Trained immunity: improving the next generation of vaccines for the older generation

Publications

A modular approach toward producing nanotherapeutics targeting the innate immune system

Author(s): Mandy M. T. van Leent, Anu E. Meerwaldt, Alexandre Berchouchi, Yohana C. Toner, Marianne E. Burnett, Emma D. Klein, Anna Vera D. Verschuur, Sheqouia A. Nauta, Jazz Munitz, Geoffrey Prévot, Esther M. van Leeuwen, Farideh Ordikhani, Vera P. Mourits, Claudia Calcagno, Philip M. Robson, George Soultanidis, Thomas Reiner, Rick R. M. Joosten, Heiner Friedrich, Joren C. Madsen, Ewelina Kluza, Roy van de
Published in: Science Advances, Issue 7/10, 2021, Page(s) eabe7853, ISSN 2375-2548
Publisher: AAAS
DOI: 10.1126/sciadv.abe7853

Defining trained immunity and its role in health and disease

Author(s): Mihai G. Netea, Jorge Domínguez-Andrés, Luis B. Barreiro, Triantafyllos Chavakis, Maziar Divangahi, Elaine Fuchs, Leo A. B. Joosten, Jos W. M. van der Meer, Musa M. Mhlanga, Willem J. M. Mulder, Niels P. Riksen, Andreas Schlitzer, Joachim L. Schultze, Christine Stabell Benn, Joseph C. Sun, Ramnik J. Xavier, Eicke Latz
Published in: Nature Reviews Immunology, Issue 20/6, 2020, Page(s) 375-388, ISSN 1474-1733
Publisher: Nature Publishing Group
DOI: 10.1038/s41577-020-0285-6

β-Glucan Induces Protective Trained Immunity against Mycobacterium tuberculosis Infection: A Key Role for IL-1

Author(s): Simone J.C.F.M. Moorlag, Nargis Khan, Boris Novakovic, Eva Kaufmann, Trees Jansen, Reinout van Crevel, Maziar Divangahi, Mihai G. Netea
Published in: Cell Reports, Issue 31/7, 2020, Page(s) 107634, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2020.107634

A higher BMI is not associated with a different immune response and disease course in critically ill COVID-19 patients

Author(s): Emma J. Kooistra, Aline H. de Nooijer, Wout J. Claassen, Inge Grondman, Nico A. F. Janssen, Mihai G. Netea, Frank L. van de Veerdonk, Johannes G. van der Hoeven, Matthijs Kox, Peter Pickkers
Published in: International Journal of Obesity, Issue 45/3, 2021, Page(s) 687-694, ISSN 0307-0565
Publisher: Nature Publishing Group
DOI: 10.1038/s41366-021-00747-z

The role of sirtuin 1 on the induction of trained immunity.

Author(s): Mourits VP, Helder LS, Matzaraki V, Koeken VACM, Groh L, de Bree LCJ, Moorlag SJCFM, van der Heijden CDCC, Keating ST, van Puffelen JH, Jaeger M, Joosten LAB, Netea MG.
Published in: Cell Immunol., 2021, Page(s) 104393, ISSN 0008-8749
Publisher: Academic Press
DOI: 10.1016/j.cellimm.2021.104393

The Set7 Lysine Methyltransferase Regulates Plasticity in Oxidative Phosphorylation Necessary for Trained Immunity Induced by β-Glucan

Author(s): Samuel T. Keating, Laszlo Groh, Charlotte D.C.C. van der Heijden, Hanah Rodriguez, Jéssica C. dos Santos, Stephanie Fanucchi, Jun Okabe, Harikrishnan Kaipananickal, Jelmer H. van Puffelen, Leonie Helder, Marlies P. Noz, Vasiliki Matzaraki, Yang Li, L. Charlotte J. de Bree, Valerie A.C.M. Koeken, Simone J.C.F.M. Moorlag, Vera P. Mourits, Jorge Domínguez-Andrés, Marije Oosting, Elianne P. Bulthui
Published in: Cell Reports, Issue 31/3, 2020, Page(s) 107548, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2020.107548

Urban living in healthy Tanzanians is associated with an inflammatory status driven by dietary and metabolic changes.

Author(s): Temba GS, Kullaya V, Pecht T, Mmbaga BT, Aschenbrenner AC, Ulas T, Kibiki G, Lyamuya F, Boahen CK, Kumar V, Joosten LAB, Schultze JL, van der Ven AJ, Netea MG, de Mast Q.
Published in: Nat Immunol., 2021, Page(s) 287-300, ISSN 1529-2908
Publisher: Nature Publishing Group
DOI: 10.1038/s41590-021-00867-8

In vitro induction of trained immunity in adherent human monocytes

Author(s): Jorge Domínguez-Andrés, Rob J.W. Arts, Siroon Bekkering, Harsh Bahrar, Bastiaan A. Blok, L. Charlotte J. de Bree, Mariolina Bruno, Özlem Bulut, Priya A. Debisarun, Helga Dijkstra, Jéssica Cristina dos Santos, Anaísa V. Ferreira, Daniela Flores-Gomez, Laszlo A. Groh, Inge Grondman, Leonie Helder, Cor Jacobs, Liesbeth Jacobs, Trees Jansen, Gizem Kilic, Viola Klück, Valerie A.C.M. Koeken, Heidi
Published in: STAR Protocols, Issue 2/1, 2021, Page(s) 100365, ISSN 2666-1667
Publisher: Cell Press
DOI: 10.1016/j.xpro.2021.100365

Outcomes Associated With Use of a Kinin B2 Receptor Antagonist Among Patients With COVID-19

Author(s): Frank L. van de Veerdonk, Ilse J. E. Kouijzer, Aline H. de Nooijer, Hans G. van der Hoeven, Coen Maas, Mihai G. Netea, Roger J. M. Brüggemann
Published in: JAMA Network Open, Issue 3/8, 2020, Page(s) e2017708, ISSN 2574-3805
Publisher: JAMA network
DOI: 10.1001/jamanetworkopen.2020.17708

Hydroxychloroquine Inhibits the Trained Innate Immune Response to Interferons

Author(s): Nils Rother, Cansu Yanginlar, Rik G.H. Lindeboom, Siroon Bekkering, Mandy M.T. van Leent, Baranca Buijsers, Inge Jonkman, Mark de Graaf, Marijke Baltissen, Lieke A. Lamers, Niels P. Riksen, Zahi A. Fayad, Willem J.M. Mulder, Luuk B. Hilbrands, Leo A.B. Joosten, Mihai G. Netea, Michiel Vermeulen, Johan van der Vlag, Raphaël Duivenvoorden
Published in: Cell Reports Medicine, Issue 1/9, 2020, Page(s) 100146, ISSN 2666-3791
Publisher: elsevier
DOI: 10.1016/j.xcrm.2020.100146

Safety and COVID-19 Symptoms in Individuals Recently Vaccinated with BCG: a Retrospective Cohort Study

Author(s): Simone J.C.F.M. Moorlag, Rosanne C. van Deuren, Cornelis H. van Werkhoven, Martin Jaeger, Priya Debisarun, Esther Taks, Vera P. Mourits, Valerie A.C.M. Koeken, L. Charlotte J. de Bree, Thijs ten Doesschate, Maartje C. Cleophas, Sanne Smeekens, Marije Oosting, Frank L. van de Veerdonk, Leo A.B. Joosten, Jaap ten Oever, Jos W.M. van der Meer, Nigel Curtis, Peter Aaby, Christine Stabell-Benn, Evangel
Published in: Cell Reports Medicine, Issue 1/5, 2020, Page(s) 100073, ISSN 2666-3791
Publisher: Elsevier
DOI: 10.1016/j.xcrm.2020.100073

Trained Immunity-Promoting Nanobiologic Therapy Suppresses Tumor Growth and Potentiates Checkpoint Inhibition.

Author(s): Priem B, van Leent MMT, Teunissen AJP, Sofias AM, Mourits VP, Willemsen L, Klein ED, Oosterwijk RS, Meerwaldt AE, Munitz J, Prévot G, Vera Verschuur A, Nauta SA, van Leeuwen EM, Fisher EL, de Jong KAM, Zhao Y, Toner YC, Soultanidis G, Calcagno C, Bomans PHH, Friedrich H, Sommerdijk N, Reiner T, Duivenvoorden R, Zupančič E, Di Martino JS, Kluza E, Rashidian M, Ploegh HL, Dijkhuizen RM, Hak S, P
Published in: Cell, 2020, Page(s) 786-801, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2020.09.059

Trained immunity as a novel approach against COVID‐19 with a focus on Bacillus Calmette–Guérin vaccine: mechanisms, challenges and perspectives

Author(s): Yahya Sohrabi, Jéssica Cristina Dos Santos, Marc Dorenkamp, Hannes Findeisen, Rinesh Godfrey, Mihai G Netea, Leo AB Joosten
Published in: Clinical & Translational Immunology, Issue 9/12, 2020, ISSN 2050-0068
Publisher: ASI
DOI: 10.1002/cti2.1228

BCG Vaccination Induces Long-Term Functional Reprogramming of Human Neutrophils

Author(s): Simone J.C.F.M. Moorlag, Yessica Alina Rodriguez-Rosales, Joshua Gillard, Stephanie Fanucchi, Kate Theunissen, Boris Novakovic, Cynthia M. de Bont, Yutaka Negishi, Ezio T. Fok, Lydia Kalafati, Panayotis Verginis, Vera P. Mourits, Valerie A.C.M. Koeken, L. Charlotte J. de Bree, Ger J.M. Pruijn, Craig Fenwick, Reinout van Crevel, Leo A.B. Joosten, Irma Joosten, Hans Koenen, Musa M. Mhlanga, Dimitri
Published in: Cell Reports, Issue 33/7, 2020, Page(s) 108387, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2020.108387

The Role of Cell Metabolism in Innate Immune Memory

Author(s): Anaisa Valido Ferreira, Jorge Domiguéz-Andrés, Mihai Gheorghe Netea
Published in: Journal of Innate Immunity, 2021, Page(s) 1-9, ISSN 1662-811X
Publisher: Karger AG
DOI: 10.1159/000512280

Influence of the microbiome, diet and genetics on inter-individual variation in the human plasma metabolome

Author(s): Andreu-Sánchez S, Wang D, Augustijn HE, Vich Vila A; Lifelines Cohort Study, Weersma RK, Medema MH, Netea MG, Kuipers F, Wijmenga C, Zhernakova A, Fu J.
Published in: Nature medicine, Issue 28 nov 2022, 2022, Page(s) 2322-2343, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-022-02014-8

Presence of Genetic Variants Among Young Men With Severe COVID-19

Author(s): Caspar I. van der Made, Annet Simons, Janneke Schuurs-Hoeijmakers, Guus van den Heuvel, Tuomo Mantere, Simone Kersten, Rosanne C. van Deuren, Marloes Steehouwer, Simon V. van Reijmersdal, Martin Jaeger, Tom Hofste, Galuh Astuti, Jordi Corominas Galbany, Vyne van der Schoot, Hans van der Hoeven, Wanda Hagmolen of ten Have, Eva Klijn, Catrien van den Meer, Jeroen Fiddelaers, Quirijn de Mast, Chantal
Published in: JAMA, Issue 324/7, 2020, Page(s) 663, ISSN 0098-7484
Publisher: American Medical Association
DOI: 10.1001/jama.2020.13719

Plasma metabolome predicts trained immunity responses after antituberculosis BCG vaccination.

Author(s): Koeken VACM, Qi C, Mourits VP, de Bree LCJ, Moorlag SJCFM, Sonawane V, Lemmers H, Dijkstra H, Joosten LAB, van Laarhoven A, Xu CJ, van Crevel R, Netea MG, Li Y.
Published in: PLoS Biology, Issue 12 Sept 2022, 20(9), 2022, Page(s) e3001765, ISSN 1544-9173
Publisher: Public Library of Science
DOI: 10.1371/journal.pbio.3001765

Deadly COVID-19 among the elderly: Innate immune memory helping those most in need

Author(s): Yahya Sohrabi, Holger Reinecke, Leo A.B. Joosten, Mihai G. Netea
Published in: Med, Issue 2/4, 2021, Page(s) 378-383, ISSN 2666-6340
Publisher: elsevier
DOI: 10.1016/j.medj.2021.02.004

Dysregulated Innate and Adaptive Immune Responses Discriminate Disease Severity in COVID-19

Author(s): Nico A F Janssen, Inge Grondman, Aline H de Nooijer, Collins K Boahen, Valerie A C M Koeken, Vasiliki Matzaraki, Vinod Kumar, Xuehui He, Matthijs Kox, Hans J P M Koenen, Ruben L Smeets, Irma Joosten, Roger J M Brüggemann, Ilse J E Kouijzer, Hans G van der Hoeven, Jeroen A Schouten, Tim Frenzel, Monique H E Reijers, Wouter Hoefsloot, Anton S M Dofferhoff, Marjan J van Apeldoorn, Marc J T Blaauw, K
Published in: The Journal of Infectious Diseases, Issue 223/8, 2021, Page(s) 1322-1333, ISSN 0022-1899
Publisher: University of Chicago Press
DOI: 10.1093/infdis/jiab065

Favorable Anakinra Responses in Severe Covid-19 Patients with Secondary Hemophagocytic Lymphohistiocytosis

Author(s): George Dimopoulos, Quirijn de Mast, Nikolaos Markou, Maria Theodorakopoulou, Apostolos Komnos, Maria Mouktaroudi, Mihai G. Netea, Themistoklis Spyridopoulos, Rebecca J. Verheggen, Jacobien Hoogerwerf, Alexandra Lachana, Frank L. van de Veerdonk, Evangelos J. Giamarellos-Bourboulis
Published in: Cell Host & Microbe, Issue 28/1, 2020, Page(s) 117-123.e1, ISSN 1931-3128
Publisher: Cell Press
DOI: 10.1016/j.chom.2020.05.007

The Association of TSH and Thyroid Hormones With Lymphopenia in Bacterial Sepsis and COVID-19

Author(s): Inge Grondman, Aline H de Nooijer, Nikolaos Antonakos, Nico A F Janssen, Maria Mouktaroudi, Konstantinos Leventogiannis, Marco Medici, Jan W A Smit, Antonius E van Herwaarden, Leo A B Joosten, Frank L van de Veerdonk, Peter Pickkers, Matthijs Kox, Martin Jaeger, Mihai G Netea, Evangelos J Giamarellos-Bourboulis, Romana T Netea-Maier
Published in: The Journal of Clinical Endocrinology & Metabolism, 2021, ISSN 0021-972X
Publisher: The Endocrine Society
DOI: 10.1210/clinem/dgab148

The anti-inflammatory cytokine interleukin-37 is an inhibitor of trained immunity

Author(s): Giulio Cavalli, Isak W. Tengesdal, Mark Gresnigt, Travis Nemkov, Rob J.W. Arts, Jorge Domínguez-Andrés, Raffaella Molteni, Davide Stefanoni, Eleonora Cantoni, Laura Cassina, Silvia Giugliano, Kiki Schraa, Taylor S. Mills, Eric M. Pietras, Elan Z. Eisenmensser, Lorenzo Dagna, Alessandra Boletta, Angelo D’Alessandro, Leo A.B. Joosten, Mihai G. Netea, Charles A. Dinarello
Published in: Cell Reports, Issue 35/1, 2021, Page(s) 108955, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2021.108955

BCG vaccination in health care providers and the protection against COVID-19

Author(s): Mihai G. Netea, Jos W.M. van der Meer, Reinout van Crevel
Published in: Journal of Clinical Investigation, Issue 131/2, 2021, ISSN 0021-9738
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci145545

Complement Activation in the Disease Course of Coronavirus Disease 2019 and Its Effects on Clinical Outcomes

Author(s): Aline H de Nooijer, Inge Grondman, Nico A F Janssen, Mihai G Netea, Loek Willems, Frank L van de Veerdonk, Evangelos J Giamarellos-Bourboulis, Erik J M Toonen, Leo A B Joosten, Martin Jaeger, Helga Dijkstra, Heidi Lemmers, Liesbeth van Emst, Kiki Schraa, Cor Jacobs, Anneke Hijmans, Trees Jansen, Fieke Weren, Liz Fransman, Jelle Gerretsen, Josephine van de Maat, Gerine Nijman, Simone Moorlag, Esthe
Published in: The Journal of Infectious Diseases, Issue 223/2, 2020, Page(s) 214-224, ISSN 0022-1899
Publisher: University of Chicago Press
DOI: 10.1093/infdis/jiaa646

New live attenuated tuberculosis vaccine MTBVAC induces trained immunity and confers protection against experimental lethal pneumonia

Author(s): Raquel Tarancón, Jorge Domínguez-Andrés, Santiago Uranga, Anaísa V. Ferreira, Laszlo A. Groh, Mirian Domenech, Fernando González-Camacho, Niels P. Riksen, Nacho Aguilo, José Yuste, Carlos Martín, Mihai G. Netea
Published in: PLOS Pathogens, Issue 16/4, 2020, Page(s) e1008404, ISSN 1553-7374
Publisher: PLOS
DOI: 10.1371/journal.ppat.1008404

Anakinra treatment in critically ill COVID-19 patients: a prospective cohort study

Author(s): Emma J. Kooistra, Nicole J. B. Waalders, Inge Grondman, Nico A. F. Janssen, Aline H. de Nooijer, Mihai G. Netea, Frank L. van de Veerdonk, Esther Ewalds, Johannes G. van der Hoeven, Matthijs Kox, Peter Pickkers
Published in: Critical Care, Issue 24/1, 2020, ISSN 1364-8535
Publisher: Springer Nature
DOI: 10.1186/s13054-020-03364-w

Glutathione Metabolism Contributes to the Induction of Trained Immunity

Author(s): Anaisa V. Ferreira, Valerie A. C. M. Koeken, Vasiliki Matzaraki, Sarantos Kostidis, Juan Carlos Alarcon-Barrera, L. Charlotte J. de Bree, Simone J. C. F. M. Moorlag, Vera P. Mourits, Boris Novakovic, Martin A. Giera, Mihai G. Netea, Jorge Domínguez-Andrés
Published in: Cells, Issue 10/5, 2021, Page(s) 971, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells10050971

BCG vaccination in humans inhibits systemic inflammation in a sex-dependent manner

Author(s): Valerie A.C.M. Koeken, L. Charlotte J. de Bree, Vera P. Mourits, Simone J.C.F.M. Moorlag, Jona Walk, Branko Cirovic, Rob J.W. Arts, Martin Jaeger, Helga Dijkstra, Heidi Lemmers, Leo A.B. Joosten, Christine S. Benn, Reinout van Crevel, Mihai G. Netea
Published in: Journal of Clinical Investigation, Issue 130/10, 2020, Page(s) 5591-5602, ISSN 0021-9738
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci133935

Immune cells fold and damage fungal hyphae

Author(s): Judith M. Bain, M. Fernanda Alonso, Delma S. Childers, Catriona A. Walls, Kevin Mackenzie, Arnab Pradhan, Leanne E. Lewis, Johanna Louw, Gabriela M. Avelar, Daniel E. Larcombe, Mihai G. Netea, Neil A. R. Gow, Gordon D. Brown, Lars P. Erwig, Alistair J. P. Brown
Published in: Proceedings of the National Academy of Sciences, Issue 118/15, 2021, Page(s) e2020484118, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2020484118

A minimal common outcome measure set for COVID-19 clinical research

Author(s): John C Marshall, Srinivas Murthy, Janet Diaz, N K Adhikari, Derek C Angus, Yaseen M Arabi, Kenneth Baillie, Michael Bauer, Scott Berry, Bronagh Blackwood, Marc Bonten, Fernando Bozza, Frank Brunkhorst, Allen Cheng, Mike Clarke, Vu Quoc Dat, Menno de Jong, Justin Denholm, Lennie Derde, Jake Dunning, Xiaobin Feng, Tom Fletcher, Nadine Foster, Rob Fowler, Nina Gobat, Charles Gomersall, Anthony Gordon
Published in: The Lancet Infectious Diseases, Issue 20/8, 2020, Page(s) e192-e197, ISSN 1473-3099
Publisher: The Lancet Publishing Group
DOI: 10.1016/s1473-3099(20)30483-7

Beneficial non-specific effects of live vaccines against COVID-19 and other unrelated infections

Author(s): Aaby P, Netea MG, Benn CS.
Published in: Lancet Inct. dis., Issue 29 aug 2022, 2022, Page(s) S1473-3099(22)00498-4, ISSN 1473-3099
Publisher: The Lancet Publishing Group
DOI: 10.1016/s1473-3099(22)00498-4

Comparative host transcriptome in response to pathogenic fungi identifies common and species-specific transcriptional antifungal host response pathways

Author(s): Mariolina Bruno, Intan M.W. Dewi, Vicky Matzaraki, Rob ter Horst, Marina Pekmezovic, Berenice Rösler, Laszlo Groh, Rutger J. Röring, Vinod Kumar, Yang Li, Agostinho Carvalho, Mihai G. Netea, Jean-Paul Latgé, Mark S. Gresnigt, Frank L. van de Veerdonk
Published in: Computational and Structural Biotechnology Journal, Issue 19, 2021, Page(s) 647-663, ISSN 2001-0370
Publisher: Elsevier
DOI: 10.1016/j.csbj.2020.12.036

BCG-induced non-specific effects on heterologous infectious disease in Ugandan neonates: an investigator-blind randomised controlled trial

Author(s): Sarah Prentice, Beatrice Nassanga, Emily L Webb, Florence Akello, Fred Kiwudhu, Hellen Akurut, Alison M Elliott, Rob J W Arts, Mihai G Netea, Hazel M Dockrell, Stephen Cose, Sarah Prentice, Beatrice Nassanga, Hellen Akurut, Florence Akello, Fred Kiwudhu, Stephen Cose, Hazel Dockrell, Emily Webb, Alison Elliott, Irene Nabaweesi, Christopher Zziwa, Milly Namutebi, Benigna Namarra, Florence Akello, E
Published in: The Lancet Infectious Diseases, 2021, ISSN 1473-3099
Publisher: The Lancet Publishing Group
DOI: 10.1016/s1473-3099(20)30653-8

Complex Immune Dysregulation in COVID-19 Patients with Severe Respiratory Failure

Author(s): Evangelos J. Giamarellos-Bourboulis, Mihai G. Netea, Nikoletta Rovina, Karolina Akinosoglou, Anastasia Antoniadou, Nikolaos Antonakos, Georgia Damoraki, Theologia Gkavogianni, Maria-Evangelia Adami, Paraskevi Katsaounou, Maria Ntaganou, Magdalini Kyriakopoulou, George Dimopoulos, Ioannis Koutsodimitropoulos, Dimitrios Velissaris, Panagiotis Koufargyris, Athanassios Karageorgos, Konstantina Katrini
Published in: Cell Host & Microbe, Issue 27/6, 2020, Page(s) 992-1000.e3, ISSN 1931-3128
Publisher: Cell Press
DOI: 10.1016/j.chom.2020.04.009

Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients

Author(s): Anna C. Aschenbrenner, Maria Mouktaroudi, Benjamin Krämer, Marie Oestreich, Nikolaos Antonakos, Melanie Nuesch-Germano, Konstantina Gkizeli, Lorenzo Bonaguro, Nico Reusch, Kevin Baßler, Maria Saridaki, Rainer Knoll, Tal Pecht, Theodore S. Kapellos, Sarandia Doulou, Charlotte Kröger, Miriam Herbert, Lisa Holsten, Arik Horne, Ioanna D. Gemünd, Nikoletta Rovina, Shobhit Agrawal, Kilian Dahm, Mart
Published in: Genome Medicine, Issue 13/1, 2021, ISSN 1756-994X
Publisher: BioMed Central
DOI: 10.1186/s13073-020-00823-5

Chronic HIV infection induces transcriptional and functional reprogramming of innate immune cells

Author(s): Wouter A. van der Heijden, Lisa Van de Wijer, Farid Keramati, Wim Trypsteen, Sofie Rutsaert, Rob ter Horst, Martin Jaeger, Hans J.P.M. Koenen, Hendrik G. Stunnenberg, Irma Joosten, Paul E. Verweij, Jan van Lunzen, Charles A. Dinarello, Leo A.B. Joosten, Linos Vandekerckhove, Mihai G. Netea, André J.A.M. van der Ven, Quirijn de Mast
Published in: JCI Insight, Issue 6/7, 2021, ISSN 2379-3708
Publisher: ASCI
DOI: 10.1172/jci.insight.145928

Controlled Human Malaria Infection Induces Long-Term Functional Changes in Monocytes

Author(s): Jona Walk, Farid Keramati, L. Charlotte J. de Bree, Rob J. W. Arts, Bas Blok, Mihai G. Netea, Hendrik G. Stunnenberg, Robert W. Sauerwein
Published in: Frontiers in Molecular Biosciences, Issue 7, 2020, ISSN 2296-889X
Publisher: Frontiers in Molecular Biosciences
DOI: 10.3389/fmolb.2020.604553

An integrative genomics approach identifies KDM4 as a modulator of trained immunity.

Author(s): Moorlag SJCFM, Matzaraki V, van Puffelen JH, van der Heijden C, Keating S, Groh L, Röring RJ, Bakker OB, Mourits VP, Koeken VACM, de Bree LCJ, Smeekens SP, Oosting M, Gamboa RA, Riksen NP, Xavier RJ, Wijmenga C, Kumar V, van Crevel R, Novakovic B, Joosten LAB, Li Y, Netea MG.
Published in: Eur J Immunol., Issue 2022, 2022, Page(s) 431-446, ISSN 0014-2980
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/eji.202149577

Lysine methyltransferase G9a is an important modulator of trained immunity

Author(s): Vera P Mourits, Jelmer H Puffelen, Boris Novakovic, Mariolina Bruno, Anaísa V Ferreira, Rob JW Arts, Laszlo Groh, Tania O Crișan, Jelle Zwaag, Elisa Jentho, Matthijs Kox, Peter Pickkers, Frank L Veerdonk, Sebastian Weis, Egbert Oosterwijk, Sita H Vermeulen, Mihai G Netea, Leo AB Joosten
Published in: Clinical & Translational Immunology, Issue 10/2, 2021, ISSN 2050-0068
Publisher: Wiley & Sons
DOI: 10.1002/cti2.1253

Impaired ketogenesis ties metabolism to T cell dysfunction in COVID-19

Author(s): Karagiannis F, Peukert K, Surace L, Michla M, Nikolka F, Fox M, Weiss P, Feuerborn C, Maier P, Schulz S, Al B, Seeliger B, Welte T, David S, Grondman I, de Nooijer AH, Pickkers P, Kleiner JL, Berger MM, Brenner T, Putensen C; Bonn COVIMMUNE Consortium, Kato H, Garbi N, Netea MG, Hiller K, Placek K, Bode C, Wilhelm C.
Published in: Nature, Issue july 28 2022, 2022, Page(s) 801-807, ISSN 1476-4687
Publisher: Nature Research
DOI: 10.1038/s41586-022-05128-8

An integrative model of cardiometabolic traits identifies two types of metabolic syndrome

Author(s): Amit Frishberg, Inge van den Munckhof, Rob ter Horst, Kiki Schraa, Leo AB Joosten, Joost HW Rutten, Adrian C Iancu, Ioana M Dregoesc, Bogdan A Tigu, Mihai G Netea, Niels P Riksen, Irit Gat-Viks
Published in: eLife, Issue 10, 2021, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.61710

The influence of the gut microbiome on BCG-induced trained immunity.

Author(s): Stražar M, Mourits VP, Koeken VACM, de Bree LCJ, Moorlag SJCFM, Joosten LAB, van Crevel R, Vlamakis H, Netea MG, Xavier RJ
Published in: Genome Biology, 2021, Page(s) 275, ISSN 1474-760X
Publisher: BMC
DOI: 10.1186/s13059-021-02482-0

Two Randomized Controlled Trials of Bacillus Calmette-Guérin Vaccination to reduce absenteeism among health care workers and hospital admission by elderly persons during the COVID-19 pandemic: A structured summary of the study protocols for two randomised controlled trials

Author(s): Thijs ten Doesschate, Simone J. C. F. M. Moorlag, Thomas W. van der Vaart, Esther Taks, Priya Debisarun, Jaap ten Oever, Chantal P. Bleeker-Rovers, Patricia Bruijning Verhagen, Arief Lalmohamed, Rob ter Heine, Reinout van Crevel, Janneke van de Wijgert, Axel B. Janssen, Marc J. Bonten, Cornelis H. van Werkhoven, Mihai G. Netea
Published in: Trials, Issue 21/1, 2020, ISSN 1745-6215
Publisher: BioMed Central
DOI: 10.1186/s13063-020-04389-w

BCG Vaccination in Humans Elicits Trained Immunity via the Hematopoietic Progenitor Compartment

Author(s): Branko Cirovic, L. Charlotte J. de Bree, Laszlo Groh, Bas A. Blok, Joyce Chan, Walter J.F.M. van der Velden, M.E.J. Bremmers, Reinout van Crevel, Kristian Händler, Simone Picelli, Jonas Schulte-Schrepping, Kathrin Klee, Marije Oosting, Valerie A.C.M. Koeken, Jakko van Ingen, Yang Li, Christine S. Benn, Joachim L. Schultze, Leo A.B. Joosten, Nigel Curtis, Mihai G. Netea, Andreas Schlitzer
Published in: Cell Host & Microbe, Issue 28/2, 2020, Page(s) 322-334.e5, ISSN 1931-3128
Publisher: Cell Press
DOI: 10.1016/j.chom.2020.05.014

Conceptualization of population-specific human functional immune-genomics projects to identify factors that contribute to variability in immune and infectious diseases

Author(s): Collins K. Boahen, Leo A.B. Joosten, Mihai G. Netea, Vinod Kumar
Published in: Heliyon, Issue 7/4, 2021, Page(s) e06755, ISSN 2405-8440
Publisher: Cellpress, Elsevier
DOI: 10.1016/j.heliyon.2021.e06755

Innate Immune Training of Human Macrophages by Cathelicidin Analogs

Author(s): Dijk A, Anten J, Bakker A, Evers N, Hoekstra AT, Chang JC, Scheenstra MR, Veldhuizen EJA, Netea MG, Berkers CR, Haagsman HP.
Published in: Front Immunol ., Issue 26 july 2022, 2022, Page(s) 13:777530, ISSN 1664-3224
Publisher: Frontiers Research Foundation
DOI: 10.3389/fimmu.2022.777530

The Architecture of Circulating Immune Cells Is Dysregulated in People Living With HIV on Long Term Antiretroviral Treatment and Relates With Markers of the HIV-1 Reservoir, Cytomegalovirus, and Microbial Translocation

Author(s): Lisa Van de Wijer, Wouter A. van der Heijden, Rob ter Horst, Martin Jaeger, Wim Trypsteen, Sofie Rutsaert, Bram van Cranenbroek, Esther van Rijssen, Irma Joosten, Leo Joosten, Linos Vandekerckhove, Till Schoofs, Jan van Lunzen, Mihai G. Netea, Hans J.P.M. Koenen, André J.A.M. van der Ven, Quirijn de Mast
Published in: Frontiers in Immunology, Issue 12, 2021, ISSN 1664-3224
Publisher: Frontiers in Immunology
DOI: 10.3389/fimmu.2021.661990

Systemic administration of β-glucan induces immune training in microglia

Author(s): Yang Heng, Xiaoming Zhang, Malte Borggrewe, Hilmar R. J. van Weering, Maaike L. Brummer, Tjalling W. Nijboer, Leo A. B. Joosten, Mihai G. Netea, Erik W. G. M. Boddeke, Jon D. Laman, Bart J. L. Eggen
Published in: Journal of Neuroinflammation, Issue 18/1, 2021, ISSN 1742-2094
Publisher: BioMed Central
DOI: 10.1186/s12974-021-02103-4

Rare variants increase the risk of severe COVID-19

Author(s): Frank L van de Veerdonk, Mihai G Netea
Published in: eLife, Issue 10, 2021, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.67860

Postinfectious Epigenetic Immune Modifications — A Double-Edged Sword

Author(s): Andrew R. DiNardo, Mihai G. Netea, Daniel M. Musher
Published in: New England Journal of Medicine, Issue 384/3, 2021, Page(s) 261-270, ISSN 0028-4793
Publisher: Massachusetts Medical Society
DOI: 10.1056/nejmra2028358

Activate: Randomized Clinical Trial of BCG Vaccination against Infection in the Elderly

Author(s): Evangelos J. Giamarellos-Bourboulis, Maria Tsilika, Simone Moorlag, Nikolaos Antonakos, Antigone Kotsaki, Jorge Domínguez-Andrés, Evdoxia Kyriazopoulou, Theologia Gkavogianni, Maria-Evangelia Adami, Georgia Damoraki, Panagiotis Koufargyris, Athanassios Karageorgos, Amalia Bolanou, Hans Koenen, Reinout van Crevel, Dionyssia-Irene Droggiti, George Renieris, Antonios Papadopoulos, Mihai G. Netea
Published in: Cell, Issue 183/2, 2020, Page(s) 315-323.e9, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2020.08.051

Bridging animal and clinical research during SARS-CoV-2 pandemic: A new-old challenge

Author(s): Martin S. Winkler, Tomasz Skirecki, Frank M. Brunkhorst, Sara Cajander, Jean-Marc Cavaillon, Ricard Ferrer, Stefanie B. Flohé, Alberto García-Salido, Evangelos J. Giamarellos-Bourboulis, Massimo Girardis, Matthijs Kox, Gunnar Lachmann, Ignacio Martin-Loeches, Mihai G. Netea, Thibaud Spinetti, Joerg C. Schefold, Antoni Torres, Florian Uhle, Fabienne Venet, Sebastian Weis, André Scherag, Ignacio
Published in: EBioMedicine, Issue 66, 2021, Page(s) 103291, ISSN 2352-3964
Publisher: Elsevier BV
DOI: 10.1016/j.ebiom.2021.103291

Neonatal BCG vaccination is associated with a long-term DNA methylation signature in circulating monocytes

Author(s): Bannister S, Kim B, Domínguez-Andrés J, Kilic G, Ansell BRE, Neeland MR, Moorlag SJCFM, Matzaraki V, Vlahos A, Shepherd R, Germano S, Bahlo M, Messina NL, Saffery R, Netea MG, Curtis N, Novakovic B.
Published in: Sci Adv, Issue 5 aug 2022, 2022, Page(s) 8(31):eabn4002, ISSN 2375-2548
Publisher: American Association for the Advancement of Science,
DOI: 10.1126/sciadv.abn4002

Innate Immune Training of Granulopoiesis Promotes Anti-tumor Activity

Author(s): Lydia Kalafati, Ioannis Kourtzelis, Jonas Schulte-Schrepping, Xiaofei Li, Aikaterini Hatzioannou, Tatyana Grinenko, Eman Hagag, Anupam Sinha, Canan Has, Sevina Dietz, Antonio Miguel de Jesus Domingues, Marina Nati, Sundary Sormendi, Ales Neuwirth, Antonios Chatzigeorgiou, Athanasios Ziogas, Mathias Lesche, Andreas Dahl, Ian Henry, Pallavi Subramanian, Ben Wielockx, Peter Murray, Peter Mirtschink,
Published in: Cell, Issue 183/3, 2020, Page(s) 771-785.e12, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2020.09.058

BCG-induced trained immunity: can it offer protection against COVID-19?

Author(s): Luke A. J. O’Neill, Mihai G. Netea
Published in: Nature Reviews Immunology, Issue 20/6, 2020, Page(s) 335-337, ISSN 1474-1733
Publisher: Nature Publishing Group
DOI: 10.1038/s41577-020-0337-y

Thyrotrophin and thyroxine support immune homeostasis in humans

Author(s): Martin Jaeger, Yvette J.E Sloot, Rob Ter Horst, Xiaojing Chu, Hans J.P.M. Koenen, Valerie A.C.M. Koeken, Simone J.C.F.M. Moorlag, Charlotte J. Bree, Vera P. Mourits, Heidi Lemmers, Helga Dijkstra, Marco Medici, Antonius E. Herwaarden, Irma Joosten, Leo A.B. Joosten, Yang Li, Johannes W.A. Smit, Mihai G. Netea, Romana T. Netea‐Maier
Published in: Immunology, Issue 163/2, 2021, Page(s) 155-168, ISSN 0019-2805
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/imm.13306

Transmission of trained immunity and heterologous resistance to infections across generations

Author(s): Katzmarski N, Domínguez-Andrés J, Cirovic B, Renieris G, Ciarlo E, Le Roy D, Lepikhov K, Kattler K, Gasparoni G, Händler K, Theis H, Beyer M, van der Meer JWM, Joosten LAB, Walter J, Schultze JL, Roger T, Giamarellos-Bourboulis EJ, Schlitzer A, Netea MG.
Published in: Nat Immunol., Issue 11, 2021, Page(s) 1382-1390, ISSN 1529-2908
Publisher: Nature Publishing Group
DOI: 10.1038/s41590-021-01052-7

Circadian rhythm influences induction of trained immunity by BCG vaccination

Author(s): L. Charlotte J. de Bree, Vera P. Mourits, Valerie A.C.M. Koeken, Simone J.C.F.M. Moorlag, Robine Janssen, Lukas Folkman, Daniele Barreca, Thomas Krausgruber, Victoria Fife-Gernedl, Boris Novakovic, Rob J.W. Arts, Helga Dijkstra, Heidi Lemmers, Christoph Bock, Leo A.B. Joosten, Reinout van Crevel, Christine S. Benn, Mihai G. Netea
Published in: Journal of Clinical Investigation, Issue 130/10, 2020, Page(s) 5603-5617, ISSN 0021-9738
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci133934

Using BCG vaccine to enhance non-specific protection of health care workers during the COVID-19 pandemic: A structured summary of a study protocol for a randomised controlled trial in Denmark

Author(s): Anne Marie Rosendahl Madsen, Frederik Schaltz-Buchholzer, Thomas Benfield, Morten Bjerregaard-Andersen, Lars Skov Dalgaard, Christine Dam, Sisse Bolm Ditlev, Gulia Faizi, Isik Somuncu Johansen, Poul-Erik Kofoed, Gitte Schultz Kristensen, Ellen Christine Leth Loekkegaard, Christian Backer Mogensen, Libin Mohamed, Anne Ostenfeld, Emilie Sundhaugen Oedegaard, Marcus Kjaer Soerensen, Christian Wejse,
Published in: Trials, Issue 21/1, 2020, ISSN 1745-6215
Publisher: BioMed Central
DOI: 10.1186/s13063-020-04714-3

Evidence for the heterologous benefits of prior BCG vaccination on COVISHIELD™ vaccine-induced immune responses in SARS-CoV-2 seronegative young Indian adults

Author(s): Chetan Kumar N, Dwarkanath P, Shivalingaiah S, Rao S, D'Souza G, Dias M, Maguire TJA, Doores KJ, Zoodsma M, Geckin B, Dasgupta P, Babji S, van Meijgaarden KE, Joosten SA, Ottenhoff THM, Li Y, Netea MG, Stuart KD, De Rosa SC, McElrath MJ, Vyakarnam A.
Published in: Front Immunol, Issue 4 Oct 2022, 2022, Page(s) 13:985938, ISSN 1664-3224
Publisher: Frontiers Research Foundation
DOI: 10.3389/fimmu.2022.985938

Trained Immunity: a Tool for Reducing Susceptibility to and the Severity of SARS-CoV-2 Infection

Author(s): Mihai G. Netea, Evangelos J. Giamarellos-Bourboulis, Jorge Domínguez-Andrés, Nigel Curtis, Reinout van Crevel, Frank L. van de Veerdonk, Marc Bonten
Published in: Cell, Issue 181/5, 2020, Page(s) 969-977, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2020.04.042

Single-cell RNA sequencing reveals induction of distinct trained-immunity programs in human monocytes.

Author(s): Zhang B, Moorlag SJ, Dominguez-Andres J, Bulut Ö, Kilic G, Liu Z, van Crevel R, Xu CJ, Joosten LA, Netea MG, Li Y.
Published in: J. Clin. Invest., Issue 7, 2022, Page(s) 132, ISSN 0021-9738
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci147719

Designing the Next Generation of Vaccines: Relevance for Future Pandemics

Author(s): Jorge Domínguez-Andrés, Reinout van Crevel, Maziar Divangahi, Mihai G. Netea
Published in: mBio, Issue 11/6, 2020, ISSN 2161-2129
Publisher: American Society for Microbiology
DOI: 10.1128/mbio.02616-20

The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity

Author(s): Marcin F Osuchowski, Martin S Winkler, Tomasz Skirecki, Sara Cajander, Manu Shankar-Hari, Gunnar Lachmann, Guillaume Monneret, Fabienne Venet, Michael Bauer, Frank M Brunkhorst, Sebastian Weis, Alberto Garcia-Salido, Matthijs Kox, Jean-Marc Cavaillon, Florian Uhle, Markus A Weigand, Stefanie B Flohé, W Joost Wiersinga, Raquel Almansa, Amanda de la Fuente, Ignacio Martin-Loeches, Christian Meisel,
Published in: The Lancet Respiratory Medicine, Issue 9/6, 2021, Page(s) 622-642, ISSN 2213-2600
Publisher: Elsevier Limited
DOI: 10.1016/s2213-2600(21)00218-6

An open label trial of anakinra to prevent respiratory failure in COVID-19

Author(s): Evdoxia Kyriazopoulou, Periklis Panagopoulos, Symeon Metallidis, George N Dalekos, Garyphallia Poulakou, Nikolaos Gatselis, Eleni Karakike, Maria Saridaki, Georgia Loli, Aggelos Stefos, Danai Prasianaki, Sarah Georgiadou, Olga Tsachouridou, Vasileios Petrakis, Konstantinos Tsiakos, Maria Kosmidou, Vassiliki Lygoura, Maria Dareioti, Haralampos Milionis, Ilias C Papanikolaou, Karolina Akinosoglou, D
Published in: eLife, Issue 10, 2021, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.66125

Characterization of sepsis inflammatory endotypes using circulatory proteins in patients with severe infection: a prospective cohort study

Author(s): Ricaño-Ponce I, Riza AL, de Nooijer AH, Pirvu A, Dorobantu S, Dragos A, Streata I, Roskanovic M, Grondman I, Dumitrescu F, Kumar V, Netea MG, Ioana M.
Published in: BMC infectious diseases, Issue 2022 Oct 8, 2022, Page(s) 22(1):778., ISSN 1471-2334
Publisher: BioMed Central
DOI: 10.1186/s12879-022-07761-0

Stronger induction of trained immunity by mucosal BCG or MTBVAC vaccination compared to standard intradermal vaccination

Author(s): Michel P.M. Vierboom, Karin Dijkman, Claudia C. Sombroek, Sam O. Hofman, Charelle Boot, Richard A.W. Vervenne, Krista G. Haanstra, Maarten van der Sande, Liesbeth van Emst, Jorge Domínguez-Andrés, Simone J.C.F.M. Moorlag, Clemens H.M. Kocken, Jelle Thole, Esteban Rodríguez, Eugenia Puentes, Joost H.A. Martens, Reinout van Crevel, Mihai G. Netea, Nacho Aguilo, Carlos Martin, Frank A.W. Verreck
Published in: Cell Reports Medicine, Issue 2/1, 2021, Page(s) 100185, ISSN 2666-3791
Publisher: Elsevier
DOI: 10.1016/j.xcrm.2020.100185

Data of common and species-specific transcriptional host responses to pathogenic fungi

Author(s): Mariolina Bruno, Robter Horst, Marina Pekmezovic, Vinod Kumar, Yang Li, Mihai G. Netea, Jean-Paul Latgé, Mark S. Gresnigt, Frank L. van de Veerdonk
Published in: Data in Brief, Issue 35, 2021, Page(s) 106928, ISSN 2352-3409
Publisher: Elsevier BV
DOI: 10.1016/j.dib.2021.106928

BCG-Induced Trained Immunity in Healthy Individuals: The Effect of Plasma Muramyl Dipeptide Concentrations

Author(s): Vera P. Mourits, Valerie A. C. M. Koeken, L. Charlotte J. de Bree, Simone J. C. F. M. Moorlag, Wern Cui Chu, Xiaoli Xu, Helga Dijkstra, Heidi Lemmers, Leo A. B. Joosten, Yue Wang, Reinout van Crevel, Mihai G. Netea
Published in: Journal of Immunology Research, Issue 2020, 2020, Page(s) 1-8, ISSN 2314-8861
Publisher: Hindawi Publishing Corporation
DOI: 10.1155/2020/5812743

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