CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.
I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .
Risultati finali
Report on utility of genetic variants to improve prediction of outcome (si apre in una nuova finestra)
White paper on biomarker assay performance (si apre in una nuova finestra)
White paper on biomarker assay performance (samples tested, cross validation, performance statistics)
Testing 800 FFPE and serology material (si apre in una nuova finestra)Report on HPV16E6 serology and recurrence prediction for HPV driven OPSCC (si apre in una nuova finestra)
SOPs for FFPE tissue accession sectioning, tissue array processing, and storage to be available on the website (si apre in una nuova finestra)
SOPs for FFPE tissue accession sectioning, tissue array processing, and storage will be available to all members on the HEADSpAcE project website
Report on immunological profile of oropharyngeal cases (si apre in una nuova finestra)Report of genome-wide association study of oral and oropharyngeal cancer (si apre in una nuova finestra)
Scientific publication on prognostic value of lifestyle, clinical and genetic factors in OPC patients by HPV status (si apre in una nuova finestra)
Updated report on biorepository availability (si apre in una nuova finestra)
Annual report on biorepository availability including new recruitment and followup
Design panel including targeted regions and primer sequences freely available for all scientific community (si apre in una nuova finestra)***FUNDING DEPENDENT - This report will be delivered only if funds are made available to Brazil-based partner receiving no EU funding, INCA.***Design panel including targeted regions and primer sequences freely available for all scientific community
Report on transcriptomic analysis on 400 cases (si apre in una nuova finestra)Statistical analyses reports (si apre in una nuova finestra)
Statistical analyses reports comparing HPV analysis region lifestyle and clinical factors
Workshop on HPV16 E6 ELISA assay (si apre in una nuova finestra)A 2-day hands-on workshop on HPV16 E6 ELISA assay for all WP3 participating centers will be organized in Heidelberg
Report of second scientific meeting (si apre in una nuova finestra)Report of second scientific meeting of HEADSpAcE
Workshop on tissue array processing and good practices in IHC techniques (si apre in una nuova finestra)A 2-day workshop on tissue array processing and good practices in IHC techniques for all HEADSpAcE participating centers will be organized in Bogotá, in particular for clinical institutions with pathology services
Report on assessment of risk determinants of late stage head and neck cancer diagnosis (si apre in una nuova finestra)Report on assessment of risk determinants of late stage head and neck cancer diagnosis – to identify relative importance and interactions of socioeconomic, logistic, and biological factors; and to identify potential areas and timing of interventions to achieve early detection and diagnosis
Report on HPV-driven fraction in OPC in Europe and Latin America, determinants and time-trends of HPV-positivity (si apre in una nuova finestra)Protocol for prospective recruitment of 1100 HNC cases in Europe and SA (si apre in una nuova finestra)
Selection of 800 cases for comprehensive genomic analysis (si apre in una nuova finestra)
Selection of 800 cases for comprehensive genomic analysis including 200 cases from Europe and 600 from South America
Development of head and neck cancer referral pathways guideline recommendations (si apre in una nuova finestra)Development of head and neck cancer referral pathways guideline recommendations – to provide evidence to inform policy and practice, tailored to countries across study
Report of a validated protocol with guidelines for in situ hybridization to E6/E7 mRNA (si apre in una nuova finestra)Updated report on communication strategy (si apre in una nuova finestra)
Updated report on the communication strategy at M66
Annual report on the communication strategy (si apre in una nuova finestra)Annual report on the communication strategy on M12, M24, M36, and M48
Report on rigorous bioinformatics analysis and contribution on prognostic factors (si apre in una nuova finestra)Report on rigorous bioinformatics analysis and contribution to WP4 on prognostic factors
Report of first scientific meeting (si apre in una nuova finestra)Report of first scientific meeting of HEADSpAcE
Report on clinical biomarkers classification of HPV driven oropharyngeal cancers (si apre in una nuova finestra)Development of protocol for patient interviews (si apre in una nuova finestra)
Development of protocol for patient interviews to obtain information of reasons for delay in diagnosis
Annual report on biorepository availability (si apre in una nuova finestra)Annual report on biorepository availability, including new recruitment and follow-up. Will be due on M12, M24, M36, and M48.
Evaluation of national and international treatment protocols (si apre in una nuova finestra)Report on epigenetic analysis on 800 cases (si apre in una nuova finestra)
Report on epigenetic analysis on 100 cases
Report on in-depth comparison between two centres on infrastructure causes of delay to diagnosis (si apre in una nuova finestra)Report on indepth comparison between two centres on infrastructure causes of delay to diagnosis
SOPs for plasma collection, processing, and storage on the website (si apre in una nuova finestra)SOPs for plasma collection, processing, and storage will be available to all members on the HEADSpAcE project website
Report on ELISA assay validation (si apre in una nuova finestra)Development of a reference standard for HPV16 E6 (si apre in una nuova finestra)
Development of a reference standard for HPV16 E6 for international harmonization of HPV16 E6 serology
Report on ctDNA detection for monitoring Head and Neck cancer (si apre in una nuova finestra)Development of ethics guidelines, documents and procedures (si apre in una nuova finestra)
Development of ethics guidelines, documents and procedures. Ethics guidelines will be developed by M3. Rules of data protection will be established at inception. The ethics guidelines will be posted in the website and regularly monitored
Report on the utility of genomic information on clinical prediction (si apre in una nuova finestra)Report on analysis of rare variants and sequencing follow-up (si apre in una nuova finestra)
Report on exome sequencing analysis of 800 cases (si apre in una nuova finestra)
Summary of sample management systems available in centers with HNC biorepositories (si apre in una nuova finestra)
Summary of sample management systems available in centers with HNC biorepositories, ensuring compatibility of all systems
Development of project website (si apre in una nuova finestra)
Development of project website. Website will be subsequently updated regularly when new reports,documents,outcome will become available
Publicly available genome-wide association summary statistics for oral and pharyngeal cancer survival (si apre in una nuova finestra)Data management plan including the organisation and coordination of biosample and data sharing between partner institutes
Pubblicazioni
Autori:
Kelten Clements, Alekh Thapa, Anna Cowell, David Conway, Catriona M Douglas, Claire Paterson
Pubblicato in:
Clinical Otolaryngology, Numero 49, 2024, Pagina/e 363-375, ISSN 1749-4478
Editore:
Blackwell Publishing Inc.
DOI:
10.1111/coa.14152
Autori:
Maja Popovic, Valentina Fiano, Giovenale Moirano, Luigi Chiusa, David I. Conway, Paolo Garzino Demo, Marco Gilardetti, Giuseppe Carlo Iorio, Chiara Moccia, Oliviero Ostellino, Giancarlo Pecorari, Guglielmo Ramieri, Umberto Ricardi, Giuseppe Riva, Shama Virani, Lorenzo Richiardi
Pubblicato in:
Frontiers in public health, Numero 21 Feb 2022, 2022, Pagina/e 1-10, ISSN 2296-2565
Editore:
Frontiers Media
DOI:
10.3389/fpubh.2022.809283
Autori:
Josefina Martínez‐Ramírez, Cristina Saldivia‐Siracusa, Leonor‐Victoria González‐Pérez, Florence Juana Maria Cuadra Zelaya, Roberto Gerber‐Mora, Osmani Fabricio Guevara Cabrera, Ronell Bologna‐Molina, Gerardo Gilligan, Wilson Delgado‐Azañero, Arvind Babu Rajendra Santosh, Wilfredo Alejandro González‐Arriagada, Mariana Villarroel‐Dorrego, Bernardo Venegas Rojas, Karen Patri
Pubblicato in:
Oral Diseases, Numero 21 Feb 2024, 2024, ISSN 1354-523X
Editore:
Wiley-Blackwell
DOI:
10.1111/odi.14903
Autori:
Lady Paola Aristizabal Arboleda, Genival Barbosa de Carvalho, Alan Roger Santos-Silva, Gisele Aparecida Fernandes, Jose Guilherme Vartanian, David I. Conway, Shama Virani, Paul Brennan, Luiz Paulo Kowalski, and Maria Paula Curado
Pubblicato in:
Cancers, Numero 3 Sep 2023, 2023, Pagina/e 1-13, ISSN 2072-6694
Editore:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/cancers15174405
Autori:
Kelten Clements, Anna Cowell, Gillian White, William Flynn, David I. Conway, Catriona M. Douglas, Claire Paterson
Pubblicato in:
Clinical Otolaryngology, Numero 16 March 2023, 2023, Pagina/e 587-594, ISSN 1749-4486
Editore:
Wiley-Blackwell
DOI:
10.1111/coa.14048
Autori:
Paola Fernandes Pansini, Isabella Bittencourt do Valle, Thabata Coeli Dias Damasceno, Priscila Marinho de Abreu, Anna Clara Gregório Có, Rossana Verónica Mendoza López, Jeferson Lenzi, Ricardo Mai Rocha, Evandro Duccini Souza, Maria Paula Curado, Hisham Mehanna, Paul Nankivell, José Roberto Vasconcelos de Podestá, Sandra Ventorin von Zeidler.
Pubblicato in:
Head and neck pathology, Numero 11 April 2021, 2021, Pagina/e 1127–1136, ISSN 1936-0568
Editore:
Secaucus, NJ : Humana Press
DOI:
10.1007/s12105-021-01322-8
Autori:
Mark Gormley, Grant Creaney, Andrew Schache, Kate Ingarfield, David I Conway
Pubblicato in:
British Dental Journal, Numero 11 November 2022, 2022, ISSN 1476-5373
Editore:
Nature Portfolio
DOI:
10.1038/s41415-022-5166-x
Autori:
Grant Creaney, Alex D. McMahon, Alastair J. Ross, Lesley A. Bhatti, Claire Paterson, and David I. Conway
Pubblicato in:
British Dental Journal, Numero 11 November 2022, 2022, Pagina/e 787-793, ISSN 1476-5373
Editore:
Nature Portfolio
DOI:
10.1038/s41415-022-5151-4
Autori:
Aida Ferreiro-Iglesias; James McKay; Nicole Brenner; Shama Virani; Corina Lesseur; Corina Lesseur; Valerie Gaborieau; Andy R Ness; Andy R Ness; Rayjean J. Hung; Geoffrey Liu; Brenda Diergaarde; Andrew F. Olshan; Neil Hayes; Mark C. Weissler; Lea Schroeder; Noemi Bender; Michael Pawlita; Steve Thomas; Miranda Pring; Tom Dudding; Beatriz Kanterewicz; Robert L. Ferris; Sera Thomas; Yonathan Brhane; V
Pubblicato in:
Nature Communications, Numero 12 October 2021, 2021, Pagina/e 1-11, ISSN 2041-1723
Editore:
Nature Publishing Group
DOI:
10.1038/s41467-021-26151-9
Autori:
Craig D. L. Smith, Alex D. McMahon, Donald M. Lyall, Mariel Goulart, Gareth J. Inman, Al Ross, Mark Gormley, Tom Dudding, Gary J. Macfarlane, Max Robinson, Lorenzo Richiardi, Diego Serraino, Jerry Polesel, Cristina Canova, Wolfgang Ahrens, Claire M. Healy, Pagona Lagiou, Ivana Holcatova, Laia Alemany, Ariana Znoar, Tim Waterboer, Paul Brennan, Shama Virani, David I. Conway
Pubblicato in:
Head & Neck, Numero 46, 2024, Pagina/e 2261-2273, ISSN 1043-3074
Editore:
John Wiley & Sons Inc.
DOI:
10.1002/hed.27834
Autori:
Leandro Luongo Matos, Luiz Paulo Kowalski, Aline Lauda Freitas Chaves, Thiago Bueno de Oliveira, Gustavo Nader Marta, Maria Paula Curado, Gilberto de Castro Junior, Terence P. Farias, Gustavo Sarria Bardales, Mario Avila Cabrera, Renato de Castro Capuzzo, Genival Barbosa de Carvalho, Claudio Roberto Cernea, Rogério Aparecido Dedivitis, Fernando Luiz Dias, Andrés Munyo Estefan, Agustin Horacio Fa
Pubblicato in:
JCO Global Oncology, Numero 10 April 2024, 2024, ISSN 2687-8941
Editore:
Lippincott Williams & Wilkins
DOI:
10.1200/go.23.00343
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