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CORDIS - Resultados de investigaciones de la UE
CORDIS

Translational studies of HEAD and neck cancer in South America and Europe

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Development of communication strategy (se abrirá en una nueva ventana)
Report on utility of genetic variants to improve prediction of outcome (se abrirá en una nueva ventana)
White paper on biomarker assay performance (se abrirá en una nueva ventana)

White paper on biomarker assay performance (samples tested, cross validation, performance statistics)

Testing 800 FFPE and serology material (se abrirá en una nueva ventana)
Report on HPV16E6 serology and recurrence prediction for HPV driven OPSCC (se abrirá en una nueva ventana)
SOPs for FFPE tissue accession sectioning, tissue array processing, and storage to be available on the website (se abrirá en una nueva ventana)

SOPs for FFPE tissue accession sectioning, tissue array processing, and storage will be available to all members on the HEADSpAcE project website

Report on immunological profile of oropharyngeal cases (se abrirá en una nueva ventana)
Report of genome-wide association study of oral and oropharyngeal cancer (se abrirá en una nueva ventana)
Scientific publication on prognostic value of lifestyle, clinical and genetic factors in OPC patients by HPV status (se abrirá en una nueva ventana)
Updated report on biorepository availability (se abrirá en una nueva ventana)

Annual report on biorepository availability including new recruitment and followup

Design panel including targeted regions and primer sequences freely available for all scientific community (se abrirá en una nueva ventana)

***FUNDING DEPENDENT - This report will be delivered only if funds are made available to Brazil-based partner receiving no EU funding, INCA.***Design panel including targeted regions and primer sequences freely available for all scientific community

Report on transcriptomic analysis on 400 cases (se abrirá en una nueva ventana)
Statistical analyses reports (se abrirá en una nueva ventana)

Statistical analyses reports comparing HPV analysis region lifestyle and clinical factors

Workshop on HPV16 E6 ELISA assay (se abrirá en una nueva ventana)

A 2-day hands-on workshop on HPV16 E6 ELISA assay for all WP3 participating centers will be organized in Heidelberg

Report of second scientific meeting (se abrirá en una nueva ventana)

Report of second scientific meeting of HEADSpAcE

Workshop on tissue array processing and good practices in IHC techniques (se abrirá en una nueva ventana)

A 2-day workshop on tissue array processing and good practices in IHC techniques for all HEADSpAcE participating centers will be organized in Bogotá, in particular for clinical institutions with pathology services

Report on assessment of risk determinants of late stage head and neck cancer diagnosis (se abrirá en una nueva ventana)

Report on assessment of risk determinants of late stage head and neck cancer diagnosis – to identify relative importance and interactions of socioeconomic, logistic, and biological factors; and to identify potential areas and timing of interventions to achieve early detection and diagnosis

Report on HPV-driven fraction in OPC in Europe and Latin America, determinants and time-trends of HPV-positivity (se abrirá en una nueva ventana)
Protocol for prospective recruitment of 1100 HNC cases in Europe and SA (se abrirá en una nueva ventana)
Selection of 800 cases for comprehensive genomic analysis (se abrirá en una nueva ventana)

Selection of 800 cases for comprehensive genomic analysis including 200 cases from Europe and 600 from South America

Development of head and neck cancer referral pathways guideline recommendations (se abrirá en una nueva ventana)

Development of head and neck cancer referral pathways guideline recommendations – to provide evidence to inform policy and practice, tailored to countries across study

Report of a validated protocol with guidelines for in situ hybridization to E6/E7 mRNA (se abrirá en una nueva ventana)
Updated report on communication strategy (se abrirá en una nueva ventana)

Updated report on the communication strategy at M66

Annual report on the communication strategy (se abrirá en una nueva ventana)

Annual report on the communication strategy on M12, M24, M36, and M48

Report on rigorous bioinformatics analysis and contribution on prognostic factors (se abrirá en una nueva ventana)

Report on rigorous bioinformatics analysis and contribution to WP4 on prognostic factors

Report of first scientific meeting (se abrirá en una nueva ventana)

Report of first scientific meeting of HEADSpAcE

Report on clinical biomarkers classification of HPV driven oropharyngeal cancers (se abrirá en una nueva ventana)
Development of protocol for patient interviews (se abrirá en una nueva ventana)

Development of protocol for patient interviews to obtain information of reasons for delay in diagnosis

Annual report on biorepository availability (se abrirá en una nueva ventana)

Annual report on biorepository availability, including new recruitment and follow-up. Will be due on M12, M24, M36, and M48.

Evaluation of national and international treatment protocols (se abrirá en una nueva ventana)
Report on epigenetic analysis on 800 cases (se abrirá en una nueva ventana)

Report on epigenetic analysis on 100 cases

Report on in-depth comparison between two centres on infrastructure causes of delay to diagnosis (se abrirá en una nueva ventana)

Report on indepth comparison between two centres on infrastructure causes of delay to diagnosis

SOPs for plasma collection, processing, and storage on the website (se abrirá en una nueva ventana)

SOPs for plasma collection, processing, and storage will be available to all members on the HEADSpAcE project website

Report on ELISA assay validation (se abrirá en una nueva ventana)
Development of a reference standard for HPV16 E6 (se abrirá en una nueva ventana)

Development of a reference standard for HPV16 E6 for international harmonization of HPV16 E6 serology

Report on ctDNA detection for monitoring Head and Neck cancer (se abrirá en una nueva ventana)
Development of ethics guidelines, documents and procedures (se abrirá en una nueva ventana)

Development of ethics guidelines, documents and procedures. Ethics guidelines will be developed by M3. Rules of data protection will be established at inception. The ethics guidelines will be posted in the website and regularly monitored

Report on the utility of genomic information on clinical prediction (se abrirá en una nueva ventana)
Report on analysis of rare variants and sequencing follow-up (se abrirá en una nueva ventana)
Report on exome sequencing analysis of 800 cases (se abrirá en una nueva ventana)
Summary of sample management systems available in centers with HNC biorepositories (se abrirá en una nueva ventana)

Summary of sample management systems available in centers with HNC biorepositories, ensuring compatibility of all systems

Data management plan (se abrirá en una nueva ventana)

Data management plan including the organisation and coordination of biosample and data sharing between partner institutes

Publicaciones

Impact of the COVID‐19 pandemic on stage and incidence of head and neck cancer: A rapid review and meta‐analysis (se abrirá en una nueva ventana)

Autores: Kelten Clements, Alekh Thapa, Anna Cowell, David Conway, Catriona M Douglas, Claire Paterson
Publicado en: Clinical Otolaryngology, Edición 49, 2024, Página(s) 363-375, ISSN 1749-4478
Editor: Blackwell Publishing Inc.
DOI: 10.1111/coa.14152

The Impact of the COVID-19 Pandemic on Head and Neck Cancer Diagnosis in the Piedmont Region, Italy: Interrupted Time-Series Analysis (se abrirá en una nueva ventana)

Autores: Maja Popovic, Valentina Fiano, Giovenale Moirano, Luigi Chiusa, David I. Conway, Paolo Garzino Demo, Marco Gilardetti, Giuseppe Carlo Iorio, Chiara Moccia, Oliviero Ostellino, Giancarlo Pecorari, Guglielmo Ramieri, Umberto Ricardi, Giuseppe Riva, Shama Virani, Lorenzo Richiardi
Publicado en: Frontiers in public health, Edición 21 Feb 2022, 2022, Página(s) 1-10, ISSN 2296-2565
Editor: Frontiers Media
DOI: 10.3389/fpubh.2022.809283

Barriers to early diagnosis and management of oral cancer in Latin America and the Caribbean (se abrirá en una nueva ventana)

Autores: Josefina Martínez‐Ramírez, Cristina Saldivia‐Siracusa, Leonor‐Victoria González‐Pérez, Florence Juana Maria Cuadra Zelaya, Roberto Gerber‐Mora, Osmani Fabricio Guevara Cabrera, Ronell Bologna‐Molina, Gerardo Gilligan, Wilson Delgado‐Azañero, Arvind Babu Rajendra Santosh, Wilfredo Alejandro González‐Arriagada, Mariana Villarroel‐Dorrego, Bernardo Venegas Rojas, Karen Patri
Publicado en: Oral Diseases, Edición 21 Feb 2024, 2024, ISSN 1354-523X
Editor: Wiley-Blackwell
DOI: 10.1111/odi.14903

Squamous Cell Carcinoma of the Oral Cavity, Oropharynx, and Larynx: A Scoping Review of Treatment Guidelines Worldwide (se abrirá en una nueva ventana)

Autores: Lady Paola Aristizabal Arboleda, Genival Barbosa de Carvalho, Alan Roger Santos-Silva, Gisele Aparecida Fernandes, Jose Guilherme Vartanian, David I. Conway, Shama Virani, Paul Brennan, Luiz Paulo Kowalski, and Maria Paula Curado
Publicado en: Cancers, Edición 3 Sep 2023, 2023, Página(s) 1-13, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers15174405

The COVID-19 pandemic has not changed stage at presentation nor treatment patterns of head and neck cancer: A retrospective cohort study (se abrirá en una nueva ventana)

Autores: Kelten Clements, Anna Cowell, Gillian White, William Flynn, David I. Conway, Catriona M. Douglas, Claire Paterson
Publicado en: Clinical Otolaryngology, Edición 16 March 2023, 2023, Página(s) 587-594, ISSN 1749-4486
Editor: Wiley-Blackwell
DOI: 10.1111/coa.14048

Differential Expression of Potential Biomarkers of Oral Squamous Cell Carcinoma Development (se abrirá en una nueva ventana)

Autores: Paola Fernandes Pansini, Isabella Bittencourt do Valle, Thabata Coeli Dias Damasceno, Priscila Marinho de Abreu, Anna Clara Gregório Có, Rossana Verónica Mendoza López, Jeferson Lenzi, Ricardo Mai Rocha, Evandro Duccini Souza, Maria Paula Curado, Hisham Mehanna, Paul Nankivell, José Roberto Vasconcelos de Podestá, Sandra Ventorin von Zeidler.
Publicado en: Head and neck pathology, Edición 11 April 2021, 2021, Página(s) 1127–1136, ISSN 1936-0568
Editor: Secaucus, NJ : Humana Press
DOI: 10.1007/s12105-021-01322-8

Reviewing the epidemiology of head and neck cancer: definitions, trends and risk factors (se abrirá en una nueva ventana)

Autores: Mark Gormley, Grant Creaney, Andrew Schache, Kate Ingarfield, David I Conway
Publicado en: British Dental Journal, Edición 11 November 2022, 2022, ISSN 1476-5373
Editor: Nature Portfolio
DOI: 10.1038/s41415-022-5166-x

Head and neck cancer in the UK: what was the stage before COVID-19? UK cancer registries analysis (2011-2018) (se abrirá en una nueva ventana)

Autores: Grant Creaney, Alex D. McMahon, Alastair J. Ross, Lesley A. Bhatti, Claire Paterson, and David I. Conway
Publicado en: British Dental Journal, Edición 11 November 2022, 2022, Página(s) 787-793, ISSN 1476-5373
Editor: Nature Portfolio
DOI: 10.1038/s41415-022-5151-4

Germline determinants of humoral immune response to HPV-16 protect against oropharyngeal cancer (se abrirá en una nueva ventana)

Autores: Aida Ferreiro-Iglesias; James McKay; Nicole Brenner; Shama Virani; Corina Lesseur; Corina Lesseur; Valerie Gaborieau; Andy R Ness; Andy R Ness; Rayjean J. Hung; Geoffrey Liu; Brenda Diergaarde; Andrew F. Olshan; Neil Hayes; Mark C. Weissler; Lea Schroeder; Noemi Bender; Michael Pawlita; Steve Thomas; Miranda Pring; Tom Dudding; Beatriz Kanterewicz; Robert L. Ferris; Sera Thomas; Yonathan Brhane; V
Publicado en: Nature Communications, Edición 12 October 2021, 2021, Página(s) 1-11, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-021-26151-9

Development and external validation of a head and neck cancer risk prediction model (se abrirá en una nueva ventana)

Autores: Craig D. L. Smith, Alex D. McMahon, Donald M. Lyall, Mariel Goulart, Gareth J. Inman, Al Ross, Mark Gormley, Tom Dudding, Gary J. Macfarlane, Max Robinson, Lorenzo Richiardi, Diego Serraino, Jerry Polesel, Cristina Canova, Wolfgang Ahrens, Claire M. Healy, Pagona Lagiou, Ivana Holcatova, Laia Alemany, Ariana Znoar, Tim Waterboer, Paul Brennan, Shama Virani, David I. Conway
Publicado en: Head & Neck, Edición 46, 2024, Página(s) 2261-2273, ISSN 1043-3074
Editor: John Wiley & Sons Inc.
DOI: 10.1002/hed.27834

Latin American Consensus on the Treatment of Head and Neck Cancer (se abrirá en una nueva ventana)

Autores: Leandro Luongo Matos, Luiz Paulo Kowalski, Aline Lauda Freitas Chaves, Thiago Bueno de Oliveira, Gustavo Nader Marta, Maria Paula Curado, Gilberto de Castro Junior, Terence P. Farias, Gustavo Sarria Bardales, Mario Avila Cabrera, Renato de Castro Capuzzo, Genival Barbosa de Carvalho, Claudio Roberto Cernea, Rogério Aparecido Dedivitis, Fernando Luiz Dias, Andrés Munyo Estefan, Agustin Horacio Fa
Publicado en: JCO Global Oncology, Edición 10 April 2024, 2024, ISSN 2687-8941
Editor: Lippincott Williams & Wilkins
DOI: 10.1200/go.23.00343

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