An integrative strategy of testing systems for identification of EDs related to metabolic disorders

Leistungen

Report on the toxicokinetic models for in vitro systems
Report on exposure levels of the ten selected EDs in Europe taking data from biomonitoring studies and birth cohorts
A pregnancy PBPK model for humans and associated algorithm for parametrization
Report on the optimization of existing in silico models and development of new ones, implemented within VEGA

Report on the optimization of existing in silico models and development of new ones implemented within VEGA

Demonstration of intra- and inter-laboratory reproducibility of ZOT used to evaluate EDs as obesogens

The demonstration of intra and interlaboratory reproducibility of ZOT used to evaluate EDs as obesogens

Public symposium
Report on functional specifications and system architecture of OBERON IDM

OBERON Data Management Plan

Website, logo and communication tools

Veröffentlichungen

Pregnancy Exposure to Phenols and Anthropometric Measures in Gestation and at Birth

Autoren: Jedynak Paulina
Veröffentlicht in: Epidémiology, 2022, ISSN 1044-3983
Herausgeber: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/ede.0000000000001515

Reduced Birth Weight and Exposure to Per- and Polyfluoroalkyl Substances: A Review of Possible Underlying Mechanisms Using the AOP-HelpFinder.

Autoren: Gundacker C
Veröffentlicht in: Toxics, 2022, ISSN 2305-6304
Herausgeber: MDPI
DOI: 10.3390/toxics10110684

Exploration of structural requirements for azole chemicals towards human aromatase CYP19A1 activity: Classification modeling, structure-activity relationships and read-across study

Autoren: A. Y. Caballero Alfonso
Veröffentlicht in: Toxicology in Vitro, 2022, ISSN 0887-2333
Herausgeber: Elsevier BV
DOI: 10.1016/j.tiv.2022.105332

"""Parabens and antimicrobial compounds in conventional and “green” personal care products"""

Autoren: Veronica van der Schyff
Veröffentlicht in: Chemosphere, 2022, ISSN 0045-6535
Herausgeber: Pergamon Press Ltd.
DOI: 10.1016/j.chemosphere.2022.134019

Prenatal exposure to persistent organic pollutants and markers of obesity and cardiometabolic risk in Spanish adolescents

Autoren: N Güil-Oumrait
Veröffentlicht in: Environment Epidemiology, 2022, ISSN 2474-7882
Herausgeber: pubMed
DOI: 10.1016/j.envint.2022.107527

The Exposome and Toxicology: A Win–Win Collaboration

Autoren: Robert Barouki
Veröffentlicht in: Toxicological Sciences, 2021, ISSN 1096-6080
Herausgeber: Oxford University Press
DOI: 10.1093/toxsci/kfab149

Characterization of Potential Adverse Outcome Pathways Related to Metabolic Outcomes and Exposure to Per- and Polyfluoroalkyl Substances Using Artificial Intelligence.

Autoren: Kaiser AM
Veröffentlicht in: Toxics, 2022, ISSN 2305-6304
Herausgeber: MDPI
DOI: 10.3390/toxics10080449

Obesity II: Establishing causal links between chemical exposures and obesity.

Autoren: Heindel JJ,
Veröffentlicht in: Biochem Pharmacol., 2022, ISSN 0006-2952
Herausgeber: ELSEVIER
DOI: 10.1016/j.bcp.2022.115015

Obesity III: Obesogen assays: Limitations, strengths, and new directions.

Autoren: Kassotis CD,
Veröffentlicht in: Biochem Pharmacol., 2022
Herausgeber: ELSEVIER
DOI: 10.1016/j.bcp.2022.115014.

Obesity I: Overview and molecular and biochemical mechanisms.

Autoren: """Caroline Thunissen1, Robert Watson2, Quentin Gilleman1, Céline Borlon1, Thomas Simon1, Roger Hewson2, Pascal Mertens1 """
Veröffentlicht in: Biochem Pharmacol., 2022, ISSN 0006-2952
Herausgeber: ELSEVIER
DOI: 10.1016/j.bcp.2022.115012

Combinatorial pathway disruption is a powerful approach to delineate metabolic impacts of endocrine disruptors

Autoren: X. Coumoul - MJ Kim - K Bernal
Veröffentlicht in: FEBS Letters, 2022
Herausgeber: Wiley
DOI: 10.1002/1873-3468.14465

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