An integrative strategy of testing systems for identification of EDs related to metabolic disorders

Livrables

Report on the toxicokinetic models for in vitro systems
Report on exposure levels of the ten selected EDs in Europe taking data from biomonitoring studies and birth cohorts
A pregnancy PBPK model for humans and associated algorithm for parametrization
Report on the optimization of existing in silico models and development of new ones, implemented within VEGA

Report on the optimization of existing in silico models and development of new ones implemented within VEGA

Demonstration of intra- and inter-laboratory reproducibility of ZOT used to evaluate EDs as obesogens

The demonstration of intra and interlaboratory reproducibility of ZOT used to evaluate EDs as obesogens

Public symposium
Report on functional specifications and system architecture of OBERON IDM

OBERON Data Management Plan

Website, logo and communication tools

Publications

Pregnancy Exposure to Phenols and Anthropometric Measures in Gestation and at Birth

Auteurs: Jedynak Paulina
Publié dans: Epidémiology, 2022, ISSN 1044-3983
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/ede.0000000000001515

Reduced Birth Weight and Exposure to Per- and Polyfluoroalkyl Substances: A Review of Possible Underlying Mechanisms Using the AOP-HelpFinder.

Auteurs: Gundacker C
Publié dans: Toxics, 2022, ISSN 2305-6304
Éditeur: MDPI
DOI: 10.3390/toxics10110684

Exploration of structural requirements for azole chemicals towards human aromatase CYP19A1 activity: Classification modeling, structure-activity relationships and read-across study

Auteurs: A. Y. Caballero Alfonso
Publié dans: Toxicology in Vitro, 2022, ISSN 0887-2333
Éditeur: Elsevier BV
DOI: 10.1016/j.tiv.2022.105332

"""Parabens and antimicrobial compounds in conventional and “green” personal care products"""

Auteurs: Veronica van der Schyff
Publié dans: Chemosphere, 2022, ISSN 0045-6535
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.chemosphere.2022.134019

Prenatal exposure to persistent organic pollutants and markers of obesity and cardiometabolic risk in Spanish adolescents

Auteurs: N Güil-Oumrait
Publié dans: Environment Epidemiology, 2022, ISSN 2474-7882
Éditeur: pubMed
DOI: 10.1016/j.envint.2022.107527

The Exposome and Toxicology: A Win–Win Collaboration

Auteurs: Robert Barouki
Publié dans: Toxicological Sciences, 2021, ISSN 1096-6080
Éditeur: Oxford University Press
DOI: 10.1093/toxsci/kfab149

Characterization of Potential Adverse Outcome Pathways Related to Metabolic Outcomes and Exposure to Per- and Polyfluoroalkyl Substances Using Artificial Intelligence.

Auteurs: Kaiser AM
Publié dans: Toxics, 2022, ISSN 2305-6304
Éditeur: MDPI
DOI: 10.3390/toxics10080449

Obesity II: Establishing causal links between chemical exposures and obesity.

Auteurs: Heindel JJ,
Publié dans: Biochem Pharmacol., 2022, ISSN 0006-2952
Éditeur: ELSEVIER
DOI: 10.1016/j.bcp.2022.115015

Obesity III: Obesogen assays: Limitations, strengths, and new directions.

Auteurs: Kassotis CD,
Publié dans: Biochem Pharmacol., 2022
Éditeur: ELSEVIER
DOI: 10.1016/j.bcp.2022.115014.

Obesity I: Overview and molecular and biochemical mechanisms.

Auteurs: """Caroline Thunissen1, Robert Watson2, Quentin Gilleman1, Céline Borlon1, Thomas Simon1, Roger Hewson2, Pascal Mertens1 """
Publié dans: Biochem Pharmacol., 2022, ISSN 0006-2952
Éditeur: ELSEVIER
DOI: 10.1016/j.bcp.2022.115012

Combinatorial pathway disruption is a powerful approach to delineate metabolic impacts of endocrine disruptors

Auteurs: X. Coumoul - MJ Kim - K Bernal
Publié dans: FEBS Letters, 2022
Éditeur: Wiley
DOI: 10.1002/1873-3468.14465

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