Deciphering the mechanisms of antiviral RNA interference in mammals

Project description

RNA interference as an antiviral weapon in mammals

RNA interference (RNAi) is a widely conserved biological mechanism that represses gene expression. It is mediated by small RNA molecules that bind to and degrade target RNAs. RNAi was originally described as a defence mechanism against viruses in worms, plants and insects, but its role in mammals remains controversial. The aim of the EU-funded UncoveRNAi project is to identify where and how the antiviral RNAi mechanism takes place in mammals. Results will provide important insight into the in vivo significance of RNAi as an antiviral mechanism in comparison to type I interferons responsible for orchestrating antiviral responses in mammals.

Fields of science

• medical and health sciences › health sciences › infectious diseases › RNA viruses
• medical and health sciences › basic medicine › immunology
• natural sciences › biological sciences › genetics › RNA
• natural sciences › biological sciences › zoology › mammalogy
• medical and health sciences › basic medicine › pharmacology and pharmacy › pharmaceutical drugs › antivirals

Programme(s)

• H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme
• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility

Topic(s)

• MSCA-IF-2018 - Individual Fellowships

Call for proposal

H2020-MSCA-IF-2018

See other projects for this call

Funding Scheme

MSCA-IF-EF-ST - Standard EF

Coordinator

THE FRANCIS CRICK INSTITUTE LIMITED

Net EU contribution

€ 212 933,76

Address

1 Midland Road
NW1 1AT London
United Kingdom

Region

London › Inner London — West › Camden and City of London

Activity type

Research Organisations

Links

Other funding

€ 0,00