An integrative strategy of testing systems for identification of EDs related to metabolic disorders

Informations projet

OBERON

N° de convention de subvention: 825712

DOI

10.3030/825712

Projet clôturé

Date de signature de la CE 21 Novembre 2018

Date de début 1 Janvier 2019

Date de fin 30 Juin 2024

Financé au titre de

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Coût total

€ 6 614 222,50

Contribution de l’UE

€ 5 978 762,50

Coordonné par

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (23)

Demonstration of the test method's performances based on the testing of reference chemicals or pharmaceuticals representative of the types of EDs for which the test methods will be use

The demonstration of the test method’s performances based on the testing of reference chemicals or pharmaceuticals representative of the types of EDs for which the test methods will be used.

Report on the toxicokinetic models for in vitro systems
Report on the OBERON integrated approach to testing and assessment of EDs
Report on exposure levels of the ten selected EDs in Europe taking data from biomonitoring studies and birth cohorts
A pregnancy PBPK model for humans and associated algorithm for parametrization
Report on systems biology models for causal validation and development of AOPs

Report on systems biology models for causal validationand development of AOPs

Report on the optimization of existing in silico models and development of new ones, implemented within VEGA

Report on the optimization of existing in silico models and development of new ones implemented within VEGA

Final plan for the dissemination and exploitation of the results
Reports on the associations of prenatal and postnatal exposure to EDs and metabolic outcomes in children and adolescents
Demonstration of the interaction between the initial lipid diet composition and the chemicals used in their endocrine mode of action, as nutritional history has proved to be a significant factor in the effects of EDs

The demonstration of the interaction between the initial lipid diet composition and the chemicals used in their endocrine mode of action, as nutritional history has proved to be a significant factor in the effects of EDs

Report on the case studies
Report on the comparative characterization of the metabolic response of several in vitro models (liver, adipose, pancreas) to selected chemicals
Report on cross validation of the selected models and the final proposal for inclusion in the tiered test approach
Demonstration of intra- and inter-laboratory reproducibility of ZOT used to evaluate EDs as obesogens

The demonstration of intra and interlaboratory reproducibility of ZOT used to evaluate EDs as obesogens

Public symposium
Report on multi-omics joint pathway analysis
Analytical chemistry and omics data to be integrated with in vitro data and in silico models

Analytical chemistry and omics data to be integrated with in vitro data and in silico models (month 6, month 40)

Report on functional specifications and system architecture of OBERON IDM
Reports on the associations of prenatal and postnatal exposure to EDs and metabolic outcomes in adults
Short list of chemicals and/or their mixtures identified through epidemiological studies to alter zebrafish adipocyte lipid droplet size and adiposity and liver pathological status

A short list of chemicals and/or their mixtures identified through epidemiological studies to alter zebrafish adipocyte lipid droplet size and adiposity and liver pathological status

Report on omics high-throughput analyses of three in vitro models and their response to selected chemicals
Demonstration of intra- and inter-laboratory reproducibility of the test method used to evaluate EDs for their involvement in steatosis and in the transition to steatohepatitis

The demonstration of intra- and inter-laboratory reproducibility of the test method used to evaluate EDs for their involvement in steatosis and in the transition to steatohepatitis

Report with recommendations for the integration of HBM and epidemiological studies in ED test systems

Report with recommendations for the integration of HBM and epidemiological studies in ED test systems to allow priority-setting for more efficient testing of EDs in epidemiological studies (M46). This deliverable will integrate outputs from WP1 to WP2, 3, and 4 to WP1 as well as inputs from the aforementioned WPs to WP1.)

Open Research Data Pilot (1)

OBERON Data Management Plan

Other (1)

OBERON Integrated Data Management (IDM) system incl. bioinformatics infrastructure

Websites, patent fillings, videos etc. (1)

Website, logo and communication tools

Publications

Peer reviewed articles (35)

Pregnancy Exposure to Phenols and Anthropometric Measures in Gestation and at Birth

Auteurs: Jedynak Paulina
Publié dans: Epidémiology, 2022, ISSN 1044-3983
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/ede.0000000000001515

AOP-helpFinder webserver: a tool for comprehensive analysis of the literature to support adverse outcome pathways development

Auteurs: Florence Jornod; Thomas Jaylet; Ludek Blaha; Denis Sarigiannis; Luc Tamisier; Karine Audouze
Publié dans: Oxford Academic - Bioinformatics, 2021, ISSN 1367-4811
Éditeur: Oxford University Press
DOI: 10.1093/bioinformatics/btab750

Prenatal exposure to multiple persistent organic pollutants in association with adiposity markers and blood pressure in preadolescents

Auteurs: Elke Rouxel a , Nathalie Costet a , Christine Monfort a , Karine Audouze b , Lourdes Cirugeda c d e , Eric Gaudreau f , Joan O. Grimalt g , Jesus Ibarluzea c h i , Fabrice Lainé j , Sabrina Llop c k , Maria-Jose Lopez-Espinosa c k l , Florence Rouget m , Loreto Santa-Marina c h n , Martine Vrijheid c d e , Cécile Chevrier a , Maribel Casas c d e , Charline Warembourg
Publié dans: pubmed, 2023, ISSN 0160-4120
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2023.108056

A KNIMEWorkflow to Assist the Analogue Identification for Read-Across, Applied to Aromatase Activity

Auteurs: A. Y. Caballero Alfonso
Publié dans: Molecules, Numéro 1832, 2023, ISSN 1420-3049
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules28041832

Fetal and Infancy Exposure to Phenols, Parabens, and Phthalates andAnthropometric Measurements up to 36 Months, in the Longitudinal SEPAGESCohort

Auteurs: Marion OUIDIR
Publié dans: Environmental Health Perspectives, 2024, ISSN 0091-6765
Éditeur: US Department of Health and Human Services
DOI: 10.1289/ehp13644

Endocrine disrupting chemicals and COVID-19 relationships: A computational systems biology approach

Auteurs: Philippe Grandjean; Philippe Grandjean; Robert Barouki; Xavier Coumoul; Qier Wu; Karine Audouze
Publié dans: Environmental international, 2021, ISSN 0160-4120
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2020.106232

PBTK modeled perfluoroalkyl acid kinetics in zebrafish eleutheroembryos suggests impacts on bioconcentrations by chorion porosity dynamics

Auteurs: PA BILLAT
Publié dans: Toxicology in vitro, 2023, ISSN 0887-2333
Éditeur: Elsevier BV
DOI: 10.1016/j.tiv.2023.105588

Reduced Birth Weight and Exposure to Per- and Polyfluoroalkyl Substances: A Review of Possible Underlying Mechanisms Using the AOP-HelpFinder.

Auteurs: Gundacker C
Publié dans: Toxics, 2022, ISSN 2305-6304
Éditeur: MDPI
DOI: 10.3390/toxics10110684

Childhood exposure to non-persistent endocrine disrupting chemicals and multi-omic profiles: A panel study

Auteurs: L. Fabbri
Publié dans: Environment International, 2023, Page(s) 107856, ISSN 0160-4120
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2023.107856

Integrative systems toxicology to predict human biological systems affected by exposure to environmental chemicals

Auteurs: Taboureau, Olivier; El M'Selmi, Walid; Audouze, Karine
Publié dans: Toxicology and Applied Pharmacology, 2020, Page(s) 115210, ISSN 0041-008X
Éditeur: Academic Press
DOI: 10.1016/j.taap.2020.115210

Quantitative Structure-Activity Relationship Modeling of the Amplex Ultrared Assay to Predict Thyroperoxidase Inhibitory Activity

Auteurs: Domenico Gadaleta; Luca d’Alessandro; Marco Marzo; Emilio Benfenati; Alessandra Roncaglioni
Publié dans: Frontiers in pharmacology, 2021, Page(s) 1-12, ISSN 1663-9812
Éditeur: Frontiers Media S.A.
DOI: 10.3389/fphar.2021.713037

AOP-helpFinder 2.0: Integration of an event-event searches module.

Auteurs: K.Audouze
Publié dans: Environ Int., 2023, Page(s) 177:108017, ISSN 0160-4120
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2023.108017

A New In Vivo Zebrafish Bioassay Evaluating Liver Steatosis Identifies DDE as a Steatogenic Endocrine Disruptor, Partly through SCD1 Regulation

Auteurs: Hélène Le Mentec; Emmanuelle Monniez; Antoine Legrand; Céline Monvoisin; Dominique Lagadic-Gossmann; Normand Podechard
Publié dans: International journal of molecular sciences, Numéro 19, 2023, Page(s) 3942, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24043942

Evidenced-Based Approaches to Support the Development of Endocrine-Mediated Adverse Outcome Pathways: Challenges and Opportunities

Auteurs: Karine Audouze; Elias Zgheib; Khaled Abass; Khaled Abass; Asma H. Baig; Isabel Forner-Piquer; Henrik Holbech; Dries Knapen; Pim E. G. Leonards; Diana I. Lupu; Saranya Palaniswamy; Arja Rautio; Maria Sapounidou; Olwenn V. Martin
Publié dans: Frontiers in Toxicology, 2021, ISSN 2673-3080
Éditeur: Frontiers media S.A
DOI: 10.3389/ftox.2021.787017

Integrating -omics approaches into population-based studies of endocrine disrupting chemicals: A scoping review.

Auteurs: L.Maitre
Publié dans: Envionmental Research, Numéro 228, 2023, Page(s) 115788, ISSN 0013-9351
Éditeur: Academic Press
DOI: 10.1016/j.envres.2023.115788

ReadEDTest: A tool to assess the readiness of in vitro test methods under development for identifying endocrine disruptors

Auteurs: Crouzet, Thibault; Grignard, Elise; Brion, François; Blanc, Etienne, B; Podechard, Normand; Langouët, Sophie; Alonso-Magdalena, Paloma; Hubert, Philippe; Kim, Min-Ji; Audouze, Karine
Publié dans: https://hal.science/hal-04094681, Numéro 2, 2023, Page(s) 174:107910, ISSN 0160-4120
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2023.107910

Exploration of structural requirements for azole chemicals towards human aromatase CYP19A1 activity: Classification modeling, structure-activity relationships and read-across study

Auteurs: A. Y. Caballero Alfonso
Publié dans: Toxicology in Vitro, 2022, ISSN 0887-2333
Éditeur: Elsevier BV
DOI: 10.1016/j.tiv.2022.105332

Placental transfer of xenobiotics in pregnancy physiologically-based pharmacokinetic models: Structure and data

Auteurs: Codaccioni, Marc; Bois, Frédéric; Brochot, Céline
Publié dans: Toxicology and Applied Pharmacology, Numéro 409, 2020, ISSN 0041-008X
Éditeur: Academic Press
DOI: 10.1016/j.comtox.2019.100111

Nutritional Modulation of Associations between Prenatal Exposure to Persistent Organic Pollutants and Childhood Obesity: A Prospective Cohort Study

Auteurs: G. Cano-Sanschez
Publié dans: Environmental Health Perspectives, 2023, ISSN 0091-6765
Éditeur: US Department of Health and Human Services
DOI: 10.1289/ehp11258

Cyanotoxin cylindrospermopsin disrupts lipid homeostasis and metabolism in a 3D in vitro model of human liver.

Auteurs: R. Chowdhury
Publié dans: Chemico-Biological Interactions, Numéro 111046, 2024, Page(s) 111046, ISSN 0009-2797
Éditeur: Elsevier BV
DOI: 10.1016/j.cbi.2024.111046

Prenatal Exposure to Chemical Mixtures and Metabolic Syndrome Risk in Children

Auteurs: N. Güil-Oumrait
Publié dans: JAMA Network Open, Numéro 7(5), 2024, Page(s) e2412040, ISSN 2574-3805
Éditeur: Elsevier
DOI: 10.1001/jamanetworkopen.2024.12040

""" Exploring the Effects of Metabolism-Disrupting Chemicals on Pancreatic α-Cell Viability, Gene Expression and Function: A Screening Testing Approach"""

Auteurs: Al-Abdulla R
Publié dans: International Journal of Molecular Sciences, 2023, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24021044

"""Parabens and antimicrobial compounds in conventional and “green” personal care products"""

Auteurs: Veronica van der Schyff
Publié dans: Chemosphere, 2022, ISSN 0045-6535
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.chemosphere.2022.134019

Comprehensive mapping of the AOP-Wiki database: identifying biological and disease gaps.

Auteurs: K Audouze
Publié dans: Front Toxicol., 2024, ISSN 2673-3080
Éditeur: Frontiers
DOI: 10.3389/ftox.2024.1285768

Prenatal exposure to persistent organic pollutants and markers of obesity and cardiometabolic risk in Spanish adolescents

Auteurs: N Güil-Oumrait
Publié dans: Environment Epidemiology, 2022, ISSN 2474-7882
Éditeur: pubMed
DOI: 10.1016/j.envint.2022.107527

Prenatal exposure to multiple endocrine disruptors and childhood BMI trajectories

Auteurs: P. Montazeri
Publié dans: Environmental Health Perspectives, 2023, Page(s) 107006, ISSN 0091-6765
Éditeur: US Department of Health and Human Services
DOI: 10.1289/ehp11103

ELIXIR and Toxicology: a community in development

Auteurs: Philippe Rocca-Serra; Penny Nymark; Haralambos Sarimveis; Pavel Babica; Ferran Sanz; Marco Dilger; Danyel Jennen; Ola Spjuth; Egon Willighagen; Gerard J.P. van Westen; Antony Williams; Rob Stierum; Thomas Exner; Herbert Oberacher; Karel Berka; Ralf J. M. Weber; Tobias Schulze; Jos C. S. Kleinjans; Montserrat Cases; Dimitrios Damalas; Jaroslav Slobodnik; Iseult Lynch; Uko Maran; Noelia Ramirez; Syl
Publié dans: F1000 Research Ltd., 2021, ISSN 2046-1402
Éditeur: F1000 Research Ltd.
DOI: 10.12688/f1000research.74502.1

Integrative Strategy of Testing Systems for Identification of Endocrine Disruptors Inducing Metabolic Disorders—An Introduction to the OBERON Project

Auteurs: Robert Barouki; Robert Barouki; Denis Sarigiannis; Spyros Karakitsios; Paloma Alonso-Magdalena; Martine Vrijheid; Céline Brochot; Maribel Casas; Xavier Coumoul; Patrick J. Babin; Karine Audouze
Publié dans: International Journal of Molecular Sciences, 2020, Page(s) 2988, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21082988

Prenatal exposure to persistent organic pollutants and markers of obesity and cardiometabolic risk in Spanish adolescents

Auteurs: Güil-Oumrait, Nuria; Valvi, Damaskini; Garcia-Esteban, Raquel; Guxens, Monica; Sunyer, Jordi; Torrent, Maties; Casas, Maribel; Vrijheid, Martine
Publié dans: Environment International, 2021, ISSN 0160-4120
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2021.106469

Identification of non-validated endocrine disrupting chemical characterization methods by screening of the literature using artificial intelligence and by database exploration

Auteurs: Zgheib, Elias; Kim, Min Ji; Jornod, Florence; Bernal, Kévin; Tomkiewicz, Céline; Bortoli, Sylvie; Coumoul, Xavier; Barouki, Robert; de Jesus, Kelly; Grignard, Elise; Hubert, Philippe; Katsanou, Efrosini, S; Busquet, Francois; Audouze, Karine
Publié dans: Environment international, 2021, ISSN 0160-4120
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2021.106574

Endocrine Disrupting Chemicals: Current Understanding, New Testing Strategies and Future Research Needs

Auteurs: Maria E. Street; Karine Audouze; Juliette Legler; Hideko Sone; Paola Palanza
Publié dans: international Journal of Molecular Sciences, 2021, Page(s) Multidisciplinar y Digital Publishing Institute (MDPI), ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22020933

Assessment of endocrine disruptor impacts on lipid metabolism in a fatty acid-supplemented HepaRG human hepatic cell line

Auteurs: Kévin Bernal; Charbel Touma; Béatrice Le-Grand; Sophie Rose; Selenay Degerli; Valentine Genêt; Dominique Lagadic-Gossmann; Xavier Coumoul; Corinne Martin-Chouly; Sophie Langouët; Etienne B Blanc
Publié dans: EISSN: 1879-1298, Numéro 4, 2024, Page(s) 349:140883, ISSN 0045-6535
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.chemosphere.2023.140883

The Exposome and Toxicology: A Win–Win Collaboration

Auteurs: Robert Barouki
Publié dans: Toxicological Sciences, 2021, ISSN 1096-6080
Éditeur: Oxford University Press
DOI: 10.1093/toxsci/kfab149

Analyzing the impact of phthalate and DINCH exposure on fetal growth in a cohort with repeated urine collection

Auteurs: Marion OUIDIR
Publié dans: Environment International, Numéro 108584, 2024, ISSN 0160-4120
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2024.108584

Characterization of Potential Adverse Outcome Pathways Related to Metabolic Outcomes and Exposure to Per- and Polyfluoroalkyl Substances Using Artificial Intelligence.

Auteurs: Kaiser AM
Publié dans: Toxics, 2022, ISSN 2305-6304
Éditeur: MDPI
DOI: 10.3390/toxics10080449

Other (4)

Obesity II: Establishing causal links between chemical exposures and obesity.

Auteurs: Heindel JJ,
Publié dans: Biochem Pharmacol., 2022, ISSN 0006-2952
Éditeur: ELSEVIER
DOI: 10.1016/j.bcp.2022.115015

Obesity III: Obesogen assays: Limitations, strengths, and new directions.

Auteurs: Kassotis CD,
Publié dans: Biochem Pharmacol., 2022
Éditeur: ELSEVIER
DOI: 10.1016/j.bcp.2022.115014.

Obesity I: Overview and molecular and biochemical mechanisms.

Auteurs: """Caroline Thunissen1, Robert Watson2, Quentin Gilleman1, Céline Borlon1, Thomas Simon1, Roger Hewson2, Pascal Mertens1 """
Publié dans: Biochem Pharmacol., 2022, ISSN 0006-2952
Éditeur: ELSEVIER
DOI: 10.1016/j.bcp.2022.115012

Combinatorial pathway disruption is a powerful approach to delineate metabolic impacts of endocrine disruptors

Auteurs: X. Coumoul - MJ Kim - K Bernal
Publié dans: FEBS Letters, 2022
Éditeur: Wiley
DOI: 10.1002/1873-3468.14465