EXpanding Platforms for Efficacious mRNA Therapeutics

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

Dissemination toolkit

EXPERT audio-visual material

Public project website

Data Management Plan (DMP)

Publikacje

Dosing extracellular vesicles

Autorzy: Dhanu Gupta, Antje Maria Zickler, Samir El Andaloussi
Opublikowane w: Advanced Drug Delivery Reviews, Numer 178, 2021, Strona(/y) n/a, ISSN 0169-409X
Wydawca: Elsevier BV
DOI: 10.1016/j.addr.2021.113961

Lipid Nanoparticles With Fine‐Tuned Composition Show Enhanced Colon Targeting as a Platform for mRNA Therapeutics

Autorzy: Riccardo Rampado, Gonna Somu Naidu, Olga Karpov, Meir Goldsmith, Preeti Sharma, Assaf Ezra, Lior Stotsky, Dor Breier, Dan Peer
Opublikowane w: Advanced Science, Numer 12, 2025, ISSN 2198-3844
Wydawca: Advanced Science
DOI: 10.1002/advs.202408744

Ionizable Lipids with Optimized Linkers Enable Lung-Specific, Lipid Nanoparticle-Mediated mRNA Delivery for Treatment of Metastatic Lung Tumors

Autorzy: Gonna Somu Naidu, Riccardo Rampado, Preeti Sharma, Assaf Ezra, Govinda Reddy Kundoor, Dor Breier, Dan Peer
Opublikowane w: ACS Nano, Numer 19, 2025, Strona(/y) 6571-6587, ISSN 1936-0851
Wydawca: American Chemical Society
DOI: 10.1021/acsnano.4c18636

The Hypertensive Effect of Amphotericin B-Containing Liposomes (Abelcet) in Mice: Dissecting the Roles of C3a and C5a Anaphylatoxins, Macrophages and Thromboxane

Autorzy: Erik Őrfi; László Hricisák; László Dézsi; Péter Hamar; Zoltán Benyó; János Szebeni; Gábor Szénási
Opublikowane w: Biomedicines; Volume 10; Numer 7; Pages: 1764, Numer 10/7, 2022, Strona(/y) 1764, ISSN 2227-9059
Wydawca: Biomedicines
DOI: 10.3390/biomedicines10071764

An extracellular vesicle delivery platform based on the PTTG1IP protein

Autorzy: Carla Martin Perez, Xiuming Liang, Dhanu Gupta, Emily R. Haughton, Mariana Conceição, Imre Mäger, Samir EL Andaloussi, Matthew J.A. Wood, Thomas C. Roberts
Opublikowane w: Extracellular Vesicle, Numer 4, 2025, Strona(/y) 100054, ISSN 2773-0417
Wydawca: Extracellular Vesicle
DOI: 10.1016/j.vesic.2024.100054

Regulatory guidelines and preclinical tools to study the biodistribution of RNA therapeutics

Autorzy: P.Vervaeke, S.E.Borgos, N. N. Sanders, F.Combes
Opublikowane w: Advanced Drug Delivery Reviews, Numer 184, 2022, Strona(/y) n/a, ISSN 0169-409X
Wydawca: Elsevier BV
DOI: 10.1016/j.addr.2022.114236

Anti-PEG antibodies: Properties, formation, testing and role in adverse immune reactions to PEGylated nano-biopharmaceuticals

Autorzy: Gergely Tibor Kozma, Taro Shimizu, Tatsuhiro Ishida, Janos Szebeni
Opublikowane w: Advanced Drug Delivery Reviews, Numer 154-155, 2020, Strona(/y) 163-175, ISSN 0169-409X
Wydawca: Elsevier BV
DOI: 10.1016/j.addr.2020.07.024

A naturally hypersensitive porcine model may help understand the mechanism of COVID-19 mRNA vaccine-induced rare (pseudo) allergic reactions: complement activation as a possible contributing factor

Autorzy: László Dézsi; Tamás Mészáros; Gergely Kozma; Mária H-Velkei; Csaba Zs. Oláh; Miklós Szabó; Zsófia Patkó; Tamás Fülöp; Mark Hennies; Miklós Szebeni; Bálint András Barta; Béla Merkely; Tamás Radovits; János Szebeni
Opublikowane w: GeroScience, Numer 01619152, 2022, Strona(/y) 597–618, ISSN 0161-9152
Wydawca: Kluwer Academic Publishers
DOI: 10.1007/s11357-021-00495-y

High-throughput measurement of the content and properties of nano-sized bioparticles with single-particle profiler

Autorzy: Taras Sych, Jan Schlegel, Hanna M. G. Barriga, Miina Ojansivu, Leo Hanke, Florian Weber, R. Beklem Bostancioglu, Kariem Ezzat, Herbert Stangl, Birgit Plochberger, Jurga Laurencikiene, Samir El Andaloussi, Daniel Fürth, Molly M. Stevens, Erdinc Sezgin
Opublikowane w: Nature Biotechnology, Numer 42, 2023, Strona(/y) 587-590, ISSN 1087-0156
Wydawca: Nature Publishing Group
DOI: 10.1038/s41587-023-01825-5

Insights into the Structure of Comirnaty Covid-19 Vaccine: A Theory on Soft, Partially Bilayer-Covered Nanoparticles with Hydrogen Bond-Stabilized mRNA–Lipid Complexes

Autorzy: Szebeni, János; Kiss, Bálint; Bozó, Tamás; Turjeman, Keren; Levi-Kalisman, Yael; Barenholz, Yechezkel; Kellermayer, Miklós
Opublikowane w: ACS NANO, Numer 12, 2023, Strona(/y) 13147−13157, ISSN 1936-0851
Wydawca: American Chemical Society
DOI: 10.1021/acsnano.2c11904

Extracellular vesicles as drug delivery systems: Why and how?

Autorzy: Omnia M. Elsharkasy, Joel Z. Nordin, Daniel W. Hagey, Olivier G. de Jong, Raymond M. Schiffelers, Samir EL Andaloussi, Pieter Vader
Opublikowane w: Advanced Drug Delivery Reviews, Numer 159, 2020, Strona(/y) 332-343, ISSN 0169-409X
Wydawca: Elsevier BV
DOI: 10.1016/j.addr.2020.04.004

A single-dose F1-based mRNA-LNP vaccine provides protection against the lethal plague bacterium

Autorzy: Edo Kon, Yinon Levy, Uri Elia, Hila Cohen, Inbal Hazan-Halevy, Moshe Aftalion, Assaf Ezra, Erez Bar-Haim, Gonna Somu Naidu, Yael Diesendruck, Shahar Rotem, Nitay Ad-El, Meir Goldsmith, Emanuelle Mamroud, Dan Peer, and Ofer Cohen
Opublikowane w: Science Advances, Numer Volume 9, No 10, 2023, Strona(/y) n/a, ISSN 2375-2548
Wydawca: Science Advances
DOI: 10.1126/sciadv.adg1036

Complement-mediated hypersensitivity reactions to an amphotericin B-containing lipid complex (Abelcet) in pediatric patients and anesthetized rats: Benefits of slow infusion

Autorzy: Gergely Milosevits; Tamás Mészáros; Erik Őrfi; Tamás Bakos; Miklós Garami; Gabor G. Kovacs; László Dézsi; Péter Hamar; Balázs Győrffy; András Szabó; Gábor Szénási; Janos Szebeni
Opublikowane w: Nanomedicine: Nanotechnology, Biology and Medicine, Numer 15499634, 2021, Strona(/y) n/a, ISSN 1549-9634
Wydawca: Elsevier BV
DOI: 10.1016/j.nano.2021.102366

Polyethylene glycol (PEG) as a broad applicability marker for LC–MS/MS-based biodistribution analysis of nanomedicines

Autorzy: Hyldbakk, Astrid; Hansen, Terkel; Hak, Sjoerd; Borgos, Sven Even F.
Opublikowane w: Journal of Controlled Release, Numer Volume 366, 2024, Strona(/y) 611-620, ISSN 0168-3659
Wydawca: Elsevier BV
DOI: 10.1016/j.jconrel.2024.01.016

To PEGylate or not to PEGylate: Immunological properties of nanomedicine’s most popular component, polyethylene glycol and its alternatives

Autorzy: Da Shi, Damian Beasock, Adam Fessler, Janos Szebeni, Julia Y. Ljubimova, Kirill A. Afonin, Marina A. Dobrovolskaia
Opublikowane w: Advanced Drug Delivery Reviews, Numer 0169409X, 2022, Strona(/y) n/a, ISSN 0169-409X
Wydawca: Elsevier BV
DOI: 10.1016/j.addr.2021.114079

Endosomal escape: A bottleneck for LNP-mediated therapeutics

Autorzy: Sushmita Chatterjee, Edo Kon, Preeti Sharma, and Dan Peer
Opublikowane w: PNAS, Numer 121 (11), 2024, Strona(/y) n/a, ISSN 1091-6490
Wydawca: PNAS
DOI: 10.1073/pnas.2307800120

Applying lessons learned from nanomedicines to understand rare hypersensitivity reactions to mRNA-based SARS-CoV-2 vaccines

Autorzy: Janos Szebeni, Gert Storm, Julia Y. Ljubimova, Mariana Castells, Elizabeth J. Phillips, Keren Turjeman, Yechezkel Barenholz, Daan J. A. Crommelin, Marina A. Dobrovolskaia
Opublikowane w: Nature Nanotechnology, Numer 17, 2022, Strona(/y) 337-346, ISSN 1748-3387
Wydawca: Nature Publishing Group
DOI: 10.1038/s41565-022-01071-x

Role of anti-polyethylene glycol (PEG) antibodies in the allergic reactions to PEG-containing Covid-19 vaccines: Evidence for immunogenicity of PEG

Autorzy: Gergely Tibor Kozma, Tamás Mészáros, Petra Berényi, Réka Facskó, Zsófia Patkó, Csaba Zs. Oláh, Adrienne Nagy, Tamás Gyula Fülöp, Kathryn Anne Glatter, Tamás Radovits, Béla Merkely, János Szebeni
Opublikowane w: Vaccine, Numer Volume 41, Numer 31, 2023, Strona(/y) 4561-4570, ISSN 0264-410X
Wydawca: Elsevier BV
DOI: 10.1016/j.vaccine.2023.06.009

A state of the art in analytical quality-by-design and perspectives in characterization of nano-enabled medicinal products

Autorzy: Bastogne, Thierry; Caputo, Fanny; Prina-Mello, Adriele; Borgos, Sven; Barberi-Heyob, Muriel
Opublikowane w: Journal of Pharmaceutical and Biomedical Analysis, Numer 219, 2022, Strona(/y) n/a, ISSN 0731-7085
Wydawca: Elsevier BV
DOI: 10.1016/j.jpba.2022.114911

Anti-PEG antibodies compromise the integrity of PEGylated lipid-based nanoparticles via complement

Autorzy: Mariona Estapé Senti; Caroline A. de Jongh; Kim Dijkxhoorn; Johan J.F. Verhoef; Janos Szebeni; Gert Storm; C. Erik Hack; Raymond M. Schiffelers; Marcel H. Fens; Peter Boross
Opublikowane w: Advanced Drug Delivery Reviews, Numer 154-155, 2020, Strona(/y) 163-175, ISSN 0169-409X
Wydawca: Elsevier BV
DOI: 10.1016/j.jconrel.2021.11.042

Unlocking the therapeutic potential of locked nucleic acids through lipid nanoparticle delivery

Autorzy: Shahd Qassem, Dor Breier, Gonna Somu Naidu, Inbal Hazan-Halevy, Dan Peer
Opublikowane w: Molecular Therapy - Nucleic Acids, Numer 35, 2024, Strona(/y) 102224, ISSN 2162-2531
Wydawca: Nature Publishing Group
DOI: 10.1016/j.omtn.2024.102224

Measuring particle concentration of multimodal synthetic reference materials and extracellular vesicles with orthogonal techniques: Who is up to the challenge?

Autorzy: Robert Vogel, John Savage, Julien Muzard, Giacomo Della Camera, Gabriele Vella, Alice Law, Marianne Marchioni, Dora Mehn, Otmar Geiss, Ben Peacock, Dimitri Aubert, Luigi Calzolai, Fanny Caputo, Adriele Prina‐Mello
Opublikowane w: Journal of Extracellular Vesicles, Numer 10/3, 2021, Strona(/y) e12052, ISSN 2001-3078
Wydawca: Wiley Online Library
DOI: 10.1002/jev2.12052

Targeting cancer with mRNA–lipid nanoparticles: key considerations and future prospects

Autorzy: Edo Kon, Nitay Ad-El, Inbal Hazan-Halevy, Lior Stotsky-Oterin & Dan Peer
Opublikowane w: nature reviews clinical oncology, Numer 20, 2023, 2023, Strona(/y) 739-754, ISSN 1759-4774
Wydawca: Nature Publishing Group
DOI: 10.1038/s41571-023-00811-9

A Bayesian implementation of Quality-by-Design for the development of Cationic Nano-Lipid for siRNA Transfection

Autorzy: Thierry Bastogne, Lucie Hassler, Jonathan Bruniaux, Magalie Thomassin, Xavier Gidrol, Eric Sulpice and Fabrice P. Navarro
Opublikowane w: IEEE Transactions on NanoBioscience, Numer Year: 2023, Volume: 22, Numer: 3, 2022, Strona(/y) 1-1, ISSN 1536-1241
Wydawca: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tnb.2022.3213412

Covid-19 vaccines elicit effective IgG responses in an elderly thymus cancer patient with chemotherapy

Autorzy: Akos Koller, Janos Szebeni
Opublikowane w: Human Vaccines & Immunotherapeutics, Numer Volume 19, 2023, Numer 1, 2023, Strona(/y) n/a, ISSN 2164-5515
Wydawca: Landes Bioscience
DOI: 10.1080/21645515.2023.2188035

Quality assessment of LNP-RNA therapeutics with orthogonal analytical techniques

Autorzy: Jeremie Parot, Dora Mehn, Hanna Jankevics, Natalia Markova, Michele Carboni, Camilla Olaisen, Andrea D. Hoel, Margr´et S. Sigfúsd´ottir, Florian Meier, Roland Drexel, Gabriele Vella, Birgitte McDonagh, Terkel Hansen, Huong Bui, Geir Klinkenberg, Torkild Visnes, Sabrina Gioria b, Patricia Urban-Lopez, Adriele Prina-Mello, Sven Even Borgos, Fanny Caputo, Luigi Calzolai
Opublikowane w: Journal of Controlled Release, Numer Volume 367, 2024, Strona(/y) 385-401, ISSN 0346-251X
Wydawca: Pergamon Press Ltd.
DOI: 10.1016/j.jconrel.2024.01.037

A magnetic separation method for isolating and characterizing the biomolecular corona of lipid nanoparticles

Autorzy: Valentina Francia, Yao Zhang, Miffy Hok Yan Cheng, Raymond M. Schiffelers, Dominik Witzigmann, and Pieter R. Cullis
Opublikowane w: PNAS, Numer 121 (11), 2024, Strona(/y) n/a, ISSN 1091-6490
Wydawca: PNAS
DOI: 10.1073/pnas.2307803120

Cryo-XPS for Surface Characterization of Nanomedicines

Autorzy: David J. H. Cant, Yiwen Pei, Andrey Shchukarev, Madeleine Ramstedt, Sara S. Marques, Marcela A. Segundo, Jeremie Parot, Alicja Molska, Sven E. Borgos, Alexander G. Shard, and Caterina Minelli
Opublikowane w: The Journal of Physical Chemistry A, Numer 127, 39, 2023, Strona(/y) 8220–8227, ISSN 1520-5215
Wydawca: ACS Publications
DOI: 10.1021/acs.jpca.3c03879

Identification of scaffold proteins for improved endogenous engineering of extracellular vesicles

Autorzy: Wenyi Zheng, Julia Rädler, Helena Sork, Zheyu Niu, Samantha Roudi, Jeremy P. Bost, André Görgens, Ying Zhao, Doste R. Mamand, Xiuming Liang, Oscar P. B. Wiklander, Taavi Lehto, Dhanu Gupta, Joel Z. Nordin, Samir EL Andaloussi
Opublikowane w: nature communications, Numer 14, 2023, Strona(/y) n/a, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-023-40453-0

Identification of storage conditions stabilizing extracellular vesicles preparations

Autorzy: André Görgens, Giulia Corso, Daniel W. Hagey, Rim Jawad Wiklander, Manuela O. Gustafsson, Ulrika Felldin, Yi Lee, R. Beklem Bostancioglu, Helena Sork, Xiuming Liang, Wenyi Zheng, Dara K. Mohammad, Simonides I. van de Wakker, Pieter Vader, Antje M. Zickler, Doste R. Mamand, Li Ma, Margaret N. Holme, Molly M. Stevens, Oscar P. B. Wiklander, Samir EL Andaloussi
Opublikowane w: Journal of Extracellular Vesicles, Numer 11/6, 2022, Strona(/y) n/a, ISSN 2001-3078
Wydawca: John Wiley & Sons, Ltd
DOI: 10.1002/jev2.12238

Fusogenic Coiled-Coil Peptides Enhance Lipid Nanoparticle-Mediated mRNA Delivery upon Intramyocardial Administration

Autorzy: Ye Zeng, Mariona Estapé Senti, M. Clara I. Labonia, Panagiota Papadopoulou, Maike A. D. Brans, Inge Dokter, Marcel H. Fens, Alain van Mil, Joost P. G. Sluijter, Raymond M. Schiffelers, Pieter Vader, and Alexander Kros
Opublikowane w: ACS Nano, Numer 17, 2023, 2023, Strona(/y) 23466−23477, ISSN 1936-0851
Wydawca: American Chemical Society
DOI: 10.1021/acsnano.3c05341

Physicochemical characterization and quantification of nanoplastics: applicability, limitations and complementarity of batch and fractionation methods

Autorzy: Maximilian J. Huber, Natalia P. Ivleva, Andy M. Booth, Irina Beer, Ivana Bianchi, Roland Drexel, Otmar Geiss, Dora Mehn, Florian Meier, Alicja Molska, Jeremie Parot, Lisbet Sørensen, Gabriele Vella, Adriele Prina‑Mell, Robert Vogel, Fanny Caputo
Opublikowane w: Analytical and Bioanalytical Chemistry, Numer Volume 415, 2023, Strona(/y) 3007-3031, ISSN 1618-2650
Wydawca: Springer
DOI: 10.1007/s00216-023-04689-5

Mini-Factor H Modulates Complement-Dependent IL-6 and IL-10 Release in an Immune Cell Culture (PBMC) Model: Potential Benefits Against Cytokine Storm

Autorzy: Gergely Tibor Kozma, Tamás Mészáros, Tamás Bakos, Mark Hennies, Dániel Bencze, Barbara Uzonyi, Balázs Gyorffy, Edward Cedrone, Marina A. Dobrovolskaia, Mihály Józsi, János Szebeni
Opublikowane w: Frontiers in Immunology, Numer 12, 2021, Strona(/y) n/a, ISSN 1662-4548
Wydawca: Frontiers Research Foundation
DOI: 10.3389/fimmu.2021.642860

Surface display of functional moieties on extracellular vesicles usinglipid anchors

Autorzy: Wenyi Zheng, Melanie Schürz, Rim Jawad Wiklander, Oskar Gustafsson, Dhanu Gupta, Radka Slovak, Andrei Traista, Arianna Coluzzi, Samantha Roudi, Antonella Barone, Daria Farcas, Eleni Kyriakopoulou, Valentina Galli, Heena Sharma, Nicole Meisner-Kober, Malgorzata Honcharenko, Samir E.L. Andaloussi
Opublikowane w: Journal of Controlled Release, Numer Volume 357, 2023, Strona(/y) 630–640, ISSN 0168-3659
Wydawca: Elsevier BV
DOI: 10.1016/j.jconrel.2023.04.033

Modulation of Pro-Inflammatory IL-6 Trans-Signaling Axis by Splice Switching Oligonucleotides as a Therapeutic Modality in Inflammation

Autorzy: Dhanu Gupta, Sara Orehek, Janne Turunen, Liz O'Donovan, Michael J Gait, Samir El-Andaloussi, Matthew J A Wood
Opublikowane w: Cells, Numer 12 (18), 2023, Strona(/y) 2285, ISSN 2073-4409
Wydawca: Cells
DOI: 10.3390/cells12182285

Barcoded Hybrids of Extracellular Vesicles and Lipid Nanoparticles for Multiplexed Analysis of Tissue Distribution

Autorzy: Alena Ivanova, Renata Chalupska, Ana Filipa Louro, Mike Firth, Hernán González‐King Garibotti, Leif Hultin, Franziska Kohl, Elisa Lázaro‐Ibáñez, Julia Lindgren, Gentian Musa, Erik Oude Blenke, Andreia M. Silva, Louis Szeponik, Agnes Taylor, Ida Viken, Xiaoqin Wang, Karin Jennbacken, John Wiseman, Niek Dekker
Opublikowane w: Advanced Science, Numer 12, 2025, Strona(/y) n/a, ISSN 2198-3844
Wydawca: Advanced Science
DOI: 10.1002/advs.202407850

Identification of robust and abundant reference transcripts for EV mRNA cargo normalization

Autorzy: Antje M. Zickler, Radosław Grochowski, André Görgens, Erik Bäcklin, Maximilian Kordes, J.-Matthias Löhr, Joel Z. Nordin, Samir EL Andaloussi, Daniel W. Hagey
Opublikowane w: Extracellular Vesicle, Numer 5, 2025, Strona(/y) 100065, ISSN 2773-0417
Wydawca: Extracellular Vesicle
DOI: 10.1016/j.vesic.2025.100065

mRNA-LNP vaccines tuned for systemic immunization induce strong antitumor immunity by engaging splenic immune cells

Autorzy: Sanne Bevers, Sander A.A. Kooijmans, Elien Van de Velde, Martijn J.W. Evers, Sofie Seghers, Jerney J.J.M. Gitz-Francois, Nicky C.H. van Kronenburg, Marcel H.A.M. Fens, Enrico Mastrobattista, Lucie Hassler, Helena Sork, Taavi Lehto, Kariem E. Ahmed, Samir El Andaloussi, Katja Fiedler, Karine Breckpot, Michael Maes, Diane Van Hoorick, Thierry Bastogne, Raymond M. Schiffelers, Stefaan De Koker
Opublikowane w: Molecular Therapy, Numer 30/9, 2022, Strona(/y) 3078-3094, ISSN 1525-0024
Wydawca: Cell Press
DOI: 10.1016/j.ymthe.2022.07.007

Quantification of extracellular vesicles in vitro and in vivo using sensitive bioluminescence imaging

Autorzy: Dhanu Gupta, Xiuming Liang, Svetlana Pavlova, Oscar P.B Wiklander, Giulia Corso, Ying Zhao, Osama Saher, Jeremy Bost, Antje M. Zickler, Andras Piffko, Cecile L. Maire, Franz L. Ricklefs, Oskar Gustafsson, Virginia Castilla Llorente, Manuela O. Gustafsson, R. Beklem Bostancioglu, Doste R Mamand, Daniel W. Hagey, André Görgens, Joel Z. Nordin, Samir EL Andaloussi
Opublikowane w: Journal of Extracellular Vesicles, Numer 9/1, 2020, Strona(/y) n/a, ISSN 2001-3078
Wydawca: John Wiley & Sons, Ltd
DOI: 10.1080/20013078.2020.1800222

A porcine model of hemodialyzer reactions: roles of complement activation and rinsing back of extracorporeal blood

Autorzy: Ákos Pethő, Dorothea Piecha, Tamás Mészáros, Rudolf Urbanics, Christoph Moore, Bernard Canaud, László Rosivall, Tom Eirik Mollnes, Sonja Steppan, Gábor Szénási, János Szebeni, László Dézsi
Opublikowane w: Renal Failure, Numer 0886022X, 2021, Strona(/y) 1609-1620, ISSN 0886-022X
Wydawca: Marcel Dekker Inc.
DOI: 10.1080/0886022x.2021.2007127

Novel Orthogonally Hydrocarbon-Modified Cell-Penetrating Peptide Nanoparticles Mediate Efficient Delivery of Splice-Switching Antisense Oligonucleotides In Vitro and In Vivo

Autorzy: Safa Bazaz, Tõnis Lehto, Rahel Tops, Olof Gissberg, Dhanu Gupta, Burcu Bestas, Jeremy Bost, Oscar P. B. Wiklander, Helena Sork, Eman M. Zaghloul, Doste R. Mamand, Mattias Hällbrink, Rannar Sillard, Osama Saher, Kariem Ezzat, C. I. Edvard Smith, Samir EL Andaloussi, Taavi Lehto
Opublikowane w: Biomedicines, Numer 9 (8), 2021, Strona(/y) 1046, ISSN 2227-9059
Wydawca: Biomedicines
DOI: 10.3390/biomedicines9081046

Targeted CRISPR/Cas9 Lipid Nanoparticles Elicits Therapeutic Genome Editing in Head and Neck Cancer

Autorzy: Razan Masarwy, Dor Breier, Lior Stotsky‐Oterin, Nitay Ad‐El, Shahd Qassem, Gonna Somu Naidu, Anjaiah Aitha, Assaf Ezra, Meir Goldsmith, Inbal Hazan‐Halevy, Dan Peer
Opublikowane w: Advanced Science, Numer 12, 2025, ISSN 2198-3844
Wydawca: Advanced Science
DOI: 10.1002/advs.202411032

Delivery of nucleic acid based genome editing platforms via lipid nanoparticles: Clinical applications

Autorzy: Razan Masarwy, Lior Stotsky-Oterin, Aviad Elisha, Inbal Hazan-Halevy, Dan Peer
Opublikowane w: Advanced Drug Delivery Reviews, Numer 211, 2024, Strona(/y) 115359, ISSN 0169-409X
Wydawca: Elsevier BV
DOI: 10.1016/j.addr.2024.115359

Delivery of modified mRNA to damaged myocardium by systemic administration of lipid nanoparticles

Autorzy: Martijn J.W. Evers, Wenjuan Du, Qiangbing Yang, Sander A.A. Kooijmans, Aryan Vink, Mies van Steenbergen, Pieter Vader, Saskia C.A. de Jager, Sabine A. Fuchs, Enrico Mastrobattista, Joost P.G. Sluijter, Zhiyong Lei, Raymond Schiffelers
Opublikowane w: Journal of Controlled Release, Numer 343, 2022, Strona(/y) 207-216, ISSN 0168-3659
Wydawca: Elsevier BV
DOI: 10.1016/j.jconrel.2022.01.027

Antibody-displaying extracellular vesicles for targeted cancer therapy

Autorzy: Oscar P. B. Wiklander, Doste R. Mamand, Dara K. Mohammad, Wenyi Zheng, Rim Jawad Wiklander, Taras Sych, Antje M. Zickler, Xiuming Liang, Heena Sharma, Andrea Lavado, Jeremy Bost, Samantha Roudi, Giulia Corso, Angus J. Lennaárd, Manuchehr Abedi-Valugerdi, Imre Mäger, Evren Alici, Erdinc Sezgin, Joel Z. Nordin, Dhanu Gupta, André Görgens, Samir EL Andaloussi
Opublikowane w: Nature Biomedical Engineering, Numer Vol 8 No 4, 2024, Strona(/y) n/a, ISSN 2157-846X
Wydawca: Nature
DOI: 10.1038/s41551-024-01214-6

Novel Endogenous Engineering Platform for Robust Loading and Delivery of Functional mRNA by Extracellular Vesicles

Autorzy: Antje M. Zickler, Xiuming Liang, Dhanu Gupta, Doste R. Mamand, Mariacristina De Luca, Giulia Corso, Lorenzo Errichelli, Justin Hean, Titash Sen, Omnia M. Elsharkasy, Noriyasu Kamei, Zheyu Niu, Guannan Zhou, Houze Zhou, Samantha Roudi, Oscar P. B. Wiklander, André Görgens, Joel Z. Nordin, Virginia Castilla‐Llorente, Samir EL Andaloussi
Opublikowane w: Advanced Science, Numer 11, 2024, ISSN 2198-3844
Wydawca: Advanced Science
DOI: 10.1002/advs.202407619

The Critical Choice of Animal Models in Nanomedicine Safety Assessment: A Lesson Learned From Hemoglobin-Based Oxygen Carriers

Autorzy: Peter Bedőcs, János Szebeni
Opublikowane w: Frontiers in Immunology, Numer 11, 2020, Strona(/y) n/a, ISSN 1662-4548
Wydawca: Frontiers Research Foundation
DOI: 10.3389/fimmu.2020.584966

The future of genetic medicines delivered via targeted lipid nanoparticles to leukocytes

Autorzy: Dana Tarab-Ravski, Lior Stotsky-Oterin, Aviad Elisha, Govinda Reddy Kundoor, Srinivas Ramishetti, Inbal Hazan-Halevy, Heinrich Haas, Dan Peer
Opublikowane w: Journal of Controlled Release, Numer 376, 2024, Strona(/y) 286-302, ISSN 0168-3659
Wydawca: Elsevier BV
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Opublikowane w: Journal of Extracellular Vesicles, Numer Volume 11, Numer 12, 2022, Strona(/y) n/a, ISSN 2001-3078
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Opublikowane w: Scientific Reports, Numer 14, 2024, ISSN 2045-2322
Wydawca: Nature Publishing Group
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Tumor cell derived osteopontin and prostaglandin E2 synergistically promote the expansion of myeloid derived suppressor cells during the tumor immune escape phase

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Opublikowane w: International Immunopharmacology, Numer Volume 129, 2024, Strona(/y) 111584, ISSN 0346-251X
Wydawca: Pergamon Press Ltd.
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Intratumoral delivery of lipid nanoparticle-formulated mRNA encoding IL-21, IL-7, and 4-1BBL induces systemic anti-tumor immunity

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The cellular response to extracellular vesicles is dependent on their cell source and dose

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Opublikowane w: Cancer Cell Culture, Methods in Molecular Biology, Numer volume 2645, 2023, Strona(/y) 241-249, ISBN 978-1-0716-3056-3
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Opublikowane w: Methods in Pharmacology and Toxicology, Cancer-Targeted Drug Delivery, 2025, Strona(/y) 125-153
Wydawca: Springer US
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Autorzy: M.A. Tutty, A Prina-Mello
Opublikowane w: Cancer Cell Culture, Methods in Molecular Biology, Numer volume 2645, 2023, Strona(/y) 65-103, ISBN 978-1-0716-3056-3
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Opublikowane w: Methods in Pharmacology and Toxicology, Cancer-Targeted Drug Delivery, 2025, Strona(/y) 155-175
Wydawca: Springer US
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Opublikowane w: Cancer Cell Culture, Methods in Molecular Biology, Numer volume 2645, 2023, Strona(/y) 3-40, ISBN 978-1-0716-3056-3
Wydawca: Springer
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