Translational studies of HEAD and neck cancer in South America and Europe

Projektinformationen

HEADSpAcE

ID Finanzhilfevereinbarung: 825771

DOI

10.3030/825771

Projekt abgeschlossen

EK-Unterschriftsdatum 14 Dezember 2018

Startdatum 1 Januar 2019

Enddatum 30 Juni 2024

Finanziert unter

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Gesamtkosten

€ 4 097 233,75

EU-Beitrag

€ 3 153 447,50

Koordiniert durch

CENTRE INTERNATIONAL DE RECHERCHE SUR LE CANCER
France

CORDIS bietet Links zu öffentlichen Ergebnissen und Veröffentlichungen von HORIZONT-Projekten.

Links zu Ergebnissen und Veröffentlichungen von RP7-Projekten sowie Links zu einigen Typen spezifischer Ergebnisse wie Datensätzen und Software werden dynamisch von OpenAIRE abgerufen.

Leistungen

Documents, reports (41)

Development of communication strategy
Report on utility of genetic variants to improve prediction of outcome
White paper on biomarker assay performance

White paper on biomarker assay performance (samples tested, cross validation, performance statistics)

Testing 800 FFPE and serology material
Report on HPV16E6 serology and recurrence prediction for HPV driven OPSCC
SOPs for FFPE tissue accession sectioning, tissue array processing, and storage to be available on the website

SOPs for FFPE tissue accession sectioning, tissue array processing, and storage will be available to all members on the HEADSpAcE project website

Report on immunological profile of oropharyngeal cases
Report of genome-wide association study of oral and oropharyngeal cancer
Scientific publication on prognostic value of lifestyle, clinical and genetic factors in OPC patients by HPV status
Updated report on biorepository availability

Annual report on biorepository availability including new recruitment and followup

Design panel including targeted regions and primer sequences freely available for all scientific community

***FUNDING DEPENDENT - This report will be delivered only if funds are made available to Brazil-based partner receiving no EU funding, INCA.***Design panel including targeted regions and primer sequences freely available for all scientific community

Report on transcriptomic analysis on 400 cases
Statistical analyses reports

Statistical analyses reports comparing HPV analysis region lifestyle and clinical factors

Workshop on HPV16 E6 ELISA assay

A 2-day hands-on workshop on HPV16 E6 ELISA assay for all WP3 participating centers will be organized in Heidelberg

Report of second scientific meeting

Report of second scientific meeting of HEADSpAcE

Workshop on tissue array processing and good practices in IHC techniques

A 2-day workshop on tissue array processing and good practices in IHC techniques for all HEADSpAcE participating centers will be organized in Bogotá, in particular for clinical institutions with pathology services

Report on assessment of risk determinants of late stage head and neck cancer diagnosis

Report on assessment of risk determinants of late stage head and neck cancer diagnosis – to identify relative importance and interactions of socioeconomic, logistic, and biological factors; and to identify potential areas and timing of interventions to achieve early detection and diagnosis

Report on HPV-driven fraction in OPC in Europe and Latin America, determinants and time-trends of HPV-positivity
Protocol for prospective recruitment of 1100 HNC cases in Europe and SA
Selection of 800 cases for comprehensive genomic analysis

Selection of 800 cases for comprehensive genomic analysis including 200 cases from Europe and 600 from South America

Development of head and neck cancer referral pathways guideline recommendations

Development of head and neck cancer referral pathways guideline recommendations – to provide evidence to inform policy and practice, tailored to countries across study

Report of a validated protocol with guidelines for in situ hybridization to E6/E7 mRNA
Updated report on communication strategy

Updated report on the communication strategy at M66

Annual report on the communication strategy

Annual report on the communication strategy on M12, M24, M36, and M48

Report on rigorous bioinformatics analysis and contribution on prognostic factors

Report on rigorous bioinformatics analysis and contribution to WP4 on prognostic factors

Report of first scientific meeting

Report of first scientific meeting of HEADSpAcE

Report on clinical biomarkers classification of HPV driven oropharyngeal cancers
Development of protocol for patient interviews

Development of protocol for patient interviews to obtain information of reasons for delay in diagnosis

Annual report on biorepository availability

Annual report on biorepository availability, including new recruitment and follow-up. Will be due on M12, M24, M36, and M48.

Evaluation of national and international treatment protocols
Report on epigenetic analysis on 800 cases

Report on epigenetic analysis on 100 cases

Report on in-depth comparison between two centres on infrastructure causes of delay to diagnosis

Report on indepth comparison between two centres on infrastructure causes of delay to diagnosis

SOPs for plasma collection, processing, and storage on the website

SOPs for plasma collection, processing, and storage will be available to all members on the HEADSpAcE project website

Report on ELISA assay validation
Development of a reference standard for HPV16 E6

Development of a reference standard for HPV16 E6 for international harmonization of HPV16 E6 serology

Report on ctDNA detection for monitoring Head and Neck cancer
Development of ethics guidelines, documents and procedures

Development of ethics guidelines, documents and procedures. Ethics guidelines will be developed by M3. Rules of data protection will be established at inception. The ethics guidelines will be posted in the website and regularly monitored

Report on the utility of genomic information on clinical prediction
Report on analysis of rare variants and sequencing follow-up
Report on exome sequencing analysis of 800 cases
Summary of sample management systems available in centers with HNC biorepositories

Summary of sample management systems available in centers with HNC biorepositories, ensuring compatibility of all systems

Websites, patent fillings, videos etc. (3)

Public release of data via EGA, DbGAP and ICGC
Development of project website

Development of project website. Website will be subsequently updated regularly when new reports,documents,outcome will become available

Publicly available genome-wide association summary statistics for oral and pharyngeal cancer survival

Open Research Data Pilot (1)

Data management plan

Data management plan including the organisation and coordination of biosample and data sharing between partner institutes

Veröffentlichungen

Peer reviewed articles (11)

Impact of the COVID‐19 pandemic on stage and incidence of head and neck cancer: A rapid review and meta‐analysis

Autoren: Kelten Clements, Alekh Thapa, Anna Cowell, David Conway, Catriona M Douglas, Claire Paterson
Veröffentlicht in: Clinical Otolaryngology, Ausgabe 49, 2024, Seite(n) 363-375, ISSN 1749-4478
Herausgeber: Blackwell Publishing Inc.
DOI: 10.1111/coa.14152

The Impact of the COVID-19 Pandemic on Head and Neck Cancer Diagnosis in the Piedmont Region, Italy: Interrupted Time-Series Analysis

Autoren: Maja Popovic, Valentina Fiano, Giovenale Moirano, Luigi Chiusa, David I. Conway, Paolo Garzino Demo, Marco Gilardetti, Giuseppe Carlo Iorio, Chiara Moccia, Oliviero Ostellino, Giancarlo Pecorari, Guglielmo Ramieri, Umberto Ricardi, Giuseppe Riva, Shama Virani, Lorenzo Richiardi
Veröffentlicht in: Frontiers in public health, Ausgabe 21 Feb 2022, 2022, Seite(n) 1-10, ISSN 2296-2565
Herausgeber: Frontiers Media
DOI: 10.3389/fpubh.2022.809283

Barriers to early diagnosis and management of oral cancer in Latin America and the Caribbean

Autoren: Josefina Martínez‐Ramírez, Cristina Saldivia‐Siracusa, Leonor‐Victoria González‐Pérez, Florence Juana Maria Cuadra Zelaya, Roberto Gerber‐Mora, Osmani Fabricio Guevara Cabrera, Ronell Bologna‐Molina, Gerardo Gilligan, Wilson Delgado‐Azañero, Arvind Babu Rajendra Santosh, Wilfredo Alejandro González‐Arriagada, Mariana Villarroel‐Dorrego, Bernardo Venegas Rojas, Karen Patri
Veröffentlicht in: Oral Diseases, Ausgabe 21 Feb 2024, 2024, ISSN 1354-523X
Herausgeber: Wiley-Blackwell
DOI: 10.1111/odi.14903

Squamous Cell Carcinoma of the Oral Cavity, Oropharynx, and Larynx: A Scoping Review of Treatment Guidelines Worldwide

Autoren: Lady Paola Aristizabal Arboleda, Genival Barbosa de Carvalho, Alan Roger Santos-Silva, Gisele Aparecida Fernandes, Jose Guilherme Vartanian, David I. Conway, Shama Virani, Paul Brennan, Luiz Paulo Kowalski, and Maria Paula Curado
Veröffentlicht in: Cancers, Ausgabe 3 Sep 2023, 2023, Seite(n) 1-13, ISSN 2072-6694
Herausgeber: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers15174405

The COVID-19 pandemic has not changed stage at presentation nor treatment patterns of head and neck cancer: A retrospective cohort study

Autoren: Kelten Clements, Anna Cowell, Gillian White, William Flynn, David I. Conway, Catriona M. Douglas, Claire Paterson
Veröffentlicht in: Clinical Otolaryngology, Ausgabe 16 March 2023, 2023, Seite(n) 587-594, ISSN 1749-4486
Herausgeber: Wiley-Blackwell
DOI: 10.1111/coa.14048

Differential Expression of Potential Biomarkers of Oral Squamous Cell Carcinoma Development

Autoren: Paola Fernandes Pansini, Isabella Bittencourt do Valle, Thabata Coeli Dias Damasceno, Priscila Marinho de Abreu, Anna Clara Gregório Có, Rossana Verónica Mendoza López, Jeferson Lenzi, Ricardo Mai Rocha, Evandro Duccini Souza, Maria Paula Curado, Hisham Mehanna, Paul Nankivell, José Roberto Vasconcelos de Podestá, Sandra Ventorin von Zeidler.
Veröffentlicht in: Head and neck pathology, Ausgabe 11 April 2021, 2021, Seite(n) 1127–1136, ISSN 1936-0568
Herausgeber: Secaucus, NJ : Humana Press
DOI: 10.1007/s12105-021-01322-8

Reviewing the epidemiology of head and neck cancer: definitions, trends and risk factors

Autoren: Mark Gormley, Grant Creaney, Andrew Schache, Kate Ingarfield, David I Conway
Veröffentlicht in: British Dental Journal, Ausgabe 11 November 2022, 2022, ISSN 1476-5373
Herausgeber: Nature Portfolio
DOI: 10.1038/s41415-022-5166-x

Head and neck cancer in the UK: what was the stage before COVID-19? UK cancer registries analysis (2011-2018)

Autoren: Grant Creaney, Alex D. McMahon, Alastair J. Ross, Lesley A. Bhatti, Claire Paterson, and David I. Conway
Veröffentlicht in: British Dental Journal, Ausgabe 11 November 2022, 2022, Seite(n) 787-793, ISSN 1476-5373
Herausgeber: Nature Portfolio
DOI: 10.1038/s41415-022-5151-4

Germline determinants of humoral immune response to HPV-16 protect against oropharyngeal cancer

Autoren: Aida Ferreiro-Iglesias; James McKay; Nicole Brenner; Shama Virani; Corina Lesseur; Corina Lesseur; Valerie Gaborieau; Andy R Ness; Andy R Ness; Rayjean J. Hung; Geoffrey Liu; Brenda Diergaarde; Andrew F. Olshan; Neil Hayes; Mark C. Weissler; Lea Schroeder; Noemi Bender; Michael Pawlita; Steve Thomas; Miranda Pring; Tom Dudding; Beatriz Kanterewicz; Robert L. Ferris; Sera Thomas; Yonathan Brhane; V
Veröffentlicht in: Nature Communications, Ausgabe 12 October 2021, 2021, Seite(n) 1-11, ISSN 2041-1723
Herausgeber: Nature Publishing Group
DOI: 10.1038/s41467-021-26151-9

Development and external validation of a head and neck cancer risk prediction model

Autoren: Craig D. L. Smith, Alex D. McMahon, Donald M. Lyall, Mariel Goulart, Gareth J. Inman, Al Ross, Mark Gormley, Tom Dudding, Gary J. Macfarlane, Max Robinson, Lorenzo Richiardi, Diego Serraino, Jerry Polesel, Cristina Canova, Wolfgang Ahrens, Claire M. Healy, Pagona Lagiou, Ivana Holcatova, Laia Alemany, Ariana Znoar, Tim Waterboer, Paul Brennan, Shama Virani, David I. Conway
Veröffentlicht in: Head & Neck, Ausgabe 46, 2024, Seite(n) 2261-2273, ISSN 1043-3074
Herausgeber: John Wiley & Sons Inc.
DOI: 10.1002/hed.27834

Latin American Consensus on the Treatment of Head and Neck Cancer

Autoren: Leandro Luongo Matos, Luiz Paulo Kowalski, Aline Lauda Freitas Chaves, Thiago Bueno de Oliveira, Gustavo Nader Marta, Maria Paula Curado, Gilberto de Castro Junior, Terence P. Farias, Gustavo Sarria Bardales, Mario Avila Cabrera, Renato de Castro Capuzzo, Genival Barbosa de Carvalho, Claudio Roberto Cernea, Rogério Aparecido Dedivitis, Fernando Luiz Dias, Andrés Munyo Estefan, Agustin Horacio Fa
Veröffentlicht in: JCO Global Oncology, Ausgabe 10 April 2024, 2024, ISSN 2687-8941
Herausgeber: Lippincott Williams & Wilkins
DOI: 10.1200/go.23.00343