EXpanding Platforms for Efficacious mRNA Therapeutics

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Dissemination toolkit

EXPERT audio-visual material

Public project website

Data Management Plan (DMP)

Pubblicazioni

Dosing extracellular vesicles

Autori: Dhanu Gupta, Antje Maria Zickler, Samir El Andaloussi
Pubblicato in: Advanced Drug Delivery Reviews, Numero 178, 2021, Pagina/e n/a, ISSN 0169-409X
Editore: Elsevier BV
DOI: 10.1016/j.addr.2021.113961

Lipid Nanoparticles With Fine‐Tuned Composition Show Enhanced Colon Targeting as a Platform for mRNA Therapeutics

Autori: Riccardo Rampado, Gonna Somu Naidu, Olga Karpov, Meir Goldsmith, Preeti Sharma, Assaf Ezra, Lior Stotsky, Dor Breier, Dan Peer
Pubblicato in: Advanced Science, Numero 12, 2025, ISSN 2198-3844
Editore: Advanced Science
DOI: 10.1002/advs.202408744

Ionizable Lipids with Optimized Linkers Enable Lung-Specific, Lipid Nanoparticle-Mediated mRNA Delivery for Treatment of Metastatic Lung Tumors

Autori: Gonna Somu Naidu, Riccardo Rampado, Preeti Sharma, Assaf Ezra, Govinda Reddy Kundoor, Dor Breier, Dan Peer
Pubblicato in: ACS Nano, Numero 19, 2025, Pagina/e 6571-6587, ISSN 1936-0851
Editore: American Chemical Society
DOI: 10.1021/acsnano.4c18636

The Hypertensive Effect of Amphotericin B-Containing Liposomes (Abelcet) in Mice: Dissecting the Roles of C3a and C5a Anaphylatoxins, Macrophages and Thromboxane

Autori: Erik Őrfi; László Hricisák; László Dézsi; Péter Hamar; Zoltán Benyó; János Szebeni; Gábor Szénási
Pubblicato in: Biomedicines; Volume 10; Numero 7; Pages: 1764, Numero 10/7, 2022, Pagina/e 1764, ISSN 2227-9059
Editore: Biomedicines
DOI: 10.3390/biomedicines10071764

An extracellular vesicle delivery platform based on the PTTG1IP protein

Autori: Carla Martin Perez, Xiuming Liang, Dhanu Gupta, Emily R. Haughton, Mariana Conceição, Imre Mäger, Samir EL Andaloussi, Matthew J.A. Wood, Thomas C. Roberts
Pubblicato in: Extracellular Vesicle, Numero 4, 2025, Pagina/e 100054, ISSN 2773-0417
Editore: Extracellular Vesicle
DOI: 10.1016/j.vesic.2024.100054

Regulatory guidelines and preclinical tools to study the biodistribution of RNA therapeutics

Autori: P.Vervaeke, S.E.Borgos, N. N. Sanders, F.Combes
Pubblicato in: Advanced Drug Delivery Reviews, Numero 184, 2022, Pagina/e n/a, ISSN 0169-409X
Editore: Elsevier BV
DOI: 10.1016/j.addr.2022.114236

Anti-PEG antibodies: Properties, formation, testing and role in adverse immune reactions to PEGylated nano-biopharmaceuticals

Autori: Gergely Tibor Kozma, Taro Shimizu, Tatsuhiro Ishida, Janos Szebeni
Pubblicato in: Advanced Drug Delivery Reviews, Numero 154-155, 2020, Pagina/e 163-175, ISSN 0169-409X
Editore: Elsevier BV
DOI: 10.1016/j.addr.2020.07.024

A naturally hypersensitive porcine model may help understand the mechanism of COVID-19 mRNA vaccine-induced rare (pseudo) allergic reactions: complement activation as a possible contributing factor

Autori: László Dézsi; Tamás Mészáros; Gergely Kozma; Mária H-Velkei; Csaba Zs. Oláh; Miklós Szabó; Zsófia Patkó; Tamás Fülöp; Mark Hennies; Miklós Szebeni; Bálint András Barta; Béla Merkely; Tamás Radovits; János Szebeni
Pubblicato in: GeroScience, Numero 01619152, 2022, Pagina/e 597–618, ISSN 0161-9152
Editore: Kluwer Academic Publishers
DOI: 10.1007/s11357-021-00495-y

High-throughput measurement of the content and properties of nano-sized bioparticles with single-particle profiler

Autori: Taras Sych, Jan Schlegel, Hanna M. G. Barriga, Miina Ojansivu, Leo Hanke, Florian Weber, R. Beklem Bostancioglu, Kariem Ezzat, Herbert Stangl, Birgit Plochberger, Jurga Laurencikiene, Samir El Andaloussi, Daniel Fürth, Molly M. Stevens, Erdinc Sezgin
Pubblicato in: Nature Biotechnology, Numero 42, 2023, Pagina/e 587-590, ISSN 1087-0156
Editore: Nature Publishing Group
DOI: 10.1038/s41587-023-01825-5

Insights into the Structure of Comirnaty Covid-19 Vaccine: A Theory on Soft, Partially Bilayer-Covered Nanoparticles with Hydrogen Bond-Stabilized mRNA–Lipid Complexes

Autori: Szebeni, János; Kiss, Bálint; Bozó, Tamás; Turjeman, Keren; Levi-Kalisman, Yael; Barenholz, Yechezkel; Kellermayer, Miklós
Pubblicato in: ACS NANO, Numero 12, 2023, Pagina/e 13147−13157, ISSN 1936-0851
Editore: American Chemical Society
DOI: 10.1021/acsnano.2c11904

Extracellular vesicles as drug delivery systems: Why and how?

Autori: Omnia M. Elsharkasy, Joel Z. Nordin, Daniel W. Hagey, Olivier G. de Jong, Raymond M. Schiffelers, Samir EL Andaloussi, Pieter Vader
Pubblicato in: Advanced Drug Delivery Reviews, Numero 159, 2020, Pagina/e 332-343, ISSN 0169-409X
Editore: Elsevier BV
DOI: 10.1016/j.addr.2020.04.004

A single-dose F1-based mRNA-LNP vaccine provides protection against the lethal plague bacterium

Autori: Edo Kon, Yinon Levy, Uri Elia, Hila Cohen, Inbal Hazan-Halevy, Moshe Aftalion, Assaf Ezra, Erez Bar-Haim, Gonna Somu Naidu, Yael Diesendruck, Shahar Rotem, Nitay Ad-El, Meir Goldsmith, Emanuelle Mamroud, Dan Peer, and Ofer Cohen
Pubblicato in: Science Advances, Numero Volume 9, No 10, 2023, Pagina/e n/a, ISSN 2375-2548
Editore: Science Advances
DOI: 10.1126/sciadv.adg1036

Complement-mediated hypersensitivity reactions to an amphotericin B-containing lipid complex (Abelcet) in pediatric patients and anesthetized rats: Benefits of slow infusion

Autori: Gergely Milosevits; Tamás Mészáros; Erik Őrfi; Tamás Bakos; Miklós Garami; Gabor G. Kovacs; László Dézsi; Péter Hamar; Balázs Győrffy; András Szabó; Gábor Szénási; Janos Szebeni
Pubblicato in: Nanomedicine: Nanotechnology, Biology and Medicine, Numero 15499634, 2021, Pagina/e n/a, ISSN 1549-9634
Editore: Elsevier BV
DOI: 10.1016/j.nano.2021.102366

Polyethylene glycol (PEG) as a broad applicability marker for LC–MS/MS-based biodistribution analysis of nanomedicines

Autori: Hyldbakk, Astrid; Hansen, Terkel; Hak, Sjoerd; Borgos, Sven Even F.
Pubblicato in: Journal of Controlled Release, Numero Volume 366, 2024, Pagina/e 611-620, ISSN 0168-3659
Editore: Elsevier BV
DOI: 10.1016/j.jconrel.2024.01.016

To PEGylate or not to PEGylate: Immunological properties of nanomedicine’s most popular component, polyethylene glycol and its alternatives

Autori: Da Shi, Damian Beasock, Adam Fessler, Janos Szebeni, Julia Y. Ljubimova, Kirill A. Afonin, Marina A. Dobrovolskaia
Pubblicato in: Advanced Drug Delivery Reviews, Numero 0169409X, 2022, Pagina/e n/a, ISSN 0169-409X
Editore: Elsevier BV
DOI: 10.1016/j.addr.2021.114079

Endosomal escape: A bottleneck for LNP-mediated therapeutics

Autori: Sushmita Chatterjee, Edo Kon, Preeti Sharma, and Dan Peer
Pubblicato in: PNAS, Numero 121 (11), 2024, Pagina/e n/a, ISSN 1091-6490
Editore: PNAS
DOI: 10.1073/pnas.2307800120

Applying lessons learned from nanomedicines to understand rare hypersensitivity reactions to mRNA-based SARS-CoV-2 vaccines

Autori: Janos Szebeni, Gert Storm, Julia Y. Ljubimova, Mariana Castells, Elizabeth J. Phillips, Keren Turjeman, Yechezkel Barenholz, Daan J. A. Crommelin, Marina A. Dobrovolskaia
Pubblicato in: Nature Nanotechnology, Numero 17, 2022, Pagina/e 337-346, ISSN 1748-3387
Editore: Nature Publishing Group
DOI: 10.1038/s41565-022-01071-x

Role of anti-polyethylene glycol (PEG) antibodies in the allergic reactions to PEG-containing Covid-19 vaccines: Evidence for immunogenicity of PEG

Autori: Gergely Tibor Kozma, Tamás Mészáros, Petra Berényi, Réka Facskó, Zsófia Patkó, Csaba Zs. Oláh, Adrienne Nagy, Tamás Gyula Fülöp, Kathryn Anne Glatter, Tamás Radovits, Béla Merkely, János Szebeni
Pubblicato in: Vaccine, Numero Volume 41, Numero 31, 2023, Pagina/e 4561-4570, ISSN 0264-410X
Editore: Elsevier BV
DOI: 10.1016/j.vaccine.2023.06.009

A state of the art in analytical quality-by-design and perspectives in characterization of nano-enabled medicinal products

Autori: Bastogne, Thierry; Caputo, Fanny; Prina-Mello, Adriele; Borgos, Sven; Barberi-Heyob, Muriel
Pubblicato in: Journal of Pharmaceutical and Biomedical Analysis, Numero 219, 2022, Pagina/e n/a, ISSN 0731-7085
Editore: Elsevier BV
DOI: 10.1016/j.jpba.2022.114911

Anti-PEG antibodies compromise the integrity of PEGylated lipid-based nanoparticles via complement

Autori: Mariona Estapé Senti; Caroline A. de Jongh; Kim Dijkxhoorn; Johan J.F. Verhoef; Janos Szebeni; Gert Storm; C. Erik Hack; Raymond M. Schiffelers; Marcel H. Fens; Peter Boross
Pubblicato in: Advanced Drug Delivery Reviews, Numero 154-155, 2020, Pagina/e 163-175, ISSN 0169-409X
Editore: Elsevier BV
DOI: 10.1016/j.jconrel.2021.11.042

Unlocking the therapeutic potential of locked nucleic acids through lipid nanoparticle delivery

Autori: Shahd Qassem, Dor Breier, Gonna Somu Naidu, Inbal Hazan-Halevy, Dan Peer
Pubblicato in: Molecular Therapy - Nucleic Acids, Numero 35, 2024, Pagina/e 102224, ISSN 2162-2531
Editore: Nature Publishing Group
DOI: 10.1016/j.omtn.2024.102224

Measuring particle concentration of multimodal synthetic reference materials and extracellular vesicles with orthogonal techniques: Who is up to the challenge?

Autori: Robert Vogel, John Savage, Julien Muzard, Giacomo Della Camera, Gabriele Vella, Alice Law, Marianne Marchioni, Dora Mehn, Otmar Geiss, Ben Peacock, Dimitri Aubert, Luigi Calzolai, Fanny Caputo, Adriele Prina‐Mello
Pubblicato in: Journal of Extracellular Vesicles, Numero 10/3, 2021, Pagina/e e12052, ISSN 2001-3078
Editore: Wiley Online Library
DOI: 10.1002/jev2.12052

Targeting cancer with mRNA–lipid nanoparticles: key considerations and future prospects

Autori: Edo Kon, Nitay Ad-El, Inbal Hazan-Halevy, Lior Stotsky-Oterin & Dan Peer
Pubblicato in: nature reviews clinical oncology, Numero 20, 2023, 2023, Pagina/e 739-754, ISSN 1759-4774
Editore: Nature Publishing Group
DOI: 10.1038/s41571-023-00811-9

A Bayesian implementation of Quality-by-Design for the development of Cationic Nano-Lipid for siRNA Transfection

Autori: Thierry Bastogne, Lucie Hassler, Jonathan Bruniaux, Magalie Thomassin, Xavier Gidrol, Eric Sulpice and Fabrice P. Navarro
Pubblicato in: IEEE Transactions on NanoBioscience, Numero Year: 2023, Volume: 22, Numero: 3, 2022, Pagina/e 1-1, ISSN 1536-1241
Editore: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tnb.2022.3213412

Covid-19 vaccines elicit effective IgG responses in an elderly thymus cancer patient with chemotherapy

Autori: Akos Koller, Janos Szebeni
Pubblicato in: Human Vaccines & Immunotherapeutics, Numero Volume 19, 2023, Numero 1, 2023, Pagina/e n/a, ISSN 2164-5515
Editore: Landes Bioscience
DOI: 10.1080/21645515.2023.2188035

Quality assessment of LNP-RNA therapeutics with orthogonal analytical techniques

Autori: Jeremie Parot, Dora Mehn, Hanna Jankevics, Natalia Markova, Michele Carboni, Camilla Olaisen, Andrea D. Hoel, Margr´et S. Sigfúsd´ottir, Florian Meier, Roland Drexel, Gabriele Vella, Birgitte McDonagh, Terkel Hansen, Huong Bui, Geir Klinkenberg, Torkild Visnes, Sabrina Gioria b, Patricia Urban-Lopez, Adriele Prina-Mello, Sven Even Borgos, Fanny Caputo, Luigi Calzolai
Pubblicato in: Journal of Controlled Release, Numero Volume 367, 2024, Pagina/e 385-401, ISSN 0346-251X
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.jconrel.2024.01.037

A magnetic separation method for isolating and characterizing the biomolecular corona of lipid nanoparticles

Autori: Valentina Francia, Yao Zhang, Miffy Hok Yan Cheng, Raymond M. Schiffelers, Dominik Witzigmann, and Pieter R. Cullis
Pubblicato in: PNAS, Numero 121 (11), 2024, Pagina/e n/a, ISSN 1091-6490
Editore: PNAS
DOI: 10.1073/pnas.2307803120

Cryo-XPS for Surface Characterization of Nanomedicines

Autori: David J. H. Cant, Yiwen Pei, Andrey Shchukarev, Madeleine Ramstedt, Sara S. Marques, Marcela A. Segundo, Jeremie Parot, Alicja Molska, Sven E. Borgos, Alexander G. Shard, and Caterina Minelli
Pubblicato in: The Journal of Physical Chemistry A, Numero 127, 39, 2023, Pagina/e 8220–8227, ISSN 1520-5215
Editore: ACS Publications
DOI: 10.1021/acs.jpca.3c03879

Identification of scaffold proteins for improved endogenous engineering of extracellular vesicles

Autori: Wenyi Zheng, Julia Rädler, Helena Sork, Zheyu Niu, Samantha Roudi, Jeremy P. Bost, André Görgens, Ying Zhao, Doste R. Mamand, Xiuming Liang, Oscar P. B. Wiklander, Taavi Lehto, Dhanu Gupta, Joel Z. Nordin, Samir EL Andaloussi
Pubblicato in: nature communications, Numero 14, 2023, Pagina/e n/a, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-023-40453-0

Identification of storage conditions stabilizing extracellular vesicles preparations

Autori: André Görgens, Giulia Corso, Daniel W. Hagey, Rim Jawad Wiklander, Manuela O. Gustafsson, Ulrika Felldin, Yi Lee, R. Beklem Bostancioglu, Helena Sork, Xiuming Liang, Wenyi Zheng, Dara K. Mohammad, Simonides I. van de Wakker, Pieter Vader, Antje M. Zickler, Doste R. Mamand, Li Ma, Margaret N. Holme, Molly M. Stevens, Oscar P. B. Wiklander, Samir EL Andaloussi
Pubblicato in: Journal of Extracellular Vesicles, Numero 11/6, 2022, Pagina/e n/a, ISSN 2001-3078
Editore: John Wiley & Sons, Ltd
DOI: 10.1002/jev2.12238

Fusogenic Coiled-Coil Peptides Enhance Lipid Nanoparticle-Mediated mRNA Delivery upon Intramyocardial Administration

Autori: Ye Zeng, Mariona Estapé Senti, M. Clara I. Labonia, Panagiota Papadopoulou, Maike A. D. Brans, Inge Dokter, Marcel H. Fens, Alain van Mil, Joost P. G. Sluijter, Raymond M. Schiffelers, Pieter Vader, and Alexander Kros
Pubblicato in: ACS Nano, Numero 17, 2023, 2023, Pagina/e 23466−23477, ISSN 1936-0851
Editore: American Chemical Society
DOI: 10.1021/acsnano.3c05341

Physicochemical characterization and quantification of nanoplastics: applicability, limitations and complementarity of batch and fractionation methods

Autori: Maximilian J. Huber, Natalia P. Ivleva, Andy M. Booth, Irina Beer, Ivana Bianchi, Roland Drexel, Otmar Geiss, Dora Mehn, Florian Meier, Alicja Molska, Jeremie Parot, Lisbet Sørensen, Gabriele Vella, Adriele Prina‑Mell, Robert Vogel, Fanny Caputo
Pubblicato in: Analytical and Bioanalytical Chemistry, Numero Volume 415, 2023, Pagina/e 3007-3031, ISSN 1618-2650
Editore: Springer
DOI: 10.1007/s00216-023-04689-5

Mini-Factor H Modulates Complement-Dependent IL-6 and IL-10 Release in an Immune Cell Culture (PBMC) Model: Potential Benefits Against Cytokine Storm

Autori: Gergely Tibor Kozma, Tamás Mészáros, Tamás Bakos, Mark Hennies, Dániel Bencze, Barbara Uzonyi, Balázs Gyorffy, Edward Cedrone, Marina A. Dobrovolskaia, Mihály Józsi, János Szebeni
Pubblicato in: Frontiers in Immunology, Numero 12, 2021, Pagina/e n/a, ISSN 1662-4548
Editore: Frontiers Research Foundation
DOI: 10.3389/fimmu.2021.642860

Surface display of functional moieties on extracellular vesicles usinglipid anchors

Autori: Wenyi Zheng, Melanie Schürz, Rim Jawad Wiklander, Oskar Gustafsson, Dhanu Gupta, Radka Slovak, Andrei Traista, Arianna Coluzzi, Samantha Roudi, Antonella Barone, Daria Farcas, Eleni Kyriakopoulou, Valentina Galli, Heena Sharma, Nicole Meisner-Kober, Malgorzata Honcharenko, Samir E.L. Andaloussi
Pubblicato in: Journal of Controlled Release, Numero Volume 357, 2023, Pagina/e 630–640, ISSN 0168-3659
Editore: Elsevier BV
DOI: 10.1016/j.jconrel.2023.04.033

Modulation of Pro-Inflammatory IL-6 Trans-Signaling Axis by Splice Switching Oligonucleotides as a Therapeutic Modality in Inflammation

Autori: Dhanu Gupta, Sara Orehek, Janne Turunen, Liz O'Donovan, Michael J Gait, Samir El-Andaloussi, Matthew J A Wood
Pubblicato in: Cells, Numero 12 (18), 2023, Pagina/e 2285, ISSN 2073-4409
Editore: Cells
DOI: 10.3390/cells12182285

Barcoded Hybrids of Extracellular Vesicles and Lipid Nanoparticles for Multiplexed Analysis of Tissue Distribution

Autori: Alena Ivanova, Renata Chalupska, Ana Filipa Louro, Mike Firth, Hernán González‐King Garibotti, Leif Hultin, Franziska Kohl, Elisa Lázaro‐Ibáñez, Julia Lindgren, Gentian Musa, Erik Oude Blenke, Andreia M. Silva, Louis Szeponik, Agnes Taylor, Ida Viken, Xiaoqin Wang, Karin Jennbacken, John Wiseman, Niek Dekker
Pubblicato in: Advanced Science, Numero 12, 2025, Pagina/e n/a, ISSN 2198-3844
Editore: Advanced Science
DOI: 10.1002/advs.202407850

Identification of robust and abundant reference transcripts for EV mRNA cargo normalization

Autori: Antje M. Zickler, Radosław Grochowski, André Görgens, Erik Bäcklin, Maximilian Kordes, J.-Matthias Löhr, Joel Z. Nordin, Samir EL Andaloussi, Daniel W. Hagey
Pubblicato in: Extracellular Vesicle, Numero 5, 2025, Pagina/e 100065, ISSN 2773-0417
Editore: Extracellular Vesicle
DOI: 10.1016/j.vesic.2025.100065

mRNA-LNP vaccines tuned for systemic immunization induce strong antitumor immunity by engaging splenic immune cells

Autori: Sanne Bevers, Sander A.A. Kooijmans, Elien Van de Velde, Martijn J.W. Evers, Sofie Seghers, Jerney J.J.M. Gitz-Francois, Nicky C.H. van Kronenburg, Marcel H.A.M. Fens, Enrico Mastrobattista, Lucie Hassler, Helena Sork, Taavi Lehto, Kariem E. Ahmed, Samir El Andaloussi, Katja Fiedler, Karine Breckpot, Michael Maes, Diane Van Hoorick, Thierry Bastogne, Raymond M. Schiffelers, Stefaan De Koker
Pubblicato in: Molecular Therapy, Numero 30/9, 2022, Pagina/e 3078-3094, ISSN 1525-0024
Editore: Cell Press
DOI: 10.1016/j.ymthe.2022.07.007

Quantification of extracellular vesicles in vitro and in vivo using sensitive bioluminescence imaging

Autori: Dhanu Gupta, Xiuming Liang, Svetlana Pavlova, Oscar P.B Wiklander, Giulia Corso, Ying Zhao, Osama Saher, Jeremy Bost, Antje M. Zickler, Andras Piffko, Cecile L. Maire, Franz L. Ricklefs, Oskar Gustafsson, Virginia Castilla Llorente, Manuela O. Gustafsson, R. Beklem Bostancioglu, Doste R Mamand, Daniel W. Hagey, André Görgens, Joel Z. Nordin, Samir EL Andaloussi
Pubblicato in: Journal of Extracellular Vesicles, Numero 9/1, 2020, Pagina/e n/a, ISSN 2001-3078
Editore: John Wiley & Sons, Ltd
DOI: 10.1080/20013078.2020.1800222

A porcine model of hemodialyzer reactions: roles of complement activation and rinsing back of extracorporeal blood

Autori: Ákos Pethő, Dorothea Piecha, Tamás Mészáros, Rudolf Urbanics, Christoph Moore, Bernard Canaud, László Rosivall, Tom Eirik Mollnes, Sonja Steppan, Gábor Szénási, János Szebeni, László Dézsi
Pubblicato in: Renal Failure, Numero 0886022X, 2021, Pagina/e 1609-1620, ISSN 0886-022X
Editore: Marcel Dekker Inc.
DOI: 10.1080/0886022x.2021.2007127

Novel Orthogonally Hydrocarbon-Modified Cell-Penetrating Peptide Nanoparticles Mediate Efficient Delivery of Splice-Switching Antisense Oligonucleotides In Vitro and In Vivo

Autori: Safa Bazaz, Tõnis Lehto, Rahel Tops, Olof Gissberg, Dhanu Gupta, Burcu Bestas, Jeremy Bost, Oscar P. B. Wiklander, Helena Sork, Eman M. Zaghloul, Doste R. Mamand, Mattias Hällbrink, Rannar Sillard, Osama Saher, Kariem Ezzat, C. I. Edvard Smith, Samir EL Andaloussi, Taavi Lehto
Pubblicato in: Biomedicines, Numero 9 (8), 2021, Pagina/e 1046, ISSN 2227-9059
Editore: Biomedicines
DOI: 10.3390/biomedicines9081046

Targeted CRISPR/Cas9 Lipid Nanoparticles Elicits Therapeutic Genome Editing in Head and Neck Cancer

Autori: Razan Masarwy, Dor Breier, Lior Stotsky‐Oterin, Nitay Ad‐El, Shahd Qassem, Gonna Somu Naidu, Anjaiah Aitha, Assaf Ezra, Meir Goldsmith, Inbal Hazan‐Halevy, Dan Peer
Pubblicato in: Advanced Science, Numero 12, 2025, ISSN 2198-3844
Editore: Advanced Science
DOI: 10.1002/advs.202411032

Delivery of nucleic acid based genome editing platforms via lipid nanoparticles: Clinical applications

Autori: Razan Masarwy, Lior Stotsky-Oterin, Aviad Elisha, Inbal Hazan-Halevy, Dan Peer
Pubblicato in: Advanced Drug Delivery Reviews, Numero 211, 2024, Pagina/e 115359, ISSN 0169-409X
Editore: Elsevier BV
DOI: 10.1016/j.addr.2024.115359

Delivery of modified mRNA to damaged myocardium by systemic administration of lipid nanoparticles

Autori: Martijn J.W. Evers, Wenjuan Du, Qiangbing Yang, Sander A.A. Kooijmans, Aryan Vink, Mies van Steenbergen, Pieter Vader, Saskia C.A. de Jager, Sabine A. Fuchs, Enrico Mastrobattista, Joost P.G. Sluijter, Zhiyong Lei, Raymond Schiffelers
Pubblicato in: Journal of Controlled Release, Numero 343, 2022, Pagina/e 207-216, ISSN 0168-3659
Editore: Elsevier BV
DOI: 10.1016/j.jconrel.2022.01.027

Antibody-displaying extracellular vesicles for targeted cancer therapy

Autori: Oscar P. B. Wiklander, Doste R. Mamand, Dara K. Mohammad, Wenyi Zheng, Rim Jawad Wiklander, Taras Sych, Antje M. Zickler, Xiuming Liang, Heena Sharma, Andrea Lavado, Jeremy Bost, Samantha Roudi, Giulia Corso, Angus J. Lennaárd, Manuchehr Abedi-Valugerdi, Imre Mäger, Evren Alici, Erdinc Sezgin, Joel Z. Nordin, Dhanu Gupta, André Görgens, Samir EL Andaloussi
Pubblicato in: Nature Biomedical Engineering, Numero Vol 8 No 4, 2024, Pagina/e n/a, ISSN 2157-846X
Editore: Nature
DOI: 10.1038/s41551-024-01214-6

Novel Endogenous Engineering Platform for Robust Loading and Delivery of Functional mRNA by Extracellular Vesicles

Autori: Antje M. Zickler, Xiuming Liang, Dhanu Gupta, Doste R. Mamand, Mariacristina De Luca, Giulia Corso, Lorenzo Errichelli, Justin Hean, Titash Sen, Omnia M. Elsharkasy, Noriyasu Kamei, Zheyu Niu, Guannan Zhou, Houze Zhou, Samantha Roudi, Oscar P. B. Wiklander, André Görgens, Joel Z. Nordin, Virginia Castilla‐Llorente, Samir EL Andaloussi
Pubblicato in: Advanced Science, Numero 11, 2024, ISSN 2198-3844
Editore: Advanced Science
DOI: 10.1002/advs.202407619

The Critical Choice of Animal Models in Nanomedicine Safety Assessment: A Lesson Learned From Hemoglobin-Based Oxygen Carriers

Autori: Peter Bedőcs, János Szebeni
Pubblicato in: Frontiers in Immunology, Numero 11, 2020, Pagina/e n/a, ISSN 1662-4548
Editore: Frontiers Research Foundation
DOI: 10.3389/fimmu.2020.584966

The future of genetic medicines delivered via targeted lipid nanoparticles to leukocytes

Autori: Dana Tarab-Ravski, Lior Stotsky-Oterin, Aviad Elisha, Govinda Reddy Kundoor, Srinivas Ramishetti, Inbal Hazan-Halevy, Heinrich Haas, Dan Peer
Pubblicato in: Journal of Controlled Release, Numero 376, 2024, Pagina/e 286-302, ISSN 0168-3659
Editore: Elsevier BV
DOI: 10.1016/j.jconrel.2024.10.014

Cell‐specific targeting of extracellular vesicles though engineering the glycocalyx

Autori: Wenyi Zheng; Rui He; Xiuming Liang; Samantha Roudi; Jeremy Bost; Pierre‐Michael Coly; Guillaume van Niel; Samir E. L. Andaloussi
Pubblicato in: Journal of Extracellular Vesicles, Numero Volume 11, Numero 12, 2022, Pagina/e n/a, ISSN 2001-3078
Editore: Wiley Online Library
DOI: 10.1002/jev2.12290

In vivo phage display identifies novel peptides for cardiac targeting

Autori: Alena Ivanova, Franziska Kohl, Hernán González-King Garibotti, Renata Chalupska, Aleksander Cvjetkovic, Mike Firth, Karin Jennbacken, Sofia Martinsson, Andreia M. Silva, Ida Viken, Qing-Dong Wang, John Wiseman, Niek Dekker
Pubblicato in: Scientific Reports, Numero 14, 2024, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-024-62953-9

Tumor cell derived osteopontin and prostaglandin E2 synergistically promote the expansion of myeloid derived suppressor cells during the tumor immune escape phase

Autori: Doste R Mamand, Safa Bazaz, Dara K Mohammad, Osama Saher, Oscar P B Wiklander, Behnam Sadeghi, Moustapha Hassan, Samir El-Andaloussi, Manuchehr Abedi-Valugerdi
Pubblicato in: International Immunopharmacology, Numero Volume 129, 2024, Pagina/e 111584, ISSN 0346-251X
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.intimp.2024.111584

Intratumoral delivery of lipid nanoparticle-formulated mRNA encoding IL-21, IL-7, and 4-1BBL induces systemic anti-tumor immunity

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Pubblicato in: Nature Communications, Numero 15, 2024, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-024-54877-9

The cellular response to extracellular vesicles is dependent on their cell source and dose

Autori: Daniel W Hagey, Miina Ojansivu, Beklem R Bostancioglu, Osama Saher, Jeremy P Bost, Manuela O Gustafsson, Roberto Gramignoli, Mathias Svahn, Dhanu Gupta, Molly M Stevens, André Görgens, Samir El Andaloussi
Pubblicato in: Science Advances, Numero Volume 9, Numero 35, 2023, Pagina/e n/a, ISSN 2375-2548
Editore: Science Advances
DOI: 10.1126/sciadv.adh1168

Paving the Road for RNA Therapeutics.

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Pubblicato in: Trends in Pharmacological Sciences, Numero 41/10, 2020, Pagina/e 755-775, ISSN 0165-6147
Editore: Elsevier BV
DOI: 10.1016/j.tips.2020.08.004

mRNA delivery systems for cancer immunotherapy: Lipid nanoparticles and beyond

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Pubblicato in: Advanced Drug Delivery Reviews, Numero Volume 206, 2024, Pagina/e n/a, ISSN 0346-251X
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.addr.2024.115190

A Method for the In Vitro Cytotoxicity Assessment of Anti-cancer Compounds and Materials Using High Content Screening Analysis

Autori: M.A. Tutty, A Prina-Mello
Pubblicato in: Cancer Cell Culture, Methods in Molecular Biology, Numero volume 2645, 2023, Pagina/e 241-249, ISBN 978-1-0716-3056-3
Editore: Springer
DOI: 10.1007/978-1-0716-3056-3_15

Targeted Tumor Delivery Using Extracellular Vesicles

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Pubblicato in: Methods in Pharmacology and Toxicology, Cancer-Targeted Drug Delivery, 2025, Pagina/e 125-153
Editore: Springer US
DOI: 10.1007/978-1-0716-4374-7_7

Three-Dimensional Spheroids for Cancer Research

Autori: M.A. Tutty, A Prina-Mello
Pubblicato in: Cancer Cell Culture, Methods in Molecular Biology, Numero volume 2645, 2023, Pagina/e 65-103, ISBN 978-1-0716-3056-3
Editore: Springer
DOI: 10.1007/978-1-0716-3056-3

Peptide-Assisted CRISPR/Cas9 Delivery to Tumors

Autori: Oskar Gustafsson, Samir EL Andaloussi, Joel Z. Nordin
Pubblicato in: Methods in Pharmacology and Toxicology, Cancer-Targeted Drug Delivery, 2025, Pagina/e 155-175
Editore: Springer US
DOI: 10.1007/978-1-0716-4374-7_8

Cancer Cell Culture: The Basics and Two-Dimensional Cultures

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Pubblicato in: Cancer Cell Culture, Methods in Molecular Biology, Numero volume 2645, 2023, Pagina/e 3-40, ISBN 978-1-0716-3056-3
Editore: Springer
DOI: 10.1007/978-1-0716-3056-3_1

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