson, Yun Huang, Maria Camilla Alvarez Silva, Michael Kuhn, Ema Anastasiadou, Diana Julie Leeming, Morten Karsdal, Jelle Matthijnssens, Manimozhiyan Arumugam, Lo
Published in: Journal of Hepatology, Issue 81, 2024, Page(s) 345-359, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/j.jhep.2024.03.035

Effects of human serum albumin on TNFα-induced cell death and mitochondrial dysfunction in the liver cells

Author(s): Duran Güell, Marta
Published in: 2023
Publisher: Universitat de Barcelona

Pautes per avaluar projectes de recerca i innovació en salut que utilitzin tecnologies emergents i dades personals

Author(s): Lecuona Ramírez, Itziar de Observatori de Bioètica i Dret
Published in: 2020, ISBN 978-84-9168-585-2
Publisher: Edicions de la Universitat de Barcelona

Ethical and legal analysis of the international regulation on biomedical research

Author(s): De Lecuona, Itziar
Published in: 2023, ISBN 978-84-1125-898-2
Publisher: EDITORIAL ARANZADI

Ethical-Legal Analysis of International Regulation on Biomedical Research

Author(s): de Lecuona, I.
Published in: 2023, ISBN 978-84-1125-900-2
Publisher: Aranzadi

ELPA and EU medical research project brochure 2019

Author(s): Marko Korenjak, Veronika Všetičkova, Beatrice Credi
Published in: ELPA and EU medical research project brochure 2019, Issue yearly, number 1, June 2019, 2019, Page(s) 20-23
Publisher: ELPA

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