Projektbeschreibung
Neuartiger chemischer Sensor spürt chirale Verbindungen in Echtzeit auf
Chirale Chemikalien – also Moleküle, die nicht mit ihrem Spiegelbild überlagert werden können – werden zunehmend für die Herstellung von Arzneimitteln, Agrochemikalien, Lebensmittelzutaten und Parfüms eingesetzt. Die Entsorgung chiraler Verbindungen kann jedoch aufgrund ihrer hohen biologischen Aktivität eine Gefahr für die Umwelt darstellen. Das EU-finanzierte Projekt INITIO plant die Konzeption eines tragbaren chemischen Sensors, der chirale Moleküle vor Ort und in Echtzeit analysieren und unterscheiden kann. Im Gegensatz zu den derzeitigen chemischen Sensoren verfügt die vorgeschlagene Technologie über geeignete Festkörperrezeptoren (auf der Basis von Porphyrinderivaten), die den Gehalt an chiralen Abfällen zuverlässig analysieren können.
Ziel
Chiral pollution is an environmental topic of crucial importance, considering that a large number of chemicals spreading into the environment, for example pesticides, are chiral substances. However, usually the stereoisomerism of contaminants is not considered, although the biological activity of enantiomers is significantly different, making their recognition critical for environmental control. Enantiomeric excess is currently determined by off-site analysis, requiring collection, transportation, eventual pre-treating of the sample, and expensive instrumentations and specifically trained staff. Thus, providing devices able to allow for rapid on site detection and chiral discrimination of target analytes would have a dramatic impact in all the fields of environmental control with significant economic benefits. The development of chemical sensors has been conceived to bypass restrictions related to classical analytical protocols and supports the use of conventional laboratory techniques for environmental control. While the technological foundation for chemical sensors already exists, it has been difficult to apply them to chiral discrimination and analysis, due to the lack of suitable solid state receptors. The main aims of the project are: a) the development of novel molecular receptors, mainly based on porphyrin derivatives, b) integration of the receptors with different nanostructures and characterization of their solid state organization, c) deposition of the structures onto transducer surfaces, d) testing and validation of the new chemical sensor devices with enantiomeric pairs of model analytes. The synergistic complementary know-how of six academic units and two private companies will allow a breakthrough development through delivery of sensing probes ranging from the synthesis of macrocyclic molecular receptors to the building and testing of analytical and electronic parts for final, field-capable devices.
Wissenschaftliches Gebiet
Schlüsselbegriffe
Programm/Programme
Aufforderung zur Vorschlagseinreichung
Andere Projekte für diesen Aufruf anzeigenUnterauftrag
H2020-FETOPEN-2018-2019-2020-01
Finanzierungsplan
RIA - Research and Innovation actionKoordinator
00133 Roma
Italien