MICROBiome-based biomarkers to PREDICT decompensation of liver cirrhosis and treatment response

Rezultaty

Go-online of the public project website
Second patient and layman event
Project brochure and professional templates
Dissemination activity at IHMC congress in Barcelona 2020
First patient and layman event

Final version of study protocol to be approved by ethics committee(s)

Final version of study protocol to be approved by ethics committees

Report on Acquire proteomics data
Report on lipidomics and bile acids data
Brochure to inform in brief about MICROB-PREDICT for participants involved in the clinical study

Brochure to inform in brief about MICROBPREDICT for participants involved in the clinical study

Codes of conduct applicable and research integrity policy including publications in journals
Registration number of clinical study in a WHO- or ICMJE- approved registry

Registration number of clinical study in a WHO or ICMJE approved registry

First written draft of a model describing typical treatment paths in decompensated cirrhosis
Information and Informed consent template for participation of human beings (patients/healthy volunteers), for using biological samples of human origin in research and for the use of personal data (including genetic data) in research
Policy for integrating the 6 agendas (ethics, gender equality, public engagement, governance, scientific education and open access) of responsible research and innovation
Checklist for participants to assure informed consent / other mechanisms for those unable to give a written consent
Report on histological data of gut barrier
Report on metabolomics data
Public engagement strategy to design MICROB-PREDICT along with the need of patients

Implementation of model in a software package

Publikacje

The Specific NLRP3 Antagonist IFM-514 Decreases Fibrosis and Inflammation in Experimental Murine Non-Alcoholic Steatohepatitis

Autorzy: Torres Sandra, Brol Maximilian J, Magdaleno Fernando, Schierwagen Robert, Uschner Frank E., Klein Sabine, Ortiz Cristina, Tyc Olaf, Bachtler Nadine, Stunden James, Bertheloot Damien, Kitanovic Ana, Sanchez Brian, Schrum Jacob, Roush William R., Franchi Luigi, Byth Kate, Latz Eicke, Trebicka Jonel
Opublikowane w: Frontiers in Molecular Biosciences, Numer Volume 8, 2021, ISSN 2296-889X
Wydawca: Frontiers Media
DOI: 10.3389/fmolb.2021.715765

Prognostic Value of the CLIF-C AD Score in Patients With Implantation of Transjugular Intrahepatic Portosystemic Shunt

Autorzy: Sturm, L., Praktiknjo, M., Bettinger, D., Huber, J.P., Volkwein, L., Schmidt, A.R., Kaeser, R., Chang, J., Jansen, C., Meyer, C.H., Thomas, D.K., Thimme, R., Trebicka, J., & Schultheiss, M
Opublikowane w: Hepatology Communications, Numer Volume 5, 2021, Strona(/y) 650-660, ISSN 2471-254X
Wydawca: AASLD
DOI: 10.1002/hep4.1654

Bile Acids, Liver Cirrhosis, and Extrahepatic Vascular Dysfunction

Autorzy: Tilman Sauerbruch, Martin Hennenberg, Jonel Trebicka and Ulrich Beuers
Opublikowane w: Frontiers in Physiology, Numer 29.07.2021, 2021, ISSN 2296-858X
Wydawca: Frontiers of Medicine
DOI: 10.3389/fphys.2021.718783

The Development and Outcome of Acute‐on‐Chronic Liver Failure After Surgical Interventions

Autorzy: Leah Maria Klein, Johannes Chang, Wenyi Gu, Steffen Manekeller, Christian Jansen, Philipp Lingohr, Michael Praktiknjo, Jörg C. Kalf, Martin Schulz, Ulrich Spengler, Christian Strassburg, Andrés Cárdenas, Vicente Arroyo, Jonel Trebicka
Opublikowane w: Liver Transplantation, Numer 26/2, 2019, Strona(/y) 227-237, ISSN 1527-6465
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/lt.25675

Epidemiology of liver transplantation and post-LT complications in Germany: nationwide study (2005-2018).

Autorzy: Gu, W., Schaaf, L., Hortlik, H., Zeleke, Y., Brol, M. J., Schnitzbauer, A. A., Bechstein, W. O., Zeuzem, S., Queck, A., Peiffer, K. H., Tischendorf, M., Pascher, A., Laleman, W., Praktiknjo, M., Schulz, M. S., Uschner, F. E., Rennebaum, F., & Trebicka, J.
Opublikowane w: European journal of gastroenterology & hepatology, 2023, ISSN 1473-5687
Wydawca: Wolters Kluwer
DOI: 10.1097/meg.0000000000002640

Total area of spontaneous portosystemic shunts independently predicts hepatic encephalopathy and mortality in liver cirrhosis

Autorzy: Michael Praktiknjo, Macarena Simón-Talero, Julia Römer, Davide Roccarina, Javier Martínez, Katharina Lampichler, Anna Baiges, Gavin Low, Elba Llop, Martin H. Maurer, Alexander Zipprich, Michela Triolo, Geert Maleux, Annette Dam Fialla, Claus Dam, Judit Vidal-González, Avik Majumdar, Carmen Picón, Daniel Toth, Anna Darnell, Juan G. Abraldes, Marta López, Christian Jansen, Johannes Chang, Robe
Opublikowane w: Journal of Hepatology, Numer 72/6, 2020, Strona(/y) 1140-1150, ISSN 0168-8278
Wydawca: Elsevier BV
DOI: 10.1016/j.jhep.2019.12.021

The Role of Macrophage-Inducible C-Type Lectin in Different Stages of Chronic Liver Disease

Autorzy: Robert Schierwagen, Frank E. Uschner, Cristina Ortiz, Sandra Torres, Max J. Brol, Olaf Tyc, Wenyi Gu, Christian Grimm, Stefan Zeuzem, Andreas Plamper, Philipp Pfeifer, Sebastian Zimmer, Christoph Welsch, Liliana Schaefer, Karl P. Rheinwalt, Joan Clària, Vicente Arroyo, Jonel Trebicka, Sabine Klein
Opublikowane w: Frontiers in Immunology, Numer 11, 2020, ISSN 1664-3224
Wydawca: Frontiers Media SA
DOI: 10.3389/fimmu.2020.01352

Liver Transplantation as a Cornerstone Treatment for Acute-On-Chronic Liver Failure.

Autorzy: Schulz, M. S., Gu, W., Schnitzbauer, A. A., & Trebicka, J.
Opublikowane w: Transplant international : official journal of the European Society for Organ Transplantation, 2022, ISSN 1432-2277
Wydawca: Frontiers Media
DOI: 10.3389/ti.2022.10108

Beta-blockers in patients with liver cirrhosis: Pragmatism or perfection?.

Autorzy: Sauerbruch, T., Hennenberg, M., Trebicka, J., & Schierwagen, R.
Opublikowane w: Frontiers in medicine, 2023, ISSN 2296-858X
Wydawca: Frontiers media
DOI: 10.3389/fmed.2022.1100966

Baseline Presence of NAFLD Predicts Weight Loss after Gastric Bypass Surgery for Morbid Obesity

Autorzy: Karl P. Rheinwalt; Uta Drebber; orcid Robert Schierwagen; Sabine D. Klein; Ulf P. Neumann; Tom Florian Ulmer; Andreas Plamper;orcid bw Andreas Kroh; Sandra Schipper; Margarete Odenthal; Frank Erhard Uschner; Philipp Lingohr; Jonel Trebicka; Maximilian J. Brol;
Opublikowane w: Journal of Clinical Medicine, Numer Volume 9, Numer 11, 2020, ISSN 2077-0383
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm9113430

Controlled underdilation using novel VIATORR® controlled expansion stents improves survival after transjugular intrahepatic portosystemic shunt implantation

Autorzy: Michael Praktiknjo, Jasmin Abu-Omar, Johannes Chang, Daniel Thomas, Christian Jansen, Patrick Kupczyk, Filippo Schepis, Juan Carlos Garcia-Pagan, Manuela Merli, Carsten Meyer, Christian P. Strassburg, Claus C. Pieper, Jonel Trebicka
Opublikowane w: JHEP, Numer Volume 3, Numer 3, 2021, ISSN 0346-251X
Wydawca: Pergamon Press Ltd.
DOI: 10.1016/j.jhepr.2021.100264

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction-associated fatty liver disease

Autorzy: López-Vicario, C., Sebastián, D., Casulleras, M., Duran-Güell, M., Flores-Costa, R., Aguilar, F., Lozano, J. J., Zhang, I. W., Titos, E., Kang, J. X., Zorzano, A., Arita, M., & Clària, J.
Opublikowane w: Hepatology, 2023, ISSN 1527-3350
Wydawca: Wiley
DOI: 10.1002/hep.32647

Dynamic human liver proteome atlas reveals functional insights into disease pathways.

Autorzy: Niu L, Geyer PE, Gupta R, Santos A, Meier F, Doll S, Wewer Albrechtsen NJ, Klein S, Ortiz C, Uschner FE, Schierwagen R, Trebicka J, Mann M
Opublikowane w: Mol Syst Biol., 2022, ISSN 1744-4292
Wydawca: Nature Publishing Group
DOI: 10.15252/msb.202210947

Mitochondrial Dysfunction in Advanced Liver Disease: Emerging Concepts

Autorzy: Ingrid W. Zhang; Ingrid W. Zhang; Cristina López-Vicario; Cristina López-Vicario; Cristina López-Vicario; Marta Duran-Güell; Marta Duran-Güell; Joan Clària; Joan Clària; Joan Clària; Joan Clària
Opublikowane w: instname:Universidad de Barcelona, Numer 3, 2021, ISSN 2296-889X
Wydawca: Frontiers
DOI: 10.3389/fmolb.2021.772174

Extrahepatic Surgery in Cirrhosis Significantly Increases Portal Pressure in Preclinical Animal Models

Autorzy: Chang Johannes, Meinke Jonathan, Geck Moritz, Hebest Marc, Böhling Nina, Dolscheid-Pommerich Ramona, Stoffel-Wagner Birgit, Kristiansen Glen, Overhaus Marcus, Peyman Leon O., Klein Sabine, Uschner Frank E., Brol Maximilian J., Vilz Tim O., Lingohr Philipp, Kalff Jörg C., Jansen Christian, Strassburg Christian P., Wehner Sven, Trebicka Jonel, Praktiknjo Michael
Opublikowane w: Frontiers in Physiology, Numer Volume 12, 2021, ISSN 1664-042X
Wydawca: Frontiers Research Foundation
DOI: 10.3389/fphys.2021.720898

Autorzy: Xiaojie Yu, Natalia Elfimova, Marion Müller, Daniel Bachurski, Ulrike Koitzsch, Uta Drebber, Esther Mahabir, Hinrich P Hansen, Scott L Friedman, Sabine Klein, Hans Peter Dienes, Marianna Hösel, Reinhard Buettner, Jonel Trebicka, Vangelis Kondylis, Inge Mannaerts, Margarete Odenthal
Opublikowane w: cmgh, Numer Volume 13, Numer 6, 2022, Strona(/y) 1701- 1716, ISSN 2352-345X
Wydawca: Elsevier Inc.
DOI: 10.1016/j.jcmgh.2022.02.013

Acute-On-Chronic Liver Failure: Current Interventional Treatment Options and Future Challenges.

Autorzy: Kimmann, M., & Trebicka, J.
Opublikowane w: Journal of personalized medicine, 2023, ISSN 2075-4426
Wydawca: MDPI
DOI: 10.3390/jpm13071052

Use and outcome of TIPS in hospitalized patients in Germany: A Nationwide study (2007-2018)

Autorzy: Gu, W., Zeleke, Y., Hortlik, H., Schaaf, L., Uschner, F. E., Schulz, M., Tischendorf, M., Peiffer, K. H., Brol, M. J., Kimmann, M., Vogl, T., Köhler, M., Meyer, C., Gerbes, A., Rössle, M., Laleman, W., Zipprich, A., Steib, C., Praktiknjo, M., Trebicka, J., …German TIPS Working Group
Opublikowane w: Hepatology communications, 2023, ISSN 2471-254X
Wydawca: Wolters Kluwer Health, Inc.
DOI: 10.1097/hc9.0000000000000237

Nanodiagnostics to Face SARS-CoV‑2 and Future Pandemics: From an Idea to the Market and Beyond

Autorzy: Rosati G., Idili A., Parolo C., Fuentes-Chust C., Calucho E., Hu L., De Carvalho Castro Silva C., Rivas L., Nguyen E., Bergua J., Alvarez-Diduk R., Muñoz J., Junot C., Penon O., Monferrer D., Delamarche, E. Merkoçi A.
Opublikowane w: ACS Nano, Numer Volume 15, Numer 11, 2021, Strona(/y) 17137–17149, ISSN 1936-0851
Wydawca: American Chemical Society
DOI: 10.1021/acsnano.1c06839

Follistatin-controlled activin-HNF4α-coagulation factor axis in liver progenitor cells determines outcome of acute liver failure

Autorzy: Tao Lin, Shanshan Wang, Stefan Munker, Kyounghwa Jung, Ricardo U. Macías-Rodríguez, Astrid Ruiz-Margáin, Robert Schierwagen, Hui Liu, Chen Shao, Chunlei Fan, Rilu Feng, Xiaodong Yuan, Sai Wang, Franziska Wandrer, Christoph Meyer, Ralf Wimmer, Roman Liebe, Jens Kroll, Long Zhang, Tobias Schiergens, Peter ten Dijke, Andreas Teufel, Alexander Marx, Peter R. Mertens, Hua Wang, Matthias P.A. Ebert,
Opublikowane w: Hepatology, Numer Volume 75, Numer 2, 2021, Strona(/y) 322-337, ISSN 2471-254X
Wydawca: AASLD
DOI: 10.1002/hep.32119

Trends and the course of liver cirrhosis and its complications in Germany: Nationwide population-based study (2005 to 2018)

Autorzy: Wenyi Gu, Hannah Hortlik, Hans-Peter Erasmus, Louisa Schaaf, Yasmin Zeleke, Frank E. Uschner, Philip Ferstl, Martin Schulz, Kai-Henrik Peiffer, Alexander Queck, Tilman Sauerbruch, Maximilian Joseph Brol, Gernot Rohde, Cristina Sanchez, Richard Moreau, Vicente Arroyo, Stefan Zeuzem, Christoph Welsch, Jonel Trebicka
Opublikowane w: The Lancet Regional Health - Europe, Numer Volume 12, 2022, ISSN 2666-7762
Wydawca: Elsevier Ltd.
DOI: 10.1016/j.lanepe.2021.100240

Assessment of portal hypertension severity using machine learning models in patients with compensated cirrhosis

Autorzy: Reiniš, J., Petrenko, O., Simbrunner, B., Hofer, B. S., Schepis, F., Scoppettuolo, M., Saltini, D., Indulti, F., Guasconi, T., Albillos, A., Téllez, L., Villanueva, C., Brujats, A., Garcia-Pagan, J. C., Perez-Campuzano, V., Hernández-Gea, V., Rautou, P. E., Moga, L., Vanwolleghem, T., Kwanten, W. J., … Reiberger, T.
Opublikowane w: Journal of hepatology, 2023, ISSN 1600-0641
Wydawca: Elsevier Open Access
DOI: 10.1016/j.jhep.2022.09.012

Trust is good, control is better: technical considerations in blood microbiome analysis

Autorzy: Robert Schierwagen, Camila Alvarez-Silva, Florence Servant, Jonel Trebicka, Benjamin Lelouvier, Manimozhiyan Arumugam
Opublikowane w: Gut, Numer 69/7, 2020, Strona(/y) 1362-1363, ISSN 0017-5749
Wydawca: BMJ Publishing Group
DOI: 10.1136/gutjnl-2019-319123

Precipitants of Acute‐on‐Chronic Liver Failure: An Opportunity for Preventative Measures to Improve Outcomes

Autorzy: Giuseppe Cullaro, Rajani Sharma, Jonel Trebicka, Andrés Cárdenas, Elizabeth C. Verna
Opublikowane w: Liver Transplantation, Numer 26/2, 2019, Strona(/y) 283-293, ISSN 1527-6465
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/lt.25678

Essential role for albumin in preserving liver cells from TNFα-induced mitochondrial injury.

Autorzy: Duran-Güell, M., Garrabou, G., Flores-Costa, R., Casulleras, M., López-Vicario, C., Zhang, I. W., Cantó-Santos, J., Contreras, B. J., Sánchez-Rodríguez, M. B., Romero-Grimaldo, B., Horrillo, R., Costa, M., Arroyo, V., & Clària, J.
Opublikowane w: FASEB, 2023, ISSN 1530-6860
Wydawca: Wiley
DOI: 10.1096/fj.202201526r

The Role of Decorin and Biglycan Signaling in Tumorigenesis

Autorzy: Diehl Valentina, Huber Lisa Sophie, Trebicka Jonel, Wygrecka Malgorzata, Iozzo Renato V., Schaefer Liliana
Opublikowane w: Frontiers in Oncology, Numer Volume 11, 2021, ISSN 2234-943X
Wydawca: Frontiers Media S. A.
DOI: 10.3389/fonc.2021.801801

Sex specificity of kidney markers to assess prognosis in cirrhotic patients with TIPS

Autorzy: Maria Torner, Adjmal Mangal, Hubert Scharnagl, Christian Jansen, Michael Praktiknjo, Alexander Queck, Wenyi Gu, Robert Schierwagen, Jennifer Lehmann, Frank E. Uschner, Christiana Graf, Christian P. Strassburg, Javier Fernandez, Tatjana Stojakovic, Rainer Woitas, Jonel Trebicka
Opublikowane w: Liver International, Numer 40/1, 2019, Strona(/y) 186-193, ISSN 1478-3223
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/liv.14230

Plasma Proteomes Can Be Reidentifiable and Potentially Contain Personally Sensitive and Incidental Findings

Autorzy: Geyer PE, Mann SP, Treit PV, Mann M. Plasma
Opublikowane w: Molecula & Cellular Proteomics, Numer 20, 2021, ISSN 1535-9476
Wydawca: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/mcp.ra120.002359

Definition, diagnosis and epidemiology of acute‐on‐chronic liver failure

Autorzy: Ruben Hernaez; Hai Li; Richard Moreau; Minneke J. Coenraad
Opublikowane w: Crossref, Numer 2, 2023, ISSN 1478-3223
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/liv.15670

Leveraging omics to understand the molecular basis of acute-on-chronic liver failure

Autorzy: Joan Clària
Opublikowane w: instname:Universidad de Barcelona, Numer 2, 2021, ISSN 2628-491X
Wydawca: De Gruyter
DOI: 10.1515/almed-2021-0023

Janus kinase 2 inhibition by pacritinib as potential therapeutic target for liver fibrosis.

Autorzy: orres, S., Ortiz, C., Bachtler, N., Gu, W., Grünewald, L. D., Kraus, N., Schierwagen, R., Hieber, C., Meier, C., Tyc, O., Joseph Brol, M., Uschner, F. E., Nijmeijer, B., Welsch, C., Berres, M. L., Garcia-Ruiz, C., Fernandez-Checa, J. C., Trautwein, C., Vogl, T. J., Zeuzem, S., … Klein, S.
Opublikowane w: Hepatology, 2023, ISSN 0270-9139
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/hep.32746

Variation in Bile Microbiome by the Etiology of Cholestatic Liver Disease

Autorzy: Olaf Tyc, Christian Jansen, Robert Schierwagen, Frank Erhard Uschner, Mads Israelsen, Sabine Klein, Cristina Ortiz, Christian P. Strassburg, Stefan Zeuzem, Wenyi Gu, Sandra Torres, Michael Praktiknjo, Stephan Kersting, Melanie Langheinrich, Jacob Nattermann, Florence Servant, Manimozhiyan Arumugam, Aleksander Krag, Benjamin Lelouvier, Tobias J. Weismüller, Jonel Trebicka
Opublikowane w: Liver Transplantation, 2020, ISSN 1527-6465
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/lt.25882

Ethical Principles, Constraints, and Opportunities in Clinical Proteomics

Autorzy: Sebastian Porsdam Mann, Peter V.Treit, Philipp E.Geyer, Gilbert S.Omenn, MatthiasMann
Opublikowane w: MCP, Numer Volume20, 2021, ISSN 1535-9476
Wydawca: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.mcpro.2021.100046

Restoration of the gut microbiota is associated with a decreased risk of hepatic encephalopathy after TIPS

Autorzy: Menghao Li, Kai Li, Shihao Tang, Yong Lv, Qiuhe Wang, Zhengyu Wang, Bohan Luo, Jing Niu, Ying Zhu, Wengang Guo, Wei Bai, Enxin Wang, Dongdong Xia, Zhexuan Wang, Xiaomei Li, Jie Yuan, Zhanxin Yin, Jonel Trebicka, Guohong Han
Opublikowane w: JHEP Reports, Numer Volume 4, Numer 5, 2022, ISSN 2589-5559
Wydawca: Elsevier BV
DOI: 10.1016/j.jhepr.2022.100448

Genetic variation in TERT modifies the risk of hepatocellular carcinoma in alcohol-related cirrhosis: results from a genome-wide case-control study.

Autorzy: Buch, S., Innes, H., Lutz, P. L., Nischalke, H. D., Marquardt, J. U., Fischer, J., Weiss, K. H., Rosendahl, J., Marot, A., Krawczyk, M., Casper, M., Lammert, F., Eyer, F., Vogel, A., Marhenke, S., von Felden, J., Sharma, R., Atkinson, S. R., McQuillin, A., Nattermann, J., … Stickel, F.
Opublikowane w: Gut, 2023, ISSN 1468-3288
Wydawca: BMJ Group
DOI: 10.1136/gutjnl-2022-327196

Stratifying the risk of NAFLD in patients with HIV under combination antiretroviral therapy (cART)

Autorzy: Jenny Bischoff, Wenyi Gu, Carolynne Schwarze-Zander, Christoph Boesecke, Jan-Christian Wasmuth, Kathrin van Bremen, Leona Dold, Jürgen K Rockstroh, Jonel Trebicka
Opublikowane w: EClinicalMedicine, Numer Volume 40, 2021, ISSN 2589-5370
Wydawca: Elsevier
DOI: 10.1016/j.eclinm.2021.101116

Granulocyte-colony stimulating factor (G-CSF) to treat acute-on-chronic liver failure: A multicenter randomized trial (GRAFT study)

Autorzy: Cornelius Engelmann, Adam Herber, Annegret Franke, Tony Bruns, Philipp Reuken, Ingolf Schiefke, Alexander Zipprich, Stefan Zeuzem, Tobias Goeser, Ali Canbay, Christoph Berg, Jonel Trebicka, Frank E. Uschner, Johannes Chang, Tobias Mueller, Niklas Aehling, Moritz Schmelzle, Katrin Splith, Frank Lammert, Christian M. Lange, Christoph Sarrazin, Christian Trautwein, Michael Manns, Dieter Häussinger,
Opublikowane w: Journal of Hepatology, Numer Volume 75, Numer 6, 2021, Strona(/y) 1346-1354, ISSN 0168-8278
Wydawca: Elsevier BV
DOI: 10.1016/j.jhep.2021.07.033

Role of circulating angiogenin levels in portal hypertension and TIPS

Autorzy: Alexander Queck, Frank E Uschner, Philip G Ferstl, Martin Schulz, Maximilian J Brol, Michael Praktiknjo, Robert Schierwagen, Sabine Klein, Christian P Strassburg, Carsten Meyer, Christian Jansen, Marie-Luise Berres, Jonel Trebicka
Opublikowane w: PLoS One, Numer Volume 16, Numer 8, 2021, ISSN 1932-6203
Wydawca: Public Library of Science
DOI: 10.1371/journal.pone.0256473

To TIPS or Not to TIPS in High Risk of Variceal Rebleeding and Acute-on-Chronic Liver Failure.

Autorzy: Gu, W., Kimmann, M., Laleman, W., Praktiknjo, M., & Trebicka, J.
Opublikowane w: Seminars in liver disease, 2023, ISSN 1098-8971
Wydawca: Georg Thieme Verlag
DOI: 10.1055/a-2107-0576

The rs429358 Locus in Apolipoprotein E Is Associated With Hepatocellular Carcinoma in Patients With Cirrhosis

Autorzy: Innes H, Nischalke HD, Guha IN, Weiss KH, Irving W, Gotthardt D, Barnes E, Fischer J, Ansari MA, Rosendahl J, Lin SK, Marot A, Pedergnana V, Casper M, Benselin J, Lammert F, McLauchlan J, Lutz PL, Hamill V, Mueller S, Morling JR, Semmler G, Eyer F, von Felden J, Link A, Vogel A, Marquardt JU, Sulk S, Trebicka J, Valenti L, Datz C, Reiberger T, Schafmayer C, Berg T, Deltenre P, Hampe J, Stickel F,
Opublikowane w: Hepatology Communications, Numer Volume6, Numer 5, 2022, Strona(/y) 1213-1226, ISSN 2471-254X
Wydawca: AASLD
DOI: 10.1002/hep4.1886

Roles of systemic inflammatory and metabolic responses in the pathophysiology of acute-on-chronic liver failure

Autorzy: Clària, J., Arroyo, V., & Moreau, R.
Opublikowane w: JHEP reports : innovation in hepatology, 2023, ISSN 1744-4292
Wydawca: Nature Publishing Group

Systemic MCP-1 Levels Derive Mainly From Injured Liver and Are Associated With Complications in Cirrhosis

Autorzy: Alexander Queck, Hannah Bode, Frank E. Uschner, Maximilian J. Brol, Christiana Graf, Martin Schulz, Christian Jansen, Michael Praktiknjo, Robert Schierwagen, Sabine Klein, Christian Trautwein, Hermann E. Wasmuth, Marie-Luise Berres, Jonel Trebicka, Jennifer Lehmann
Opublikowane w: Frontiers in Immunology, Numer 11, 2020, ISSN 1664-3224
Wydawca: Frontiers Media SA
DOI: 10.3389/fimmu.2020.00354

The proteome landscape of the kingdoms of life

Autorzy: Johannes B. Müller, Philipp E. Geyer, Ana R. Colaço, Peter V. Treit, Maximilian T. Strauss, Mario Oroshi, Sophia Doll, Sebastian Virreira Winter, Jakob M. Bader, Niklas Köhler, Fabian Theis, Alberto Santos, Matthias Mann
Opublikowane w: Nature, Numer 582/7813, 2020, Strona(/y) 592-596, ISSN 0028-0836
Wydawca: Nature Publishing Group
DOI: 10.1038/s41586-020-2402-x

Sympathetic nervous activation, mitochondrial dysfunction and outcome in acutely decompensated cirrhosis: the metabolomic prognostic models (CLIF-C MET)

Autorzy: Weiss, E., de la Peña-Ramirez, C., Aguilar, F., Lozano, J. J., Sánchez-Garrido, C., Sierra, P., Martin, P. I., Diaz, J. M., Fenaille, F., Castelli, F. A., Gustot, T., Laleman, W., Albillos, A., Alessandria, C., Domenicali, M., Caraceni, P., Piano, S., Saliba, F., Zeuzem, S., Gerbes, A. L., … Arroyo, V.
Opublikowane w: Gut, 2023, ISSN 0017-5749
Wydawca: BMJ Publishing Group
DOI: 10.1136/gutjnl

Differential inflammasome activation predisposes to acute-on-chronic liver failure in human and experimental cirrhosis with and without previous decompensation

Autorzy: Sofia Monteiro, Josephine Grandt, Frank Erhard Uschner, Nina Kimer, Jan Lysgård Madsen, Robert Schierwagen, Sabine Klein, Christoph Welsch, Liliana Schäfer, Christian Jansen, Joan Claria, José Alcaraz-Quiles, Vicente Arroyo, Richard Moreau, Javier Fernandez, Flemming Bendtsen, Gautam Mehta, Lise Lotte Gluud, Søren Møller, Michael Praktiknjo, Jonel Trebicka
Opublikowane w: Gut, 2020, Strona(/y) gutjnl-2019-320170, ISSN 0017-5749
Wydawca: BMJ Publishing Group
DOI: 10.1136/gutjnl-2019-320170

Communications via the Small Leucine-rich Proteoglycans: Molecular Specificity in Inflammation and Autoimmune Diseases

Autorzy: Jinyang Zeng-Brouwers, Sony Pandey, Jonel Trebicka, Malgorzata Wygrecka, Liliana Schaefer
Opublikowane w: Journal of Histochemistry & Cytochemistry, 2020, Strona(/y) 002215542093030, ISSN 0022-1554
Wydawca: Histochemical Society
DOI: 10.1369/0022155420930303

Pathophysiological role of prostanoids in coagulation of the portal venous system in liver cirrhosis

Autorzy: Alexander Queck, Dominique Thomas, Christian Jansen, Yannick Schreiber, Sabrina Rüschenbaum, Michael Praktiknjo, Katharina Maria Schwarzkopf, Marcus Maximilian Mücke, Robert Schierwagen, Frank Erhard Uschner, Carsten Meyer, Joan Clària, Stefan Zeuzem, Gerd Geisslinger, Jonel Trebicka, Christian Markus Lange
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