Sarcoma as a model to improve diagnosis and clinical care of rare tumors through a European and Latin American multidisciplinary network

Informazioni relative al progetto

SELNET

ID dell’accordo di sovvenzione: 825806

DOI 10.3030/825806

Progetto chiuso

Data della firma CE 14 Dicembre 2018

Data di avvio 1 Gennaio 2019

Data di completamento 31 Dicembre 2023

Finanziato da

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Costo totale € 3 294 306,01

Contributo UE € 3 092 400,00

Coordinato da

INSTITUTO INVESTIGACION SANITARIA FUNDACION JIMENEZ DIAZ
Spain

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (28)

Strategic actions results report
EC/IRB/RA approvals and SIV report

EC/IRB/RA approvals and SIV report Note:This deliverable will include a First study subject approvals package including study protocol, registration number of the study in a WHO- or ICMJE registry.

Report on final results report for STS, BS, and GIST cohorts

Report on Final results report for STS BS and GIST cohortsNote This deliverable will include a midterm recruitment report when 50 of the study population is recruited In addition D64 will include a report on status of posting results This also applies to the rare sarcoma cohort single protocol unites all cohorts

Report on the international platform for preclinical research
Second opinion activity report
Update on clinical guidelines

Update on clinical guidelines on sarcoma patient management

Project website up and running
Project handbook
Report on written feedback from ethics advisory board
Plan for Using and Disseminating Foreground
Sarcoma Specialist Center requirements report
Validated web-based registry tool

Report on validated web-based registry tool

Interim report on dissemination activities
Pathologic peer review results report
Consortium CPGs

Consortium CPGs - clinical guidelines on sarcoma patient management

SELNET virtual biobank report
Report on Minutes and presentations of relevant Project meetings
Foundation of Latin American sarcoma network report
Report on locked database for STS, BS, and GIST cohorts

locked database for STS BS and GIST cohorts

Healthcare providers report

Healthcare providers/barriers report

Sarcoma courses report

D52 Sarcoma courses report month 24 and 36

Strategic actions plan
Risk assessment procedure report
Final results report for translational study in rare sarcomas
Communication Plan
Clinical and translational trainings report
Final report of accreditation results in each country
Final dissemination report

Open Research Data Pilot (1)

Diagnosis networks creation report

Pubblicazioni

Peer reviewed articles (23)

Phase II trial of CDK4/6 inhibitor palbociclib in advanced sarcoma based on mRNA expression of CDK4/ CDKN2A

Autori: Martin-Broto J, Martinez-Garcia J, Moura DS, Redondo A, Gutierrez A, Lopez-Pousa A, Martinez-Trufero J, Sevilla I, Diaz-Beveridge R, Solis-Hernandez MP, Carnero A, Perez M, Marcilla D, Garcia-Foncillas J, Romero P, Fernandez-Jara J, Lopez-Lopez D, Arribas I, Hindi N
Pubblicato in: Signal Transduct Target Ther, 2023, ISSN 2059-3635
Editore: Springer Nature
DOI: 10.1038/s41392-023-01661-8

Platinum-Based Regimens Are Active in Advanced Pediatric-Type Rhabdomyosarcoma in Adults and Depending on HMGB1 Expression

Autori: Hindi N, Carrillo-García J, Blanco-Alcaina E, Renshaw M, Luna P, Durán J, Jiménez N, Sancho P, Ramos R, Moura DS, Martín-Broto J
Pubblicato in: Int J Mol Sci, 2022, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24010856

Extraskeletal Myxoid Chondrosarcoma: State of the Art and Current Research on Biology and Clinical Management.

Autori: Stacchiotti S, Baldi GG, Morosi C, Gronchi A, Maestro R.
Pubblicato in: Cancers, 2020, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12092703

Efficacy of Eribulin Plus Gemcitabine Combination in L-Sarcomas

Autori: López-Álvarez M, González-Aguilera C, Moura DS, Sánchez-Bustos P, Mondaza-Hernández JL, Martín-Ruiz M, Renshaw M, Ramos R, Castilla C, Blanco-Alcaina E, Hindi N, Martín-Broto J
Pubblicato in: Int J Mol Sci, 2022, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24010680

Efficacy of immune checkpoint inhibitors in alveolar soft-part sarcoma: results from a retrospective worldwide registry

Autori: Hindi N, Razak A, Rosenbaum E, Jonczak E, Hamacher R, Rutkowski P, Bhadri VA, Skryd A, Brahmi M, Alshibany A, Jagodzinska-Mucha P, Bauer S, Connolly E, Gelderblom H, Boye K, Henon C, Bae S, Bogefors K, Vincenzi B, Martinez-Trufero J, Lopez-Martin JA, Redondo A, Valverde C, Blay JY, Moura DS, Gutierrez A, Tap W, Martin-Broto J
Pubblicato in: ESMO Open, 2023, ISSN 2059-7029
Editore: Elsevier Ltd.
DOI: 10.1016/j.esmoop.2023.102045

Peripheral Inflammatory Indexes Neutrophil/Lymphocyte Ratio (NLR) and Red Cell DistributionWidth (RDW) as Prognostic Biomarkers in Advanced Solitary Fibrous Tumour (SFT) Treated withPazopanib.

Autori: Hidalgo-Ríos S, Carrillo-García J, Moura DS, Stacchiotti S, López-Pousa A, Redondo A, Italiano A, Gutiérrez A, Grignani G, Hindi N, López-Guerrero JA, Muro XGD, Trufero JM, Palmerini E, García AS, Bernabeu D, Le Cesne A, Casali PG, Blay JY, Cruz Jurado J, Martin-Broto J.
Pubblicato in: Cancers (Basel), 2022, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14174186

A Comprehensive Review on Solitary Fibrous Tumor: New Insights for New Horizons.

Autori: Martin-Broto J, Mondaza-Hernandez JL, Moura DS, Hindi N.
Pubblicato in: Cancers, 2021, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13122913

Rare Primary Malignant Bone Sarcomas

Autori: Emanuela Palmerini; Alberto Righi; Eric L. Staals
Pubblicato in: Cancers, Numero 1, 2020, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12113092

Desmoplastic Small Round Cell Tumor: A Review of Main Molecular Abnormalities and Emerging Therapy.

Autori: Celso Abdon Lopes de Mello; Fernando Augusto Batista Campos; Tiago G. Santos; Maria Leticia Gobo Silva; Giovana Tardin Torrezan; Felipe D'Almeida Costa; Maria Nirvana Formiga; Ulisses Ribaldo Nicolau; Antonio Geraldo Nascimento; Cassia Silva; Suely Akiko Nakagawa; Maria Paula Curado; Ademar Lopes; Samuel Aguiar
Pubblicato in: Cancers, Numero 1, 2021, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13030498

Sarcoma European and Latin American Network (SELNET) Recommendations on Prioritization in Sarcoma Care During the COVID-19 Pandemic

Autori: Javier Martin-Broto; Nadia Hindi; Samuel Aguiar; Ronald Badilla-González; Victor Castro-Oliden; Matías Chacón; Raquel Correa-Generoso; Enrique de Álava; Davide Maria Donati; Mikael Eriksson; Martin Falla-Jimenez; Gisela German; Maria Leticia Gobo Silva; François Gouin; Alessandro Gronchi; Juan Carlos Haro-Varas; Natalia Jiménez-Brenes; Bernd Kasper; Celso Abdon Lopes de Mello; Robert G. Maki
Pubblicato in: The Oncologist, Numero 1, 2020, ISSN 1083-7159
Editore: AlphaMed Press Inc
DOI: 10.1634/theoncologist.2020-0516

Pazopanib for treatment of typical solitary fibrous tumours: a multicentre, single-arm, phase 2 trial

Autori: Martin-Broto J, Cruz J, Penel N, Le Cesne A, Hindi N, Luna P, Moura DS, Bernabeu D, de Alava E, Lopez-Guerrero JA, Dopazo J, Peña-Chilet M, Gutierrez A, Collini P, Karanian M, Redondo A, Lopez-Pousa A, Grignani G, Diaz-Martin J, Marcilla D, Fernandez-Serra A, Gonzalez-Aguilera C, Casali PG, Blay JY, Stacchiotti S.
Pubblicato in: Lancet Oncol, 2020, ISSN 1470-2045
Editore: The Lancet Publishing Group
DOI: 10.1016/s1470-2045(19)30826-5

A phase II trial of weekly nab-paclitaxel for progressive and symptomatic desmoid tumors

Autori: Martin-Broto J, Redondo A, Moura DS, Valverde C, Morales JM, Lopez-Pousa A, Martinez-Trufero J, Gutierrez A, Díaz-Beveridge R, Luna P, Martinez-Marin V, Marcilla D, Arribas I, Ledesma P, Lopez-Martin JA, Di Lernia D, Zamora J, Hindi N
Pubblicato in: Nat Commun, 2022, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-022-33975-6

REGISTRI: Regorafenib in first-line of KIT/PDGFRA wild type metastatic GIST: a collaborative Spanish (GEIS), Italian (ISG) and French Sarcoma Group (FSG) phase II trial

Autori: Martin-Broto J, Valverde C, Hindi N, Vincenzi B, Martinez-Trufero J, Grignani G, Italiano A, Lavernia J, Vallejo A, Tos PD, Le Loarer F, Gonzalez-Campora R, Ramos R, Hernández-Jover D, Gutierrez A, Serrano C, Monteagudo M, Letón R, Robledo M, Moura DS, Martin-Ruiz M, López-Guerrero JA, Cruz J, Fernandez-Serra A, Blay JY, Fumagalli E, Martinez-Marin V
Pubblicato in: Mol Cancer, 2023, ISSN 1476-4598
Editore: BioMed Central
DOI: 10.1186/s12943-023-01832-9

SELNET clinical practice guidelines for bone sarcoma

Autori: Blay JY, Palmerini E, Bollard J, Aguiar S, Angel M, Araya B, Badilla R, Bernabeu D, Campos F, Chs CS, Carvajal Montoya A, Casavilca-Zambrano S, Castro-Oliden 5th, Chacón M, Clara-Altamirano MA, Collini P, Correa Genoroso R, Costa FD, Cuellar M, Dei Tos AP, Dominguez Malagon HR, Donati DM, Dufresne A, Eriksson M, Farias-Loza M, Frezza AM, Frisoni T, Garcia-Ortega DY, Gerderblom H, Gouin F, Gómez-
Pubblicato in: Crit Rev Oncol Hematol, 2022, ISSN 1040-8428
Editore: Elsevier BV
DOI: 10.1016/j.critrevonc.2022.103685

High Dose Ifosfamide in Relapsed and Unresectable High-Grade Osteosarcoma Patients: A Retrospective Series.

Autori: Palmerini E, Setola E, Grignani G, D'Ambrosio L, Comandone A, Righi A, Longhi A, Cesari M, Paioli A, Hakim R, Pierini M, Marchesi E, Vanel D, Pignochino Y, Donati DM, Picci P, Ferrari S.
Pubblicato in: Cells, 2020, ISSN 2073-4409
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cells9112389

Circulating TNF-RII, IP-10 and HGF are associated with severity of COVID-19 in oncologic patients.

Autori: arrillo-García J, Lacerenza S, Hindi N, Moura DS, Marquina G, Parra Corral D, Olalla J, María Cano Cano J, Hoyos S, Renshaw M, Mondaza-Hernández JL, Di Lernia D, Casado A, Manzano A, Gutierrez A, Martin-Broto J
Pubblicato in: Cytokine, 2024, ISSN 1096-0023
Editore: Cytokine
DOI: 10.1016/j.cyto.2024.156542

Desmoid-Type Fibromatosis

Autori: Garcia-Ortega DY, Martín-Tellez KS, Cuellar-Hubbe M, Martínez-Said H, Álvarez-Cano A, Brener-Chaoul M, Alegría-Baños JA, Martínez-Tlahuel JL.
Pubblicato in: Cancers, 2020, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12071851

Trabectedin Plus Radiotherapy for Advanced Soft-Tissue Sarcoma: Experience in Forty Patients Treated at a Sarcoma Reference Center.

Autori: Hindi N, Carrasco García I, Sánchez-Camacho A, Gutierrez A, Peinado J, Rincón I, Benedetti J, Sancho P, Santos P, Sánchez-Bustos P, Marcilla D, Encinas V, Chacon S, Muñoz-Casares C, Moura D, Martin-Broto J.
Pubblicato in: Cancers, 2020, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12123740

A Novel NFIX-STAT6 Gene Fusion in Solitary Fibrous Tumor: A Case Report

Autori: David S Moura, Juan Díaz-Martín, Silvia Bagué, Ruth Orellana-Fernandez, Ana Sebio, Jose L Mondaza-Hernandez, Carmen Salguero-Aranda, Federico Rojo, Nadia Hindi, Christopher D M Fletcher, Javier Martin-Broto
Pubblicato in: Int J Mol Sci, 2021, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22147514

Uncommon Subtypes of Malignant Melanomas: A Review Based on Clinical and Molecular Perspectives

Autori: Chacón M, Pfluger Y, Angel M, Waisberg F, Enrico D
Pubblicato in: Cancers, 2020, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13071557

ISG15 as a prognostic biomarker in solitary fibrous tumour

Autori: Mondaza-Hernandez JL, Moura DS, Lopez-Alvarez M, Sanchez-Bustos P, Blanco-Alcaina E, Castilla-Ramirez C, Collini P, Merino-Garcia J, Zamora J, Carrillo-Garcia J, Maestro R, Hindi N, Garcia-Foncillas J, Martin-Broto J.
Pubblicato in: Cell Mol Life Sci, 2022, ISSN 1420-682X
Editore: Birkhauser Verlag
DOI: 10.1007/s00018-022-04454-4

SELNET clinical practice guidelines for soft tissue sarcoma and GIST.

Autori: Jean-Yves Blay; Nadia Hindi; J. Bollard; S. Aguiar; M. Angel; B. Araya; R. Badilla; Daniel Bernabeu; F. Campos; Claudia Haydee Sarai Caro-Sánchez; B. Carvajal; A. Carvajal Montoya; S. Casavilca-Zambrano; V. Castro-Oliden; M. Chacón; M. Clara; Paola Collini; R. Correa Genoroso; F. D. Costa; M. Cuellar; A. P. Dei Tos; H. R. Dominguez Malagon; D. Donati; Armelle Dufresne; Mikael Eriksson; M. Farias
Pubblicato in: reponame:r-IIB SANT PAU: Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau, Numero 1, 2021, ISSN 0305-7372
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.ctrv.2021.102312

Antiangiogenics in Malignant Granular Cell Tumors: Review of the Literature

Autori: Torrado C, Camaño M, Hindi N, Ortega J, Sevillano AR, Civantos G, Moura DS, Dimino A, Martín-Broto J.
Pubblicato in: Cancers (Basel), 2023, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers15215187