MICROBiome-based biomarkers to PREDICT decompensation of liver cirrhosis and treatment response

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Go-online of the public project website
Second patient and layman event
Project brochure and professional templates
Dissemination activity at IHMC congress in Barcelona 2020

Dissemination activity at IHMC congress in Barcelona 2020.

First patient and layman event

Final version of study protocol to be approved by ethics committee(s)
Report on Acquire proteomics data
Report on lipidomics and bile acids data
Brochure to inform in brief about MICROB-PREDICT for participants involved in the clinical study

Brochure to inform in brief about MICROB-PREDICT for participants involved in the clinical study.

Codes of conduct applicable and research integrity policy including publications in journals
Registration number of clinical study in a WHO- or ICMJE- approved registry
First written draft of a model describing typical treatment paths in decompensated cirrhosis
Information and Informed consent template for participation of human beings (patients/healthy volunteers), for using biological samples of human origin in research and for the use of personal data (including genetic data) in research
Policy for integrating the 6 agendas (ethics, gender equality, public engagement, governance, scientific education and open access) of responsible research and innovation
Checklist for participants to assure informed consent / other mechanisms for those unable to give a written consent
Report on histological data of gut barrier
Report on metabolomics data
Public engagement strategy to design MICROB-PREDICT along with the need of patients

Multi-omic data analysis software public release
Implementation of model in a software package

Publicaciones

The Specific NLRP3 Antagonist IFM-514 Decreases Fibrosis and Inflammation in Experimental Murine Non-Alcoholic Steatohepatitis

Autores: Torres Sandra, Brol Maximilian J, Magdaleno Fernando, Schierwagen Robert, Uschner Frank E., Klein Sabine, Ortiz Cristina, Tyc Olaf, Bachtler Nadine, Stunden James, Bertheloot Damien, Kitanovic Ana, Sanchez Brian, Schrum Jacob, Roush William R., Franchi Luigi, Byth Kate, Latz Eicke, Trebicka Jonel
Publicado en: Frontiers in Molecular Biosciences, Edición Volume 8, 2021, ISSN 2296-889X
Editor: Frontiers Media
DOI: 10.3389/fmolb.2021.715765

Prognostic Value of the CLIF-C AD Score in Patients With Implantation of Transjugular Intrahepatic Portosystemic Shunt

Autores: Sturm, L., Praktiknjo, M., Bettinger, D., Huber, J.P., Volkwein, L., Schmidt, A.R., Kaeser, R., Chang, J., Jansen, C., Meyer, C.H., Thomas, D.K., Thimme, R., Trebicka, J., & Schultheiss, M
Publicado en: Hepatology Communications, Edición Volume 5, 2021, Página(s) 650-660, ISSN 2471-254X
Editor: AASLD
DOI: 10.1002/hep4.1654

Bile Acids, Liver Cirrhosis, and Extrahepatic Vascular Dysfunction

Autores: Tilman Sauerbruch, Martin Hennenberg, Jonel Trebicka and Ulrich Beuers
Publicado en: Frontiers in Physiology, Edición 29.07.2021, 2021, ISSN 2296-858X
Editor: Frontiers of Medicine
DOI: 10.3389/fphys.2021.718783

The Development and Outcome of Acute‐on‐Chronic Liver Failure After Surgical Interventions

Autores: Leah Maria Klein, Johannes Chang, Wenyi Gu, Steffen Manekeller, Christian Jansen, Philipp Lingohr, Michael Praktiknjo, Jörg C. Kalf, Martin Schulz, Ulrich Spengler, Christian Strassburg, Andrés Cárdenas, Vicente Arroyo, Jonel Trebicka
Publicado en: Liver Transplantation, Edición 26/2, 2019, Página(s) 227-237, ISSN 1527-6465
Editor: John Wiley & Sons Inc.
DOI: 10.1002/lt.25675

Epidemiology of liver transplantation and post-LT complications in Germany: nationwide study (2005-2018).

Autores: Gu, W., Schaaf, L., Hortlik, H., Zeleke, Y., Brol, M. J., Schnitzbauer, A. A., Bechstein, W. O., Zeuzem, S., Queck, A., Peiffer, K. H., Tischendorf, M., Pascher, A., Laleman, W., Praktiknjo, M., Schulz, M. S., Uschner, F. E., Rennebaum, F., & Trebicka, J.
Publicado en: European journal of gastroenterology & hepatology, 2023, ISSN 1473-5687
Editor: Wolters Kluwer
DOI: 10.1097/meg.0000000000002640

Total area of spontaneous portosystemic shunts independently predicts hepatic encephalopathy and mortality in liver cirrhosis

Autores: Michael Praktiknjo, Macarena Simón-Talero, Julia Römer, Davide Roccarina, Javier Martínez, Katharina Lampichler, Anna Baiges, Gavin Low, Elba Llop, Martin H. Maurer, Alexander Zipprich, Michela Triolo, Geert Maleux, Annette Dam Fialla, Claus Dam, Judit Vidal-González, Avik Majumdar, Carmen Picón, Daniel Toth, Anna Darnell, Juan G. Abraldes, Marta López, Christian Jansen, Johannes Chang, Robe
Publicado en: Journal of Hepatology, Edición 72/6, 2020, Página(s) 1140-1150, ISSN 0168-8278
Editor: Elsevier BV
DOI: 10.1016/j.jhep.2019.12.021

The Role of Macrophage-Inducible C-Type Lectin in Different Stages of Chronic Liver Disease

Autores: Robert Schierwagen, Frank E. Uschner, Cristina Ortiz, Sandra Torres, Max J. Brol, Olaf Tyc, Wenyi Gu, Christian Grimm, Stefan Zeuzem, Andreas Plamper, Philipp Pfeifer, Sebastian Zimmer, Christoph Welsch, Liliana Schaefer, Karl P. Rheinwalt, Joan Clària, Vicente Arroyo, Jonel Trebicka, Sabine Klein
Publicado en: Frontiers in Immunology, Edición 11, 2020, ISSN 1664-3224
Editor: Frontiers Media SA
DOI: 10.3389/fimmu.2020.01352

Liver Transplantation as a Cornerstone Treatment for Acute-On-Chronic Liver Failure.

Autores: Schulz, M. S., Gu, W., Schnitzbauer, A. A., & Trebicka, J.
Publicado en: Transplant international : official journal of the European Society for Organ Transplantation, 2022, ISSN 1432-2277
Editor: Frontiers Media
DOI: 10.3389/ti.2022.10108

Beta-blockers in patients with liver cirrhosis: Pragmatism or perfection?.

Autores: Sauerbruch, T., Hennenberg, M., Trebicka, J., & Schierwagen, R.
Publicado en: Frontiers in medicine, 2023, ISSN 2296-858X
Editor: Frontiers media
DOI: 10.3389/fmed.2022.1100966

Baseline Presence of NAFLD Predicts Weight Loss after Gastric Bypass Surgery for Morbid Obesity

Autores: Karl P. Rheinwalt; Uta Drebber; orcid Robert Schierwagen; Sabine D. Klein; Ulf P. Neumann; Tom Florian Ulmer; Andreas Plamper;orcid bw Andreas Kroh; Sandra Schipper; Margarete Odenthal; Frank Erhard Uschner; Philipp Lingohr; Jonel Trebicka; Maximilian J. Brol;
Publicado en: Journal of Clinical Medicine, Edición Volume 9, Edición 11, 2020, ISSN 2077-0383
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm9113430

Controlled underdilation using novel VIATORR® controlled expansion stents improves survival after transjugular intrahepatic portosystemic shunt implantation

Autores: Michael Praktiknjo, Jasmin Abu-Omar, Johannes Chang, Daniel Thomas, Christian Jansen, Patrick Kupczyk, Filippo Schepis, Juan Carlos Garcia-Pagan, Manuela Merli, Carsten Meyer, Christian P. Strassburg, Claus C. Pieper, Jonel Trebicka
Publicado en: JHEP, Edición Volume 3, Edición 3, 2021, ISSN 0346-251X
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.jhepr.2021.100264

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction-associated fatty liver disease

Autores: López-Vicario, C., Sebastián, D., Casulleras, M., Duran-Güell, M., Flores-Costa, R., Aguilar, F., Lozano, J. J., Zhang, I. W., Titos, E., Kang, J. X., Zorzano, A., Arita, M., & Clària, J.
Publicado en: Hepatology, 2023, ISSN 1527-3350
Editor: Wiley
DOI: 10.1002/hep.32647

Deep Visual Proteomics maps proteotoxicity in a genetic liver disease

Autores: Florian A. Rosenberger, Sophia C. Mädler, Katrine Holtz Thorhauge, Sophia Steigerwald, Malin Fromme, Mikhail Lebedev, Caroline A. M. Weiss, Marc Oeller, Maria Wahle, Andreas Metousis, Maximilian Zwiebel, Niklas A. Schmacke, Sönke Detlefsen, Peter Boor, Ondřej Fabián, Soňa Fraňková, Aleksander Krag, Pavel Strnad, Matthias Mann
Publicado en: Nature, 2025, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-025-08885-4

Dynamic human liver proteome atlas reveals functional insights into disease pathways.

Autores: Niu L, Geyer PE, Gupta R, Santos A, Meier F, Doll S, Wewer Albrechtsen NJ, Klein S, Ortiz C, Uschner FE, Schierwagen R, Trebicka J, Mann M
Publicado en: Mol Syst Biol., 2022, ISSN 1744-4292
Editor: Nature Publishing Group
DOI: 10.15252/msb.202210947

Mitochondrial Dysfunction in Advanced Liver Disease: Emerging Concepts

Autores: Ingrid W. Zhang; Ingrid W. Zhang; Cristina López-Vicario; Cristina López-Vicario; Cristina López-Vicario; Marta Duran-Güell; Marta Duran-Güell; Joan Clària; Joan Clària; Joan Clària; Joan Clària
Publicado en: instname:Universidad de Barcelona, Edición 3, 2021, ISSN 2296-889X
Editor: Frontiers
DOI: 10.3389/fmolb.2021.772174

Extrahepatic Surgery in Cirrhosis Significantly Increases Portal Pressure in Preclinical Animal Models

Autores: Chang Johannes, Meinke Jonathan, Geck Moritz, Hebest Marc, Böhling Nina, Dolscheid-Pommerich Ramona, Stoffel-Wagner Birgit, Kristiansen Glen, Overhaus Marcus, Peyman Leon O., Klein Sabine, Uschner Frank E., Brol Maximilian J., Vilz Tim O., Lingohr Philipp, Kalff Jörg C., Jansen Christian, Strassburg Christian P., Wehner Sven, Trebicka Jonel, Praktiknjo Michael
Publicado en: Frontiers in Physiology, Edición Volume 12, 2021, ISSN 1664-042X
Editor: Frontiers Research Foundation
DOI: 10.3389/fphys.2021.720898

Autores: Xiaojie Yu, Natalia Elfimova, Marion Müller, Daniel Bachurski, Ulrike Koitzsch, Uta Drebber, Esther Mahabir, Hinrich P Hansen, Scott L Friedman, Sabine Klein, Hans Peter Dienes, Marianna Hösel, Reinhard Buettner, Jonel Trebicka, Vangelis Kondylis, Inge Mannaerts, Margarete Odenthal
Publicado en: cmgh, Edición Volume 13, Edición 6, 2022, Página(s) 1701- 1716, ISSN 2352-345X
Editor: Elsevier Inc.
DOI: 10.1016/j.jcmgh.2022.02.013

Acute-On-Chronic Liver Failure: Current Interventional Treatment Options and Future Challenges.

Autores: Kimmann, M., & Trebicka, J.
Publicado en: Journal of personalized medicine, 2023, ISSN 2075-4426
Editor: MDPI
DOI: 10.3390/jpm13071052

Use and outcome of TIPS in hospitalized patients in Germany: A Nationwide study (2007-2018)

Autores: Gu, W., Zeleke, Y., Hortlik, H., Schaaf, L., Uschner, F. E., Schulz, M., Tischendorf, M., Peiffer, K. H., Brol, M. J., Kimmann, M., Vogl, T., Köhler, M., Meyer, C., Gerbes, A., Rössle, M., Laleman, W., Zipprich, A., Steib, C., Praktiknjo, M., Trebicka, J., …German TIPS Working Group
Publicado en: Hepatology communications, 2023, ISSN 2471-254X
Editor: Wolters Kluwer Health, Inc.
DOI: 10.1097/hc9.0000000000000237

Serological response and breakthrough infection after COVID-19 vaccination in patients with cirrhosis and post-liver transplant

Autores: Gautam Mehta, Antonio Riva, Maria Pilar Ballester, Eva Uson, Montserrat Pujadas, Ângela Carvalho-Gomes, Ivan Sahuco, Ariadna Bono, Federico D’Amico, Raffaela Viganò, Elena Diago, Beatriz Tormo Lanseros, Elvira Inglese, Dani Martinez Vazquez, Rajni Sharma, Hio Lam Phoebe Tsou, Nicola Harris, Annelotte Broekhoven, Marjolein Kikkert, Shessy P. Torres Morales, Sebenzile K. Myeni, Mar Riveiro-Barci
Publicado en: Hepatology Communications, Edición 7, 2024, ISSN 2471-254X
Editor: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1097/hc9.0000000000000273

Harnessing Bioluminescent Bacteria to Develop an Enzymatic-free Enzyme-linked immunosorbent assay for the Detection of Clinically Relevant Biomarkers

Autores: Liming Hu, Marianna Rossetti, José Francisco Bergua, Claudio Parolo, Ruslan Álvarez-Diduk, Lourdes Rivas, Andrea Idili, Arben Merkoçi
Publicado en: ACS Applied Materials & Interfaces, Edición 16, 2024, Página(s) 30636-30647, ISSN 1944-8244
Editor: American Chemical Society
DOI: 10.1021/acsami.4c01744

Nanodiagnostics to Face SARS-CoV‑2 and Future Pandemics: From an Idea to the Market and Beyond

Autores: Rosati G., Idili A., Parolo C., Fuentes-Chust C., Calucho E., Hu L., De Carvalho Castro Silva C., Rivas L., Nguyen E., Bergua J., Alvarez-Diduk R., Muñoz J., Junot C., Penon O., Monferrer D., Delamarche, E. Merkoçi A.
Publicado en: ACS Nano, Edición Volume 15, Edición 11, 2021, Página(s) 17137–17149, ISSN 1936-0851
Editor: American Chemical Society
DOI: 10.1021/acsnano.1c06839

Follistatin-controlled activin-HNF4α-coagulation factor axis in liver progenitor cells determines outcome of acute liver failure

Autores: Tao Lin, Shanshan Wang, Stefan Munker, Kyounghwa Jung, Ricardo U. Macías-Rodríguez, Astrid Ruiz-Margáin, Robert Schierwagen, Hui Liu, Chen Shao, Chunlei Fan, Rilu Feng, Xiaodong Yuan, Sai Wang, Franziska Wandrer, Christoph Meyer, Ralf Wimmer, Roman Liebe, Jens Kroll, Long Zhang, Tobias Schiergens, Peter ten Dijke, Andreas Teufel, Alexander Marx, Peter R. Mertens, Hua Wang, Matthias P.A. Ebert,
Publicado en: Hepatology, Edición Volume 75, Edición 2, 2021, Página(s) 322-337, ISSN 2471-254X
Editor: AASLD
DOI: 10.1002/hep.32119

Trends and the course of liver cirrhosis and its complications in Germany: Nationwide population-based study (2005 to 2018)

Autores: Wenyi Gu, Hannah Hortlik, Hans-Peter Erasmus, Louisa Schaaf, Yasmin Zeleke, Frank E. Uschner, Philip Ferstl, Martin Schulz, Kai-Henrik Peiffer, Alexander Queck, Tilman Sauerbruch, Maximilian Joseph Brol, Gernot Rohde, Cristina Sanchez, Richard Moreau, Vicente Arroyo, Stefan Zeuzem, Christoph Welsch, Jonel Trebicka
Publicado en: The Lancet Regional Health - Europe, Edición Volume 12, 2022, ISSN 2666-7762
Editor: Elsevier Ltd.
DOI: 10.1016/j.lanepe.2021.100240

Assessment of portal hypertension severity using machine learning models in patients with compensated cirrhosis

Autores: Reiniš, J., Petrenko, O., Simbrunner, B., Hofer, B. S., Schepis, F., Scoppettuolo, M., Saltini, D., Indulti, F., Guasconi, T., Albillos, A., Téllez, L., Villanueva, C., Brujats, A., Garcia-Pagan, J. C., Perez-Campuzano, V., Hernández-Gea, V., Rautou, P. E., Moga, L., Vanwolleghem, T., Kwanten, W. J., … Reiberger, T.
Publicado en: Journal of hepatology, 2023, ISSN 1600-0641
Editor: Elsevier Open Access
DOI: 10.1016/j.jhep.2022.09.012

Trust is good, control is better: technical considerations in blood microbiome analysis

Autores: Robert Schierwagen, Camila Alvarez-Silva, Florence Servant, Jonel Trebicka, Benjamin Lelouvier, Manimozhiyan Arumugam
Publicado en: Gut, Edición 69/7, 2020, Página(s) 1362-1363, ISSN 0017-5749
Editor: BMJ Publishing Group
DOI: 10.1136/gutjnl-2019-319123

Precipitants of Acute‐on‐Chronic Liver Failure: An Opportunity for Preventative Measures to Improve Outcomes

Autores: Giuseppe Cullaro, Rajani Sharma, Jonel Trebicka, Andrés Cárdenas, Elizabeth C. Verna
Publicado en: Liver Transplantation, Edición 26/2, 2019, Página(s) 283-293, ISSN 1527-6465
Editor: John Wiley & Sons Inc.
DOI: 10.1002/lt.25678

Essential role for albumin in preserving liver cells from TNFα-induced mitochondrial injury.

Autores: Duran-Güell, M., Garrabou, G., Flores-Costa, R., Casulleras, M., López-Vicario, C., Zhang, I. W., Cantó-Santos, J., Contreras, B. J., Sánchez-Rodríguez, M. B., Romero-Grimaldo, B., Horrillo, R., Costa, M., Arroyo, V., & Clària, J.
Publicado en: FASEB, 2023, ISSN 1530-6860
Editor: Wiley
DOI: 10.1096/fj.202201526r

The Role of Decorin and Biglycan Signaling in Tumorigenesis

Autores: Diehl Valentina, Huber Lisa Sophie, Trebicka Jonel, Wygrecka Malgorzata, Iozzo Renato V., Schaefer Liliana
Publicado en: Frontiers in Oncology, Edición Volume 11, 2021, ISSN 2234-943X
Editor: Frontiers Media S. A.
DOI: 10.3389/fonc.2021.801801

Sex specificity of kidney markers to assess prognosis in cirrhotic patients with TIPS

Autores: Maria Torner, Adjmal Mangal, Hubert Scharnagl, Christian Jansen, Michael Praktiknjo, Alexander Queck, Wenyi Gu, Robert Schierwagen, Jennifer Lehmann, Frank E. Uschner, Christiana Graf, Christian P. Strassburg, Javier Fernandez, Tatjana Stojakovic, Rainer Woitas, Jonel Trebicka
Publicado en: Liver International, Edición 40/1, 2019, Página(s) 186-193, ISSN 1478-3223
Editor: Blackwell Publishing Inc.
DOI: 10.1111/liv.14230

Plasma Proteomes Can Be Reidentifiable and Potentially Contain Personally Sensitive and Incidental Findings

Autores: Geyer PE, Mann SP, Treit PV, Mann M. Plasma
Publicado en: Molecula & Cellular Proteomics, Edición 20, 2021, ISSN 1535-9476
Editor: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/mcp.ra120.002359

Definition, diagnosis and epidemiology of acute‐on‐chronic liver failure

Autores: Ruben Hernaez; Hai Li; Richard Moreau; Minneke J. Coenraad
Publicado en: Crossref, Edición 2, 2023, ISSN 1478-3223
Editor: Blackwell Publishing Inc.
DOI: 10.1111/liv.15670

Leveraging omics to understand the molecular basis of acute-on-chronic liver failure

Autores: Joan Clària
Publicado en: instname:Universidad de Barcelona, Edición 2, 2021, ISSN 2628-491X
Editor: De Gruyter
DOI: 10.1515/almed-2021-0023

Janus kinase 2 inhibition by pacritinib as potential therapeutic target for liver fibrosis.

Autores: orres, S., Ortiz, C., Bachtler, N., Gu, W., Grünewald, L. D., Kraus, N., Schierwagen, R., Hieber, C., Meier, C., Tyc, O., Joseph Brol, M., Uschner, F. E., Nijmeijer, B., Welsch, C., Berres, M. L., Garcia-Ruiz, C., Fernandez-Checa, J. C., Trautwein, C., Vogl, T. J., Zeuzem, S., … Klein, S.
Publicado en: Hepatology, 2023, ISSN 0270-9139
Editor: John Wiley & Sons Inc.
DOI: 10.1002/hep.32746

Variation in Bile Microbiome by the Etiology of Cholestatic Liver Disease

Autores: Olaf Tyc, Christian Jansen, Robert Schierwagen, Frank Erhard Uschner, Mads Israelsen, Sabine Klein, Cristina Ortiz, Christian P. Strassburg, Stefan Zeuzem, Wenyi Gu, Sandra Torres, Michael Praktiknjo, Stephan Kersting, Melanie Langheinrich, Jacob Nattermann, Florence Servant, Manimozhiyan Arumugam, Aleksander Krag, Benjamin Lelouvier, Tobias J. Weismüller, Jonel Trebicka
Publicado en: Liver Transplantation, 2020, ISSN 1527-6465
Editor: John Wiley & Sons Inc.
DOI: 10.1002/lt.25882

Ethical Principles, Constraints, and Opportunities in Clinical Proteomics

Autores: Sebastian Porsdam Mann, Peter V.Treit, Philipp E.Geyer, Gilbert S.Omenn, MatthiasMann
Publicado en: MCP, Edición Volume20, 2021, ISSN 1535-9476
Editor: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.mcpro.2021.100046

Restoration of the gut microbiota is associated with a decreased risk of hepatic encephalopathy after TIPS

Autores: Menghao Li, Kai Li, Shihao Tang, Yong Lv, Qiuhe Wang, Zhengyu Wang, Bohan Luo, Jing Niu, Ying Zhu, Wengang Guo, Wei Bai, Enxin Wang, Dongdong Xia, Zhexuan Wang, Xiaomei Li, Jie Yuan, Zhanxin Yin, Jonel Trebicka, Guohong Han
Publicado en: JHEP Reports, Edición Volume 4, Edición 5, 2022, ISSN 2589-5559
Editor: Elsevier BV
DOI: 10.1016/j.jhepr.2022.100448

Genetic variation in TERT modifies the risk of hepatocellular carcinoma in alcohol-related cirrhosis: results from a genome-wide case-control study.

Autores: Buch, S., Innes, H., Lutz, P. L., Nischalke, H. D., Marquardt, J. U., Fischer, J., Weiss, K. H., Rosendahl, J., Marot, A., Krawczyk, M., Casper, M., Lammert, F., Eyer, F., Vogel, A., Marhenke, S., von Felden, J., Sharma, R., Atkinson, S. R., McQuillin, A., Nattermann, J., … Stickel, F.
Publicado en: Gut, 2023, ISSN 1468-3288
Editor: BMJ Group
DOI: 10.1136/gutjnl-2022-327196

Stratifying the risk of NAFLD in patients with HIV under combination antiretroviral therapy (cART)

Autores: Jenny Bischoff, Wenyi Gu, Carolynne Schwarze-Zander, Christoph Boesecke, Jan-Christian Wasmuth, Kathrin van Bremen, Leona Dold, Jürgen K Rockstroh, Jonel Trebicka
Publicado en: EClinicalMedicine, Edición Volume 40, 2021, ISSN 2589-5370
Editor: Elsevier
DOI: 10.1016/j.eclinm.2021.101116

Granulocyte-colony stimulating factor (G-CSF) to treat acute-on-chronic liver failure: A multicenter randomized trial (GRAFT study)

Autores: Cornelius Engelmann, Adam Herber, Annegret Franke, Tony Bruns, Philipp Reuken, Ingolf Schiefke, Alexander Zipprich, Stefan Zeuzem, Tobias Goeser, Ali Canbay, Christoph Berg, Jonel Trebicka, Frank E. Uschner, Johannes Chang, Tobias Mueller, Niklas Aehling, Moritz Schmelzle, Katrin Splith, Frank Lammert, Christian M. Lange, Christoph Sarrazin, Christian Trautwein, Michael Manns, Dieter Häussinger,
Publicado en: Journal of Hepatology, Edición Volume 75, Edición 6, 2021, Página(s) 1346-1354, ISSN 0168-8278
Editor: Elsevier BV
DOI: 10.1016/j.jhep.2021.07.033

Role of circulating angiogenin levels in portal hypertension and TIPS

Autores: Alexander Queck, Frank E Uschner, Philip G Ferstl, Martin Schulz, Maximilian J Brol, Michael Praktiknjo, Robert Schierwagen, Sabine Klein, Christian P Strassburg, Carsten Meyer, Christian Jansen, Marie-Luise Berres, Jonel Trebicka
Publicado en: PLoS One, Edición Volume 16, Edición 8, 2021, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0256473

To TIPS or Not to TIPS in High Risk of Variceal Rebleeding and Acute-on-Chronic Liver Failure.

Autores: Gu, W., Kimmann, M., Laleman, W., Praktiknjo, M., & Trebicka, J.
Publicado en: Seminars in liver disease, 2023, ISSN 1098-8971
Editor: Georg Thieme Verlag
DOI: 10.1055/a-2107-0576

The rs429358 Locus in Apolipoprotein E Is Associated With Hepatocellular Carcinoma in Patients With Cirrhosis

Autores: Innes H, Nischalke HD, Guha IN, Weiss KH, Irving W, Gotthardt D, Barnes E, Fischer J, Ansari MA, Rosendahl J, Lin SK, Marot A, Pedergnana V, Casper M, Benselin J, Lammert F, McLauchlan J, Lutz PL, Hamill V, Mueller S, Morling JR, Semmler G, Eyer F, von Felden J, Link A, Vogel A, Marquardt JU, Sulk S, Trebicka J, Valenti L, Datz C, Reiberger T, Schafmayer C, Berg T, Deltenre P, Hampe J, Stickel F,
Publicado en: Hepatology Communications, Edición Volume6, Edición 5, 2022, Página(s) 1213-1226, ISSN 2471-254X
Editor: AASLD
DOI: 10.1002/hep4.1886

Roles of systemic inflammatory and metabolic responses in the pathophysiology of acute-on-chronic liver failure

Autores: Clària, J., Arroyo, V., & Moreau, R.
Publicado en: JHEP reports : innovation in hepatology, 2023, ISSN 1744-4292
Editor: Nature Publishing Group

Systemic MCP-1 Levels Derive Mainly From Injured Liver and Are Associated With Complications in Cirrhosis

Autores: Alexander Queck, Hannah Bode, Frank E. Uschner, Maximilian J. Brol, Christiana Graf, Martin Schulz, Christian Jansen, Michael Praktiknjo, Robert Schierwagen, Sabine Klein, Christian Trautwein, Hermann E. Wasmuth, Marie-Luise Berres, Jonel Trebicka, Jennifer Lehmann
Publicado en: Frontiers in Immunology, Edición 11, 2020, ISSN 1664-3224
Editor: Frontiers Media SA
DOI: 10.3389/fimmu.2020.00354

The proteome landscape of the kingdoms of life

Autores: Johannes B. Müller, Philipp E. Geyer, Ana R. Colaço, Peter V. Treit, Maximilian T. Strauss, Mario Oroshi, Sophia Doll, Sebastian Virreira Winter, Jakob M. Bader, Niklas Köhler, Fabian Theis, Alberto Santos, Matthias Mann
Publicado en: Nature, Edición 582/7813, 2020, Página(s) 592-596, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-020-2402-x

Sympathetic nervous activation, mitochondrial dysfunction and outcome in acutely decompensated cirrhosis: the metabolomic prognostic models (CLIF-C MET)

Autores: Weiss, E., de la Peña-Ramirez, C., Aguilar, F., Lozano, J. J., Sánchez-Garrido, C., Sierra, P., Martin, P. I., Diaz, J. M., Fenaille, F., Castelli, F. A., Gustot, T., Laleman, W., Albillos, A., Alessandria, C., Domenicali, M., Caraceni, P., Piano, S., Saliba, F., Zeuzem, S., Gerbes, A. L., … Arroyo, V.
Publicado en: Gut, 2023, ISSN 0017-5749
Editor: BMJ Publishing Group
DOI: 10.1136/gutjnl

Differential inflammasome activation predisposes to acute-on-chronic liver failure in human and experimental cirrhosis with and without previous decompensation

Autores: Sofia Monteiro, Josephine Grandt, Frank Erhard Uschner, Nina Kimer, Jan Lysgård Madsen, Robert Schierwagen, Sabine Klein, Christoph Welsch, Liliana Schäfer, Christian Jansen, Joan Claria, José Alcaraz-Quiles, Vicente Arroyo, Richard Moreau, Javier Fernandez, Flemming Bendtsen, Gautam Mehta, Lise Lotte Gluud, Søren Møller, Michael Praktiknjo, Jonel Trebicka
Publicado en: Gut, 2020, Página(s) gutjnl-2019-320170, ISSN 0017-5749
Editor: BMJ Publishing Group
DOI: 10.1136/gutjnl-2019-320170

Communications via the Small Leucine-rich Proteoglycans: Molecular Specificity in Inflammation and Autoimmune Diseases

Autores: Jinyang Zeng-Brouwers, Sony Pandey, Jonel Trebicka, Malgorzata Wygrecka, Liliana Schaefer
Publicado en: Journal of Histochemistry & Cytochemistry, 2020, Página(s) 002215542093030, ISSN 0022-1554
Editor: Histochemical Society
DOI: 10.1369/0022155420930303

Pathophysiological role of prostanoids in coagulation of the portal venous system in liver cirrhosis

Autores: Alexander Queck, Dominique Thomas, Christian Jansen, Yannick Schreiber, Sabrina Rüschenbaum, Michael Praktiknjo, Katharina Maria Schwarzkopf, Marcus Maximilian Mücke, Robert Schierwagen, Frank Erhard Uschner, Carsten Meyer, Joan Clària, Stefan Zeuzem, Gerd Geisslinger, Jonel Trebicka, Christian Markus Lange
Publicado en: PLOS ONE, Edición 14/10, 2019, Página(s) e0222840, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0222840

Freiburg index of post-TIPS survival (FIPS) identifies patients at risk of further decompensation and ACLF after TIPS

Autores: Lukas Sturm, Michael Schultheiss, Fabian Stöhr, Christian Labenz, Benjamin Maasoumy, Anja Tiede, Michael Praktiknjo, Leon Louis Seifert, Timo Alexander Auer, Uli Fehrenbach, Felix Piecha, Aenne Harberts, Johannes Kluwe, Tony Bruns, Maike Rebecca Pollmanns, Johannes Chang, Jakub Grobelski, Christian Jansen, Carsten Meyer, Marlene Reincke, Charlotte Rohrer, Sina Rastin Philipp Arbabi, Markus Kimman
Publicado en: Journal of Hepatology, 2025, ISSN 0168-8278
Editor: Elsevier BV
DOI: 10.1016/j.jhep.2025.01.030

Role of portal venous platelet activation in patients with decompensated cirrhosis and TIPS

Autores: Alexander Queck, Roberto Carnevale, Frank Erhard Uschner, Robert Schierwagen, Sabine Klein, Christian Jansen, Carsten Meyer, Michael Praktiknjo, Daniel Thomas, Christian Strassburg, Stefan Zeuzem, Francesco Violi, Jonel Trebicka
Publicado en: Gut, Edición 69/8, 2020, Página(s) 1535-1536, ISSN 0017-5749
Editor: BMJ Publishing Group
DOI: 10.1136/gutjnl-2019-319044

Effect of sarcopenia on survival in patients with cirrhosis: A meta-analysis

Autores: Xinxing Tantai, Yi Liu, Yee Hui Yeo, Michael Praktiknjo, Ezequiel Mauro, Yuhei Hamaguchi, Cornelius Engelmann, Peng Zhang, Jae Yoon Jeong, Jeroen Laurens Ad van Vugt, Huijuan Xiao, Huan Deng, Xu Gao, Qing Ye, Jiayuan Zhang, Longbao Yang, Yaqin Cai, Yixin Liu, Na Liu, Zongfang Li, Tao Han, Toshimi Kaido, Joo Hyun Sohn, Christian Strassburg, Thomas Berg, Jonel Trebicka, Yao-Chun Hsu, Jan Nicolaas Ma
Publicado en: Journal of Hepatology, Edición Volume 76, Edición 3, 2021, Página(s) 588-599, ISSN 0168-8278
Editor: Elsevier BV
DOI: 10.1016/j.jhep.2021.11.006

Two-dimensional shear wave elastography predicts survival in advanced chronic liver disease

Autores: Trebicka J, Gu W, de Ledinghen V, Aubé C, Krag A, Praktiknjo M, Castera L, Dumortier J, Bauer DJM, Friedrich-Rust M, Pol S, Grgurevic I, Zheng R, Francque S, Gottfriedovà H, Mustapic S, Sporea I, Berzigotti A, Uschner FE, Simbrunner B, Ronot M, Cassinotto C, Kjaergaard M, Andrade F, Schulz M, Semmler G, Drinkovic IT, Chang J, Brol MJ, Rautou PE, Vanwolleghem T, Strassburg CP, Boursier J, Ferstl
Publicado en: GUT, Edición Volume 71, Edición 3, 2022, ISSN 0017-5749
Editor: BMJ Publishing Group
DOI: 10.1136/gutjnl-2020-323419

Acute Decompensation and Acute-on-Chronic Liver Failure

Autores: Dr. med. Philip Ferstl, Dr. med. Jonel Trebicka
Publicado en: Clinics in Liver Disease, Edición Volume 25, Edición 2, May 2021, 2022, Página(s) 419 -430, ISSN 1089-3261
Editor: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.cld.2021.01.009

β-Arrestin2 is increased in liver fibrosis in humans and rodents

Autores: Robert Schierwagen, Peter Dietrich, Sabine Klein, Frank Erhard Uschner, Cristina Ortiz, Olaf Tyc, Sandra Torres, Claus Hellerbrand, Tilman Sauerbruch, Jonel Trebicka
Publicado en: PNAS, Edición Volume 117, No. 44, 2020, Página(s) 27082-27084, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.2014337117

Sarcopenia Is Associated With Development of Acute-on-Chronic Liver Failure in Decompensated Liver Cirrhosis Receiving Transjugular Intrahepatic Portosystemic Shunt

Autores: Michael Praktiknjo, Caroline Clees, Alessandra Pigliacelli, Stefan Fischer, Christian Jansen, Jennifer Lehmann, Alessandra Pohlmann, Barbara Lattanzi, Viktoria Katharina Krabbe, Christian P. Strassburg, Vicente Arroyo, Manuela Merli, Carsten Meyer, Jonel Trebicka
Publicado en: Clinical and Translational Gastroenterology, Edición 10/4, 2019, Página(s) e00025, ISSN 2155-384X
Editor: Nature Publishing Group
DOI: 10.14309/ctg.0000000000000025

The Role of Hypoxia-Inducible Factor 1 Alpha in Acute-on-Chronic Liver Failure

Autores: Marcus M. Mücke, Nihad El Bali, Katharina M. Schwarzkopf, Frank Erhard Uschner, Nico Kraus, Larissa Eberle, Victoria Therese Mücke, Julia Bein, Sandra Beyer, Peter J. Wild, Robert Schierwagen, Sabine Klein, Stefan Zeuzem, Christoph Welsch, Jonel Trebicka, Angela Brieger
Publicado en: International Journal of Molecular Sciences, Edición 25, 2025, Página(s) 1542, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms25031542

Targeting the gut-liver-immune axis to treat cirrhosis

Autores: Thomas Henry Tranah, Lindsey A Edwards, Bernd Schnabl, Debbie Lindsay Shawcross
Publicado en: Gut, 2020, Página(s) gutjnl-2020-320786, ISSN 0017-5749
Editor: BMJ Publishing Group
DOI: 10.1136/gutjnl-2020-320786

Hyperammonemia induces programmed liver cell death

Autores: Annarein J. C. Kerbert, Cornelius Engelmann, Abeba Habtesion, Pavitra Kumar, Mohsin Hassan, Tingting Qi, Ines Volkert, Tobias Otto, Andrew Hall, Varun U. Khetan, Steven Olde Damink, Ferran Aguilar, Céline Chollet, Ludovic Brunet, Joan Clària, Richard Moreau, Vicente Arroyo, Minneke J. Coenraad, Gautam Mehta, Florence Castelli, Christian Trautwein, François Fenaille, Fausto Andreola, Rajiv Jalan
Publicado en: Science Advances, Edición 11, 2025, ISSN 2375-2548
Editor: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/sciadv.ado1648

Reduced Plasma Extracellular Vesicle CD5L Content in Patients With Acute-On-Chronic Liver Failure: Interplay With Specialized Pro-Resolving Lipid Mediators

Autores: Sánchez-Rodríguez, M. B., Téllez, É., Casulleras, M., Borràs, F. E., Arroyo, V., Clària, J., & Sarrias, M. R.
Publicado en: Frontiers in immunology, 2022, ISSN 1664-3224
Editor: Frontiers Media
DOI: 10.3389/fimmu.2022.842996

Low-cost inkjet-printed nanostructured biosensor based on CRISPR/Cas12a system for pathogen detection

Autores: Angela Gilda Carota, Andrea Bonini, Massimo Urban, Noemi Poma, Federico Maria Vivaldi, Arianna Tavanti, Marianna Rossetti, Giulio Rosati, Arben Merkoçi, Fabio Di Francesco
Publicado en: Biosensors and Bioelectronics, Edición 258, 2024, Página(s) 116340, ISSN 0956-5663
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.bios.2024.116340

Using liver stiffness to predict and monitor the risk of decompensation and mortality in patients with alcohol-related liver disease

Autores: Katrine Holtz Thorhauge, Georg Semmler, Stine Johansen, Katrine Prier Lindvig, Maria Kjærgaard, Johanne Kragh Hansen, Nikolaj Torp, Camilla Dalby Hansen, Peter Andersen, Benedikt Silvester Hofer, Wenyi Gu, Mads Israelsen, Mattias Mandorfer, Thomas Reiberger, Jonel Trebicka, Maja Thiele, Aleksander Krag
Publicado en: Journal of Hepatology, Edición 81, 2024, Página(s) 23-32, ISSN 0168-8278
Editor: Elsevier BV
DOI: 10.1016/j.jhep.2024.02.019

Neprilysin-dependent neuropeptide Y cleavage in the liver promotes fibrosis by blocking NPY-receptor 1.

Autores: Ortiz, C., Klein, S., Reul, W. H., Magdaleno, F., Gröschl, S., Dietrich, P., Schierwagen, R., Uschner, F. E., Torres, S., Hieber, C., Meier, C., Kraus, N., Tyc, O., Brol, M., Zeuzem, S., Welsch, C., Poglitsch, M., Hellerbrand, C., Alfonso-Prieto, M., Mira, F., … Trebicka, J.
Publicado en: Cell reports, 2023, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2023.112059

Mechanisms of immunity in acutely decompensated cirrhosis and acute-on-chronic liver failure

Autores: Engelmann, C., Zhang, I. W., & Clària, J.
Publicado en: Liver International, 2023, ISSN 1478-3231
Editor: Wiley

Editorial: Portal Hypertension in Cirrhosis: From Pathogenesis to Novel Treatments

Autores: Chandana B. Herath, Peter W. Angus and Jonel Trebicka
Publicado en: Frontiers in Physiology, Edición Volume 13, 2022, ISSN 1664-042X
Editor: Frontiers Research Foundation
DOI: 10.3389/fphys.2022.864083

Rectal colonization by resistant bacteria increases the risk of infection by the colonizing strain in critically ill patients with cirrhosis

Autores: Verónica Prado, María Hernández-Tejero, Marcus M. Mücke, Francesc Marco, Wenyi Gu, Alex Amoros, David Toapanta, Enric Reverter, Carlos de la Peña-Ramirez, Laura Altenpeter, Octavi Bassegoda, Gabriel Mezzano, Fátima Aziz, Adria Juanola, Sergio Rodríguez-Tajes, Vanessa Chamorro, David López, Marta Reyes, Michael Hogardt, Volkhard A.J. Kempf, Philip G. Ferstl, Stefan Zeuzem, José Antonio Mar
Publicado en: Journal of Hepatology, Edición Volume 76, Edición 5, 2022, Página(s) 1079-1089, ISSN 0168-8278
Editor: Elsevier BV
DOI: 10.1016/j.jhep.2021.12.042

Acute-on-chronic liver failure: a global disease

Autores: Martin Schulz, Jonel Trebicka
Publicado en: Gut BMJ, Edición Volume 71, Edición 1, 2021, Página(s) 5-6, ISSN 0017-5749
Editor: BMJ Publishing Group
DOI: 10.1136/gutjnl-2020-323973

Liver Transplantation for Acute‐on‐Chronic Liver Failure: Science or Fiction?

Autores: Jonel Trebicka, Vinay Sundaram, Richard Moreau, Rajiv Jalan, Vicente Arroyo
Publicado en: Liver Transplantation, Edición 26/7, 2020, Página(s) 906-915, ISSN 1527-6465
Editor: John Wiley & Sons Inc.
DOI: 10.1002/lt.25788

Gene score to quantify systemic inflammation in patients with acutely decompensated cirrhosis

Autores: Jonel Trebicka, Ferran Aguilar, Alberto Queiroz Farias, Juan-José Lozano, Cristina Sánchez-Garrido, Eva Usón-Raposo, Carlos de la Peña-Ramirez, Julia Sidorova, Anna Curto-Vilalta, Patricia Sierra-Casas, Patricia Momoyo Zitelli, Maria Papp, Gustavo Pereira, Paolo Caraceni, Luciana L Goncalves, Carlo Alessandria, Aldo Torre, Wim Laleman, Adrián Gadano, Salvatore Piano, Angelo Z Mattos, Wenyi Gu
Publicado en: Gut, Edición Feb 2025, 2025, Página(s) gutjnl-2024-333876, ISSN 0017-5749
Editor: BMJ Publishing Group
DOI: 10.1136/gutjnl-2024-333876

Serum levels of bone sialoprotein correlate with portal pressure in patients with liver cirrhosis

Autores: Fabian Benz, Andreas Bogen, Michael Praktiknjo, Christian Jansen, Carsten Meyer, Alexander Wree, Muenevver Demir, Sven Loosen, Mihael Vucur, Robert Schierwagen, Frank Tacke, Jonel Trebicka, Christoph Roderburg
Publicado en: PLOS ONE, Edición 15/4, 2020, Página(s) e0231701, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0231701

Untargeted lipidomics uncovers lipid signatures that distinguish severe from moderate forms of acutely decompensated cirrhosis

Autores: Clària, J., Curto, A., Moreau, R., Colsch, B., López-Vicario, C., Lozano, J. J., Aguilar, F., Castelli, F. A., Fenaille, F., Junot, C., Zhang, I., Vinaixa, M., Yanes, O., Caraceni, P., Trebicka, J., Fernández, J., Angeli, P., Jalan, R., & Arroyo, V.
Publicado en: Journal of Hepatology, Edición Volume 75, Edición 5, 2021, Página(s) 1116-1127, ISSN 0168-8278
Editor: Elsevier BV
DOI: 10.1016/j.jhep.2021.06.043

Rebleeding and mortality risk are increased by ACLF but reduced by pre-emptive TIPS

Autores: Jonel Trebicka; Wenyi Gu; Wenyi Gu; Luis Ibáñez-Samaniego; Virginia Hernández-Gea; Carla Pitarch; Elisabet Garcia; Bogdan Procopet; Álvaro Giráldez; Lucio Amitrano; Càndid Villanueva; Dominique Thabut; Gilberto Silva-Junior; Javier Martínez; Joan Genescà; C. Bureau; Elba Llop; Wim Laleman; José María Palazón; José Castellote; Susanag Rodrigues; L.L. Gluud; Carlos Noronha Ferreira; Rafa
Publicado en: ISSNe: 01688278, Edición 3, 2020, ISSN 1600-0641
Editor: Elsevier
DOI: 10.1016/j.jhep.2020.04.024

Combination of Fat-Free Muscle Index and Total Spontaneous Portosystemic Shunt Area Identifies High-Risk Cirrhosis Patients.

Autores: Faron, A., Abu-Omar, J., Chang, J., Böhling, N., Sprinkart, A. M., Attenberger, U., Rockstroh, J. K., Luu, A. M., Jansen, C., Strassburg, C. P., Trebicka, J., Luetkens, J., & Praktiknjo, M.
Publicado en: Frontiers in medicine, 2022, ISSN 2296-858X
Editor: Frontiers Media
DOI: 10.3389/fmed.2022.831005

Selection and characterisation of bioreceptors to develop nanoparticle-based lateral-flow immunoassays in the context of the SARS-CoV-2 outbreak

Autores: Liming Hu; Enric Calucho; Celia Fuentes-Chust; Claudio Parolo; Andrea Idili; Ruslan Álvarez-Diduk; Lourdes Rivas; Arben Merkoçi
Publicado en: instname:Universitat Autònoma de Barcelona, Edición 1, 2022, ISSN 1473-0197
Editor: Royal Society of Chemistry
DOI: 10.1039/d2lc00486k

Sympathetic nervous activation, mitochondrial dysfunction and outcome in acutely decompensated cirrhosis: the metabolomic prognostic models (CLIF-C MET)

Autores: Emmanuel Weiss; Carlos de la Peña-Ramirez; Ferran Aguilar; Juan-Jose Lozano; Cristina Sánchez-Garrido; Patricia Sierra; Pedro Izquierdo-Bueno Martin; Juan Manuel Diaz; François Fenaille; Florence A Castelli; Thierry Gustot; Wim Laleman; Agustín Albillos; Carlo Alessandria; Marco Domenicali; Paolo Caraceni; Salvatore Piano; Faouzi Saliba; Stefan Zeuzem; Alexander L Gerbes; Julia A Wendon; Chris
Publicado en: Crossref, Edición 3, 2023, ISSN 0017-5749
Editor: BMJ Publishing Group
DOI: 10.1136/gutjnl-2022-328708

Recent Advances in Practical Methods for Liver Cell Biology: A Short Overview

Autores: Sandra Torres, Zeinab Abdullah, Maximilian J Brol, Claus Hellerbrand, Mercedes Fernandez, Romina Fiorotto, Sabine Klein, Philipp Königshofer, Christian Liedtke, Sophie Lotersztajn, Yulia A. Nevzorova, Robert Schierwagen, Thomas Reiberger, Frank Erhard Uschner, Frank Tacke, Ralf Weiskirchen, Jonel Trebicka
Publicado en: International Journal of Molecular Sciences, Edición 21/6, 2020, Página(s) 2027, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21062027

Pathogenetic mechanisms and therapeutic approaches of acute-to-chronic liver failure.

Autores: Schierwagen, R., Gu, W., Brieger, A., Brüne, B., Ciesek, S., Đikić, I., Dimmeler, S., Geisslinger, G., Greten, F. R., Hermann, E., Hildt, E., Kempf, V. A. J., Klein, S., Koch, I., Mühl, H., Müller, V., Peiffer, K. H., Kestner, R. I., Piiper, A., Rohde, G., … Trebicka, J.
Publicado en: American journal of physiology. Cell physiology, 2023, ISSN 1522-1563
Editor: American Physiological Society
DOI: 10.1152/ajpcell.00101.2023

The microbiota in cirrhosis and its role in hepatic decompensation

Autores: Trebicka J, MacNaughtan J, Schnabl B, Shawcross DL and Bajaj JS.
Publicado en: Journal of Hepatology, Edición Vol 75 Suppl 1, 2021, Página(s) 67-81, ISSN 0168-8278
Editor: Elsevier BV
DOI: 10.1016/j.jhep.2020.11.013

Myostatin is associated with the presence and development of acute-on-chronic liver failure

Autores: Ruiz-Margáin, A., Pohlmann, A., Lanzerath, S., Langheinrich, M., Campos-Murguía, A., Román-Calleja, B. M., Schierwagen, R., Klein, S., Uschner, F. E., Brol, M. J., Torre-Delgadillo, A., Flores-García, N. C., Praktiknjo, M., Macías Rodríguez, R. U., & Trebicka, J.
Publicado en: JHEP reports, 2023, ISSN 2589-5559
Editor: Elsevier
DOI: 10.1016/j.jhepr.2023.100761

Distinct immunometabolic signatures in circulating immune cells define disease outcome in acute-on-chronic liver failure

Autores: Rita Feio-Azevedo, Markus Boesch, Silvia Radenkovic, Lukas van Melkebeke, Lena Smets, Marie Wallays, Bram Boeckx, Gino Philips, Janaíne Prata de Oliveira, Mohammad Ghorbani, Wim Laleman, Philippe Meersseman, Alexander Wilmer, David Cassiman, Hannah van Malenstein, Evangelos Triantafyllou, Cristina Sánchez, Ferran Aguilar, Frederik Nevens, Jef Verbeek, Richard Moreau, Vicente Arroyo, Alexandre De
Publicado en: Hepatology, Edición 81, 2025, Página(s) 509-522, ISSN 0270-9139
Editor: John Wiley & Sons Inc.
DOI: 10.1097/hep.0000000000000907

Circulating levels of endotrophin and cross-linked type III collagen reflect liver fibrosis in people with HIV.

Autores: Dold, L., Nielsen, M. J., Praktiknjo, M., Schwarze-Zander, C., Boesecke, C., Wasmuth, J. C., Bischoff, J., Rockstroh, J. K., Karsdal, M. A., Spengler, U., Trebicka, J., Strassburg, C. P., Leeming, D. J., & Langhans, B.
Publicado en: BMC infectious diseases, 2023, ISSN 1471-2334
Editor: BioMed Central
DOI: 10.1186/s12879-023-08000-w

Short-Term Western Diet Aggravates Non-Alcoholic Fatty Liver Disease (NAFLD) With Portal Hypertension in TGR(mREN2)27 Rats

Autores: Carla Cremonese, Robert Schierwagen, Frank Erhard Uschner, Sandra Torres, Olaf Tyc, Cristina Ortiz, Martin Schulz, Alexander Queck, Glen Kristiansen, Michael Bader, Tilman Sauerbruch, Ralf Weiskirchen, Thomas Walther, Jonel Trebicka, Sabine Klein
Publicado en: International Journal of Molecular Sciences, Edición 21/9, 2020, Página(s) 3308, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21093308

The non-selective Rho-kinase inhibitors Y-27632 and Y-33075 decrease contraction but increase migration in murine and human hepatic stellate cells.

Autores: Bachtler, N., Torres, S., Ortiz, C., Schierwagen, R., Tyc, O., Hieber, C., Berres, M. L., Meier, C., Kraus, N., Zeuzem, S., Nijmeijer, B., Pronk, S., Trebicka, J., & Klein, S.
Publicado en: PloS one, 2023, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0270288

Activation of the Alternate Renin-Angiotensin System Correlates with the Clinical Status in Human Cirrhosis and Corrects Post Liver Transplantation

Autores: Stephen Casey, Robert Schierwagen, Kai Mak, Sabine Klein, Frank Uschner, Christian Jansen, Michael Praktiknjo, Carsten Meyer, Daniel Thomas, Chandana Herath, Robert Jones, Jonel Trebicka, Peter Angus
Publicado en: Journal of Clinical Medicine, Edición 8/4, 2019, Página(s) 419, ISSN 2077-0383
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm8040419

Baveno VII - Renewing consensus in portal hypertension

Autores: Abraldes JG, Albillos A, Baiges A, Bajaj J, Bañares R, Barrufet M, Benajiba L, Berzigotti A, Bureau C, Calvaruso V, Cardenas A, D'Amico G, De Gottardi A, Dell'Era A, Escorsell A, Fallowfield J, Ferral H, Francque S, Gaba R, Garcia-Pagàn JC, Genescà J, Rodrigues SG, Gracia-Sancho J, Han G, Hernandez-Gea V, Jia J, Kiladjian JJ, Krag A, Laleman W, La Mura V, Lens S, Luo X, Mandorfer M, Murad SD, P
Publicado en: Journal of Hepatology, Edición Volume 76, Edición 4, 2021, Página(s) 959-974, ISSN 0168-8278
Editor: Elsevier BV
DOI: 10.1016/j.jhep.2021.12.022

Elective Surgery but not Transjugular Intrahepatic Portosystemic Shunt Precipitates Acute-On-Chronic Liver Failure

Autores: Johannes Chang, Avend Bamarni, Nina Böhling, Xin Zhou, Leah-Marie Klein, Jonathan Meinke, Georg Daniel Duerr, Philipp Lingohr, Sven Wehner, Maximilian J. Brol, Jürgen K. Rockstroh, Jörg C. Kalff, Steffen Manekeller, Carsten Meyer, Ulrich Spengler, Christian Jansen, Vicente Arroyo, Christian P. Strassburg, Jonel Trebicka, Michael Praktiknjo
Publicado en: Hepatology Communications, Edición Volume 5, Edición 7, 2021, Página(s) 1265-1277, ISSN 2471-254X
Editor: AASLD
DOI: 10.1002/hep4.1712

Early transplantation maximizes survival in severe acute-on-chronic liver failure: Results of a Markov decision process model

Autores: SuyanpengZhang, Sze-Chuan Suen, Cynthia L.Gong, JessicaPham, JonelTrebicka, ChristopheDuvoux, Andrew S.Klein, TiffanyWu, RajivJalan, VinaySundaram
Publicado en: JHEP Reports, Edición Volume 3, Edición 6, 2021, ISSN 2589-5559
Editor: Elsevier
DOI: 10.1016/j.jhepr.2021.100367

Preoperative TIPS prevents the development of postoperative acute-on-chronic liver failure in patients with high CLIF-C AD score

Autores: Johannes Chang, Pauline Höfer, Nina Böhling, Philipp Lingohr, Steffen Manekeller, Jörg C. Kalff, Jonas Dohmen, Dominik J. Kaczmarek, Christian Jansen, Carsten Meyer, Christian P. Strassburg, Jonel Trebicka, Michael Praktiknjo
Publicado en: JHEP Reports, Edición Volume 4, Edición 3, 2022, ISSN 2589-5559
Editor: Elsevier
DOI: 10.1016/j.jhepr.2022.100442

Proteome profiling in cerebrospinal fluid reveals novel biomarkers of Alzheimer's disease

Autores: Jakob M Bader, Philipp E Geyer, Johannes B Müller, Maximilian T Strauss, Manja Koch, Frank Leypoldt, Peter Koertvelyessy, Daniel Bittner, Carola G Schipke, Enise I Incesoy, Oliver Peters, Nikolaus Deigendesch, Mikael Simons, Majken K Jensen, Henrik Zetterberg, Matthias Mann
Publicado en: Molecular Systems Biology, Edición 16/6, 2020, ISSN 1744-4292
Editor: Nature Publishing Group
DOI: 10.15252/msb.20199356

Editorial: Acute-on-chronic liver failure: systemic inflammation and immunosuppression.

Autores: Tyc, O., Shi, Y., Fan, Y. C., Trebicka, J., & Xiang, X.
Publicado en: Frontiers in immunology, 2023, ISSN 1664-3224
Editor: Frontiers Media
DOI: 10.3389/fimmu.2023.1260749

Letter: improve survival! Place early pre-emptive TIPSS in high-risk variceal bleeders

Autores: Juan Carlos García-Pagán, Jaume Bosch, Jonel Trebicka, Juan G Abraldes, Agustín Albillos, Henning Grønbaek, Álvaro Giráldez, Alexander Zipprich, Christophe Bureau, Virginia Hernández-Gea
Publicado en: Alimentary Pharmacology & Therapeutics, Edición 52/5, 2020, Página(s) 927-928, ISSN 0269-2813
Editor: Blackwell Publishing Inc.
DOI: 10.1111/apt.15926

Portal hypertension in cirrhosis: Pathophysiological mechanisms and therapy

Autores: Yasuko Iwakiri, Jonel Trebicka
Publicado en: JHEP Reports, Edición Volume 3, Edición 4, 2021, ISSN 2589-5559
Editor: Elsevier
DOI: 10.1016/j.jhepr.2021.100316

Profiling circulating microRNAs in patients with cirrhosis and acute-on-chronic liver failure

Autores: Delia Blaya, Elisa Pose, Mar Coll, Juan José Lozano, Isabel Graupera, Robert Schierwagen, Christian Jansen, Pedro Castro, Sara Fernandez, Julia Sidorova, Mariuca Vasa-Nicotera, Elsa Solà, Joan Caballería, Jonel Trebicka, Pere Ginès, Pau Sancho-Bru
Publicado en: JHEP Reports, Edición Volume 3, Edición 2, 2021, ISSN 2589-5559
Editor: Elsevier
DOI: 10.1016/j.jhepr.2021.100233

Controversies regarding albumin therapy in cirrhosis

Autores: Jonel Trebicka, Guadalupe Garcia-Tsao
Publicado en: Hepatology, Edición 81, 2025, Página(s) 288-303, ISSN 0270-9139
Editor: John Wiley & Sons Inc.
DOI: 10.1097/hep.0000000000000521

OS-041-YI A spatiotemporal map of the hepatocyte proteome in alpha-1 antitrypsin deficiency by single-cell and visual proteomics

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Publicado en: Journal of Hepatology, Edición 80, 2024, Página(s) S32, ISSN 0168-8278
Editor: Elsevier BV
DOI: 10.1016/s0168-8278(24)00482-3

MICROB-PREDICT: 15 millió eurós költségvetéssel induló mikrobiom kutatási vizsgálat az Európai Unióban

Autores: Coenraad, M., Papp, M., Trebica, J., De Lecuona, I., Klein, S., Junot, C., Mann, M., Krag, A., Bork, P., Arumugam, M.
Publicado en: Central European Journal of Gastroenterology and Hepatology, Edición June/2019, Volume 5, Edición 2, 2019, 2019, Página(s) 40-42, ISSN 2415-9107
Editor: Promenade Publishing House

Imaging-based diagnosis of sarcopenia for transplant-free survival in primary sclerosing cholangitis

Autores: Pedram Keshoofi, Philipp Schindler, Florian Rennebaum, Friederike Cordes, Haluk Morgul, Moritz Wildgruber, Hauke S. Heinzow, Andreas Pascher, Hartmut H. Schmidt, Anna Hüsing-Kabar, Michael Praktiknjo, Jonel Trebicka, Leon Louis Seifert
Publicado en: BMC Gastroenterology, Edición 24, 2024, ISSN 1471-230X
Editor: BioMed Central
DOI: 10.1186/s12876-024-03232-9

Alcohol-associated hepatitis: a neutrophile disease?

Autores: Maximilian Joseph Brol, Ali Canbay, Jonel Trebicka
Publicado en: Gut, Edición 74, 2024, Página(s) 6-8, ISSN 0017-5749
Editor: BMJ Publishing Group
DOI: 10.1136/gutjnl-2024-333222

Atorvastatin for patients with cirrhosis. A randomized, placebo-controlled trial

Autores: Thit M. Kronborg, Robert Schierwagen, Kajetan Trošt, Qian Gao, Thomas Moritz, Flemming Bendtsen, Rasmus H. Gantzel, Mette L. Andersen, Ane S. Teisner, Henning Grønbæk, Lise Hobolth, Søren Møller, Jonel Trebicka, Nina Kimer
Publicado en: Hepatology Communications, Edición 7, 2024, Página(s) 2023 Dec 1;7(12):e0332., ISSN 2471-254X
Editor: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1097/hc9.0000000000000332

Palmitoylcarnitine impairs immunity in decompensated cirrhosis

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Publicado en: JHEP Reports, Edición 6, 2024, Página(s) 101187, ISSN 2589-5559
Editor: Elsevier BV
DOI: 10.1016/j.jhepr.2024.101187

Noninvasive assessment of hepatic decompensation

Autores: Maja Thiele, Stine Johansen, Mads Israelsen, Jonel Trebicka, Juan G. Abraldes, Pere Gines, Aleksander Krag
Publicado en: Hepatology, Edición 81, 2025, Página(s) 1019-1037, ISSN 0270-9139
Editor: John Wiley & Sons Inc.
DOI: 10.1097/hep.0000000000000618

Terlipressin therapy is associated with increased risk of colonisation with multidrug‐resistant bacteria in patients with decompensated cirrhosis

Autores: Marcus M. Mücke, María Hernández‐Tejero, Wenyi Gu, Michael Kuhn, Malte Janz, Marisa I. Keller, Anthony Fullam, Laura Altepeter, Victoria T. Mücke, Fabian Finkelmeier, Katharina M. Schwarzkopf, Carla Cremonese, Peter‐Merton Hunyady, Myriam W. Heilani, Frank Erhard Uschner, Robert Schierwagen, Maximilian J. Brol, Julia Fischer, Sabine Klein, Kai‐Henrik Peiffer, Michael Hogardt, Saeed Shoai
Publicado en: Alimentary Pharmacology & Therapeutics, Edición 59, 2024, Página(s) 877-888, ISSN 0269-2813
Editor: Blackwell Publishing Inc.
DOI: 10.1111/apt.17899

Association between endotoxemia and blood no in the portal circulation of cirrhotic patients: results of a pilot study

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Publicado en: Internal and Emergency Medicine, Edición 19, 2024, Página(s) 713-720, ISSN 1828-0447
Editor: CEPI-AIM Group
DOI: 10.1007/s11739-024-03534-6

Novel prognostic biomarkers in decompensated cirrhosis: a systematic review and meta-analysis

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Publicado en: Gut, Edición 73, 2024, Página(s) 156-165, ISSN 0017-5749
Editor: BMJ Publishing Group
DOI: 10.1136/gutjnl-2023-329923

Utilizing the gut microbiome in decompensated cirrhosis and acute-on-chronic liver failure.

Autores: Trebicka J., Bork P., Krag A., Arumugam M.
Publicado en: Nature Reviews Gastroenterology & Hepatology, Edición Volume 18, Edición 3, 2021, Página(s) 167-180, ISSN 1759-5045
Editor: Nature Publishing Group
DOI: 10.1038/s41575-020-00376-3

The Microbiome Meets Nanotechnology: Opportunities and Challenges in Developing New Diagnostic Devices

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Publicado en: Advanced Materials, Edición Volume 33, Edición 18, 2021, Página(s) 1-18, ISSN 0935-9648
Editor: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202006104

Fecal microbial load is a major determinant of gut microbiome variation and a confounder for disease associations

Autores: Suguru Nishijima, Evelina Stankevic, Oliver Aasmets, Thomas S.B. Schmidt, Naoyoshi Nagata, Marisa Isabell Keller, Pamela Ferretti, Helene Bæk Juel, Anthony Fullam, Shahriyar Mahdi Robbani, Christian Schudoma, Johanne Kragh Hansen, Louise Aas Holm, Mads Israelsen, Robert Schierwagen, Nikolaj Torp, Anja Telzerow, Rajna Hercog, Stefanie Kandels, Diënty H.M. Hazenbrink, Manimozhiyan Arumugam, Flemmi
Publicado en: Cell, Edición 188, 2025, Página(s) 222-236.e15, ISSN 0092-8674
Editor: Cell Press
DOI: 10.1016/j.cell.2024.10.022

Endoscopic procedures in hepatology: Current trends and new developments

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Publicado en: Journal of Hepatology, Edición 80, 2024, Página(s) 124-139, ISSN 0168-8278
Editor: Elsevier BV
DOI: 10.1016/j.jhep.2023.08.032

Albumin reprograms the B cell transcriptional landscape and improves neutrophil antimicrobial function in patients with decompensated cirrhosis

Autores: Joan Clària, Ferran Aguilar, Juan-José Lozano, Laura Jiménez-Gracia, Juan C. Nieto, Berta Romero-Grimaldo, Xavi Marcos-Fa, Emma Giarracco, Emmanuel Weiss, Jonel Trebicka, Inmaculada Hernàndez, Javier Fernandez, Mireia Casulleras, Cristina López-Vicario, Sinan Muldur, Alex Hopke, Alexandru Vlagea, Ana M. Aransay, Domenica Marchese, Mauro Bernardi, Rajiv Jalan, Paolo Angeli, Giuliana Magri, And
Publicado en: JHEP Reports, Edición 6, 2024, Página(s) 101184, ISSN 2589-5559
Editor: Elsevier BV
DOI: 10.1016/j.jhepr.2024.101184

WED-111 Plasma proteomics uncovers progression markers of acute-onchronic liver failure

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Publicado en: Journal of Hepatology, Edición 80, 2024, Página(s) S193, ISSN 0168-8278
Editor: Elsevier BV
DOI: 10.1016/s0168-8278(24)00816-x

Role of endoscopy in hepatology

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Publicado en: Digestive and Liver Disease, Edición 56, 2024, Página(s) 1185-1195, ISSN 1590-8658
Editor: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.dld.2023.11.032

Hepatocellular Cancer Surveillance in Patients with Advanced Chronic Liver Disease

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Publicado en: NEJM Evidence, Edición 3, 2025, Página(s) EVIDoa2400062, ISSN 2766-5526
Editor: Massachusetts Medical Society
DOI: 10.1056/evidoa2400062

Operating under pressure: Is there a place for preoperative TIPS?

Autores: Michael Praktiknjo, Jonel Trebicka
Publicado en: JHEP Reports, Edición 6, 2024, Página(s) 101034, ISSN 2589-5559
Editor: Elsevier BV
DOI: 10.1016/j.jhepr.2024.101034

Personalised human albumin in patients with cirrhosis and ascites: design and rationale for the ALB-TRIAL - a randomised clinical biomarker validation trial

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Publicado en: BMJ Open, Edición 14, 2024, Página(s) e079309, ISSN 2044-6055
Editor: BMJ Publishing Group
DOI: 10.1136/bmjopen-2023-079309

Metabolomics for personalized medicine: the input of analytical chemistry from biomarker discovery to point-of-care tests

Autores: Castelli F.A., Rosati G., Moguet C., Fuentes C., Marrugo-Rmírez J.,Lefebvre T.,Volland H., Merkoçi A., Junot C.
Publicado en: Analytical and Bioanalytical Chemistry, Edición Volume 414, Edición 2, 2021, Página(s) 759-789, ISSN 1618-2650
Editor: Springer Link
DOI: 10.1007/s00216-021-03586-z

Stage of fibrosis is not a predictive determinant of weight loss in patients undergoing bariatric surgery

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Publicado en: Surgery for Obesity and Related Diseases, Edición 20, 2024, Página(s) 759-766, ISSN 1550-7289
Editor: Elsevier BV
DOI: 10.1016/j.soard.2024.02.006

Diversity within species: interpreting strains in microbiomes

Autores: Thea Van Rossum, Pamela Ferretti, Oleksandr M. Maistrenko, Peer Bork
Publicado en: Nature Reviews Microbiology, Edición 18/9, 2020, Página(s) 491-506, ISSN 1740-1526
Editor: Nature Publishing Group
DOI: 10.1038/s41579-020-0368-1

Acute and non‐acute decompensation of liver cirrhosis (47/130)

Autores: Martin S. Schulz, Paolo Angeli, Jonel Trebicka
Publicado en: Liver International, Edición 45, 2025, Página(s) Liver International, ISSN 1478-3223
Editor: Blackwell Publishing Inc.
DOI: 10.1111/liv.15861

Targeted lipidomics reveals extensive changes in circulating lipid mediators in patients with acutely decompensated cirrhosis

Autores: Cristina López-Vicario, Antonio Checa, Arantxa Urdangarin, Ferran Aguilar, José Alcaraz-Quiles, Paolo Caraceni, Alex Amorós, Marco Pavesi, David Gómez-Cabrero, Jonel Trebicka, Karl Oettl, Richard Moreau, Núria Planell, Vicente Arroyo, Craig E. Wheelock, Joan Clària
Publicado en: Journal of Hepatology, Edición 73/4, 2020, Página(s) 817-828, ISSN 0168-8278
Editor: Elsevier BV
DOI: 10.1016/j.jhep.2020.03.046

Decompensated MASH-Cirrhosis Model by Acute and Toxic Effects of Phenobarbital

Autores: Nico Kraus, Frank Erhard Uschner, Magnus Moeslein, Robert Schierwagen, Wenyi Gu, Maximilian Joseph Brol, Eike Fürst, Inga Grünewald, Sophie Lotersztajn, Pierre-Emmanuel Rautou, Marta Duran-Güell, Roger Flores Costa, Joan Clària, Jonel Trebicka, Sabine Klein
Publicado en: Cells, Edición 13, 2025, Página(s) 1707, ISSN 2073-4409
Editor: MDPI AG
DOI: 10.3390/cells13201707

A plug, print & play inkjet printing and impedance-based biosensing technology operating through a smartphone for clinical diagnostics

Autores: Rosati G., Urban M., Zhao L., Yang Q., De Carvalho Castro e Silva C., Bonaldo S., Parolo C., Nguyen E., Ortega G., Fornasiero P., Paccagnella A., Merkoci A.
Publicado en: Biosensors and Bioelectronics, Edición 196, 113737, 29 October 2021, 2021, Página(s) 1 –10, ISSN 0956-5663
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.bios.2021.113737

Recent advances in the prevention and treatment of decompensated cirrhosis and acute-on-chronic liver failure (ACLF) and the role of biomarkers

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Publicado en: Gut, Edición 73, 2024, Página(s) 1015-1024, ISSN 0017-5749
Editor: BMJ Publishing Group
DOI: 10.1136/gutjnl-2023-330584

Electrochromism: An emerging and promising approach in (bio)sensing technology

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Publicado en: Materials Today, Edición 1, 2021, ISSN 1872-6291
Editor: Science Direct
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A robust clustering strategy for stratification unveils unique patient subgroups in acutely decompensated cirrhosis

Autores: Palomino-Echeverria S, Huergo E, Ortega-Legarreta A, Uson Raposo EM, Aguilar F, de la Peña-Ramirez C, López-Vicario C, Alessandria C, Laleman W, Farias AQ, Moreau R, Fernandez J, Arroyo V, Caraceni P, Lagani V, Sánchez-Garrido C, Clària J, Tegner J, Trebicka J, Kiani NA, Planell N, Rautou PE, Gomez-Cabrero D
Publicado en: J Tranl Med., Edición 2024 Jun 27;22(1):599., 2024, Página(s) 599, ISSN 1479-5876
Editor: BioMed Central
DOI: 10.1186/s12967-024-05386-2

Opportunities and barriers in omics-based biomarker discovery for steatotic liver diseases

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Editor: Elsevier BV
DOI: 10.1016/j.jhep.2024.03.035

Effects of human serum albumin on TNFα-induced cell death and mitochondrial dysfunction in the liver cells

Autores: Duran Güell, Marta
Publicado en: 2023
Editor: Universitat de Barcelona

Pautes per avaluar projectes de recerca i innovació en salut que utilitzin tecnologies emergents i dades personals

Autores: Lecuona Ramírez, Itziar de Observatori de Bioètica i Dret
Publicado en: 2020, ISBN 978-84-9168-585-2
Editor: Edicions de la Universitat de Barcelona

Ethical and legal analysis of the international regulation on biomedical research

Autores: De Lecuona, Itziar
Publicado en: 2023, ISBN 978-84-1125-898-2
Editor: EDITORIAL ARANZADI

Ethical-Legal Analysis of International Regulation on Biomedical Research

Autores: de Lecuona, I.
Publicado en: 2023, ISBN 978-84-1125-900-2
Editor: Aranzadi

ELPA and EU medical research project brochure 2019

Autores: Marko Korenjak, Veronika Všetičkova, Beatrice Credi
Publicado en: ELPA and EU medical research project brochure 2019, Edición yearly, number 1, June 2019, 2019, Página(s) 20-23
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