An integrative strategy of testing systems for identification of EDs related to metabolic disorders

Risultati finali

Report on the toxicokinetic models for in vitro systems
Report on exposure levels of the ten selected EDs in Europe taking data from biomonitoring studies and birth cohorts
A pregnancy PBPK model for humans and associated algorithm for parametrization
Report on the optimization of existing in silico models and development of new ones, implemented within VEGA

Report on the optimization of existing in silico models and development of new ones implemented within VEGA

Demonstration of intra- and inter-laboratory reproducibility of ZOT used to evaluate EDs as obesogens

The demonstration of intra and interlaboratory reproducibility of ZOT used to evaluate EDs as obesogens

Public symposium
Report on functional specifications and system architecture of OBERON IDM

OBERON Data Management Plan

Website, logo and communication tools

Pubblicazioni

Pregnancy Exposure to Phenols and Anthropometric Measures in Gestation and at Birth

Autori: Jedynak Paulina
Pubblicato in: Epidémiology, 2022, ISSN 1044-3983
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/ede.0000000000001515

Reduced Birth Weight and Exposure to Per- and Polyfluoroalkyl Substances: A Review of Possible Underlying Mechanisms Using the AOP-HelpFinder.

Autori: Gundacker C
Pubblicato in: Toxics, 2022, ISSN 2305-6304
Editore: MDPI
DOI: 10.3390/toxics10110684

Exploration of structural requirements for azole chemicals towards human aromatase CYP19A1 activity: Classification modeling, structure-activity relationships and read-across study

Autori: A. Y. Caballero Alfonso
Pubblicato in: Toxicology in Vitro, 2022, ISSN 0887-2333
Editore: Elsevier BV
DOI: 10.1016/j.tiv.2022.105332

"""Parabens and antimicrobial compounds in conventional and “green” personal care products"""

Autori: Veronica van der Schyff
Pubblicato in: Chemosphere, 2022, ISSN 0045-6535
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.chemosphere.2022.134019

Prenatal exposure to persistent organic pollutants and markers of obesity and cardiometabolic risk in Spanish adolescents

Autori: N Güil-Oumrait
Pubblicato in: Environment Epidemiology, 2022, ISSN 2474-7882
Editore: pubMed
DOI: 10.1016/j.envint.2022.107527

The Exposome and Toxicology: A Win–Win Collaboration

Autori: Robert Barouki
Pubblicato in: Toxicological Sciences, 2021, ISSN 1096-6080
Editore: Oxford University Press
DOI: 10.1093/toxsci/kfab149

Characterization of Potential Adverse Outcome Pathways Related to Metabolic Outcomes and Exposure to Per- and Polyfluoroalkyl Substances Using Artificial Intelligence.

Autori: Kaiser AM
Pubblicato in: Toxics, 2022, ISSN 2305-6304
Editore: MDPI
DOI: 10.3390/toxics10080449

Obesity II: Establishing causal links between chemical exposures and obesity.

Autori: Heindel JJ,
Pubblicato in: Biochem Pharmacol., 2022, ISSN 0006-2952
Editore: ELSEVIER
DOI: 10.1016/j.bcp.2022.115015

Obesity III: Obesogen assays: Limitations, strengths, and new directions.

Autori: Kassotis CD,
Pubblicato in: Biochem Pharmacol., 2022
Editore: ELSEVIER
DOI: 10.1016/j.bcp.2022.115014.

Obesity I: Overview and molecular and biochemical mechanisms.

Autori: """Caroline Thunissen1, Robert Watson2, Quentin Gilleman1, Céline Borlon1, Thomas Simon1, Roger Hewson2, Pascal Mertens1 """
Pubblicato in: Biochem Pharmacol., 2022, ISSN 0006-2952
Editore: ELSEVIER
DOI: 10.1016/j.bcp.2022.115012

Combinatorial pathway disruption is a powerful approach to delineate metabolic impacts of endocrine disruptors

Autori: X. Coumoul - MJ Kim - K Bernal
Pubblicato in: FEBS Letters, 2022
Editore: Wiley
DOI: 10.1002/1873-3468.14465

Risultati finali

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