Trained immunity: improving the next generation of vaccines for the older generation

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Pubblicazioni

RORα negatively regulates BCG-induced trained immunity

Autori: Kilic G, Matzaraki V, Bulut O, Baydemir I, Ferreira AV, Rabold K, Moorlag SJCFM, Koeken VACM, de Bree LCJ, Mourits VP, Joosten LAB, Domínguez-Andrés J, Netea MG.
Pubblicato in: Cellular Immunology, Numero 2024 Sep-Oct;, 2024, Pagina/e 403-404, ISSN 0008-8749
Editore: Academic Press
DOI: 10.1016/j.cellimm.2024.104862

A modular approach toward producing nanotherapeutics targeting the innate immune system

Autori: Mandy M. T. van Leent, Anu E. Meerwaldt, Alexandre Berchouchi, Yohana C. Toner, Marianne E. Burnett, Emma D. Klein, Anna Vera D. Verschuur, Sheqouia A. Nauta, Jazz Munitz, Geoffrey Prévot, Esther M. van Leeuwen, Farideh Ordikhani, Vera P. Mourits, Claudia Calcagno, Philip M. Robson, George Soultanidis, Thomas Reiner, Rick R. M. Joosten, Heiner Friedrich, Joren C. Madsen, Ewelina Kluza, Roy van de
Pubblicato in: Science Advances, Numero 7/10, 2021, Pagina/e eabe7853, ISSN 2375-2548
Editore: AAAS
DOI: 10.1126/sciadv.abe7853

The impact of BNT162b2 mRNA vaccine on adaptive and innate immune responses

Autori: : Föhse K, Geckin B, Zoodsma M, Kilic G, Liu Z, Röring RJ, Overheul GJ, van de Maat J, Bulut O, Hoogerwerf JJ, Ten Oever J, Simonetti E, Schaal H, Adams O, Müller L, Ostermann PN, van de Veerdonk FL, Joosten LAB, Haagmans BL, van Crevel R, van Rij RP, GeurtsvanKessel C, de Jonge MI, Li Y, Domínguez-Andrés J, Netea MG.
Pubblicato in: Clinical Immunology, Numero Volume 255, October 2023,, 2023, Pagina/e 109762, ISSN 1521-6616
Editore: Academic Press
DOI: 10.1016/j.clim.2023.109762

Defining trained immunity and its role in health and disease

Autori: Mihai G. Netea, Jorge Domínguez-Andrés, Luis B. Barreiro, Triantafyllos Chavakis, Maziar Divangahi, Elaine Fuchs, Leo A. B. Joosten, Jos W. M. van der Meer, Musa M. Mhlanga, Willem J. M. Mulder, Niels P. Riksen, Andreas Schlitzer, Joachim L. Schultze, Christine Stabell Benn, Joseph C. Sun, Ramnik J. Xavier, Eicke Latz
Pubblicato in: Nature Reviews Immunology, Numero 20/6, 2020, Pagina/e 375-388, ISSN 1474-1733
Editore: Nature Publishing Group
DOI: 10.1038/s41577-020-0285-6

β-Glucan Induces Protective Trained Immunity against Mycobacterium tuberculosis Infection: A Key Role for IL-1

Autori: Simone J.C.F.M. Moorlag, Nargis Khan, Boris Novakovic, Eva Kaufmann, Trees Jansen, Reinout van Crevel, Maziar Divangahi, Mihai G. Netea
Pubblicato in: Cell Reports, Numero 31/7, 2020, Pagina/e 107634, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2020.107634

Trained immunity: implications for vaccination

Autori: Büsranur Geckin, Friedrich Konstantin Föhse, Jorge Domínguez-Andrés, Mihai G Netea
Pubblicato in: Current Opinion in Immunology, Numero 77, 2023, Pagina/e 102190, ISSN 0952-7915
Editore: Elsevier BV
DOI: 10.1016/j.coi.2022.102190

A higher BMI is not associated with a different immune response and disease course in critically ill COVID-19 patients

Autori: Emma J. Kooistra, Aline H. de Nooijer, Wout J. Claassen, Inge Grondman, Nico A. F. Janssen, Mihai G. Netea, Frank L. van de Veerdonk, Johannes G. van der Hoeven, Matthijs Kox, Peter Pickkers
Pubblicato in: International Journal of Obesity, Numero 45/3, 2021, Pagina/e 687-694, ISSN 0307-0565
Editore: Nature Publishing Group
DOI: 10.1038/s41366-021-00747-z

Engineering cytokine therapeutics

Autori: : Deckers J, Anbergen T, Hokke AM, de Dreu A, Schrijver DP, de Bruin K, Toner YC, Beldman TJ, Spangler JB, de Greef TFA, Grisoni F, van der Meel R, Joosten LAB, Merkx M, Netea MG, Mulder WJM.
Pubblicato in: Nature Reviews Bioengineering, Numero 2023, 1, 2023, Pagina/e 286–303, ISSN 2731-6092
Editore: Clockss
DOI: 10.1038/s44222-023-00030-y

The role of sirtuin 1 on the induction of trained immunity.

Autori: Mourits VP, Helder LS, Matzaraki V, Koeken VACM, Groh L, de Bree LCJ, Moorlag SJCFM, van der Heijden CDCC, Keating ST, van Puffelen JH, Jaeger M, Joosten LAB, Netea MG.
Pubblicato in: Cell Immunol., 2021, Pagina/e 104393, ISSN 0008-8749
Editore: Academic Press
DOI: 10.1016/j.cellimm.2021.104393

The Set7 Lysine Methyltransferase Regulates Plasticity in Oxidative Phosphorylation Necessary for Trained Immunity Induced by β-Glucan

Autori: Samuel T. Keating, Laszlo Groh, Charlotte D.C.C. van der Heijden, Hanah Rodriguez, Jéssica C. dos Santos, Stephanie Fanucchi, Jun Okabe, Harikrishnan Kaipananickal, Jelmer H. van Puffelen, Leonie Helder, Marlies P. Noz, Vasiliki Matzaraki, Yang Li, L. Charlotte J. de Bree, Valerie A.C.M. Koeken, Simone J.C.F.M. Moorlag, Vera P. Mourits, Jorge Domínguez-Andrés, Marije Oosting, Elianne P. Bulthui
Pubblicato in: Cell Reports, Numero 31/3, 2020, Pagina/e 107548, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2020.107548

Urban living in healthy Tanzanians is associated with an inflammatory status driven by dietary and metabolic changes.

Autori: Temba GS, Kullaya V, Pecht T, Mmbaga BT, Aschenbrenner AC, Ulas T, Kibiki G, Lyamuya F, Boahen CK, Kumar V, Joosten LAB, Schultze JL, van der Ven AJ, Netea MG, de Mast Q.
Pubblicato in: Nat Immunol., 2021, Pagina/e 287-300, ISSN 1529-2908
Editore: Nature Publishing Group
DOI: 10.1038/s41590-021-00867-8

C5a-licensed phagocytes drive sterilizing immunity during systemic fungal infection

Autori: Desai JV, Kumar D, Freiwald T, Chauss D, Johnson MD, Abers MS, Steinbrink JM, Perfect JR, Alexander B, Matzaraki V, Snarr BD, Zarakas MA, Oikonomou V, Silva LM, Shivarathri R, Beltran E, Demontel LN, Wang L, Lim JK, Launder D, Conti HR, Swamydas M, McClain MT, Moutsopoulos NM, Kazemian M, Netea MG, Kumar V, Köhl J, Kemper C, Afzali B, Lionakis MS.
Pubblicato in: cell, Numero Volume 186, Numero 13, 22 June 2023, 2023, Pagina/e 2802-2822.e22, ISSN 0092-8674
Editore: Cell Press
DOI: 10.1016/j.cell.2023.04.031

In vitro induction of trained immunity in adherent human monocytes

Autori: Jorge Domínguez-Andrés, Rob J.W. Arts, Siroon Bekkering, Harsh Bahrar, Bastiaan A. Blok, L. Charlotte J. de Bree, Mariolina Bruno, Özlem Bulut, Priya A. Debisarun, Helga Dijkstra, Jéssica Cristina dos Santos, Anaísa V. Ferreira, Daniela Flores-Gomez, Laszlo A. Groh, Inge Grondman, Leonie Helder, Cor Jacobs, Liesbeth Jacobs, Trees Jansen, Gizem Kilic, Viola Klück, Valerie A.C.M. Koeken, Heidi
Pubblicato in: STAR Protocols, Numero 2/1, 2021, Pagina/e 100365, ISSN 2666-1667
Editore: Cell Press
DOI: 10.1016/j.xpro.2021.100365

Outcomes Associated With Use of a Kinin B2 Receptor Antagonist Among Patients With COVID-19

Autori: Frank L. van de Veerdonk, Ilse J. E. Kouijzer, Aline H. de Nooijer, Hans G. van der Hoeven, Coen Maas, Mihai G. Netea, Roger J. M. Brüggemann
Pubblicato in: JAMA Network Open, Numero 3/8, 2020, Pagina/e e2017708, ISSN 2574-3805
Editore: JAMA network
DOI: 10.1001/jamanetworkopen.2020.17708

Regulation of plasma soluble receptors of TNF and IL-1 in patients with COVID-19 differs from that observed in sepsis

Autori: Aksu MD, van der Ent T, Zhang Z, Riza AL, de Nooijer AH, Ricaño-Ponce I, Janssen N, Engel JJ, Streata I, Dijkstra H, Lemmers H, Grondman I, Koeken VACM, Antoniadou E, Antonakos N, van de Veerdonk FL, Li Y, Giamarellos-Bourboulis EJ, Netea MG, Ziogas A.
Pubblicato in: Journal of Infection, Numero Volume 89, Numero 6, December 2024,, 2024, Pagina/e 106300, ISSN 0163-4453
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.jinf.2024.106300

Hydroxychloroquine Inhibits the Trained Innate Immune Response to Interferons

Autori: Nils Rother, Cansu Yanginlar, Rik G.H. Lindeboom, Siroon Bekkering, Mandy M.T. van Leent, Baranca Buijsers, Inge Jonkman, Mark de Graaf, Marijke Baltissen, Lieke A. Lamers, Niels P. Riksen, Zahi A. Fayad, Willem J.M. Mulder, Luuk B. Hilbrands, Leo A.B. Joosten, Mihai G. Netea, Michiel Vermeulen, Johan van der Vlag, Raphaël Duivenvoorden
Pubblicato in: Cell Reports Medicine, Numero 1/9, 2020, Pagina/e 100146, ISSN 2666-3791
Editore: elsevier
DOI: 10.1016/j.xcrm.2020.100146

Safety and COVID-19 Symptoms in Individuals Recently Vaccinated with BCG: a Retrospective Cohort Study

Autori: Simone J.C.F.M. Moorlag, Rosanne C. van Deuren, Cornelis H. van Werkhoven, Martin Jaeger, Priya Debisarun, Esther Taks, Vera P. Mourits, Valerie A.C.M. Koeken, L. Charlotte J. de Bree, Thijs ten Doesschate, Maartje C. Cleophas, Sanne Smeekens, Marije Oosting, Frank L. van de Veerdonk, Leo A.B. Joosten, Jaap ten Oever, Jos W.M. van der Meer, Nigel Curtis, Peter Aaby, Christine Stabell-Benn, Evangel
Pubblicato in: Cell Reports Medicine, Numero 1/5, 2020, Pagina/e 100073, ISSN 2666-3791
Editore: Elsevier
DOI: 10.1016/j.xcrm.2020.100073

Trained Immunity-Promoting Nanobiologic Therapy Suppresses Tumor Growth and Potentiates Checkpoint Inhibition.

Autori: Priem B, van Leent MMT, Teunissen AJP, Sofias AM, Mourits VP, Willemsen L, Klein ED, Oosterwijk RS, Meerwaldt AE, Munitz J, Prévot G, Vera Verschuur A, Nauta SA, van Leeuwen EM, Fisher EL, de Jong KAM, Zhao Y, Toner YC, Soultanidis G, Calcagno C, Bomans PHH, Friedrich H, Sommerdijk N, Reiner T, Duivenvoorden R, Zupančič E, Di Martino JS, Kluza E, Rashidian M, Ploegh HL, Dijkhuizen RM, Hak S, P
Pubblicato in: Cell, 2020, Pagina/e 786-801, ISSN 0092-8674
Editore: Cell Press
DOI: 10.1016/j.cell.2020.09.059

Clonal hematopoiesis driven by mutated DNMT3A promotes inflammatory bone loss

Autori: Wang H, Divaris K, Pan B, Li X, Lim JH, Saha G, Barovic M, Giannakou D, Korostoff JM, Bing Y, Sen S, Moss K, Wu D, Beck JD, Ballantyne CM, Natarajan P, North KE, Netea MG, Chavakis T, Hajishengallis G.
Pubblicato in: Cell, Numero Volume 187, Numero 14, 11 July 2024,, 2024, Pagina/e 3690-3711.e19, ISSN 1097-4172
Editore: Cellpress
DOI: 10.1016/j.cell.2024.05.003

Trained immunity as a novel approach against COVID‐19 with a focus on Bacillus Calmette–Guérin vaccine: mechanisms, challenges and perspectives

Autori: Yahya Sohrabi, Jéssica Cristina Dos Santos, Marc Dorenkamp, Hannes Findeisen, Rinesh Godfrey, Mihai G Netea, Leo AB Joosten
Pubblicato in: Clinical & Translational Immunology, Numero 9/12, 2020, ISSN 2050-0068
Editore: ASI
DOI: 10.1002/cti2.1228

BCG Vaccination Induces Long-Term Functional Reprogramming of Human Neutrophils

Autori: Simone J.C.F.M. Moorlag, Yessica Alina Rodriguez-Rosales, Joshua Gillard, Stephanie Fanucchi, Kate Theunissen, Boris Novakovic, Cynthia M. de Bont, Yutaka Negishi, Ezio T. Fok, Lydia Kalafati, Panayotis Verginis, Vera P. Mourits, Valerie A.C.M. Koeken, L. Charlotte J. de Bree, Ger J.M. Pruijn, Craig Fenwick, Reinout van Crevel, Leo A.B. Joosten, Irma Joosten, Hans Koenen, Musa M. Mhlanga, Dimitri
Pubblicato in: Cell Reports, Numero 33/7, 2020, Pagina/e 108387, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2020.108387

The Role of Cell Metabolism in Innate Immune Memory

Autori: Anaisa Valido Ferreira, Jorge Domiguéz-Andrés, Mihai Gheorghe Netea
Pubblicato in: Journal of Innate Immunity, 2021, Pagina/e 1-9, ISSN 1662-811X
Editore: Karger AG
DOI: 10.1159/000512280

Toward personalized immunotherapy in sepsis: The PROVIDE randomized clinical trial

Autori: : Leventogiannis K, Kyriazopoulou E, Antonakos N, Kotsaki A, Tsangaris I, Markopoulou D, Grondman I, Rovina N, Theodorou V, Antoniadou E, Koutsodimitropoulos I, Dalekos G, Vlachogianni G, Akinosoglou K, Koulouras V, Komnos A, Kontopoulou T, Prekates A, Koutsoukou A, van der Meer JWM, Dimopoulos G, Kyprianou M, Netea MG, Giamarellos-Bourboulis EJ.
Pubblicato in: Cell Reports Medicine, Numero Volume 3, Numero 11, 15 November 2022,, 2022, Pagina/e 100817, ISSN 2666-3791
Editore: Cell Pres Elsevier Inc.
DOI: 10.1016/j.xcrm.2022.100817

Influence of the microbiome, diet and genetics on inter-individual variation in the human plasma metabolome

Autori: Andreu-Sánchez S, Wang D, Augustijn HE, Vich Vila A; Lifelines Cohort Study, Weersma RK, Medema MH, Netea MG, Kuipers F, Wijmenga C, Zhernakova A, Fu J.
Pubblicato in: Nature medicine, Numero 28 nov 2022, 2022, Pagina/e 2322-2343, ISSN 1078-8956
Editore: Nature Publishing Group
DOI: 10.1038/s41591-022-02014-8

Presence of Genetic Variants Among Young Men With Severe COVID-19

Autori: Caspar I. van der Made, Annet Simons, Janneke Schuurs-Hoeijmakers, Guus van den Heuvel, Tuomo Mantere, Simone Kersten, Rosanne C. van Deuren, Marloes Steehouwer, Simon V. van Reijmersdal, Martin Jaeger, Tom Hofste, Galuh Astuti, Jordi Corominas Galbany, Vyne van der Schoot, Hans van der Hoeven, Wanda Hagmolen of ten Have, Eva Klijn, Catrien van den Meer, Jeroen Fiddelaers, Quirijn de Mast, Chantal
Pubblicato in: JAMA, Numero 324/7, 2020, Pagina/e 663, ISSN 0098-7484
Editore: American Medical Association
DOI: 10.1001/jama.2020.13719

Plasma metabolome predicts trained immunity responses after antituberculosis BCG vaccination.

Autori: Koeken VACM, Qi C, Mourits VP, de Bree LCJ, Moorlag SJCFM, Sonawane V, Lemmers H, Dijkstra H, Joosten LAB, van Laarhoven A, Xu CJ, van Crevel R, Netea MG, Li Y.
Pubblicato in: PLoS Biology, Numero 12 Sept 2022, 20(9), 2022, Pagina/e e3001765, ISSN 1544-9173
Editore: Public Library of Science
DOI: 10.1371/journal.pbio.3001765

Deadly COVID-19 among the elderly: Innate immune memory helping those most in need

Autori: Yahya Sohrabi, Holger Reinecke, Leo A.B. Joosten, Mihai G. Netea
Pubblicato in: Med, Numero 2/4, 2021, Pagina/e 378-383, ISSN 2666-6340
Editore: elsevier
DOI: 10.1016/j.medj.2021.02.004

Trained immunity: adaptation within innate immune mechanisms

Autori: Jorge Domínguez-Andrés, Jéssica Cristina dos Santos, Siroon Bekkering, Willem J. M. Mulder, Jos W. M. van der Meer, Niels P. Riksen, Leo A. B. Joosten, Mihai G. Netea
Pubblicato in: Physiological Reviews, Numero 103, 2022, Pagina/e 313-346, ISSN 0031-9333
Editore: American Physiological Society
DOI: 10.1152/physrev.00031.2021

MMR vaccination induces trained immunity via functional and metabolic reprogramming of γδ T cells

Autori: Röring RJ, Debisarun PA, Botey-Bataller J, Suen TK, Bulut Ö, Kilic G, Koeken VA, Sarlea A, Bahrar H, Dijkstra H, Lemmers H, Gössling KL, Rüchel N, Ostermann PN, Müller L, Schaal H, Adams O, Borkhardt A, Ariyurek Y, de Meijer EJ, Kloet SL, Ten Oever J, Placek K, Li Y, Netea MG.
Pubblicato in: Journal of clinical investigation, Numero Published January 30, 2024, 2024, Pagina/e 106851, ISSN 1558-8238
Editore: London Open Access Text
DOI: 10.1172/jci170848

Dysregulated Innate and Adaptive Immune Responses Discriminate Disease Severity in COVID-19

Autori: Nico A F Janssen, Inge Grondman, Aline H de Nooijer, Collins K Boahen, Valerie A C M Koeken, Vasiliki Matzaraki, Vinod Kumar, Xuehui He, Matthijs Kox, Hans J P M Koenen, Ruben L Smeets, Irma Joosten, Roger J M Brüggemann, Ilse J E Kouijzer, Hans G van der Hoeven, Jeroen A Schouten, Tim Frenzel, Monique H E Reijers, Wouter Hoefsloot, Anton S M Dofferhoff, Marjan J van Apeldoorn, Marc J T Blaauw, K
Pubblicato in: The Journal of Infectious Diseases, Numero 223/8, 2021, Pagina/e 1322-1333, ISSN 0022-1899
Editore: University of Chicago Press
DOI: 10.1093/infdis/jiab065

The effect of BCG vaccination in the elderly on infectious and non-infectious immune-mediated diseases

Autori: Dulfer EA, Föhse K, Taks EJM, Moorlag SJCFM, Koekenbier EL, van de Maat JS, Ten Oever J, Hoogerwerf JJ, van Werkhoven CH, Bonten MJM, van Hylckama Vlieg A, Rosendaal FR, Netea MG
Pubblicato in: Journal of Infection, Numero Volume 89, Numero 6, December 2024, 2024, Pagina/e 106344, ISSN 1532-2742
Editore: sassari
DOI: 10.1016/j.jinf.2024.106344

A protein-free vaccine stimulates innate immunity and protects against nosocomial pathogens

Autori: Yan J, Nielsen TB, Lu P, Talyansky Y, Slarve M, Reza H, Novakovic B, Netea MG, Keller AE, Warren T, DiGiandomenico A, Sellman BR, Luna BM, Spellberg B. A
Pubblicato in: Science translational medicine, Numero 4 Oct 2023 Vol 15, Numero 716, 2023, Pagina/e 9556, ISSN 1946-6234
Editore: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.adf9556

Favorable Anakinra Responses in Severe Covid-19 Patients with Secondary Hemophagocytic Lymphohistiocytosis

Autori: George Dimopoulos, Quirijn de Mast, Nikolaos Markou, Maria Theodorakopoulou, Apostolos Komnos, Maria Mouktaroudi, Mihai G. Netea, Themistoklis Spyridopoulos, Rebecca J. Verheggen, Jacobien Hoogerwerf, Alexandra Lachana, Frank L. van de Veerdonk, Evangelos J. Giamarellos-Bourboulis
Pubblicato in: Cell Host & Microbe, Numero 28/1, 2020, Pagina/e 117-123.e1, ISSN 1931-3128
Editore: Cell Press
DOI: 10.1016/j.chom.2020.05.007

Fatty acid desaturation and lipoxygenase pathways support trained immunity

Autori: Ferreira AV, Alarcon-Barrera JC, Domínguez-Andrés J, Bulut Ö, Kilic G, Debisarun PA, Röring RJ, Özhan HN, Terschlüsen E, Ziogas A, Kostidis S, Mohammed Y, Matzaraki V, Renieris G, Giamarellos-Bourboulis EJ, Netea MG, Giera M.
Pubblicato in: Nature Communications, Numero 2023 Nov 15;14(1), 2023, Pagina/e 7385, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-023-43315-x

The Association of TSH and Thyroid Hormones With Lymphopenia in Bacterial Sepsis and COVID-19

Autori: Inge Grondman, Aline H de Nooijer, Nikolaos Antonakos, Nico A F Janssen, Maria Mouktaroudi, Konstantinos Leventogiannis, Marco Medici, Jan W A Smit, Antonius E van Herwaarden, Leo A B Joosten, Frank L van de Veerdonk, Peter Pickkers, Matthijs Kox, Martin Jaeger, Mihai G Netea, Evangelos J Giamarellos-Bourboulis, Romana T Netea-Maier
Pubblicato in: The Journal of Clinical Endocrinology & Metabolism, 2021, ISSN 0021-972X
Editore: The Endocrine Society
DOI: 10.1210/clinem/dgab148

The anti-inflammatory cytokine interleukin-37 is an inhibitor of trained immunity

Autori: Giulio Cavalli, Isak W. Tengesdal, Mark Gresnigt, Travis Nemkov, Rob J.W. Arts, Jorge Domínguez-Andrés, Raffaella Molteni, Davide Stefanoni, Eleonora Cantoni, Laura Cassina, Silvia Giugliano, Kiki Schraa, Taylor S. Mills, Eric M. Pietras, Elan Z. Eisenmensser, Lorenzo Dagna, Alessandra Boletta, Angelo D’Alessandro, Leo A.B. Joosten, Mihai G. Netea, Charles A. Dinarello
Pubblicato in: Cell Reports, Numero 35/1, 2021, Pagina/e 108955, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2021.108955

BCG vaccination in health care providers and the protection against COVID-19

Autori: Mihai G. Netea, Jos W.M. van der Meer, Reinout van Crevel
Pubblicato in: Journal of Clinical Investigation, Numero 131/2, 2021, ISSN 0021-9738
Editore: American Society for Clinical Investigation
DOI: 10.1172/jci145545

Seasonal variation in BCG-induced trained immunity

Autori: Kilic G, Debisarun PA, Alaswad A, Baltissen MP, Lamers LA, de Bree LCJ, Benn CS, Aaby P, Dijkstra H, Lemmers H, Martens JHA, Domínguez-Andrés J, van Crevel R, Li Y, Xu CJ, Netea MG.
Pubblicato in: Vaccine, Numero Volume 42, Numero 24, 24 October 2024, 2024, Pagina/e 126109, ISSN 2230-2298
Editore: Dove medical press
DOI: 10.1016/j.vaccine.2024.07.010

Persistent bone marrow hemozoin accumulation confers a survival advantage against bacterial infection via cell-intrinsic Myd88 signaling

Autori: Zhu Y, Gao Q, Zhang J, Cheng Y, Yang S, Xu R, Yuan J, Novakovic B, Netea MG, Cheng SC.
Pubblicato in: signaling. Cell Rep., Numero 2024 Oct 22;43 (10), 2024, Pagina/e 114850, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2024.114850

Sepsis pathogenesis and outcome are shaped by the balance between the transcriptional states of systemic inflammation and antimicrobial response

Autori: Rachel Brandes-Leibovitz, Anca Riza, Gal Yankovitz, Andrei Pirvu, Stefania Dorobantu, Adina Dragos, Ioana Streata, Isis Ricaño-Ponce, Aline de Nooijer, Florentina Dumitrescu, Nikolaos Antonakos, Eleni Antoniadou, George Dimopoulos, Ioannis Koutsodimitropoulos, Theano Kontopoulou, Dimitra Markopoulou, Eleni Aimoniotou, Apostolos Komnos, George N. Dalekos, Mihai Ioana, Evangelos J. Giamarellos-Bour
Pubblicato in: Cell Reports Medicine, Numero 5, 2024, Pagina/e 101829, ISSN 2666-3791
Editore: Cell Pres Elsevier Inc.
DOI: 10.1016/j.xcrm.2024.101829

BCG vaccination alters the epigenetic landscape of progenitor cells in human bone marrow to influence innate immune responses

Autori: Sun SJ, Aguirre-Gamboa R, de Bree LCJ, Sanz J, Dumaine A, van der Velden WJFM, Joosten LAB, Khader S, Divangahi M, Netea MG, Barreiro LB.
Pubblicato in: Immunity, Numero Volume 57, Numero 9, 10 September 2024, 2024, Pagina/e 2095-2107.e8, ISSN 1097-4180
Editore: cellpress
DOI: 10.1016/j.immuni.2024.07.021

Complement Activation in the Disease Course of Coronavirus Disease 2019 and Its Effects on Clinical Outcomes

Autori: Aline H de Nooijer, Inge Grondman, Nico A F Janssen, Mihai G Netea, Loek Willems, Frank L van de Veerdonk, Evangelos J Giamarellos-Bourboulis, Erik J M Toonen, Leo A B Joosten, Martin Jaeger, Helga Dijkstra, Heidi Lemmers, Liesbeth van Emst, Kiki Schraa, Cor Jacobs, Anneke Hijmans, Trees Jansen, Fieke Weren, Liz Fransman, Jelle Gerretsen, Josephine van de Maat, Gerine Nijman, Simone Moorlag, Esthe
Pubblicato in: The Journal of Infectious Diseases, Numero 223/2, 2020, Pagina/e 214-224, ISSN 0022-1899
Editore: University of Chicago Press
DOI: 10.1093/infdis/jiaa646

New live attenuated tuberculosis vaccine MTBVAC induces trained immunity and confers protection against experimental lethal pneumonia

Autori: Raquel Tarancón, Jorge Domínguez-Andrés, Santiago Uranga, Anaísa V. Ferreira, Laszlo A. Groh, Mirian Domenech, Fernando González-Camacho, Niels P. Riksen, Nacho Aguilo, José Yuste, Carlos Martín, Mihai G. Netea
Pubblicato in: PLOS Pathogens, Numero 16/4, 2020, Pagina/e e1008404, ISSN 1553-7374
Editore: PLOS
DOI: 10.1371/journal.ppat.1008404

Anakinra treatment in critically ill COVID-19 patients: a prospective cohort study

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Controlled Human Malaria Infection Induces Long-Term Functional Changes in Monocytes

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VPM1002 as Prophylaxis Against Severe Respiratory Tract Infections Including Coronavirus Disease 2019 in the Elderly: A Phase 3 Randomized, Double-Blind, Placebo-Controlled, Multicenter Clinical Study

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The Architecture of Circulating Immune Cells Is Dysregulated in People Living With HIV on Long Term Antiretroviral Treatment and Relates With Markers of the HIV-1 Reservoir, Cytomegalovirus, and Microbial Translocation

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Rare variants increase the risk of severe COVID-19

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Postinfectious Epigenetic Immune Modifications — A Double-Edged Sword

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BCG vaccination-induced acquired control of mycobacterial growth differs from growth control preexisting to BCG vaccination

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Routine vaccination for influenza and pneumococcal disease and its effect on COVID-19 in a population of Dutch older adults

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Activate: Randomized Clinical Trial of BCG Vaccination against Infection in the Elderly

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Neonatal BCG vaccination is associated with a long-term DNA methylation signature in circulating monocytes

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Trained Immunity: a Tool for Reducing Susceptibility to and the Severity of SARS-CoV-2 Infection

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Designing the Next Generation of Vaccines: Relevance for Future Pandemics

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DOI: 10.1128/mbio.02616-20

Trained immunity: Target for prophylaxis and therapy

Autori: Ziogas A, Bruno M, van der Meel R, Mulder WJM, Netea MG.
Pubblicato in: Cell Host & Microbe, Numero 2023 Nov 8;31(11), 2023, Pagina/e 1776-1791, ISSN 1931-3128
Editore: Cell Press
DOI: 10.1016/j.chom.2023.10.015

A single-cell view on host immune transcriptional response to in vivo BCG-induced trained immunity

Autori: : Li W, Moorlag SJCFM, Koeken VACM, Röring RJ, de Bree LCJ, Mourits VP, Gupta MK, Zhang B, Fu J, Zhang Z, Grondman I, van Meijgaarden KE, Zhou L, Alaswad A, Joosten LAB, van Crevel R, Xu CJ, Netea MG, Li Y.
Pubblicato in: Cell Reports, Numero Volume 42, Numero 5, 30 May 2023,, 2023, Pagina/e 112487, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2023.112487

The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity

Autori: Marcin F Osuchowski, Martin S Winkler, Tomasz Skirecki, Sara Cajander, Manu Shankar-Hari, Gunnar Lachmann, Guillaume Monneret, Fabienne Venet, Michael Bauer, Frank M Brunkhorst, Sebastian Weis, Alberto Garcia-Salido, Matthijs Kox, Jean-Marc Cavaillon, Florian Uhle, Markus A Weigand, Stefanie B Flohé, W Joost Wiersinga, Raquel Almansa, Amanda de la Fuente, Ignacio Martin-Loeches, Christian Meisel,
Pubblicato in: The Lancet Respiratory Medicine, Numero 9/6, 2021, Pagina/e 622-642, ISSN 2213-2600
Editore: Elsevier Limited
DOI: 10.1016/s2213-2600(21)00218-6

An open label trial of anakinra to prevent respiratory failure in COVID-19

Autori: Evdoxia Kyriazopoulou, Periklis Panagopoulos, Symeon Metallidis, George N Dalekos, Garyphallia Poulakou, Nikolaos Gatselis, Eleni Karakike, Maria Saridaki, Georgia Loli, Aggelos Stefos, Danai Prasianaki, Sarah Georgiadou, Olga Tsachouridou, Vasileios Petrakis, Konstantinos Tsiakos, Maria Kosmidou, Vassiliki Lygoura, Maria Dareioti, Haralampos Milionis, Ilias C Papanikolaou, Karolina Akinosoglou, D
Pubblicato in: eLife, Numero 10, 2021, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.66125

Characterization of sepsis inflammatory endotypes using circulatory proteins in patients with severe infection: a prospective cohort study

Autori: Ricaño-Ponce I, Riza AL, de Nooijer AH, Pirvu A, Dorobantu S, Dragos A, Streata I, Roskanovic M, Grondman I, Dumitrescu F, Kumar V, Netea MG, Ioana M.
Pubblicato in: BMC infectious diseases, Numero 2022 Oct 8, 2022, Pagina/e 22(1):778., ISSN 1471-2334
Editore: BioMed Central
DOI: 10.1186/s12879-022-07761-0

Stronger induction of trained immunity by mucosal BCG or MTBVAC vaccination compared to standard intradermal vaccination

Autori: Michel P.M. Vierboom, Karin Dijkman, Claudia C. Sombroek, Sam O. Hofman, Charelle Boot, Richard A.W. Vervenne, Krista G. Haanstra, Maarten van der Sande, Liesbeth van Emst, Jorge Domínguez-Andrés, Simone J.C.F.M. Moorlag, Clemens H.M. Kocken, Jelle Thole, Esteban Rodríguez, Eugenia Puentes, Joost H.A. Martens, Reinout van Crevel, Mihai G. Netea, Nacho Aguilo, Carlos Martin, Frank A.W. Verreck
Pubblicato in: Cell Reports Medicine, Numero 2/1, 2021, Pagina/e 100185, ISSN 2666-3791
Editore: Elsevier
DOI: 10.1016/j.xcrm.2020.100185

Data of common and species-specific transcriptional host responses to pathogenic fungi

Autori: Mariolina Bruno, Robter Horst, Marina Pekmezovic, Vinod Kumar, Yang Li, Mihai G. Netea, Jean-Paul Latgé, Mark S. Gresnigt, Frank L. van de Veerdonk
Pubblicato in: Data in Brief, Numero 35, 2021, Pagina/e 106928, ISSN 2352-3409
Editore: Elsevier BV
DOI: 10.1016/j.dib.2021.106928

BCG-Induced Trained Immunity in Healthy Individuals: The Effect of Plasma Muramyl Dipeptide Concentrations

Autori: Vera P. Mourits, Valerie A. C. M. Koeken, L. Charlotte J. de Bree, Simone J. C. F. M. Moorlag, Wern Cui Chu, Xiaoli Xu, Helga Dijkstra, Heidi Lemmers, Leo A. B. Joosten, Yue Wang, Reinout van Crevel, Mihai G. Netea
Pubblicato in: Journal of Immunology Research, Numero 2020, 2020, Pagina/e 1-8, ISSN 2314-8861
Editore: Hindawi Publishing Corporation
DOI: 10.1155/2020/5812743

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