MICROBiome-based biomarkers to PREDICT decompensation of liver cirrhosis and treatment response

Livrables

Go-online of the public project website
Second patient and layman event
Project brochure and professional templates
Dissemination activity at IHMC congress in Barcelona 2020
First patient and layman event

Final version of study protocol to be approved by ethics committee(s)

Final version of study protocol to be approved by ethics committees

Report on Acquire proteomics data
Report on lipidomics and bile acids data
Brochure to inform in brief about MICROB-PREDICT for participants involved in the clinical study

Brochure to inform in brief about MICROBPREDICT for participants involved in the clinical study

Codes of conduct applicable and research integrity policy including publications in journals
Registration number of clinical study in a WHO- or ICMJE- approved registry

Registration number of clinical study in a WHO or ICMJE approved registry

First written draft of a model describing typical treatment paths in decompensated cirrhosis
Information and Informed consent template for participation of human beings (patients/healthy volunteers), for using biological samples of human origin in research and for the use of personal data (including genetic data) in research
Policy for integrating the 6 agendas (ethics, gender equality, public engagement, governance, scientific education and open access) of responsible research and innovation
Checklist for participants to assure informed consent / other mechanisms for those unable to give a written consent
Report on histological data of gut barrier
Report on metabolomics data
Public engagement strategy to design MICROB-PREDICT along with the need of patients

Implementation of model in a software package

Publications

The Specific NLRP3 Antagonist IFM-514 Decreases Fibrosis and Inflammation in Experimental Murine Non-Alcoholic Steatohepatitis

Auteurs: Torres Sandra, Brol Maximilian J, Magdaleno Fernando, Schierwagen Robert, Uschner Frank E., Klein Sabine, Ortiz Cristina, Tyc Olaf, Bachtler Nadine, Stunden James, Bertheloot Damien, Kitanovic Ana, Sanchez Brian, Schrum Jacob, Roush William R., Franchi Luigi, Byth Kate, Latz Eicke, Trebicka Jonel
Publié dans: Frontiers in Molecular Biosciences, Numéro Volume 8, 2021, ISSN 2296-889X
Éditeur: Frontiers Media
DOI: 10.3389/fmolb.2021.715765

Prognostic Value of the CLIF-C AD Score in Patients With Implantation of Transjugular Intrahepatic Portosystemic Shunt

Auteurs: Sturm, L., Praktiknjo, M., Bettinger, D., Huber, J.P., Volkwein, L., Schmidt, A.R., Kaeser, R., Chang, J., Jansen, C., Meyer, C.H., Thomas, D.K., Thimme, R., Trebicka, J., & Schultheiss, M
Publié dans: Hepatology Communications, Numéro Volume 5, 2021, Page(s) 650-660, ISSN 2471-254X
Éditeur: AASLD
DOI: 10.1002/hep4.1654

Bile Acids, Liver Cirrhosis, and Extrahepatic Vascular Dysfunction

Auteurs: Tilman Sauerbruch, Martin Hennenberg, Jonel Trebicka and Ulrich Beuers
Publié dans: Frontiers in Physiology, Numéro 29.07.2021, 2021, ISSN 2296-858X
Éditeur: Frontiers of Medicine
DOI: 10.3389/fphys.2021.718783

The Development and Outcome of Acute‐on‐Chronic Liver Failure After Surgical Interventions

Auteurs: Leah Maria Klein, Johannes Chang, Wenyi Gu, Steffen Manekeller, Christian Jansen, Philipp Lingohr, Michael Praktiknjo, Jörg C. Kalf, Martin Schulz, Ulrich Spengler, Christian Strassburg, Andrés Cárdenas, Vicente Arroyo, Jonel Trebicka
Publié dans: Liver Transplantation, Numéro 26/2, 2019, Page(s) 227-237, ISSN 1527-6465
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/lt.25675

Epidemiology of liver transplantation and post-LT complications in Germany: nationwide study (2005-2018).

Auteurs: Gu, W., Schaaf, L., Hortlik, H., Zeleke, Y., Brol, M. J., Schnitzbauer, A. A., Bechstein, W. O., Zeuzem, S., Queck, A., Peiffer, K. H., Tischendorf, M., Pascher, A., Laleman, W., Praktiknjo, M., Schulz, M. S., Uschner, F. E., Rennebaum, F., & Trebicka, J.
Publié dans: European journal of gastroenterology & hepatology, 2023, ISSN 1473-5687
Éditeur: Wolters Kluwer
DOI: 10.1097/meg.0000000000002640

Total area of spontaneous portosystemic shunts independently predicts hepatic encephalopathy and mortality in liver cirrhosis

Auteurs: Michael Praktiknjo, Macarena Simón-Talero, Julia Römer, Davide Roccarina, Javier Martínez, Katharina Lampichler, Anna Baiges, Gavin Low, Elba Llop, Martin H. Maurer, Alexander Zipprich, Michela Triolo, Geert Maleux, Annette Dam Fialla, Claus Dam, Judit Vidal-González, Avik Majumdar, Carmen Picón, Daniel Toth, Anna Darnell, Juan G. Abraldes, Marta López, Christian Jansen, Johannes Chang, Robe
Publié dans: Journal of Hepatology, Numéro 72/6, 2020, Page(s) 1140-1150, ISSN 0168-8278
Éditeur: Elsevier BV
DOI: 10.1016/j.jhep.2019.12.021

The Role of Macrophage-Inducible C-Type Lectin in Different Stages of Chronic Liver Disease

Auteurs: Robert Schierwagen, Frank E. Uschner, Cristina Ortiz, Sandra Torres, Max J. Brol, Olaf Tyc, Wenyi Gu, Christian Grimm, Stefan Zeuzem, Andreas Plamper, Philipp Pfeifer, Sebastian Zimmer, Christoph Welsch, Liliana Schaefer, Karl P. Rheinwalt, Joan Clària, Vicente Arroyo, Jonel Trebicka, Sabine Klein
Publié dans: Frontiers in Immunology, Numéro 11, 2020, ISSN 1664-3224
Éditeur: Frontiers Media SA
DOI: 10.3389/fimmu.2020.01352

Liver Transplantation as a Cornerstone Treatment for Acute-On-Chronic Liver Failure.

Auteurs: Schulz, M. S., Gu, W., Schnitzbauer, A. A., & Trebicka, J.
Publié dans: Transplant international : official journal of the European Society for Organ Transplantation, 2022, ISSN 1432-2277
Éditeur: Frontiers Media
DOI: 10.3389/ti.2022.10108

Beta-blockers in patients with liver cirrhosis: Pragmatism or perfection?.

Auteurs: Sauerbruch, T., Hennenberg, M., Trebicka, J., & Schierwagen, R.
Publié dans: Frontiers in medicine, 2023, ISSN 2296-858X
Éditeur: Frontiers media
DOI: 10.3389/fmed.2022.1100966

Baseline Presence of NAFLD Predicts Weight Loss after Gastric Bypass Surgery for Morbid Obesity

Auteurs: Karl P. Rheinwalt; Uta Drebber; orcid Robert Schierwagen; Sabine D. Klein; Ulf P. Neumann; Tom Florian Ulmer; Andreas Plamper;orcid bw Andreas Kroh; Sandra Schipper; Margarete Odenthal; Frank Erhard Uschner; Philipp Lingohr; Jonel Trebicka; Maximilian J. Brol;
Publié dans: Journal of Clinical Medicine, Numéro Volume 9, Numéro 11, 2020, ISSN 2077-0383
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm9113430

Controlled underdilation using novel VIATORR® controlled expansion stents improves survival after transjugular intrahepatic portosystemic shunt implantation

Auteurs: Michael Praktiknjo, Jasmin Abu-Omar, Johannes Chang, Daniel Thomas, Christian Jansen, Patrick Kupczyk, Filippo Schepis, Juan Carlos Garcia-Pagan, Manuela Merli, Carsten Meyer, Christian P. Strassburg, Claus C. Pieper, Jonel Trebicka
Publié dans: JHEP, Numéro Volume 3, Numéro 3, 2021, ISSN 0346-251X
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.jhepr.2021.100264

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction-associated fatty liver disease

Auteurs: López-Vicario, C., Sebastián, D., Casulleras, M., Duran-Güell, M., Flores-Costa, R., Aguilar, F., Lozano, J. J., Zhang, I. W., Titos, E., Kang, J. X., Zorzano, A., Arita, M., & Clària, J.
Publié dans: Hepatology, 2023, ISSN 1527-3350
Éditeur: Wiley
DOI: 10.1002/hep.32647

Dynamic human liver proteome atlas reveals functional insights into disease pathways.

Auteurs: Niu L, Geyer PE, Gupta R, Santos A, Meier F, Doll S, Wewer Albrechtsen NJ, Klein S, Ortiz C, Uschner FE, Schierwagen R, Trebicka J, Mann M
Publié dans: Mol Syst Biol., 2022, ISSN 1744-4292
Éditeur: Nature Publishing Group
DOI: 10.15252/msb.202210947

Mitochondrial Dysfunction in Advanced Liver Disease: Emerging Concepts

Auteurs: Ingrid W. Zhang; Ingrid W. Zhang; Cristina López-Vicario; Cristina López-Vicario; Cristina López-Vicario; Marta Duran-Güell; Marta Duran-Güell; Joan Clària; Joan Clària; Joan Clària; Joan Clària
Publié dans: instname:Universidad de Barcelona, Numéro 3, 2021, ISSN 2296-889X
Éditeur: Frontiers
DOI: 10.3389/fmolb.2021.772174

Extrahepatic Surgery in Cirrhosis Significantly Increases Portal Pressure in Preclinical Animal Models

Auteurs: Chang Johannes, Meinke Jonathan, Geck Moritz, Hebest Marc, Böhling Nina, Dolscheid-Pommerich Ramona, Stoffel-Wagner Birgit, Kristiansen Glen, Overhaus Marcus, Peyman Leon O., Klein Sabine, Uschner Frank E., Brol Maximilian J., Vilz Tim O., Lingohr Philipp, Kalff Jörg C., Jansen Christian, Strassburg Christian P., Wehner Sven, Trebicka Jonel, Praktiknjo Michael
Publié dans: Frontiers in Physiology, Numéro Volume 12, 2021, ISSN 1664-042X
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fphys.2021.720898

Auteurs: Xiaojie Yu, Natalia Elfimova, Marion Müller, Daniel Bachurski, Ulrike Koitzsch, Uta Drebber, Esther Mahabir, Hinrich P Hansen, Scott L Friedman, Sabine Klein, Hans Peter Dienes, Marianna Hösel, Reinhard Buettner, Jonel Trebicka, Vangelis Kondylis, Inge Mannaerts, Margarete Odenthal
Publié dans: cmgh, Numéro Volume 13, Numéro 6, 2022, Page(s) 1701- 1716, ISSN 2352-345X
Éditeur: Elsevier Inc.
DOI: 10.1016/j.jcmgh.2022.02.013

Acute-On-Chronic Liver Failure: Current Interventional Treatment Options and Future Challenges.

Auteurs: Kimmann, M., & Trebicka, J.
Publié dans: Journal of personalized medicine, 2023, ISSN 2075-4426
Éditeur: MDPI
DOI: 10.3390/jpm13071052

Use and outcome of TIPS in hospitalized patients in Germany: A Nationwide study (2007-2018)

Auteurs: Gu, W., Zeleke, Y., Hortlik, H., Schaaf, L., Uschner, F. E., Schulz, M., Tischendorf, M., Peiffer, K. H., Brol, M. J., Kimmann, M., Vogl, T., Köhler, M., Meyer, C., Gerbes, A., Rössle, M., Laleman, W., Zipprich, A., Steib, C., Praktiknjo, M., Trebicka, J., …German TIPS Working Group
Publié dans: Hepatology communications, 2023, ISSN 2471-254X
Éditeur: Wolters Kluwer Health, Inc.
DOI: 10.1097/hc9.0000000000000237

Nanodiagnostics to Face SARS-CoV‑2 and Future Pandemics: From an Idea to the Market and Beyond

Auteurs: Rosati G., Idili A., Parolo C., Fuentes-Chust C., Calucho E., Hu L., De Carvalho Castro Silva C., Rivas L., Nguyen E., Bergua J., Alvarez-Diduk R., Muñoz J., Junot C., Penon O., Monferrer D., Delamarche, E. Merkoçi A.
Publié dans: ACS Nano, Numéro Volume 15, Numéro 11, 2021, Page(s) 17137–17149, ISSN 1936-0851
Éditeur: American Chemical Society
DOI: 10.1021/acsnano.1c06839

Follistatin-controlled activin-HNF4α-coagulation factor axis in liver progenitor cells determines outcome of acute liver failure

Auteurs: Tao Lin, Shanshan Wang, Stefan Munker, Kyounghwa Jung, Ricardo U. Macías-Rodríguez, Astrid Ruiz-Margáin, Robert Schierwagen, Hui Liu, Chen Shao, Chunlei Fan, Rilu Feng, Xiaodong Yuan, Sai Wang, Franziska Wandrer, Christoph Meyer, Ralf Wimmer, Roman Liebe, Jens Kroll, Long Zhang, Tobias Schiergens, Peter ten Dijke, Andreas Teufel, Alexander Marx, Peter R. Mertens, Hua Wang, Matthias P.A. Ebert,
Publié dans: Hepatology, Numéro Volume 75, Numéro 2, 2021, Page(s) 322-337, ISSN 2471-254X
Éditeur: AASLD
DOI: 10.1002/hep.32119

Trends and the course of liver cirrhosis and its complications in Germany: Nationwide population-based study (2005 to 2018)

Auteurs: Wenyi Gu, Hannah Hortlik, Hans-Peter Erasmus, Louisa Schaaf, Yasmin Zeleke, Frank E. Uschner, Philip Ferstl, Martin Schulz, Kai-Henrik Peiffer, Alexander Queck, Tilman Sauerbruch, Maximilian Joseph Brol, Gernot Rohde, Cristina Sanchez, Richard Moreau, Vicente Arroyo, Stefan Zeuzem, Christoph Welsch, Jonel Trebicka
Publié dans: The Lancet Regional Health - Europe, Numéro Volume 12, 2022, ISSN 2666-7762
Éditeur: Elsevier Ltd.
DOI: 10.1016/j.lanepe.2021.100240

Assessment of portal hypertension severity using machine learning models in patients with compensated cirrhosis

Auteurs: Reiniš, J., Petrenko, O., Simbrunner, B., Hofer, B. S., Schepis, F., Scoppettuolo, M., Saltini, D., Indulti, F., Guasconi, T., Albillos, A., Téllez, L., Villanueva, C., Brujats, A., Garcia-Pagan, J. C., Perez-Campuzano, V., Hernández-Gea, V., Rautou, P. E., Moga, L., Vanwolleghem, T., Kwanten, W. J., … Reiberger, T.
Publié dans: Journal of hepatology, 2023, ISSN 1600-0641
Éditeur: Elsevier Open Access
DOI: 10.1016/j.jhep.2022.09.012

Trust is good, control is better: technical considerations in blood microbiome analysis

Auteurs: Robert Schierwagen, Camila Alvarez-Silva, Florence Servant, Jonel Trebicka, Benjamin Lelouvier, Manimozhiyan Arumugam
Publié dans: Gut, Numéro 69/7, 2020, Page(s) 1362-1363, ISSN 0017-5749
Éditeur: BMJ Publishing Group
DOI: 10.1136/gutjnl-2019-319123

Precipitants of Acute‐on‐Chronic Liver Failure: An Opportunity for Preventative Measures to Improve Outcomes

Auteurs: Giuseppe Cullaro, Rajani Sharma, Jonel Trebicka, Andrés Cárdenas, Elizabeth C. Verna
Publié dans: Liver Transplantation, Numéro 26/2, 2019, Page(s) 283-293, ISSN 1527-6465
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/lt.25678

Essential role for albumin in preserving liver cells from TNFα-induced mitochondrial injury.

Auteurs: Duran-Güell, M., Garrabou, G., Flores-Costa, R., Casulleras, M., López-Vicario, C., Zhang, I. W., Cantó-Santos, J., Contreras, B. J., Sánchez-Rodríguez, M. B., Romero-Grimaldo, B., Horrillo, R., Costa, M., Arroyo, V., & Clària, J.
Publié dans: FASEB, 2023, ISSN 1530-6860
Éditeur: Wiley
DOI: 10.1096/fj.202201526r

The Role of Decorin and Biglycan Signaling in Tumorigenesis

Auteurs: Diehl Valentina, Huber Lisa Sophie, Trebicka Jonel, Wygrecka Malgorzata, Iozzo Renato V., Schaefer Liliana
Publié dans: Frontiers in Oncology, Numéro Volume 11, 2021, ISSN 2234-943X
Éditeur: Frontiers Media S. A.
DOI: 10.3389/fonc.2021.801801

Sex specificity of kidney markers to assess prognosis in cirrhotic patients with TIPS

Auteurs: Maria Torner, Adjmal Mangal, Hubert Scharnagl, Christian Jansen, Michael Praktiknjo, Alexander Queck, Wenyi Gu, Robert Schierwagen, Jennifer Lehmann, Frank E. Uschner, Christiana Graf, Christian P. Strassburg, Javier Fernandez, Tatjana Stojakovic, Rainer Woitas, Jonel Trebicka
Publié dans: Liver International, Numéro 40/1, 2019, Page(s) 186-193, ISSN 1478-3223
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/liv.14230

Plasma Proteomes Can Be Reidentifiable and Potentially Contain Personally Sensitive and Incidental Findings

Auteurs: Geyer PE, Mann SP, Treit PV, Mann M. Plasma
Publié dans: Molecula & Cellular Proteomics, Numéro 20, 2021, ISSN 1535-9476
Éditeur: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/mcp.ra120.002359

Definition, diagnosis and epidemiology of acute‐on‐chronic liver failure

Auteurs: Ruben Hernaez; Hai Li; Richard Moreau; Minneke J. Coenraad
Publié dans: Crossref, Numéro 2, 2023, ISSN 1478-3223
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/liv.15670

Leveraging omics to understand the molecular basis of acute-on-chronic liver failure

Auteurs: Joan Clària
Publié dans: instname:Universidad de Barcelona, Numéro 2, 2021, ISSN 2628-491X
Éditeur: De Gruyter
DOI: 10.1515/almed-2021-0023

Janus kinase 2 inhibition by pacritinib as potential therapeutic target for liver fibrosis.

Auteurs: orres, S., Ortiz, C., Bachtler, N., Gu, W., Grünewald, L. D., Kraus, N., Schierwagen, R., Hieber, C., Meier, C., Tyc, O., Joseph Brol, M., Uschner, F. E., Nijmeijer, B., Welsch, C., Berres, M. L., Garcia-Ruiz, C., Fernandez-Checa, J. C., Trautwein, C., Vogl, T. J., Zeuzem, S., … Klein, S.
Publié dans: Hepatology, 2023, ISSN 0270-9139
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/hep.32746

Variation in Bile Microbiome by the Etiology of Cholestatic Liver Disease

Auteurs: Olaf Tyc, Christian Jansen, Robert Schierwagen, Frank Erhard Uschner, Mads Israelsen, Sabine Klein, Cristina Ortiz, Christian P. Strassburg, Stefan Zeuzem, Wenyi Gu, Sandra Torres, Michael Praktiknjo, Stephan Kersting, Melanie Langheinrich, Jacob Nattermann, Florence Servant, Manimozhiyan Arumugam, Aleksander Krag, Benjamin Lelouvier, Tobias J. Weismüller, Jonel Trebicka
Publié dans: Liver Transplantation, 2020, ISSN 1527-6465
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/lt.25882

Ethical Principles, Constraints, and Opportunities in Clinical Proteomics

Auteurs: Sebastian Porsdam Mann, Peter V.Treit, Philipp E.Geyer, Gilbert S.Omenn, MatthiasMann
Publié dans: MCP, Numéro Volume20, 2021, ISSN 1535-9476
Éditeur: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.mcpro.2021.100046

Restoration of the gut microbiota is associated with a decreased risk of hepatic encephalopathy after TIPS

Auteurs: Menghao Li, Kai Li, Shihao Tang, Yong Lv, Qiuhe Wang, Zhengyu Wang, Bohan Luo, Jing Niu, Ying Zhu, Wengang Guo, Wei Bai, Enxin Wang, Dongdong Xia, Zhexuan Wang, Xiaomei Li, Jie Yuan, Zhanxin Yin, Jonel Trebicka, Guohong Han
Publié dans: JHEP Reports, Numéro Volume 4, Numéro 5, 2022, ISSN 2589-5559
Éditeur: Elsevier BV
DOI: 10.1016/j.jhepr.2022.100448

Genetic variation in TERT modifies the risk of hepatocellular carcinoma in alcohol-related cirrhosis: results from a genome-wide case-control study.

Auteurs: Buch, S., Innes, H., Lutz, P. L., Nischalke, H. D., Marquardt, J. U., Fischer, J., Weiss, K. H., Rosendahl, J., Marot, A., Krawczyk, M., Casper, M., Lammert, F., Eyer, F., Vogel, A., Marhenke, S., von Felden, J., Sharma, R., Atkinson, S. R., McQuillin, A., Nattermann, J., … Stickel, F.
Publié dans: Gut, 2023, ISSN 1468-3288
Éditeur: BMJ Group
DOI: 10.1136/gutjnl-2022-327196

Stratifying the risk of NAFLD in patients with HIV under combination antiretroviral therapy (cART)

Auteurs: Jenny Bischoff, Wenyi Gu, Carolynne Schwarze-Zander, Christoph Boesecke, Jan-Christian Wasmuth, Kathrin van Bremen, Leona Dold, Jürgen K Rockstroh, Jonel Trebicka
Publié dans: EClinicalMedicine, Numéro Volume 40, 2021, ISSN 2589-5370
Éditeur: Elsevier
DOI: 10.1016/j.eclinm.2021.101116

Granulocyte-colony stimulating factor (G-CSF) to treat acute-on-chronic liver failure: A multicenter randomized trial (GRAFT study)

Auteurs: Cornelius Engelmann, Adam Herber, Annegret Franke, Tony Bruns, Philipp Reuken, Ingolf Schiefke, Alexander Zipprich, Stefan Zeuzem, Tobias Goeser, Ali Canbay, Christoph Berg, Jonel Trebicka, Frank E. Uschner, Johannes Chang, Tobias Mueller, Niklas Aehling, Moritz Schmelzle, Katrin Splith, Frank Lammert, Christian M. Lange, Christoph Sarrazin, Christian Trautwein, Michael Manns, Dieter Häussinger,
Publié dans: Journal of Hepatology, Numéro Volume 75, Numéro 6, 2021, Page(s) 1346-1354, ISSN 0168-8278
Éditeur: Elsevier BV
DOI: 10.1016/j.jhep.2021.07.033

Role of circulating angiogenin levels in portal hypertension and TIPS

Auteurs: Alexander Queck, Frank E Uschner, Philip G Ferstl, Martin Schulz, Maximilian J Brol, Michael Praktiknjo, Robert Schierwagen, Sabine Klein, Christian P Strassburg, Carsten Meyer, Christian Jansen, Marie-Luise Berres, Jonel Trebicka
Publié dans: PLoS One, Numéro Volume 16, Numéro 8, 2021, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0256473

To TIPS or Not to TIPS in High Risk of Variceal Rebleeding and Acute-on-Chronic Liver Failure.

Auteurs: Gu, W., Kimmann, M., Laleman, W., Praktiknjo, M., & Trebicka, J.
Publié dans: Seminars in liver disease, 2023, ISSN 1098-8971
Éditeur: Georg Thieme Verlag
DOI: 10.1055/a-2107-0576

The rs429358 Locus in Apolipoprotein E Is Associated With Hepatocellular Carcinoma in Patients With Cirrhosis

Auteurs: Innes H, Nischalke HD, Guha IN, Weiss KH, Irving W, Gotthardt D, Barnes E, Fischer J, Ansari MA, Rosendahl J, Lin SK, Marot A, Pedergnana V, Casper M, Benselin J, Lammert F, McLauchlan J, Lutz PL, Hamill V, Mueller S, Morling JR, Semmler G, Eyer F, von Felden J, Link A, Vogel A, Marquardt JU, Sulk S, Trebicka J, Valenti L, Datz C, Reiberger T, Schafmayer C, Berg T, Deltenre P, Hampe J, Stickel F,
Publié dans: Hepatology Communications, Numéro Volume6, Numéro 5, 2022, Page(s) 1213-1226, ISSN 2471-254X
Éditeur: AASLD
DOI: 10.1002/hep4.1886

Roles of systemic inflammatory and metabolic responses in the pathophysiology of acute-on-chronic liver failure

Auteurs: Clària, J., Arroyo, V., & Moreau, R.
Publié dans: JHEP reports : innovation in hepatology, 2023, ISSN 1744-4292
Éditeur: Nature Publishing Group

Systemic MCP-1 Levels Derive Mainly From Injured Liver and Are Associated With Complications in Cirrhosis

Auteurs: Alexander Queck, Hannah Bode, Frank E. Uschner, Maximilian J. Brol, Christiana Graf, Martin Schulz, Christian Jansen, Michael Praktiknjo, Robert Schierwagen, Sabine Klein, Christian Trautwein, Hermann E. Wasmuth, Marie-Luise Berres, Jonel Trebicka, Jennifer Lehmann
Publié dans: Frontiers in Immunology, Numéro 11, 2020, ISSN 1664-3224
Éditeur: Frontiers Media SA
DOI: 10.3389/fimmu.2020.00354

The proteome landscape of the kingdoms of life

Auteurs: Johannes B. Müller, Philipp E. Geyer, Ana R. Colaço, Peter V. Treit, Maximilian T. Strauss, Mario Oroshi, Sophia Doll, Sebastian Virreira Winter, Jakob M. Bader, Niklas Köhler, Fabian Theis, Alberto Santos, Matthias Mann
Publié dans: Nature, Numéro 582/7813, 2020, Page(s) 592-596, ISSN 0028-0836
Éditeur: Nature Publishing Group
DOI: 10.1038/s41586-020-2402-x

Sympathetic nervous activation, mitochondrial dysfunction and outcome in acutely decompensated cirrhosis: the metabolomic prognostic models (CLIF-C MET)

Auteurs: Weiss, E., de la Peña-Ramirez, C., Aguilar, F., Lozano, J. J., Sánchez-Garrido, C., Sierra, P., Martin, P. I., Diaz, J. M., Fenaille, F., Castelli, F. A., Gustot, T., Laleman, W., Albillos, A., Alessandria, C., Domenicali, M., Caraceni, P., Piano, S., Saliba, F., Zeuzem, S., Gerbes, A. L., … Arroyo, V.
Publié dans: Gut, 2023, ISSN 0017-5749
Éditeur: BMJ Publishing Group
DOI: 10.1136/gutjnl

Differential inflammasome activation predisposes to acute-on-chronic liver failure in human and experimental cirrhosis with and without previous decompensation

Auteurs: Sofia Monteiro, Josephine Grandt, Frank Erhard Uschner, Nina Kimer, Jan Lysgård Madsen, Robert Schierwagen, Sabine Klein, Christoph Welsch, Liliana Schäfer, Christian Jansen, Joan Claria, José Alcaraz-Quiles, Vicente Arroyo, Richard Moreau, Javier Fernandez, Flemming Bendtsen, Gautam Mehta, Lise Lotte Gluud, Søren Møller, Michael Praktiknjo, Jonel Trebicka
Publié dans: Gut, 2020, Page(s) gutjnl-2019-320170, ISSN 0017-5749
Éditeur: BMJ Publishing Group
DOI: 10.1136/gutjnl-2019-320170

Communications via the Small Leucine-rich Proteoglycans: Molecular Specificity in Inflammation and Autoimmune Diseases

Auteurs: Jinyang Zeng-Brouwers, Sony Pandey, Jonel Trebicka, Malgorzata Wygrecka, Liliana Schaefer
Publié dans: Journal of Histochemistry & Cytochemistry, 2020, Page(s) 002215542093030, ISSN 0022-1554
Éditeur: Histochemical Society
DOI: 10.1369/0022155420930303

Pathophysiological role of prostanoids in coagulation of the portal venous system in liver cirrhosis

Auteurs: Alexander Queck, Dominique Thomas, Christian Jansen, Yannick Schreiber, Sabrina Rüschenbaum, Michael Praktiknjo, Katharina Maria Schwarzkopf, Marcus Maximilian Mücke, Robert Schierwagen, Frank Erhard Uschner, Carsten Meyer, Joan Clària, Stefan Zeuzem, Gerd Geisslinger, Jonel Trebicka, Christian Markus Lange
Publié dans: PLOS ONE, Numéro 14/10, 2019, Page(s) e0222840, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0222840

Role of portal venous platelet activation in patients with decompensated cirrhosis and TIPS

Auteurs: Alexander Queck, Roberto Carnevale, Frank Erhard Uschner, Robert Schierwagen, Sabine Klein, Christian Jansen, Carsten Meyer, Michael Praktiknjo, Daniel Thomas, Christian Strassburg, Stefan Zeuzem, Francesco Violi, Jonel Trebicka
Publié dans: Gut, Numéro 69/8, 2020, Page(s) 1535-1536, ISSN 0017-5749
Éditeur: BMJ Publishing Group
DOI: 10.1136/gutjnl-2019-319044

Effect of sarcopenia on survival in patients with cirrhosis: A meta-analysis

Auteurs: Xinxing Tantai, Yi Liu, Yee Hui Yeo, Michael Praktiknjo, Ezequiel Mauro, Yuhei Hamaguchi, Cornelius Engelmann, Peng Zhang, Jae Yoon Jeong, Jeroen Laurens Ad van Vugt, Huijuan Xiao, Huan Deng, Xu Gao, Qing Ye, Jiayuan Zhang, Longbao Yang, Yaqin Cai, Yixin Liu, Na Liu, Zongfang Li, Tao Han, Toshimi Kaido, Joo Hyun Sohn, Christian Strassburg, Thomas Berg, Jonel Trebicka, Yao-Chun Hsu, Jan Nicolaas Ma
Publié dans: Journal of Hepatology, Numéro Volume 76, Numéro 3, 2021, Page(s) 588-599, ISSN 0168-8278
Éditeur: Elsevier BV
DOI: 10.1016/j.jhep.2021.11.006

Two-dimensional shear wave elastography predicts survival in advanced chronic liver disease

Auteurs: Trebicka J, Gu W, de Ledinghen V, Aubé C, Krag A, Praktiknjo M, Castera L, Dumortier J, Bauer DJM, Friedrich-Rust M, Pol S, Grgurevic I, Zheng R, Francque S, Gottfriedovà H, Mustapic S, Sporea I, Berzigotti A, Uschner FE, Simbrunner B, Ronot M, Cassinotto C, Kjaergaard M, Andrade F, Schulz M, Semmler G, Drinkovic IT, Chang J, Brol MJ, Rautou PE, Vanwolleghem T, Strassburg CP, Boursier J, Ferstl
Publié dans: GUT, Numéro Volume 71, Numéro 3, 2022, ISSN 0017-5749
Éditeur: BMJ Publishing Group
DOI: 10.1136/gutjnl-2020-323419

Acute Decompensation and Acute-on-Chronic Liver Failure

Auteurs: Dr. med. Philip Ferstl, Dr. med. Jonel Trebicka
Publié dans: Clinics in Liver Disease, Numéro Volume 25, Numéro 2, May 2021, 2022, Page(s) 419 -430, ISSN 1089-3261
Éditeur: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.cld.2021.01.009

β-Arrestin2 is increased in liver fibrosis in humans and rodents

Auteurs: Robert Schierwagen, Peter Dietrich, Sabine Klein, Frank Erhard Uschner, Cristina Ortiz, Olaf Tyc, Sandra Torres, Claus Hellerbrand, Tilman Sauerbruch, Jonel Trebicka
Publié dans: PNAS, Numéro Volume 117, No. 44, 2020, Page(s) 27082-27084, ISSN 0027-8424
Éditeur: National Academy of Sciences
DOI: 10.1073/pnas.2014337117

Sarcopenia Is Associated With Development of Acute-on-Chronic Liver Failure in Decompensated Liver Cirrhosis Receiving Transjugular Intrahepatic Portosystemic Shunt

Auteurs: Michael Praktiknjo, Caroline Clees, Alessandra Pigliacelli, Stefan Fischer, Christian Jansen, Jennifer Lehmann, Alessandra Pohlmann, Barbara Lattanzi, Viktoria Katharina Krabbe, Christian P. Strassburg, Vicente Arroyo, Manuela Merli, Carsten Meyer, Jonel Trebicka
Publié dans: Clinical and Translational Gastroenterology, Numéro 10/4, 2019, Page(s) e00025, ISSN 2155-384X
Éditeur: Nature Publishing Group
DOI: 10.14309/ctg.0000000000000025

Targeting the gut-liver-immune axis to treat cirrhosis

Auteurs: Thomas Henry Tranah, Lindsey A Edwards, Bernd Schnabl, Debbie Lindsay Shawcross
Publié dans: Gut, 2020, Page(s) gutjnl-2020-320786, ISSN 0017-5749
Éditeur: BMJ Publishing Group
DOI: 10.1136/gutjnl-2020-320786

Reduced Plasma Extracellular Vesicle CD5L Content in Patients With Acute-On-Chronic Liver Failure: Interplay With Specialized Pro-Resolving Lipid Mediators

Auteurs: Sánchez-Rodríguez, M. B., Téllez, É., Casulleras, M., Borràs, F. E., Arroyo, V., Clària, J., & Sarrias, M. R.
Publié dans: Frontiers in immunology, 2022, ISSN 1664-3224
Éditeur: Frontiers Media
DOI: 10.3389/fimmu.2022.842996

Neprilysin-dependent neuropeptide Y cleavage in the liver promotes fibrosis by blocking NPY-receptor 1.

Auteurs: Ortiz, C., Klein, S., Reul, W. H., Magdaleno, F., Gröschl, S., Dietrich, P., Schierwagen, R., Uschner, F. E., Torres, S., Hieber, C., Meier, C., Kraus, N., Tyc, O., Brol, M., Zeuzem, S., Welsch, C., Poglitsch, M., Hellerbrand, C., Alfonso-Prieto, M., Mira, F., … Trebicka, J.
Publié dans: Cell reports, 2023, ISSN 2211-1247
Éditeur: Cell Press
DOI: 10.1016/j.celrep.2023.112059

Mechanisms of immunity in acutely decompensated cirrhosis and acute-on-chronic liver failure

Auteurs: Engelmann, C., Zhang, I. W., & Clària, J.
Publié dans: Liver International, 2023, ISSN 1478-3231
Éditeur: Wiley

Editorial: Portal Hypertension in Cirrhosis: From Pathogenesis to Novel Treatments

Auteurs: Chandana B. Herath, Peter W. Angus and Jonel Trebicka
Publié dans: Frontiers in Physiology, Numéro Volume 13, 2022, ISSN 1664-042X
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fphys.2022.864083

Rectal colonization by resistant bacteria increases the risk of infection by the colonizing strain in critically ill patients with cirrhosis

Auteurs: Verónica Prado, María Hernández-Tejero, Marcus M. Mücke, Francesc Marco, Wenyi Gu, Alex Amoros, David Toapanta, Enric Reverter, Carlos de la Peña-Ramirez, Laura Altenpeter, Octavi Bassegoda, Gabriel Mezzano, Fátima Aziz, Adria Juanola, Sergio Rodríguez-Tajes, Vanessa Chamorro, David López, Marta Reyes, Michael Hogardt, Volkhard A.J. Kempf, Philip G. Ferstl, Stefan Zeuzem, José Antonio Mar
Publié dans: Journal of Hepatology, Numéro Volume 76, Numéro 5, 2022, Page(s) 1079-1089, ISSN 0168-8278
Éditeur: Elsevier BV
DOI: 10.1016/j.jhep.2021.12.042

Acute-on-chronic liver failure: a global disease

Auteurs: Martin Schulz, Jonel Trebicka
Publié dans: Gut BMJ, Numéro Volume 71, Numéro 1, 2021, Page(s) 5-6, ISSN 0017-5749
Éditeur: BMJ Publishing Group
DOI: 10.1136/gutjnl-2020-323973

Liver Transplantation for Acute‐on‐Chronic Liver Failure: Science or Fiction?

Auteurs: Jonel Trebicka, Vinay Sundaram, Richard Moreau, Rajiv Jalan, Vicente Arroyo
Publié dans: Liver Transplantation, Numéro 26/7, 2020, Page(s) 906-915, ISSN 1527-6465
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/lt.25788

Serum levels of bone sialoprotein correlate with portal pressure in patients with liver cirrhosis

Auteurs: Fabian Benz, Andreas Bogen, Michael Praktiknjo, Christian Jansen, Carsten Meyer, Alexander Wree, Muenevver Demir, Sven Loosen, Mihael Vucur, Robert Schierwagen, Frank Tacke, Jonel Trebicka, Christoph Roderburg
Publié dans: PLOS ONE, Numéro 15/4, 2020, Page(s) e0231701, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0231701

Untargeted lipidomics uncovers lipid signatures that distinguish severe from moderate forms of acutely decompensated cirrhosis

Auteurs: Clària, J., Curto, A., Moreau, R., Colsch, B., López-Vicario, C., Lozano, J. J., Aguilar, F., Castelli, F. A., Fenaille, F., Junot, C., Zhang, I., Vinaixa, M., Yanes, O., Caraceni, P., Trebicka, J., Fernández, J., Angeli, P., Jalan, R., & Arroyo, V.
Publié dans: Journal of Hepatology, Numéro Volume 75, Numéro 5, 2021, Page(s) 1116-1127, ISSN 0168-8278
Éditeur: Elsevier BV
DOI: 10.1016/j.jhep.2021.06.043

Rebleeding and mortality risk are increased by ACLF but reduced by pre-emptive TIPS

Auteurs: Jonel Trebicka; Wenyi Gu; Wenyi Gu; Luis Ibáñez-Samaniego; Virginia Hernández-Gea; Carla Pitarch; Elisabet Garcia; Bogdan Procopet; Álvaro Giráldez; Lucio Amitrano; Càndid Villanueva; Dominique Thabut; Gilberto Silva-Junior; Javier Martínez; Joan Genescà; C. Bureau; Elba Llop; Wim Laleman; José María Palazón; José Castellote; Susanag Rodrigues; L.L. Gluud; Carlos Noronha Ferreira; Rafa
Publié dans: ISSNe: 01688278, Numéro 3, 2020, ISSN 1600-0641
Éditeur: Elsevier
DOI: 10.1016/j.jhep.2020.04.024

Combination of Fat-Free Muscle Index and Total Spontaneous Portosystemic Shunt Area Identifies High-Risk Cirrhosis Patients.

Auteurs: Faron, A., Abu-Omar, J., Chang, J., Böhling, N., Sprinkart, A. M., Attenberger, U., Rockstroh, J. K., Luu, A. M., Jansen, C., Strassburg, C. P., Trebicka, J., Luetkens, J., & Praktiknjo, M.
Publié dans: Frontiers in medicine, 2022, ISSN 2296-858X
Éditeur: Frontiers Media
DOI: 10.3389/fmed.2022.831005

Selection and characterisation of bioreceptors to develop nanoparticle-based lateral-flow immunoassays in the context of the SARS-CoV-2 outbreak

Auteurs: Liming Hu; Enric Calucho; Celia Fuentes-Chust; Claudio Parolo; Andrea Idili; Ruslan Álvarez-Diduk; Lourdes Rivas; Arben Merkoçi
Publié dans: instname:Universitat Autònoma de Barcelona, Numéro 1, 2022, ISSN 1473-0197
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d2lc00486k

Sympathetic nervous activation, mitochondrial dysfunction and outcome in acutely decompensated cirrhosis: the metabolomic prognostic models (CLIF-C MET)

Auteurs: Emmanuel Weiss; Carlos de la Peña-Ramirez; Ferran Aguilar; Juan-Jose Lozano; Cristina Sánchez-Garrido; Patricia Sierra; Pedro Izquierdo-Bueno Martin; Juan Manuel Diaz; François Fenaille; Florence A Castelli; Thierry Gustot; Wim Laleman; Agustín Albillos; Carlo Alessandria; Marco Domenicali; Paolo Caraceni; Salvatore Piano; Faouzi Saliba; Stefan Zeuzem; Alexander L Gerbes; Julia A Wendon; Chris
Publié dans: Crossref, Numéro 3, 2023, ISSN 0017-5749
Éditeur: BMJ Publishing Group
DOI: 10.1136/gutjnl-2022-328708

Recent Advances in Practical Methods for Liver Cell Biology: A Short Overview

Auteurs: Sandra Torres, Zeinab Abdullah, Maximilian J Brol, Claus Hellerbrand, Mercedes Fernandez, Romina Fiorotto, Sabine Klein, Philipp Königshofer, Christian Liedtke, Sophie Lotersztajn, Yulia A. Nevzorova, Robert Schierwagen, Thomas Reiberger, Frank Erhard Uschner, Frank Tacke, Ralf Weiskirchen, Jonel Trebicka
Publié dans: International Journal of Molecular Sciences, Numéro 21/6, 2020, Page(s) 2027, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21062027

Pathogenetic mechanisms and therapeutic approaches of acute-to-chronic liver failure.

Auteurs: Schierwagen, R., Gu, W., Brieger, A., Brüne, B., Ciesek, S., Đikić, I., Dimmeler, S., Geisslinger, G., Greten, F. R., Hermann, E., Hildt, E., Kempf, V. A. J., Klein, S., Koch, I., Mühl, H., Müller, V., Peiffer, K. H., Kestner, R. I., Piiper, A., Rohde, G., … Trebicka, J.
Publié dans: American journal of physiology. Cell physiology, 2023, ISSN 1522-1563
Éditeur: American Physiological Society
DOI: 10.1152/ajpcell.00101.2023

The microbiota in cirrhosis and its role in hepatic decompensation

Auteurs: Trebicka J, MacNaughtan J, Schnabl B, Shawcross DL and Bajaj JS.
Publié dans: Journal of Hepatology, Numéro Vol 75 Suppl 1, 2021, Page(s) 67-81, ISSN 0168-8278
Éditeur: Elsevier BV
DOI: 10.1016/j.jhep.2020.11.013

Myostatin is associated with the presence and development of acute-on-chronic liver failure

Auteurs: Ruiz-Margáin, A., Pohlmann, A., Lanzerath, S., Langheinrich, M., Campos-Murguía, A., Román-Calleja, B. M., Schierwagen, R., Klein, S., Uschner, F. E., Brol, M. J., Torre-Delgadillo, A., Flores-García, N. C., Praktiknjo, M., Macías Rodríguez, R. U., & Trebicka, J.
Publié dans: JHEP reports, 2023, ISSN 2589-5559
Éditeur: Elsevier
DOI: 10.1016/j.jhepr.2023.100761

Circulating levels of endotrophin and cross-linked type III collagen reflect liver fibrosis in people with HIV.

Auteurs: Dold, L., Nielsen, M. J., Praktiknjo, M., Schwarze-Zander, C., Boesecke, C., Wasmuth, J. C., Bischoff, J., Rockstroh, J. K., Karsdal, M. A., Spengler, U., Trebicka, J., Strassburg, C. P., Leeming, D. J., & Langhans, B.
Publié dans: BMC infectious diseases, 2023, ISSN 1471-2334
Éditeur: BioMed Central
DOI: 10.1186/s12879-023-08000-w

Short-Term Western Diet Aggravates Non-Alcoholic Fatty Liver Disease (NAFLD) With Portal Hypertension in TGR(mREN2)27 Rats

Auteurs: Carla Cremonese, Robert Schierwagen, Frank Erhard Uschner, Sandra Torres, Olaf Tyc, Cristina Ortiz, Martin Schulz, Alexander Queck, Glen Kristiansen, Michael Bader, Tilman Sauerbruch, Ralf Weiskirchen, Thomas Walther, Jonel Trebicka, Sabine Klein
Publié dans: International Journal of Molecular Sciences, Numéro 21/9, 2020, Page(s) 3308, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21093308

The non-selective Rho-kinase inhibitors Y-27632 and Y-33075 decrease contraction but increase migration in murine and human hepatic stellate cells.

Auteurs: Bachtler, N., Torres, S., Ortiz, C., Schierwagen, R., Tyc, O., Hieber, C., Berres, M. L., Meier, C., Kraus, N., Zeuzem, S., Nijmeijer, B., Pronk, S., Trebicka, J., & Klein, S.
Publié dans: PloS one, 2023, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0270288

Activation of the Alternate Renin-Angiotensin System Correlates with the Clinical Status in Human Cirrhosis and Corrects Post Liver Transplantation

Auteurs: Stephen Casey, Robert Schierwagen, Kai Mak, Sabine Klein, Frank Uschner, Christian Jansen, Michael Praktiknjo, Carsten Meyer, Daniel Thomas, Chandana Herath, Robert Jones, Jonel Trebicka, Peter Angus
Publié dans: Journal of Clinical Medicine, Numéro 8/4, 2019, Page(s) 419, ISSN 2077-0383
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm8040419

Baveno VII - Renewing consensus in portal hypertension

Auteurs: Abraldes JG, Albillos A, Baiges A, Bajaj J, Bañares R, Barrufet M, Benajiba L, Berzigotti A, Bureau C, Calvaruso V, Cardenas A, D'Amico G, De Gottardi A, Dell'Era A, Escorsell A, Fallowfield J, Ferral H, Francque S, Gaba R, Garcia-Pagàn JC, Genescà J, Rodrigues SG, Gracia-Sancho J, Han G, Hernandez-Gea V, Jia J, Kiladjian JJ, Krag A, Laleman W, La Mura V, Lens S, Luo X, Mandorfer M, Murad SD, P
Publié dans: Journal of Hepatology, Numéro Volume 76, Numéro 4, 2021, Page(s) 959-974, ISSN 0168-8278
Éditeur: Elsevier BV
DOI: 10.1016/j.jhep.2021.12.022

Elective Surgery but not Transjugular Intrahepatic Portosystemic Shunt Precipitates Acute-On-Chronic Liver Failure

Auteurs: Johannes Chang, Avend Bamarni, Nina Böhling, Xin Zhou, Leah-Marie Klein, Jonathan Meinke, Georg Daniel Duerr, Philipp Lingohr, Sven Wehner, Maximilian J. Brol, Jürgen K. Rockstroh, Jörg C. Kalff, Steffen Manekeller, Carsten Meyer, Ulrich Spengler, Christian Jansen, Vicente Arroyo, Christian P. Strassburg, Jonel Trebicka, Michael Praktiknjo
Publié dans: Hepatology Communications, Numéro Volume 5, Numéro 7, 2021, Page(s) 1265-1277, ISSN 2471-254X
Éditeur: AASLD
DOI: 10.1002/hep4.1712

Early transplantation maximizes survival in severe acute-on-chronic liver failure: Results of a Markov decision process model

Auteurs: SuyanpengZhang, Sze-Chuan Suen, Cynthia L.Gong, JessicaPham, JonelTrebicka, ChristopheDuvoux, Andrew S.Klein, TiffanyWu, RajivJalan, VinaySundaram
Publié dans: JHEP Reports, Numéro Volume 3, Numéro 6, 2021, ISSN 2589-5559
Éditeur: Elsevier
DOI: 10.1016/j.jhepr.2021.100367

Preoperative TIPS prevents the development of postoperative acute-on-chronic liver failure in patients with high CLIF-C AD score

Auteurs: Johannes Chang, Pauline Höfer, Nina Böhling, Philipp Lingohr, Steffen Manekeller, Jörg C. Kalff, Jonas Dohmen, Dominik J. Kaczmarek, Christian Jansen, Carsten Meyer, Christian P. Strassburg, Jonel Trebicka, Michael Praktiknjo
Publié dans: JHEP Reports, Numéro Volume 4, Numéro 3, 2022, ISSN 2589-5559
Éditeur: Elsevier
DOI: 10.1016/j.jhepr.2022.100442

Proteome profiling in cerebrospinal fluid reveals novel biomarkers of Alzheimer's disease

Auteurs: Jakob M Bader, Philipp E Geyer, Johannes B Müller, Maximilian T Strauss, Manja Koch, Frank Leypoldt, Peter Koertvelyessy, Daniel Bittner, Carola G Schipke, Enise I Incesoy, Oliver Peters, Nikolaus Deigendesch, Mikael Simons, Majken K Jensen, Henrik Zetterberg, Matthias Mann
Publié dans: Molecular Systems Biology, Numéro 16/6, 2020, ISSN 1744-4292
Éditeur: Nature Publishing Group
DOI: 10.15252/msb.20199356

Editorial: Acute-on-chronic liver failure: systemic inflammation and immunosuppression.

Auteurs: Tyc, O., Shi, Y., Fan, Y. C., Trebicka, J., & Xiang, X.
Publié dans: Frontiers in immunology, 2023, ISSN 1664-3224
Éditeur: Frontiers Media
DOI: 10.3389/fimmu.2023.1260749

Letter: improve survival! Place early pre-emptive TIPSS in high-risk variceal bleeders

Auteurs: Juan Carlos García-Pagán, Jaume Bosch, Jonel Trebicka, Juan G Abraldes, Agustín Albillos, Henning Grønbaek, Álvaro Giráldez, Alexander Zipprich, Christophe Bureau, Virginia Hernández-Gea
Publié dans: Alimentary Pharmacology & Therapeutics, Numéro 52/5, 2020, Page(s) 927-928, ISSN 0269-2813
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/apt.15926

Portal hypertension in cirrhosis: Pathophysiological mechanisms and therapy

Auteurs: Yasuko Iwakiri, Jonel Trebicka
Publié dans: JHEP Reports, Numéro Volume 3, Numéro 4, 2021, ISSN 2589-5559
Éditeur: Elsevier
DOI: 10.1016/j.jhepr.2021.100316

Profiling circulating microRNAs in patients with cirrhosis and acute-on-chronic liver failure

Auteurs: Delia Blaya, Elisa Pose, Mar Coll, Juan José Lozano, Isabel Graupera, Robert Schierwagen, Christian Jansen, Pedro Castro, Sara Fernandez, Julia Sidorova, Mariuca Vasa-Nicotera, Elsa Solà, Joan Caballería, Jonel Trebicka, Pere Ginès, Pau Sancho-Bru
Publié dans: JHEP Reports, Numéro Volume 3, Numéro 2, 2021, ISSN 2589-5559
Éditeur: Elsevier
DOI: 10.1016/j.jhepr.2021.100233

Effects of human serum albumin on TNFα-induced cell death and mitochondrial dysfunction in the liver cells

Auteurs: Duran Güell, Marta
Publié dans: 2023
Éditeur: Universitat de Barcelona

MICROB-PREDICT: 15 millió eurós költségvetéssel induló mikrobiom kutatási vizsgálat az Európai Unióban

Auteurs: Coenraad, M., Papp, M., Trebica, J., De Lecuona, I., Klein, S., Junot, C., Mann, M., Krag, A., Bork, P., Arumugam, M.
Publié dans: Central European Journal of Gastroenterology and Hepatology, Numéro June/2019, Volume 5, Numéro 2, 2019, 2019, Page(s) 40-42, ISSN 2415-9107
Éditeur: Promenade Publishing House

Utilizing the gut microbiome in decompensated cirrhosis and acute-on-chronic liver failure.

Auteurs: Trebicka J., Bork P., Krag A., Arumugam M.
Publié dans: Nature Reviews Gastroenterology & Hepatology, Numéro Volume 18, Numéro 3, 2021, Page(s) 167-180, ISSN 1759-5045
Éditeur: Nature Publishing Group
DOI: 10.1038/s41575-020-00376-3

The Microbiome Meets Nanotechnology: Opportunities and Challenges in Developing New Diagnostic Devices

Auteurs: Fuentes-Chust C., Parolo C., Rosati G., Rivas L., Perez-Toralla K., Simon S., de Lecuona I., Junot C., Trebicka J., Merkoçi A.
Publié dans: Advanced Materials, Numéro Volume 33, Numéro 18, 2021, Page(s) 1-18, ISSN 0935-9648
Éditeur: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202006104

Metabolomics for personalized medicine: the input of analytical chemistry from biomarker discovery to point-of-care tests

Auteurs: Castelli F.A., Rosati G., Moguet C., Fuentes C., Marrugo-Rmírez J.,Lefebvre T.,Volland H., Merkoçi A., Junot C.
Publié dans: Analytical and Bioanalytical Chemistry, Numéro Volume 414, Numéro 2, 2021, Page(s) 759-789, ISSN 1618-2650
Éditeur: Springer Link
DOI: 10.1007/s00216-021-03586-z

Diversity within species: interpreting strains in microbiomes

Auteurs: Thea Van Rossum, Pamela Ferretti, Oleksandr M. Maistrenko, Peer Bork
Publié dans: Nature Reviews Microbiology, Numéro 18/9, 2020, Page(s) 491-506, ISSN 1740-1526
Éditeur: Nature Publishing Group
DOI: 10.1038/s41579-020-0368-1

Targeted lipidomics reveals extensive changes in circulating lipid mediators in patients with acutely decompensated cirrhosis

Auteurs: Cristina López-Vicario, Antonio Checa, Arantxa Urdangarin, Ferran Aguilar, José Alcaraz-Quiles, Paolo Caraceni, Alex Amorós, Marco Pavesi, David Gómez-Cabrero, Jonel Trebicka, Karl Oettl, Richard Moreau, Núria Planell, Vicente Arroyo, Craig E. Wheelock, Joan Clària
Publié dans: Journal of Hepatology, Numéro 73/4, 2020, Page(s) 817-828, ISSN 0168-8278
Éditeur: Elsevier BV
DOI: 10.1016/j.jhep.2020.03.046

A plug, print & play inkjet printing and impedance-based biosensing technology operating through a smartphone for clinical diagnostics

Auteurs: Rosati G., Urban M., Zhao L., Yang Q., De Carvalho Castro e Silva C., Bonaldo S., Parolo C., Nguyen E., Ortega G., Fornasiero P., Paccagnella A., Merkoci A.
Publié dans: Biosensors and Bioelectronics, Numéro 196, 113737, 29 October 2021, 2021, Page(s) 1 –10, ISSN 0956-5663
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.bios.2021.113737

Electrochromism: An emerging and promising approach in (bio)sensing technology

Auteurs: Mohammad Amin Farahmand Nejad; Mohammad Amin Farahmand Nejad; Saba Ranjbar; Claudio Parolo; Emily P. Nguyen; Ruslan Álvarez-Diduk; Mohammad Reza Hormozi-Nezhad; Arben Merkoçi; Arben Merkoçi
Publié dans: Materials Today, Numéro 1, 2021, ISSN 1872-6291
Éditeur: Science Direct
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Pautes per avaluar projectes de recerca i innovació en salut que utilitzin tecnologies emergents i dades personals

Auteurs: Lecuona Ramírez, Itziar de Observatori de Bioètica i Dret
Publié dans: 2020, ISBN 978-84-9168-585-2
Éditeur: Edicions de la Universitat de Barcelona

Ethical-Legal Analysis of International Regulation on Biomedical Research

Auteurs: de Lecuona, I.
Publié dans: 2023, ISBN 978-84-1125-900-2
Éditeur: Aranzadi

ELPA and EU medical research project brochure 2019

Auteurs: Marko Korenjak, Veronika Všetičkova, Beatrice Credi
Publié dans: ELPA and EU medical research project brochure 2019, Numéro yearly, number 1, June 2019, 2019, Page(s) 20-23
Éditeur: ELPA

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