Advanced and versatile PRInting platform for the next generation of active Microfluidic dEvices

Project Information

PRIME

Grant agreement ID: 829010

DOI 10.3030/829010

Project closed

EC signature date 17 December 2018

Start date 1 May 2019

End date 31 October 2023

Funded under

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Total cost € 2 820 991,25

EU contribution € 2 820 991,25

Coordinated by

AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain

Deliverables

Documents, reports (10)

Printable materials with photomechanical response (public version)

Report including general considerations on synthetic procedures and performance of materials

Printed sensing functions (public version)

Report including basic conceptual principle of the sensing elements in a microfludic device and performance characterization

Printed actuating functions (public version)

Report including basic conceptual principle of the light activated fluidic elements in a microfludic device and performance characterization

Validated prototype of the OoC

Report including basic conceptual principle and performance characterization of the light actuated chip as an OoC device

Sensing printable materials (public version)

Report including general considerations on synthetic procedures for printable materials for sensing and nanoparticles and performance of materials

Dissemination event for stakeholders interested in PRIME's technology

Report on the dissemination event for stakeholders interested in PRIMEs technology

First printed sensing functions (public version)

Report including the basic conceptual principle of the sensing elements and performance characterization

Communication and Dissemination strategy

Report on the comprehensive Communication and Dissemination strategy of the project to ensure that all generated knowledge will be successfully transmitted to the right target groups throughout the project.

First printed actuating functions (public version)

Report including the basic conceptual principle of the light activated first printed fluidic elements and performance characterization

Validated prototype of the IVD chip

Report including basic conceptual principle and performance characterization of the light actuated chip as an IVD device

Websites, patent fillings, videos etc. (1)

Website

PRIMEs web portal to be constantly maintained and updated

Open Research Data Pilot (1)

Data management plan

Good-practice data management plan for the project.

Publications

Peer reviewed articles (19)

Photonic and magnetic materials for on-demand local drug delivery

Author(s): Ilaria Armenia; Carlos Cuestas Ayllón; Beatriz Torres Herrero; Francesca Bussolari; Gabriel Alfranca; Valeria Grazú; Jesús Martínez de la Fuente
Published in: Advanced Drug Delivery Reviews, Issue 191, 2022, ISSN 1872-8294
Publisher: Elsevier B.V.
DOI: 10.1016/j.addr.2022.114584

Direct Ink Writing of Recyclable Supramolecular Soft Actuators

Author(s): Lugger, Sean J. D.; Verbroekken, Ruth M. C.; Mulder, Dirk J.; Schenning, Albert P. H. J.
Published in: ACS Macro Letters, Issue 3, 2022, Page(s) 935-940, ISSN 2161-1653
Publisher: American Chemical Society
DOI: 10.1021/acsmacrolett.2c00359

Melt-Extruded Thermoplastic Liquid Crystal Elastomer Rotating Fiber Actuators

Author(s): Sean J. D. Lugger, Tom A. P. Engels, Ruth Cardinaels, Tom Bus, Dirk J. Mulder, Albert P.H.J. Schenning
Published in: Advanced functional materials, Issue 33, 49, 2023, Page(s) 2306853, ISSN 1616-301X
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202306853

Generation of Self-Induced Myocardial Ischemia in Large-Sized Cardiac Spheroids without Alteration of Environmental Conditions Recreates Fibrotic Remodeling and Tissue Stiffening Revealed by Constriction Assays

Author(s): Laura Paz-Artigas, Sandra González-Lana, Nicolás Polo, Pedro Vicente, Pilar Montero-Calle, Miguel A. Martínez, Gregorio Rábago, Margarida Serra, Felipe Prósper, Manuel M. Mazo, Arantxa González, Ignacio Ochoa, Jesús Ciriza
Published in: ACS Biomaterials Science & Engineering, 2024, ISSN 2373-9878
Publisher: American Chemical Society
DOI: 10.1021/acsbiomaterials.3c01302

One-pot Synthesis of Melt-Processable Supramolecular Soft Actuators

Author(s): Sean J. D. Lugger, Dirk J. Mulder, Albertus P. H. J. Schenning
Published in: Angewandte Chemie International Edition, 2021, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202115166

Current approaches for the recreation of cardiac ischaemic environment in vitro

Author(s): Paz-Artigas, L. (Laura); Montero, P. (Pilar); Iglesias-García, O. (Olalla); Mazo, M. (Manuel); Ochoa, I. (Ignacio); Ciriza, J. (Jesús)
Published in: International Journal of Pharmaceutics, Issue 1, 2023, ISSN 1873-3476
Publisher: Elsevier

Self‐sealing thermoplastic fluoroelastomer enables rapid fabrication of modular microreactors

Author(s): Alexander H. McMillan; Juan Mora-Macías; Joan Teyssandier; Raymond Thür; Emmanuel Roy; Ignacio Ochoa; Steven De Feyter; Ivo F.J. Vankelecom; Maarten B. J. Roeffaers; Sasha Cai Lesher-Perez
Published in: Nano Select, Vol 2, Iss 7, Pp 1385-1402 (2021), Issue 3, 2021, ISSN 2688-4011
Publisher: Willey-VCH GmbH
DOI: 10.1002/nano.202000241

Melt electrowriting of liquid crystal elastomer scaffolds with programmed mechanical response

Author(s): Mehrzad Javadzadeh; Jesus del Barrio; Carlos Sánchez Somolinos
Published in: Advanced materials, Issue 35-14, 2023, Page(s) art number 2209244, ISSN 0935-9648
Publisher: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202209244

Photomechanical response under physiological conditions of azobenzene-containing 4D-printed liquid crystal elastomer actuators

Author(s): Lorena Ceamanos, Dirk J. Mulder, Zehra Kahveci, María López-Valdeolivas, Albert P.H.J. Schenning, Carlos Sánchez Somolinos
Published in: Journal of Materials Chemistry B, Issue 11 (18), 2023, Page(s) 4083-4094, ISSN 2050-750X
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2tb02757g

Fully (Re)configurable Interactive Material through a Switchable Photothermal Charge Transfer Complex Gated by a Supramolecular Liquid Crystal Elastomer Actuator

Author(s): Shuang Tian, Sean J. D. Lugger, Chun-Sing Lee, Michael G. Debije, Albert P. H. J. Schenning
Published in: J. Am. Chem. Soc., Issue 145, 35, 2023, Page(s) 19347-19353, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.3c05905

From cells to form: A roadmap to study shape emergence in vivo

Author(s): Ana Patricia Ramos; Alicja Szalapak; Lucrezia Camilla Ferme; Carl D. Modes
Published in: Biophysical Journal, Issue 122, 18, 2023, Page(s) 3587-3599, ISSN 1542-0086
Publisher: Cell Press
DOI: 10.1016/j.bpj.2023.05.015

Hydrogen-Bonded Supramolecular Liquid Crystal Polymers: Smart Materials with Stimuli-Responsive, Self-Healing, and Recyclable Properties

Author(s): Sean J. D. Lugger, Simon J. A. Houben, Yari Foelen, Michael G. Debije, Albert P. H. J. Schenning, Dirk J. Mulder
Published in: Chemical Reviews, 2021, ISSN 0009-2665
Publisher: American Chemical Society
DOI: 10.1021/acs.chemrev.1c00330

4D Printing of Supramolecular Liquid Crystal Elastomer Actuators Fueled by Light

Author(s): Lugger, Sean J. D.; Ceamanos, Lorena; Mulder, Dirk Jan; Sánchez-Somolinos, Carlos; Schenning, Albert P. H. J.
Published in: Advanced materials technologies, Issue 5, 2022, Page(s) 2201472, ISSN 2365-709X
Publisher: Wiley-Blackwell
DOI: 10.1002/admt.202201472

Surface modifications of COP-based microfluidic devices for improved immobilisation of hydrogel proteins: long-term 3D culture with contractile cell types and ischaemia model

Author(s): Sandra González-Lana, Teodora Randelovic, Jesús Ciriza, María López-Valdeolivas, Rosa Monge, Carlos Sánchez Somolinos, Ignacio Ochoa
Published in: Lab on a Chip, 2023, Page(s) 2434-2446, ISSN 1473-0197
Publisher: Royal Society of Chemistry
DOI: 10.1039/d3lc00075c

Towards novel biomimetic in vitro models of the blood-brain barrier for drug permeability evaluation

Author(s): Mármol, Inés; Abizanda-Campo, Sara; Ayuso, José M.; Ochoa, Ignacio; Oliván, Sara
Published in: Bioengineering, Issue 10, 2023, ISSN 2306-5354
Publisher: MDPI

In vitro biomimetic models for glioblastoma-a promising tool for drug response studies

Author(s): Tijana Stankovića, Teodora Ranđelović, Miodrag Dragoj, Sonja Stojković Burić, LuisFernández, Ignacio Ochoa, Victor M.Pérez-García, MilicaPešić
Published in: Drug Resistance Updates, 2021, ISSN 1368-7646
Publisher: Churchill Livingstone
DOI: 10.1016/j.drup.2021.100753

Reprogrammable 4D printed liquid crystal elastomer photoactuators by means of light-resersible perylene diimide radicals

Author(s): Lorena Montesino, Jesus I. Martinez, C. Sanchez Somolinos
Published in: Advanced functional materials, 2023, ISSN 1616-301X
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202309019

Thermal Paper and Time Temperature Integrators Made From a Structural Colored Polymer Crosslinked With Hydrogen Bonded Cyclohexanoic Acid Derivatives

Author(s): Foelen, Yari; van der Heijden, Daniëlle A. C.; Verdurmen, Anne M. J.; Mulder, Dirk J.; Lub, Johan; Schenning, Albert P. H. J.
Published in: Advanced optical materials, Issue 1, 2022, Page(s) 2201462, ISSN 2195-1071
Publisher: Wiley-VCH GmbH
DOI: 10.1002/adom.202201462

Four-Dimensional Printed Liquid Crystalline Elastomer Actuators with Fast Photoinduced Mechanical Response toward Light-Driven Robotic Functions

Author(s): Lorena Ceamanos, Zehra Kahveci, María López-Valdeolivas, Danqing Liu, Dirk Jan Broer, Carlos Sánchez-Somolinos
Published in: ACS Applied Materials & Interfaces, Issue 12/39, 2020, Page(s) 44195-44204, ISSN 1944-8244
Publisher: American Chemical Society
DOI: 10.1021/acsami.0c13341