Advanced and versatile PRInting platform for the next generation of active Microfluidic dEvices

Informazioni relative al progetto

PRIME

ID dell’accordo di sovvenzione: 829010

DOI 10.3030/829010

Progetto chiuso

Data della firma CE 17 Dicembre 2018

Data di avvio 1 Maggio 2019

Data di completamento 31 Ottobre 2023

Finanziato da

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Costo totale € 2 820 991,25

Contributo UE € 2 820 991,25

Coordinato da

AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain

Risultati finali

Documents, reports (10)

Printable materials with photomechanical response (public version)

Report including general considerations on synthetic procedures and performance of materials

Printed sensing functions (public version)

Report including basic conceptual principle of the sensing elements in a microfludic device and performance characterization

Printed actuating functions (public version)

Report including basic conceptual principle of the light activated fluidic elements in a microfludic device and performance characterization

Validated prototype of the OoC

Report including basic conceptual principle and performance characterization of the light actuated chip as an OoC device

Sensing printable materials (public version)

Report including general considerations on synthetic procedures for printable materials for sensing and nanoparticles and performance of materials

Dissemination event for stakeholders interested in PRIME's technology

Report on the dissemination event for stakeholders interested in PRIMEs technology

First printed sensing functions (public version)

Report including the basic conceptual principle of the sensing elements and performance characterization

Communication and Dissemination strategy

Report on the comprehensive Communication and Dissemination strategy of the project to ensure that all generated knowledge will be successfully transmitted to the right target groups throughout the project.

First printed actuating functions (public version)

Report including the basic conceptual principle of the light activated first printed fluidic elements and performance characterization

Validated prototype of the IVD chip

Report including basic conceptual principle and performance characterization of the light actuated chip as an IVD device

Websites, patent fillings, videos etc. (1)

Website

PRIMEs web portal to be constantly maintained and updated

Open Research Data Pilot (1)

Data management plan

Good-practice data management plan for the project.

Pubblicazioni

Peer reviewed articles (19)

Photonic and magnetic materials for on-demand local drug delivery

Autori: Ilaria Armenia; Carlos Cuestas Ayllón; Beatriz Torres Herrero; Francesca Bussolari; Gabriel Alfranca; Valeria Grazú; Jesús Martínez de la Fuente
Pubblicato in: Advanced Drug Delivery Reviews, Numero 191, 2022, ISSN 1872-8294
Editore: Elsevier B.V.
DOI: 10.1016/j.addr.2022.114584

Direct Ink Writing of Recyclable Supramolecular Soft Actuators

Autori: Lugger, Sean J. D.; Verbroekken, Ruth M. C.; Mulder, Dirk J.; Schenning, Albert P. H. J.
Pubblicato in: ACS Macro Letters, Numero 3, 2022, Pagina/e 935-940, ISSN 2161-1653
Editore: American Chemical Society
DOI: 10.1021/acsmacrolett.2c00359

Melt-Extruded Thermoplastic Liquid Crystal Elastomer Rotating Fiber Actuators

Autori: Sean J. D. Lugger, Tom A. P. Engels, Ruth Cardinaels, Tom Bus, Dirk J. Mulder, Albert P.H.J. Schenning
Pubblicato in: Advanced functional materials, Numero 33, 49, 2023, Pagina/e 2306853, ISSN 1616-301X
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202306853

Generation of Self-Induced Myocardial Ischemia in Large-Sized Cardiac Spheroids without Alteration of Environmental Conditions Recreates Fibrotic Remodeling and Tissue Stiffening Revealed by Constriction Assays

Autori: Laura Paz-Artigas, Sandra González-Lana, Nicolás Polo, Pedro Vicente, Pilar Montero-Calle, Miguel A. Martínez, Gregorio Rábago, Margarida Serra, Felipe Prósper, Manuel M. Mazo, Arantxa González, Ignacio Ochoa, Jesús Ciriza
Pubblicato in: ACS Biomaterials Science & Engineering, 2024, ISSN 2373-9878
Editore: American Chemical Society
DOI: 10.1021/acsbiomaterials.3c01302

One-pot Synthesis of Melt-Processable Supramolecular Soft Actuators

Autori: Sean J. D. Lugger, Dirk J. Mulder, Albertus P. H. J. Schenning
Pubblicato in: Angewandte Chemie International Edition, 2021, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202115166

Current approaches for the recreation of cardiac ischaemic environment in vitro

Autori: Paz-Artigas, L. (Laura); Montero, P. (Pilar); Iglesias-García, O. (Olalla); Mazo, M. (Manuel); Ochoa, I. (Ignacio); Ciriza, J. (Jesús)
Pubblicato in: International Journal of Pharmaceutics, Numero 1, 2023, ISSN 1873-3476
Editore: Elsevier

Self‐sealing thermoplastic fluoroelastomer enables rapid fabrication of modular microreactors

Autori: Alexander H. McMillan; Juan Mora-Macías; Joan Teyssandier; Raymond Thür; Emmanuel Roy; Ignacio Ochoa; Steven De Feyter; Ivo F.J. Vankelecom; Maarten B. J. Roeffaers; Sasha Cai Lesher-Perez
Pubblicato in: Nano Select, Vol 2, Iss 7, Pp 1385-1402 (2021), Numero 3, 2021, ISSN 2688-4011
Editore: Willey-VCH GmbH
DOI: 10.1002/nano.202000241

Melt electrowriting of liquid crystal elastomer scaffolds with programmed mechanical response

Autori: Mehrzad Javadzadeh; Jesus del Barrio; Carlos Sánchez Somolinos
Pubblicato in: Advanced materials, Numero 35-14, 2023, Pagina/e art number 2209244, ISSN 0935-9648
Editore: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202209244

Photomechanical response under physiological conditions of azobenzene-containing 4D-printed liquid crystal elastomer actuators

Autori: Lorena Ceamanos, Dirk J. Mulder, Zehra Kahveci, María López-Valdeolivas, Albert P.H.J. Schenning, Carlos Sánchez Somolinos
Pubblicato in: Journal of Materials Chemistry B, Numero 11 (18), 2023, Pagina/e 4083-4094, ISSN 2050-750X
Editore: Royal Society of Chemistry
DOI: 10.1039/d2tb02757g

Fully (Re)configurable Interactive Material through a Switchable Photothermal Charge Transfer Complex Gated by a Supramolecular Liquid Crystal Elastomer Actuator

Autori: Shuang Tian, Sean J. D. Lugger, Chun-Sing Lee, Michael G. Debije, Albert P. H. J. Schenning
Pubblicato in: J. Am. Chem. Soc., Numero 145, 35, 2023, Pagina/e 19347-19353, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.3c05905

From cells to form: A roadmap to study shape emergence in vivo

Autori: Ana Patricia Ramos; Alicja Szalapak; Lucrezia Camilla Ferme; Carl D. Modes
Pubblicato in: Biophysical Journal, Numero 122, 18, 2023, Pagina/e 3587-3599, ISSN 1542-0086
Editore: Cell Press
DOI: 10.1016/j.bpj.2023.05.015

Hydrogen-Bonded Supramolecular Liquid Crystal Polymers: Smart Materials with Stimuli-Responsive, Self-Healing, and Recyclable Properties

Autori: Sean J. D. Lugger, Simon J. A. Houben, Yari Foelen, Michael G. Debije, Albert P. H. J. Schenning, Dirk J. Mulder
Pubblicato in: Chemical Reviews, 2021, ISSN 0009-2665
Editore: American Chemical Society
DOI: 10.1021/acs.chemrev.1c00330

4D Printing of Supramolecular Liquid Crystal Elastomer Actuators Fueled by Light

Autori: Lugger, Sean J. D.; Ceamanos, Lorena; Mulder, Dirk Jan; Sánchez-Somolinos, Carlos; Schenning, Albert P. H. J.
Pubblicato in: Advanced materials technologies, Numero 5, 2022, Pagina/e 2201472, ISSN 2365-709X
Editore: Wiley-Blackwell
DOI: 10.1002/admt.202201472

Surface modifications of COP-based microfluidic devices for improved immobilisation of hydrogel proteins: long-term 3D culture with contractile cell types and ischaemia model

Autori: Sandra González-Lana, Teodora Randelovic, Jesús Ciriza, María López-Valdeolivas, Rosa Monge, Carlos Sánchez Somolinos, Ignacio Ochoa
Pubblicato in: Lab on a Chip, 2023, Pagina/e 2434-2446, ISSN 1473-0197
Editore: Royal Society of Chemistry
DOI: 10.1039/d3lc00075c

Towards novel biomimetic in vitro models of the blood-brain barrier for drug permeability evaluation

Autori: Mármol, Inés; Abizanda-Campo, Sara; Ayuso, José M.; Ochoa, Ignacio; Oliván, Sara
Pubblicato in: Bioengineering, Numero 10, 2023, ISSN 2306-5354
Editore: MDPI

In vitro biomimetic models for glioblastoma-a promising tool for drug response studies

Autori: Tijana Stankovića, Teodora Ranđelović, Miodrag Dragoj, Sonja Stojković Burić, LuisFernández, Ignacio Ochoa, Victor M.Pérez-García, MilicaPešić
Pubblicato in: Drug Resistance Updates, 2021, ISSN 1368-7646
Editore: Churchill Livingstone
DOI: 10.1016/j.drup.2021.100753

Reprogrammable 4D printed liquid crystal elastomer photoactuators by means of light-resersible perylene diimide radicals

Autori: Lorena Montesino, Jesus I. Martinez, C. Sanchez Somolinos
Pubblicato in: Advanced functional materials, 2023, ISSN 1616-301X
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202309019

Thermal Paper and Time Temperature Integrators Made From a Structural Colored Polymer Crosslinked With Hydrogen Bonded Cyclohexanoic Acid Derivatives

Autori: Foelen, Yari; van der Heijden, Daniëlle A. C.; Verdurmen, Anne M. J.; Mulder, Dirk J.; Lub, Johan; Schenning, Albert P. H. J.
Pubblicato in: Advanced optical materials, Numero 1, 2022, Pagina/e 2201462, ISSN 2195-1071
Editore: Wiley-VCH GmbH
DOI: 10.1002/adom.202201462

Four-Dimensional Printed Liquid Crystalline Elastomer Actuators with Fast Photoinduced Mechanical Response toward Light-Driven Robotic Functions

Autori: Lorena Ceamanos, Zehra Kahveci, María López-Valdeolivas, Danqing Liu, Dirk Jan Broer, Carlos Sánchez-Somolinos
Pubblicato in: ACS Applied Materials & Interfaces, Numero 12/39, 2020, Pagina/e 44195-44204, ISSN 1944-8244
Editore: American Chemical Society
DOI: 10.1021/acsami.0c13341