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Deciphering the mechanisms of antiviral RNA interference in mammals

Project description

RNA interference as an antiviral weapon in mammals

RNA interference (RNAi) is a widely conserved biological mechanism that represses gene expression. It is mediated by small RNA molecules that bind to and degrade target RNAs. RNAi was originally described as a defence mechanism against viruses in worms, plants and insects, but its role in mammals remains controversial. The aim of the EU-funded UncoveRNAi project is to identify where and how the antiviral RNAi mechanism takes place in mammals. Results will provide important insight into the in vivo significance of RNAi as an antiviral mechanism in comparison to type I interferons responsible for orchestrating antiviral responses in mammals.


Net EU contribution
€ 212 933,76
1 Midland Road
NW1 1AT London
United Kingdom

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London Inner London — West Camden and City of London
Activity type
Research Organisations
Other funding
€ 0,00