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An integrative strategy of testing systems for identification of EDs related to metabolic disorders

Objectif

Exposure to chemical substances that can produce endocrine disrupting effects represents one of the most critical public health threats nowadays. In line with the regulatory framework implemented within the European Union to reduce the levels of endocrine disruptors (EDs) for consumers, new and effective methods for ED testing are needed. The OBERON project will build an integrated testing strategy (ITS) to detect EDs-related metabolic disorders by developing, improving and validating a battery of test systems. It will be based on the concept of an integrated approach for testing and assessment (IATA). OBERON will combine 1) experimental methods (in vitro e.g. on 2D and 3D human-derived cells and tissues, and in vivo i.e. in zebrafish at different stages), 2) high throughput omics technologies, 3) epidemiology and human biomonitoring studies and 4) advanced computational models (in silico and systems biology) on functional endpoints related to metabolism. Such interdisciplinary framework will help at deciphering EDs based on mechanistic understanding of toxicity by providing and making available more effective alternative test methods relevant for human health that are in line with regulatory needs. Data generated in OBERON will also allow the development of novel Adverse Outcome Pathways (AOPs). The assays will be pre-validated in order to select the test systems that will show acceptable performance in terms of relevance for the second step of the validation process, i.e. the inter-laboratory validation as ring tests. Therefore, the aim of the OBERON project is to support the OECD conceptual framework for testing and assessment of EDs by developing specific assays not covered by the current tests, and to propose an IATA approach for ED-related metabolic disorders detection, which will be submitted to the JRC and OECD community.

Appel à propositions

H2020-SC1-2018-Single-Stage-RTD
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Régime de financement

RIA - Research and Innovation action

Coordinateur

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Adresse
Rue De Tolbiac 101
75654 Paris
France
Type d’activité
Research Organisations
Contribution de l’UE
€ 1 900 553,75

Participants (11)

INSTITUT NATIONAL DE L ENVIRONNEMENT ET DES RISQUES INERIS
France
Contribution de l’UE
€ 558 945
Adresse
Parc Technologique Alata
60550 Verneuil En Halatte
Type d’activité
Research Organisations
BIOFYZIKALNI USTAV AKADEMIE VED CESKE REPUBLIKY
Tchéquie
Contribution de l’UE
€ 215 250
Adresse
Kralovopolska 135
CZ-61265 Brno
Type d’activité
Research Organisations
UNIVERSIDAD MIGUEL HERNANDEZ DE ELCHE
Espagne
Contribution de l’UE
€ 259 706,25
Adresse
Avenida De La Universidad S-n
03202 Elche
Type d’activité
Higher or Secondary Education Establishments
ARISTOTELIO PANEPISTIMIO THESSALONIKIS
Greece
Contribution de l’UE
€ 793 725
Adresse
Kedea Building, Tritis Septemvriou, Aristotle Univ Campus
54636 Thessaloniki
Type d’activité
Higher or Secondary Education Establishments
FUNDACION PRIVADA INSTITUTO DE SALUD GLOBAL BARCELONA
Espagne
Contribution de l’UE
€ 550 366,25
Adresse
C Rossello 132 Planta 05
08036 Barcelona
Type d’activité
Research Organisations
ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI
Italie
Contribution de l’UE
€ 304 000
Adresse
Via Mario Negri 2
20156 Milano
Type d’activité
Research Organisations
Masarykova univerzita
Tchéquie
Contribution de l’UE
€ 330 407,50
Adresse
Zerotinovo Namesti 9
60177 Brno Stred
Type d’activité
Higher or Secondary Education Establishments
METABOLON GMBH

Participation terminée

Allemagne
Contribution de l’UE
€ 0
Adresse
Zeppelinstrasse 3
85399 Hallbergmoos
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
AGENCE NATIONALE DE LA SECURITE SANITAIRE DE L ALIMENTATION DE L ENVIRONNEMENT ET DU TRAVAIL
France
Contribution de l’UE
€ 76 058,75
Adresse
14 Rue Pierre Et Marie Curie
94700 Maisons Alfort
Type d’activité
Research Organisations
INSERM TRANSFERT SA
France
Contribution de l’UE
€ 379 750
Adresse
Rue Watt 7
75013 Paris
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ENVE.X SINGLE MEMBER PC
Greece
Contribution de l’UE
€ 610 000
Adresse
Kosti Palama 11
551 33 Thesaloniki
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)