Descripción del proyecto
Un nuevo sensor químico detecta compuestos quirales al instante
Los productos químicos quirales —que comprenden moléculas que no pueden superponerse a su imagen especular— se utilizan cada vez más para la fabricación de productos farmacéuticos y agroquímicos, ingredientes alimentarios y perfumes. La eliminación de los compuestos quirales puede suponer una amenaza para el medio ambiente debido a su elevada actividad biológica. El equipo del proyecto INITIO, financiado con fondos europeos, tiene previsto desarrollar un sensor químico portátil que pueda analizar y discriminar moléculas quirales «in situ» y al instante. A diferencia de los sensores químicos actuales, la tecnología propuesta cuenta con receptores de estado sólido adecuados (basados en derivados de la porfirina) que pueden analizar de forma fiable el contenido de los residuos quirales.
Objetivo
Chiral pollution is an environmental topic of crucial importance, considering that a large number of chemicals spreading into the environment, for example pesticides, are chiral substances. However, usually the stereoisomerism of contaminants is not considered, although the biological activity of enantiomers is significantly different, making their recognition critical for environmental control. Enantiomeric excess is currently determined by off-site analysis, requiring collection, transportation, eventual pre-treating of the sample, and expensive instrumentations and specifically trained staff. Thus, providing devices able to allow for rapid on site detection and chiral discrimination of target analytes would have a dramatic impact in all the fields of environmental control with significant economic benefits. The development of chemical sensors has been conceived to bypass restrictions related to classical analytical protocols and supports the use of conventional laboratory techniques for environmental control. While the technological foundation for chemical sensors already exists, it has been difficult to apply them to chiral discrimination and analysis, due to the lack of suitable solid state receptors. The main aims of the project are: a) the development of novel molecular receptors, mainly based on porphyrin derivatives, b) integration of the receptors with different nanostructures and characterization of their solid state organization, c) deposition of the structures onto transducer surfaces, d) testing and validation of the new chemical sensor devices with enantiomeric pairs of model analytes. The synergistic complementary know-how of six academic units and two private companies will allow a breakthrough development through delivery of sensing probes ranging from the synthesis of macrocyclic molecular receptors to the building and testing of analytical and electronic parts for final, field-capable devices.
Ámbito científico
Palabras clave
Programa(s)
Convocatoria de propuestas
Consulte otros proyectos de esta convocatoriaConvocatoria de subcontratación
H2020-FETOPEN-2018-2019-2020-01
Régimen de financiación
RIA - Research and Innovation actionCoordinador
00133 Roma
Italia