Descrizione del progetto
Un innovativo sensore chimico rileva i composti chirali in tempo reale
I composti chimici chirali, che comprendono molecole che non possono essere sovrapposte alla propria immagine speculare, sono sempre più utilizzati per la fabbricazione di prodotti farmaceutici e agrochimici, nonché di ingredienti alimentari e profumi. Lo smaltimento dei composti chirali può rappresentare una minaccia all’ambiente a causa della loro elevata attività biologica. Il progetto INITIO, finanziato dall’UE, intende sviluppare un sensore chimico portatile in grado di analizzare e distinguere le molecole chirali in loco e in tempo reale. A differenza degli attuali sensori chimici, la tecnologia proposta presenta recettori idonei allo stato solido (basati sui derivati delle porfirine) che possono analizzare in maniera affidabile il contenuto dei rifiuti chirali.
Obiettivo
Chiral pollution is an environmental topic of crucial importance, considering that a large number of chemicals spreading into the environment, for example pesticides, are chiral substances. However, usually the stereoisomerism of contaminants is not considered, although the biological activity of enantiomers is significantly different, making their recognition critical for environmental control. Enantiomeric excess is currently determined by off-site analysis, requiring collection, transportation, eventual pre-treating of the sample, and expensive instrumentations and specifically trained staff. Thus, providing devices able to allow for rapid on site detection and chiral discrimination of target analytes would have a dramatic impact in all the fields of environmental control with significant economic benefits. The development of chemical sensors has been conceived to bypass restrictions related to classical analytical protocols and supports the use of conventional laboratory techniques for environmental control. While the technological foundation for chemical sensors already exists, it has been difficult to apply them to chiral discrimination and analysis, due to the lack of suitable solid state receptors. The main aims of the project are: a) the development of novel molecular receptors, mainly based on porphyrin derivatives, b) integration of the receptors with different nanostructures and characterization of their solid state organization, c) deposition of the structures onto transducer surfaces, d) testing and validation of the new chemical sensor devices with enantiomeric pairs of model analytes. The synergistic complementary know-how of six academic units and two private companies will allow a breakthrough development through delivery of sensing probes ranging from the synthesis of macrocyclic molecular receptors to the building and testing of analytical and electronic parts for final, field-capable devices.
Campo scientifico
Parole chiave
Programma(i)
Invito a presentare proposte
Vedi altri progetti per questo bandoBando secondario
H2020-FETOPEN-2018-2019-2020-01
Meccanismo di finanziamento
RIA - Research and Innovation actionCoordinatore
00133 Roma
Italia