Trained immunity: improving the next generation of vaccines for the older generation

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Publications

RORα negatively regulates BCG-induced trained immunity

Auteurs: Kilic G, Matzaraki V, Bulut O, Baydemir I, Ferreira AV, Rabold K, Moorlag SJCFM, Koeken VACM, de Bree LCJ, Mourits VP, Joosten LAB, Domínguez-Andrés J, Netea MG.
Publié dans: Cellular Immunology, Numéro 2024 Sep-Oct;, 2024, Page(s) 403-404, ISSN 0008-8749
Éditeur: Academic Press
DOI: 10.1016/j.cellimm.2024.104862

A modular approach toward producing nanotherapeutics targeting the innate immune system

Auteurs: Mandy M. T. van Leent, Anu E. Meerwaldt, Alexandre Berchouchi, Yohana C. Toner, Marianne E. Burnett, Emma D. Klein, Anna Vera D. Verschuur, Sheqouia A. Nauta, Jazz Munitz, Geoffrey Prévot, Esther M. van Leeuwen, Farideh Ordikhani, Vera P. Mourits, Claudia Calcagno, Philip M. Robson, George Soultanidis, Thomas Reiner, Rick R. M. Joosten, Heiner Friedrich, Joren C. Madsen, Ewelina Kluza, Roy van de
Publié dans: Science Advances, Numéro 7/10, 2021, Page(s) eabe7853, ISSN 2375-2548
Éditeur: AAAS
DOI: 10.1126/sciadv.abe7853

The impact of BNT162b2 mRNA vaccine on adaptive and innate immune responses

Auteurs: : Föhse K, Geckin B, Zoodsma M, Kilic G, Liu Z, Röring RJ, Overheul GJ, van de Maat J, Bulut O, Hoogerwerf JJ, Ten Oever J, Simonetti E, Schaal H, Adams O, Müller L, Ostermann PN, van de Veerdonk FL, Joosten LAB, Haagmans BL, van Crevel R, van Rij RP, GeurtsvanKessel C, de Jonge MI, Li Y, Domínguez-Andrés J, Netea MG.
Publié dans: Clinical Immunology, Numéro Volume 255, October 2023,, 2023, Page(s) 109762, ISSN 1521-6616
Éditeur: Academic Press
DOI: 10.1016/j.clim.2023.109762

Defining trained immunity and its role in health and disease

Auteurs: Mihai G. Netea, Jorge Domínguez-Andrés, Luis B. Barreiro, Triantafyllos Chavakis, Maziar Divangahi, Elaine Fuchs, Leo A. B. Joosten, Jos W. M. van der Meer, Musa M. Mhlanga, Willem J. M. Mulder, Niels P. Riksen, Andreas Schlitzer, Joachim L. Schultze, Christine Stabell Benn, Joseph C. Sun, Ramnik J. Xavier, Eicke Latz
Publié dans: Nature Reviews Immunology, Numéro 20/6, 2020, Page(s) 375-388, ISSN 1474-1733
Éditeur: Nature Publishing Group
DOI: 10.1038/s41577-020-0285-6

β-Glucan Induces Protective Trained Immunity against Mycobacterium tuberculosis Infection: A Key Role for IL-1

Auteurs: Simone J.C.F.M. Moorlag, Nargis Khan, Boris Novakovic, Eva Kaufmann, Trees Jansen, Reinout van Crevel, Maziar Divangahi, Mihai G. Netea
Publié dans: Cell Reports, Numéro 31/7, 2020, Page(s) 107634, ISSN 2211-1247
Éditeur: Cell Press
DOI: 10.1016/j.celrep.2020.107634

Trained immunity: implications for vaccination

Auteurs: Büsranur Geckin, Friedrich Konstantin Föhse, Jorge Domínguez-Andrés, Mihai G Netea
Publié dans: Current Opinion in Immunology, Numéro 77, 2023, Page(s) 102190, ISSN 0952-7915
Éditeur: Elsevier BV
DOI: 10.1016/j.coi.2022.102190

A higher BMI is not associated with a different immune response and disease course in critically ill COVID-19 patients

Auteurs: Emma J. Kooistra, Aline H. de Nooijer, Wout J. Claassen, Inge Grondman, Nico A. F. Janssen, Mihai G. Netea, Frank L. van de Veerdonk, Johannes G. van der Hoeven, Matthijs Kox, Peter Pickkers
Publié dans: International Journal of Obesity, Numéro 45/3, 2021, Page(s) 687-694, ISSN 0307-0565
Éditeur: Nature Publishing Group
DOI: 10.1038/s41366-021-00747-z

Engineering cytokine therapeutics

Auteurs: : Deckers J, Anbergen T, Hokke AM, de Dreu A, Schrijver DP, de Bruin K, Toner YC, Beldman TJ, Spangler JB, de Greef TFA, Grisoni F, van der Meel R, Joosten LAB, Merkx M, Netea MG, Mulder WJM.
Publié dans: Nature Reviews Bioengineering, Numéro 2023, 1, 2023, Page(s) 286–303, ISSN 2731-6092
Éditeur: Clockss
DOI: 10.1038/s44222-023-00030-y

The role of sirtuin 1 on the induction of trained immunity.

Auteurs: Mourits VP, Helder LS, Matzaraki V, Koeken VACM, Groh L, de Bree LCJ, Moorlag SJCFM, van der Heijden CDCC, Keating ST, van Puffelen JH, Jaeger M, Joosten LAB, Netea MG.
Publié dans: Cell Immunol., 2021, Page(s) 104393, ISSN 0008-8749
Éditeur: Academic Press
DOI: 10.1016/j.cellimm.2021.104393

The Set7 Lysine Methyltransferase Regulates Plasticity in Oxidative Phosphorylation Necessary for Trained Immunity Induced by β-Glucan

Auteurs: Samuel T. Keating, Laszlo Groh, Charlotte D.C.C. van der Heijden, Hanah Rodriguez, Jéssica C. dos Santos, Stephanie Fanucchi, Jun Okabe, Harikrishnan Kaipananickal, Jelmer H. van Puffelen, Leonie Helder, Marlies P. Noz, Vasiliki Matzaraki, Yang Li, L. Charlotte J. de Bree, Valerie A.C.M. Koeken, Simone J.C.F.M. Moorlag, Vera P. Mourits, Jorge Domínguez-Andrés, Marije Oosting, Elianne P. Bulthui
Publié dans: Cell Reports, Numéro 31/3, 2020, Page(s) 107548, ISSN 2211-1247
Éditeur: Cell Press
DOI: 10.1016/j.celrep.2020.107548

Urban living in healthy Tanzanians is associated with an inflammatory status driven by dietary and metabolic changes.

Auteurs: Temba GS, Kullaya V, Pecht T, Mmbaga BT, Aschenbrenner AC, Ulas T, Kibiki G, Lyamuya F, Boahen CK, Kumar V, Joosten LAB, Schultze JL, van der Ven AJ, Netea MG, de Mast Q.
Publié dans: Nat Immunol., 2021, Page(s) 287-300, ISSN 1529-2908
Éditeur: Nature Publishing Group
DOI: 10.1038/s41590-021-00867-8

C5a-licensed phagocytes drive sterilizing immunity during systemic fungal infection

Auteurs: Desai JV, Kumar D, Freiwald T, Chauss D, Johnson MD, Abers MS, Steinbrink JM, Perfect JR, Alexander B, Matzaraki V, Snarr BD, Zarakas MA, Oikonomou V, Silva LM, Shivarathri R, Beltran E, Demontel LN, Wang L, Lim JK, Launder D, Conti HR, Swamydas M, McClain MT, Moutsopoulos NM, Kazemian M, Netea MG, Kumar V, Köhl J, Kemper C, Afzali B, Lionakis MS.
Publié dans: cell, Numéro Volume 186, Numéro 13, 22 June 2023, 2023, Page(s) 2802-2822.e22, ISSN 0092-8674
Éditeur: Cell Press
DOI: 10.1016/j.cell.2023.04.031

In vitro induction of trained immunity in adherent human monocytes

Auteurs: Jorge Domínguez-Andrés, Rob J.W. Arts, Siroon Bekkering, Harsh Bahrar, Bastiaan A. Blok, L. Charlotte J. de Bree, Mariolina Bruno, Özlem Bulut, Priya A. Debisarun, Helga Dijkstra, Jéssica Cristina dos Santos, Anaísa V. Ferreira, Daniela Flores-Gomez, Laszlo A. Groh, Inge Grondman, Leonie Helder, Cor Jacobs, Liesbeth Jacobs, Trees Jansen, Gizem Kilic, Viola Klück, Valerie A.C.M. Koeken, Heidi
Publié dans: STAR Protocols, Numéro 2/1, 2021, Page(s) 100365, ISSN 2666-1667
Éditeur: Cell Press
DOI: 10.1016/j.xpro.2021.100365

Outcomes Associated With Use of a Kinin B2 Receptor Antagonist Among Patients With COVID-19

Auteurs: Frank L. van de Veerdonk, Ilse J. E. Kouijzer, Aline H. de Nooijer, Hans G. van der Hoeven, Coen Maas, Mihai G. Netea, Roger J. M. Brüggemann
Publié dans: JAMA Network Open, Numéro 3/8, 2020, Page(s) e2017708, ISSN 2574-3805
Éditeur: JAMA network
DOI: 10.1001/jamanetworkopen.2020.17708

Regulation of plasma soluble receptors of TNF and IL-1 in patients with COVID-19 differs from that observed in sepsis

Auteurs: Aksu MD, van der Ent T, Zhang Z, Riza AL, de Nooijer AH, Ricaño-Ponce I, Janssen N, Engel JJ, Streata I, Dijkstra H, Lemmers H, Grondman I, Koeken VACM, Antoniadou E, Antonakos N, van de Veerdonk FL, Li Y, Giamarellos-Bourboulis EJ, Netea MG, Ziogas A.
Publié dans: Journal of Infection, Numéro Volume 89, Numéro 6, December 2024,, 2024, Page(s) 106300, ISSN 0163-4453
Éditeur: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.jinf.2024.106300

Hydroxychloroquine Inhibits the Trained Innate Immune Response to Interferons

Auteurs: Nils Rother, Cansu Yanginlar, Rik G.H. Lindeboom, Siroon Bekkering, Mandy M.T. van Leent, Baranca Buijsers, Inge Jonkman, Mark de Graaf, Marijke Baltissen, Lieke A. Lamers, Niels P. Riksen, Zahi A. Fayad, Willem J.M. Mulder, Luuk B. Hilbrands, Leo A.B. Joosten, Mihai G. Netea, Michiel Vermeulen, Johan van der Vlag, Raphaël Duivenvoorden
Publié dans: Cell Reports Medicine, Numéro 1/9, 2020, Page(s) 100146, ISSN 2666-3791
Éditeur: elsevier
DOI: 10.1016/j.xcrm.2020.100146

Safety and COVID-19 Symptoms in Individuals Recently Vaccinated with BCG: a Retrospective Cohort Study

Auteurs: Simone J.C.F.M. Moorlag, Rosanne C. van Deuren, Cornelis H. van Werkhoven, Martin Jaeger, Priya Debisarun, Esther Taks, Vera P. Mourits, Valerie A.C.M. Koeken, L. Charlotte J. de Bree, Thijs ten Doesschate, Maartje C. Cleophas, Sanne Smeekens, Marije Oosting, Frank L. van de Veerdonk, Leo A.B. Joosten, Jaap ten Oever, Jos W.M. van der Meer, Nigel Curtis, Peter Aaby, Christine Stabell-Benn, Evangel
Publié dans: Cell Reports Medicine, Numéro 1/5, 2020, Page(s) 100073, ISSN 2666-3791
Éditeur: Elsevier
DOI: 10.1016/j.xcrm.2020.100073

Trained Immunity-Promoting Nanobiologic Therapy Suppresses Tumor Growth and Potentiates Checkpoint Inhibition.

Auteurs: Priem B, van Leent MMT, Teunissen AJP, Sofias AM, Mourits VP, Willemsen L, Klein ED, Oosterwijk RS, Meerwaldt AE, Munitz J, Prévot G, Vera Verschuur A, Nauta SA, van Leeuwen EM, Fisher EL, de Jong KAM, Zhao Y, Toner YC, Soultanidis G, Calcagno C, Bomans PHH, Friedrich H, Sommerdijk N, Reiner T, Duivenvoorden R, Zupančič E, Di Martino JS, Kluza E, Rashidian M, Ploegh HL, Dijkhuizen RM, Hak S, P
Publié dans: Cell, 2020, Page(s) 786-801, ISSN 0092-8674
Éditeur: Cell Press
DOI: 10.1016/j.cell.2020.09.059

Clonal hematopoiesis driven by mutated DNMT3A promotes inflammatory bone loss

Auteurs: Wang H, Divaris K, Pan B, Li X, Lim JH, Saha G, Barovic M, Giannakou D, Korostoff JM, Bing Y, Sen S, Moss K, Wu D, Beck JD, Ballantyne CM, Natarajan P, North KE, Netea MG, Chavakis T, Hajishengallis G.
Publié dans: Cell, Numéro Volume 187, Numéro 14, 11 July 2024,, 2024, Page(s) 3690-3711.e19, ISSN 1097-4172
Éditeur: Cellpress
DOI: 10.1016/j.cell.2024.05.003

Trained immunity as a novel approach against COVID‐19 with a focus on Bacillus Calmette–Guérin vaccine: mechanisms, challenges and perspectives

Auteurs: Yahya Sohrabi, Jéssica Cristina Dos Santos, Marc Dorenkamp, Hannes Findeisen, Rinesh Godfrey, Mihai G Netea, Leo AB Joosten
Publié dans: Clinical & Translational Immunology, Numéro 9/12, 2020, ISSN 2050-0068
Éditeur: ASI
DOI: 10.1002/cti2.1228

BCG Vaccination Induces Long-Term Functional Reprogramming of Human Neutrophils

Auteurs: Simone J.C.F.M. Moorlag, Yessica Alina Rodriguez-Rosales, Joshua Gillard, Stephanie Fanucchi, Kate Theunissen, Boris Novakovic, Cynthia M. de Bont, Yutaka Negishi, Ezio T. Fok, Lydia Kalafati, Panayotis Verginis, Vera P. Mourits, Valerie A.C.M. Koeken, L. Charlotte J. de Bree, Ger J.M. Pruijn, Craig Fenwick, Reinout van Crevel, Leo A.B. Joosten, Irma Joosten, Hans Koenen, Musa M. Mhlanga, Dimitri
Publié dans: Cell Reports, Numéro 33/7, 2020, Page(s) 108387, ISSN 2211-1247
Éditeur: Cell Press
DOI: 10.1016/j.celrep.2020.108387

The Role of Cell Metabolism in Innate Immune Memory

Auteurs: Anaisa Valido Ferreira, Jorge Domiguéz-Andrés, Mihai Gheorghe Netea
Publié dans: Journal of Innate Immunity, 2021, Page(s) 1-9, ISSN 1662-811X
Éditeur: Karger AG
DOI: 10.1159/000512280

Toward personalized immunotherapy in sepsis: The PROVIDE randomized clinical trial

Auteurs: : Leventogiannis K, Kyriazopoulou E, Antonakos N, Kotsaki A, Tsangaris I, Markopoulou D, Grondman I, Rovina N, Theodorou V, Antoniadou E, Koutsodimitropoulos I, Dalekos G, Vlachogianni G, Akinosoglou K, Koulouras V, Komnos A, Kontopoulou T, Prekates A, Koutsoukou A, van der Meer JWM, Dimopoulos G, Kyprianou M, Netea MG, Giamarellos-Bourboulis EJ.
Publié dans: Cell Reports Medicine, Numéro Volume 3, Numéro 11, 15 November 2022,, 2022, Page(s) 100817, ISSN 2666-3791
Éditeur: Cell Pres Elsevier Inc.
DOI: 10.1016/j.xcrm.2022.100817

Influence of the microbiome, diet and genetics on inter-individual variation in the human plasma metabolome

Auteurs: Andreu-Sánchez S, Wang D, Augustijn HE, Vich Vila A; Lifelines Cohort Study, Weersma RK, Medema MH, Netea MG, Kuipers F, Wijmenga C, Zhernakova A, Fu J.
Publié dans: Nature medicine, Numéro 28 nov 2022, 2022, Page(s) 2322-2343, ISSN 1078-8956
Éditeur: Nature Publishing Group
DOI: 10.1038/s41591-022-02014-8

Presence of Genetic Variants Among Young Men With Severe COVID-19

Auteurs: Caspar I. van der Made, Annet Simons, Janneke Schuurs-Hoeijmakers, Guus van den Heuvel, Tuomo Mantere, Simone Kersten, Rosanne C. van Deuren, Marloes Steehouwer, Simon V. van Reijmersdal, Martin Jaeger, Tom Hofste, Galuh Astuti, Jordi Corominas Galbany, Vyne van der Schoot, Hans van der Hoeven, Wanda Hagmolen of ten Have, Eva Klijn, Catrien van den Meer, Jeroen Fiddelaers, Quirijn de Mast, Chantal
Publié dans: JAMA, Numéro 324/7, 2020, Page(s) 663, ISSN 0098-7484
Éditeur: American Medical Association
DOI: 10.1001/jama.2020.13719

Plasma metabolome predicts trained immunity responses after antituberculosis BCG vaccination.

Auteurs: Koeken VACM, Qi C, Mourits VP, de Bree LCJ, Moorlag SJCFM, Sonawane V, Lemmers H, Dijkstra H, Joosten LAB, van Laarhoven A, Xu CJ, van Crevel R, Netea MG, Li Y.
Publié dans: PLoS Biology, Numéro 12 Sept 2022, 20(9), 2022, Page(s) e3001765, ISSN 1544-9173
Éditeur: Public Library of Science
DOI: 10.1371/journal.pbio.3001765

Deadly COVID-19 among the elderly: Innate immune memory helping those most in need

Auteurs: Yahya Sohrabi, Holger Reinecke, Leo A.B. Joosten, Mihai G. Netea
Publié dans: Med, Numéro 2/4, 2021, Page(s) 378-383, ISSN 2666-6340
Éditeur: elsevier
DOI: 10.1016/j.medj.2021.02.004

Trained immunity: adaptation within innate immune mechanisms

Auteurs: Jorge Domínguez-Andrés, Jéssica Cristina dos Santos, Siroon Bekkering, Willem J. M. Mulder, Jos W. M. van der Meer, Niels P. Riksen, Leo A. B. Joosten, Mihai G. Netea
Publié dans: Physiological Reviews, Numéro 103, 2022, Page(s) 313-346, ISSN 0031-9333
Éditeur: American Physiological Society
DOI: 10.1152/physrev.00031.2021

MMR vaccination induces trained immunity via functional and metabolic reprogramming of γδ T cells

Auteurs: Röring RJ, Debisarun PA, Botey-Bataller J, Suen TK, Bulut Ö, Kilic G, Koeken VA, Sarlea A, Bahrar H, Dijkstra H, Lemmers H, Gössling KL, Rüchel N, Ostermann PN, Müller L, Schaal H, Adams O, Borkhardt A, Ariyurek Y, de Meijer EJ, Kloet SL, Ten Oever J, Placek K, Li Y, Netea MG.
Publié dans: Journal of clinical investigation, Numéro Published January 30, 2024, 2024, Page(s) 106851, ISSN 1558-8238
Éditeur: London Open Access Text
DOI: 10.1172/jci170848

Dysregulated Innate and Adaptive Immune Responses Discriminate Disease Severity in COVID-19

Auteurs: Nico A F Janssen, Inge Grondman, Aline H de Nooijer, Collins K Boahen, Valerie A C M Koeken, Vasiliki Matzaraki, Vinod Kumar, Xuehui He, Matthijs Kox, Hans J P M Koenen, Ruben L Smeets, Irma Joosten, Roger J M Brüggemann, Ilse J E Kouijzer, Hans G van der Hoeven, Jeroen A Schouten, Tim Frenzel, Monique H E Reijers, Wouter Hoefsloot, Anton S M Dofferhoff, Marjan J van Apeldoorn, Marc J T Blaauw, K
Publié dans: The Journal of Infectious Diseases, Numéro 223/8, 2021, Page(s) 1322-1333, ISSN 0022-1899
Éditeur: University of Chicago Press
DOI: 10.1093/infdis/jiab065

The effect of BCG vaccination in the elderly on infectious and non-infectious immune-mediated diseases

Auteurs: Dulfer EA, Föhse K, Taks EJM, Moorlag SJCFM, Koekenbier EL, van de Maat JS, Ten Oever J, Hoogerwerf JJ, van Werkhoven CH, Bonten MJM, van Hylckama Vlieg A, Rosendaal FR, Netea MG
Publié dans: Journal of Infection, Numéro Volume 89, Numéro 6, December 2024, 2024, Page(s) 106344, ISSN 1532-2742
Éditeur: sassari
DOI: 10.1016/j.jinf.2024.106344

A protein-free vaccine stimulates innate immunity and protects against nosocomial pathogens

Auteurs: Yan J, Nielsen TB, Lu P, Talyansky Y, Slarve M, Reza H, Novakovic B, Netea MG, Keller AE, Warren T, DiGiandomenico A, Sellman BR, Luna BM, Spellberg B. A
Publié dans: Science translational medicine, Numéro 4 Oct 2023 Vol 15, Numéro 716, 2023, Page(s) 9556, ISSN 1946-6234
Éditeur: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.adf9556

Favorable Anakinra Responses in Severe Covid-19 Patients with Secondary Hemophagocytic Lymphohistiocytosis

Auteurs: George Dimopoulos, Quirijn de Mast, Nikolaos Markou, Maria Theodorakopoulou, Apostolos Komnos, Maria Mouktaroudi, Mihai G. Netea, Themistoklis Spyridopoulos, Rebecca J. Verheggen, Jacobien Hoogerwerf, Alexandra Lachana, Frank L. van de Veerdonk, Evangelos J. Giamarellos-Bourboulis
Publié dans: Cell Host & Microbe, Numéro 28/1, 2020, Page(s) 117-123.e1, ISSN 1931-3128
Éditeur: Cell Press
DOI: 10.1016/j.chom.2020.05.007

Fatty acid desaturation and lipoxygenase pathways support trained immunity

Auteurs: Ferreira AV, Alarcon-Barrera JC, Domínguez-Andrés J, Bulut Ö, Kilic G, Debisarun PA, Röring RJ, Özhan HN, Terschlüsen E, Ziogas A, Kostidis S, Mohammed Y, Matzaraki V, Renieris G, Giamarellos-Bourboulis EJ, Netea MG, Giera M.
Publié dans: Nature Communications, Numéro 2023 Nov 15;14(1), 2023, Page(s) 7385, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-023-43315-x

The Association of TSH and Thyroid Hormones With Lymphopenia in Bacterial Sepsis and COVID-19

Auteurs: Inge Grondman, Aline H de Nooijer, Nikolaos Antonakos, Nico A F Janssen, Maria Mouktaroudi, Konstantinos Leventogiannis, Marco Medici, Jan W A Smit, Antonius E van Herwaarden, Leo A B Joosten, Frank L van de Veerdonk, Peter Pickkers, Matthijs Kox, Martin Jaeger, Mihai G Netea, Evangelos J Giamarellos-Bourboulis, Romana T Netea-Maier
Publié dans: The Journal of Clinical Endocrinology & Metabolism, 2021, ISSN 0021-972X
Éditeur: The Endocrine Society
DOI: 10.1210/clinem/dgab148

The anti-inflammatory cytokine interleukin-37 is an inhibitor of trained immunity

Auteurs: Giulio Cavalli, Isak W. Tengesdal, Mark Gresnigt, Travis Nemkov, Rob J.W. Arts, Jorge Domínguez-Andrés, Raffaella Molteni, Davide Stefanoni, Eleonora Cantoni, Laura Cassina, Silvia Giugliano, Kiki Schraa, Taylor S. Mills, Eric M. Pietras, Elan Z. Eisenmensser, Lorenzo Dagna, Alessandra Boletta, Angelo D’Alessandro, Leo A.B. Joosten, Mihai G. Netea, Charles A. Dinarello
Publié dans: Cell Reports, Numéro 35/1, 2021, Page(s) 108955, ISSN 2211-1247
Éditeur: Cell Press
DOI: 10.1016/j.celrep.2021.108955

BCG vaccination in health care providers and the protection against COVID-19

Auteurs: Mihai G. Netea, Jos W.M. van der Meer, Reinout van Crevel
Publié dans: Journal of Clinical Investigation, Numéro 131/2, 2021, ISSN 0021-9738
Éditeur: American Society for Clinical Investigation
DOI: 10.1172/jci145545

Seasonal variation in BCG-induced trained immunity

Auteurs: Kilic G, Debisarun PA, Alaswad A, Baltissen MP, Lamers LA, de Bree LCJ, Benn CS, Aaby P, Dijkstra H, Lemmers H, Martens JHA, Domínguez-Andrés J, van Crevel R, Li Y, Xu CJ, Netea MG.
Publié dans: Vaccine, Numéro Volume 42, Numéro 24, 24 October 2024, 2024, Page(s) 126109, ISSN 2230-2298
Éditeur: Dove medical press
DOI: 10.1016/j.vaccine.2024.07.010

Persistent bone marrow hemozoin accumulation confers a survival advantage against bacterial infection via cell-intrinsic Myd88 signaling

Auteurs: Zhu Y, Gao Q, Zhang J, Cheng Y, Yang S, Xu R, Yuan J, Novakovic B, Netea MG, Cheng SC.
Publié dans: signaling. Cell Rep., Numéro 2024 Oct 22;43 (10), 2024, Page(s) 114850, ISSN 2211-1247
Éditeur: Cell Press
DOI: 10.1016/j.celrep.2024.114850

Sepsis pathogenesis and outcome are shaped by the balance between the transcriptional states of systemic inflammation and antimicrobial response

Auteurs: Rachel Brandes-Leibovitz, Anca Riza, Gal Yankovitz, Andrei Pirvu, Stefania Dorobantu, Adina Dragos, Ioana Streata, Isis Ricaño-Ponce, Aline de Nooijer, Florentina Dumitrescu, Nikolaos Antonakos, Eleni Antoniadou, George Dimopoulos, Ioannis Koutsodimitropoulos, Theano Kontopoulou, Dimitra Markopoulou, Eleni Aimoniotou, Apostolos Komnos, George N. Dalekos, Mihai Ioana, Evangelos J. Giamarellos-Bour
Publié dans: Cell Reports Medicine, Numéro 5, 2024, Page(s) 101829, ISSN 2666-3791
Éditeur: Cell Pres Elsevier Inc.
DOI: 10.1016/j.xcrm.2024.101829

BCG vaccination alters the epigenetic landscape of progenitor cells in human bone marrow to influence innate immune responses

Auteurs: Sun SJ, Aguirre-Gamboa R, de Bree LCJ, Sanz J, Dumaine A, van der Velden WJFM, Joosten LAB, Khader S, Divangahi M, Netea MG, Barreiro LB.
Publié dans: Immunity, Numéro Volume 57, Numéro 9, 10 September 2024, 2024, Page(s) 2095-2107.e8, ISSN 1097-4180
Éditeur: cellpress
DOI: 10.1016/j.immuni.2024.07.021

Complement Activation in the Disease Course of Coronavirus Disease 2019 and Its Effects on Clinical Outcomes

Auteurs: Aline H de Nooijer, Inge Grondman, Nico A F Janssen, Mihai G Netea, Loek Willems, Frank L van de Veerdonk, Evangelos J Giamarellos-Bourboulis, Erik J M Toonen, Leo A B Joosten, Martin Jaeger, Helga Dijkstra, Heidi Lemmers, Liesbeth van Emst, Kiki Schraa, Cor Jacobs, Anneke Hijmans, Trees Jansen, Fieke Weren, Liz Fransman, Jelle Gerretsen, Josephine van de Maat, Gerine Nijman, Simone Moorlag, Esthe
Publié dans: The Journal of Infectious Diseases, Numéro 223/2, 2020, Page(s) 214-224, ISSN 0022-1899
Éditeur: University of Chicago Press
DOI: 10.1093/infdis/jiaa646

New live attenuated tuberculosis vaccine MTBVAC induces trained immunity and confers protection against experimental lethal pneumonia

Auteurs: Raquel Tarancón, Jorge Domínguez-Andrés, Santiago Uranga, Anaísa V. Ferreira, Laszlo A. Groh, Mirian Domenech, Fernando González-Camacho, Niels P. Riksen, Nacho Aguilo, José Yuste, Carlos Martín, Mihai G. Netea
Publié dans: PLOS Pathogens, Numéro 16/4, 2020, Page(s) e1008404, ISSN 1553-7374
Éditeur: PLOS
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Anakinra treatment in critically ill COVID-19 patients: a prospective cohort study

Auteurs: Emma J. Kooistra, Nicole J. B. Waalders, Inge Grondman, Nico A. F. Janssen, Aline H. de Nooijer, Mihai G. Netea, Frank L. van de Veerdonk, Esther Ewalds, Johannes G. van der Hoeven, Matthijs Kox, Peter Pickkers
Publié dans: Critical Care, Numéro 24/1, 2020, ISSN 1364-8535
Éditeur: Springer Nature
DOI: 10.1186/s13054-020-03364-w

Glutathione Metabolism Contributes to the Induction of Trained Immunity

Auteurs: Anaisa V. Ferreira, Valerie A. C. M. Koeken, Vasiliki Matzaraki, Sarantos Kostidis, Juan Carlos Alarcon-Barrera, L. Charlotte J. de Bree, Simone J. C. F. M. Moorlag, Vera P. Mourits, Boris Novakovic, Martin A. Giera, Mihai G. Netea, Jorge Domínguez-Andrés
Publié dans: Cells, Numéro 10/5, 2021, Page(s) 971, ISSN 2073-4409
Éditeur: MDPI
DOI: 10.3390/cells10050971

BCG vaccination in humans inhibits systemic inflammation in a sex-dependent manner

Auteurs: Valerie A.C.M. Koeken, L. Charlotte J. de Bree, Vera P. Mourits, Simone J.C.F.M. Moorlag, Jona Walk, Branko Cirovic, Rob J.W. Arts, Martin Jaeger, Helga Dijkstra, Heidi Lemmers, Leo A.B. Joosten, Christine S. Benn, Reinout van Crevel, Mihai G. Netea
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Éditeur: American Society for Clinical Investigation
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Immune cells fold and damage fungal hyphae

Auteurs: Judith M. Bain, M. Fernanda Alonso, Delma S. Childers, Catriona A. Walls, Kevin Mackenzie, Arnab Pradhan, Leanne E. Lewis, Johanna Louw, Gabriela M. Avelar, Daniel E. Larcombe, Mihai G. Netea, Neil A. R. Gow, Gordon D. Brown, Lars P. Erwig, Alistair J. P. Brown
Publié dans: Proceedings of the National Academy of Sciences, Numéro 118/15, 2021, Page(s) e2020484118, ISSN 0027-8424
Éditeur: National Academy of Sciences
DOI: 10.1073/pnas.2020484118

A minimal common outcome measure set for COVID-19 clinical research

Auteurs: John C Marshall, Srinivas Murthy, Janet Diaz, N K Adhikari, Derek C Angus, Yaseen M Arabi, Kenneth Baillie, Michael Bauer, Scott Berry, Bronagh Blackwood, Marc Bonten, Fernando Bozza, Frank Brunkhorst, Allen Cheng, Mike Clarke, Vu Quoc Dat, Menno de Jong, Justin Denholm, Lennie Derde, Jake Dunning, Xiaobin Feng, Tom Fletcher, Nadine Foster, Rob Fowler, Nina Gobat, Charles Gomersall, Anthony Gordon
Publié dans: The Lancet Infectious Diseases, Numéro 20/8, 2020, Page(s) e192-e197, ISSN 1473-3099
Éditeur: The Lancet Publishing Group
DOI: 10.1016/s1473-3099(20)30483-7

Beneficial non-specific effects of live vaccines against COVID-19 and other unrelated infections

Auteurs: Aaby P, Netea MG, Benn CS.
Publié dans: Lancet Inct. dis., Numéro 29 aug 2022, 2022, Page(s) S1473-3099(22)00498-4, ISSN 1473-3099
Éditeur: The Lancet Publishing Group
DOI: 10.1016/s1473-3099(22)00498-4

Comparative host transcriptome in response to pathogenic fungi identifies common and species-specific transcriptional antifungal host response pathways

Auteurs: Mariolina Bruno, Intan M.W. Dewi, Vicky Matzaraki, Rob ter Horst, Marina Pekmezovic, Berenice Rösler, Laszlo Groh, Rutger J. Röring, Vinod Kumar, Yang Li, Agostinho Carvalho, Mihai G. Netea, Jean-Paul Latgé, Mark S. Gresnigt, Frank L. van de Veerdonk
Publié dans: Computational and Structural Biotechnology Journal, Numéro 19, 2021, Page(s) 647-663, ISSN 2001-0370
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DOI: 10.1016/j.csbj.2020.12.036

BCG-induced non-specific effects on heterologous infectious disease in Ugandan neonates: an investigator-blind randomised controlled trial

Auteurs: Sarah Prentice, Beatrice Nassanga, Emily L Webb, Florence Akello, Fred Kiwudhu, Hellen Akurut, Alison M Elliott, Rob J W Arts, Mihai G Netea, Hazel M Dockrell, Stephen Cose, Sarah Prentice, Beatrice Nassanga, Hellen Akurut, Florence Akello, Fred Kiwudhu, Stephen Cose, Hazel Dockrell, Emily Webb, Alison Elliott, Irene Nabaweesi, Christopher Zziwa, Milly Namutebi, Benigna Namarra, Florence Akello, E
Publié dans: The Lancet Infectious Diseases, 2021, ISSN 1473-3099
Éditeur: The Lancet Publishing Group
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Complex Immune Dysregulation in COVID-19 Patients with Severe Respiratory Failure

Auteurs: Evangelos J. Giamarellos-Bourboulis, Mihai G. Netea, Nikoletta Rovina, Karolina Akinosoglou, Anastasia Antoniadou, Nikolaos Antonakos, Georgia Damoraki, Theologia Gkavogianni, Maria-Evangelia Adami, Paraskevi Katsaounou, Maria Ntaganou, Magdalini Kyriakopoulou, George Dimopoulos, Ioannis Koutsodimitropoulos, Dimitrios Velissaris, Panagiotis Koufargyris, Athanassios Karageorgos, Konstantina Katrini
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Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients

Auteurs: Anna C. Aschenbrenner, Maria Mouktaroudi, Benjamin Krämer, Marie Oestreich, Nikolaos Antonakos, Melanie Nuesch-Germano, Konstantina Gkizeli, Lorenzo Bonaguro, Nico Reusch, Kevin Baßler, Maria Saridaki, Rainer Knoll, Tal Pecht, Theodore S. Kapellos, Sarandia Doulou, Charlotte Kröger, Miriam Herbert, Lisa Holsten, Arik Horne, Ioanna D. Gemünd, Nikoletta Rovina, Shobhit Agrawal, Kilian Dahm, Mart
Publié dans: Genome Medicine, Numéro 13/1, 2021, ISSN 1756-994X
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Chronic HIV infection induces transcriptional and functional reprogramming of innate immune cells

Auteurs: Wouter A. van der Heijden, Lisa Van de Wijer, Farid Keramati, Wim Trypsteen, Sofie Rutsaert, Rob ter Horst, Martin Jaeger, Hans J.P.M. Koenen, Hendrik G. Stunnenberg, Irma Joosten, Paul E. Verweij, Jan van Lunzen, Charles A. Dinarello, Leo A.B. Joosten, Linos Vandekerckhove, Mihai G. Netea, André J.A.M. van der Ven, Quirijn de Mast
Publié dans: JCI Insight, Numéro 6/7, 2021, ISSN 2379-3708
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Improving the odds of survival: transgenerational effects of infections

Auteurs: Victoria M Spanou, Theano P Andriopoulou, Evangelos J Giamarellos-Bourboulis, Mihai G Netea
Publié dans: EMBO Molecular Medicine, 2025, ISSN 1757-4684
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Controlled Human Malaria Infection Induces Long-Term Functional Changes in Monocytes

Auteurs: Jona Walk, Farid Keramati, L. Charlotte J. de Bree, Rob J. W. Arts, Bas Blok, Mihai G. Netea, Hendrik G. Stunnenberg, Robert W. Sauerwein
Publié dans: Frontiers in Molecular Biosciences, Numéro 7, 2020, ISSN 2296-889X
Éditeur: Frontiers in Molecular Biosciences
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An integrative genomics approach identifies KDM4 as a modulator of trained immunity.

Auteurs: Moorlag SJCFM, Matzaraki V, van Puffelen JH, van der Heijden C, Keating S, Groh L, Röring RJ, Bakker OB, Mourits VP, Koeken VACM, de Bree LCJ, Smeekens SP, Oosting M, Gamboa RA, Riksen NP, Xavier RJ, Wijmenga C, Kumar V, van Crevel R, Novakovic B, Joosten LAB, Li Y, Netea MG.
Publié dans: Eur J Immunol., Numéro 2022, 2022, Page(s) 431-446, ISSN 0014-2980
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Lysine methyltransferase G9a is an important modulator of trained immunity

Auteurs: Vera P Mourits, Jelmer H Puffelen, Boris Novakovic, Mariolina Bruno, Anaísa V Ferreira, Rob JW Arts, Laszlo Groh, Tania O Crișan, Jelle Zwaag, Elisa Jentho, Matthijs Kox, Peter Pickkers, Frank L Veerdonk, Sebastian Weis, Egbert Oosterwijk, Sita H Vermeulen, Mihai G Netea, Leo AB Joosten
Publié dans: Clinical & Translational Immunology, Numéro 10/2, 2021, ISSN 2050-0068
Éditeur: Wiley & Sons
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Impaired ketogenesis ties metabolism to T cell dysfunction in COVID-19

Auteurs: Karagiannis F, Peukert K, Surace L, Michla M, Nikolka F, Fox M, Weiss P, Feuerborn C, Maier P, Schulz S, Al B, Seeliger B, Welte T, David S, Grondman I, de Nooijer AH, Pickkers P, Kleiner JL, Berger MM, Brenner T, Putensen C; Bonn COVIMMUNE Consortium, Kato H, Garbi N, Netea MG, Hiller K, Placek K, Bode C, Wilhelm C.
Publié dans: Nature, Numéro july 28 2022, 2022, Page(s) 801-807, ISSN 1476-4687
Éditeur: Nature Research
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An integrative model of cardiometabolic traits identifies two types of metabolic syndrome

Auteurs: Amit Frishberg, Inge van den Munckhof, Rob ter Horst, Kiki Schraa, Leo AB Joosten, Joost HW Rutten, Adrian C Iancu, Ioana M Dregoesc, Bogdan A Tigu, Mihai G Netea, Niels P Riksen, Irit Gat-Viks
Publié dans: eLife, Numéro 10, 2021, ISSN 2050-084X
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The influence of the gut microbiome on BCG-induced trained immunity.

Auteurs: Stražar M, Mourits VP, Koeken VACM, de Bree LCJ, Moorlag SJCFM, Joosten LAB, van Crevel R, Vlamakis H, Netea MG, Xavier RJ
Publié dans: Genome Biology, 2021, Page(s) 275, ISSN 1474-760X
Éditeur: BMC
DOI: 10.1186/s13059-021-02482-0

Multi-omics analysis of innate and adaptive responses to BCG vaccination reveals epigenetic cell states that predict trained immunity

Auteurs: Moorlag SJCFM, Folkman L, Ter Horst R, Krausgruber T, Barreca D, Schuster LC, Fife V, Matzaraki V, Li W, Reichl S, Mourits VP, Koeken VACM, de Bree LCJ, Dijkstra H, Lemmers H, van Cranenbroek B, van Rijssen E, Koenen HJPM, Joosten I, Xu CJ, Li Y, Joosten LAB, van Crevel R, Netea MG, Bock C.
Publié dans: Immunity, Numéro Volume 57, Numéro 1, 9 January 2024,, 2024, Page(s) 171-187.e14, ISSN 1074-7613
Éditeur: Cell Press
DOI: 10.1016/j.immuni.2023.12.005

Two Randomized Controlled Trials of Bacillus Calmette-Guérin Vaccination to reduce absenteeism among health care workers and hospital admission by elderly persons during the COVID-19 pandemic: A structured summary of the study protocols for two randomised controlled trials

Auteurs: Thijs ten Doesschate, Simone J. C. F. M. Moorlag, Thomas W. van der Vaart, Esther Taks, Priya Debisarun, Jaap ten Oever, Chantal P. Bleeker-Rovers, Patricia Bruijning Verhagen, Arief Lalmohamed, Rob ter Heine, Reinout van Crevel, Janneke van de Wijgert, Axel B. Janssen, Marc J. Bonten, Cornelis H. van Werkhoven, Mihai G. Netea
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BCG Vaccination in Humans Elicits Trained Immunity via the Hematopoietic Progenitor Compartment

Auteurs: Branko Cirovic, L. Charlotte J. de Bree, Laszlo Groh, Bas A. Blok, Joyce Chan, Walter J.F.M. van der Velden, M.E.J. Bremmers, Reinout van Crevel, Kristian Händler, Simone Picelli, Jonas Schulte-Schrepping, Kathrin Klee, Marije Oosting, Valerie A.C.M. Koeken, Jakko van Ingen, Yang Li, Christine S. Benn, Joachim L. Schultze, Leo A.B. Joosten, Nigel Curtis, Mihai G. Netea, Andreas Schlitzer
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VPM1002 as Prophylaxis Against Severe Respiratory Tract Infections Including Coronavirus Disease 2019 in the Elderly: A Phase 3 Randomized, Double-Blind, Placebo-Controlled, Multicenter Clinical Study

Auteurs: Blossey AM, Brückner S, May M, Parzmair GP, Sharma H, Shaligram U, Grode L, Kaufmann SHE, Netea MG, Schindler C.
Publié dans: Clinical infectious diseases, Numéro Volume 76, Numéro 7, 1 April 2023,, 2023, Page(s) 1304–1310, ISSN 2684-4559
Éditeur: Oxfor university press
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Conceptualization of population-specific human functional immune-genomics projects to identify factors that contribute to variability in immune and infectious diseases

Auteurs: Collins K. Boahen, Leo A.B. Joosten, Mihai G. Netea, Vinod Kumar
Publié dans: Heliyon, Numéro 7/4, 2021, Page(s) e06755, ISSN 2405-8440
Éditeur: Cellpress, Elsevier
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Innate Immune Training of Human Macrophages by Cathelicidin Analogs

Auteurs: Dijk A, Anten J, Bakker A, Evers N, Hoekstra AT, Chang JC, Scheenstra MR, Veldhuizen EJA, Netea MG, Berkers CR, Haagsman HP.
Publié dans: Front Immunol ., Numéro 26 july 2022, 2022, Page(s) 13:777530, ISSN 1664-3224
Éditeur: Frontiers Research Foundation
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Alendronate modulates cytokine responses in healthy young individuals after BCG vaccination

Auteurs: Bulut O, Kilic G, Debisarun PA, Röring RJ, Sun S, Kolkman M, van Rijssen E, Ten Oever J, Koenen H, Barreiro L, Domínguez-Andrés J, Netea MG.
Publié dans: Immunology Letters, Numéro Volume 267, June 2024,, 2024, Page(s) 106851, ISSN 0165-2478
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The Architecture of Circulating Immune Cells Is Dysregulated in People Living With HIV on Long Term Antiretroviral Treatment and Relates With Markers of the HIV-1 Reservoir, Cytomegalovirus, and Microbial Translocation

Auteurs: Lisa Van de Wijer, Wouter A. van der Heijden, Rob ter Horst, Martin Jaeger, Wim Trypsteen, Sofie Rutsaert, Bram van Cranenbroek, Esther van Rijssen, Irma Joosten, Leo Joosten, Linos Vandekerckhove, Till Schoofs, Jan van Lunzen, Mihai G. Netea, Hans J.P.M. Koenen, André J.A.M. van der Ven, Quirijn de Mast
Publié dans: Frontiers in Immunology, Numéro 12, 2021, ISSN 1664-3224
Éditeur: Frontiers in Immunology
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Systemic administration of β-glucan induces immune training in microglia

Auteurs: Yang Heng, Xiaoming Zhang, Malte Borggrewe, Hilmar R. J. van Weering, Maaike L. Brummer, Tjalling W. Nijboer, Leo A. B. Joosten, Mihai G. Netea, Erik W. G. M. Boddeke, Jon D. Laman, Bart J. L. Eggen
Publié dans: Journal of Neuroinflammation, Numéro 18/1, 2021, ISSN 1742-2094
Éditeur: BioMed Central
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Rare variants increase the risk of severe COVID-19

Auteurs: Frank L van de Veerdonk, Mihai G Netea
Publié dans: eLife, Numéro 10, 2021, ISSN 2050-084X
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Postinfectious Epigenetic Immune Modifications — A Double-Edged Sword

Auteurs: Andrew R. DiNardo, Mihai G. Netea, Daniel M. Musher
Publié dans: New England Journal of Medicine, Numéro 384/3, 2021, Page(s) 261-270, ISSN 0028-4793
Éditeur: Massachusetts Medical Society
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Resolving sepsis-induced immunoparalysis via trained immunity by targeting interleukin-4 to myeloid cells

Auteurs: Schrijver DP, Röring RJ, Deckers J, de Dreu A, Toner YC, Prevot G, Priem B, Munitz J, Nugraha EG, van Elsas Y, Azzun A, Anbergen T, Groh LA, Becker AMD, Pérez-Medina C, Oosterwijk RS, Novakovic B, Moorlag SJCFM, Jansen A, Pickkers P, Kox M, Beldman TJ, Kluza E, van Leent MMT, Teunissen AJP, van der Meel R, Fayad ZA, Joosten LAB, Fisher EA, Merkx M, Netea MG, Mulder WJM.
Publié dans: Nature Biomedical Engineering, Numéro 2023, 7, 2023, Page(s) 1097–1112, ISSN 2157-846X
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BCG vaccination-induced acquired control of mycobacterial growth differs from growth control preexisting to BCG vaccination

Auteurs: van Meijgaarden KE, Li W, Moorlag SJCFM, Koeken VACM, Koenen HJPM, Joosten LAB, Vyakarnam A, Ahmed A, Rakshit S, Adiga V, Ottenhoff THM, Li Y, Netea MG, Joosten SA.
Publié dans: nature Communications, Numéro 2024 Jan 2;15(1):114, 2024, Page(s) 44252-5, ISSN 2041-1723
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Routine vaccination for influenza and pneumococcal disease and its effect on COVID-19 in a population of Dutch older adults

Auteurs: Esther J.M. Taks, Konstantin Föhse, Simone J.C.F.M. Moorlag, Jacobien Hoogerwerf, Reinout van Crevel, Cornelis H. van Werkhoven, Mihai G. Netea, Jaap ten Oever
Publié dans: Vaccine: X, Numéro 14, 2023, Page(s) 100344, ISSN 2590-1362
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Activate: Randomized Clinical Trial of BCG Vaccination against Infection in the Elderly

Auteurs: Evangelos J. Giamarellos-Bourboulis, Maria Tsilika, Simone Moorlag, Nikolaos Antonakos, Antigone Kotsaki, Jorge Domínguez-Andrés, Evdoxia Kyriazopoulou, Theologia Gkavogianni, Maria-Evangelia Adami, Georgia Damoraki, Panagiotis Koufargyris, Athanassios Karageorgos, Amalia Bolanou, Hans Koenen, Reinout van Crevel, Dionyssia-Irene Droggiti, George Renieris, Antonios Papadopoulos, Mihai G. Netea
Publié dans: Cell, Numéro 183/2, 2020, Page(s) 315-323.e9, ISSN 0092-8674
Éditeur: Cell Press
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Trained innate immunity: Concept, nomenclature, and future perspectives

Auteurs: Netea MG, Joosten LAB.
Publié dans: Journal of Allergy and Clinical Immunology, Numéro Volume 154, Numéro 5, November 2024,, 2024, Page(s) 1079-1084, ISSN 2772-8293
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Bridging animal and clinical research during SARS-CoV-2 pandemic: A new-old challenge

Auteurs: Martin S. Winkler, Tomasz Skirecki, Frank M. Brunkhorst, Sara Cajander, Jean-Marc Cavaillon, Ricard Ferrer, Stefanie B. Flohé, Alberto García-Salido, Evangelos J. Giamarellos-Bourboulis, Massimo Girardis, Matthijs Kox, Gunnar Lachmann, Ignacio Martin-Loeches, Mihai G. Netea, Thibaud Spinetti, Joerg C. Schefold, Antoni Torres, Florian Uhle, Fabienne Venet, Sebastian Weis, André Scherag, Ignacio
Publié dans: EBioMedicine, Numéro 66, 2021, Page(s) 103291, ISSN 2352-3964
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Neonatal BCG vaccination is associated with a long-term DNA methylation signature in circulating monocytes

Auteurs: Bannister S, Kim B, Domínguez-Andrés J, Kilic G, Ansell BRE, Neeland MR, Moorlag SJCFM, Matzaraki V, Vlahos A, Shepherd R, Germano S, Bahlo M, Messina NL, Saffery R, Netea MG, Curtis N, Novakovic B.
Publié dans: Sci Adv, Numéro 5 aug 2022, 2022, Page(s) 8(31):eabn4002, ISSN 2375-2548
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Innate Immune Training of Granulopoiesis Promotes Anti-tumor Activity

Auteurs: Lydia Kalafati, Ioannis Kourtzelis, Jonas Schulte-Schrepping, Xiaofei Li, Aikaterini Hatzioannou, Tatyana Grinenko, Eman Hagag, Anupam Sinha, Canan Has, Sevina Dietz, Antonio Miguel de Jesus Domingues, Marina Nati, Sundary Sormendi, Ales Neuwirth, Antonios Chatzigeorgiou, Athanasios Ziogas, Mathias Lesche, Andreas Dahl, Ian Henry, Pallavi Subramanian, Ben Wielockx, Peter Murray, Peter Mirtschink,
Publié dans: Cell, Numéro 183/3, 2020, Page(s) 771-785.e12, ISSN 0092-8674
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BCG-induced trained immunity: can it offer protection against COVID-19?

Auteurs: Luke A. J. O’Neill, Mihai G. Netea
Publié dans: Nature Reviews Immunology, Numéro 20/6, 2020, Page(s) 335-337, ISSN 1474-1733
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Thyrotrophin and thyroxine support immune homeostasis in humans

Auteurs: Martin Jaeger, Yvette J.E Sloot, Rob Ter Horst, Xiaojing Chu, Hans J.P.M. Koenen, Valerie A.C.M. Koeken, Simone J.C.F.M. Moorlag, Charlotte J. Bree, Vera P. Mourits, Heidi Lemmers, Helga Dijkstra, Marco Medici, Antonius E. Herwaarden, Irma Joosten, Leo A.B. Joosten, Yang Li, Johannes W.A. Smit, Mihai G. Netea, Romana T. Netea‐Maier
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Transmission of trained immunity and heterologous resistance to infections across generations

Auteurs: Katzmarski N, Domínguez-Andrés J, Cirovic B, Renieris G, Ciarlo E, Le Roy D, Lepikhov K, Kattler K, Gasparoni G, Händler K, Theis H, Beyer M, van der Meer JWM, Joosten LAB, Walter J, Schultze JL, Roger T, Giamarellos-Bourboulis EJ, Schlitzer A, Netea MG.
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Circadian rhythm influences induction of trained immunity by BCG vaccination

Auteurs: L. Charlotte J. de Bree, Vera P. Mourits, Valerie A.C.M. Koeken, Simone J.C.F.M. Moorlag, Robine Janssen, Lukas Folkman, Daniele Barreca, Thomas Krausgruber, Victoria Fife-Gernedl, Boris Novakovic, Rob J.W. Arts, Helga Dijkstra, Heidi Lemmers, Christoph Bock, Leo A.B. Joosten, Reinout van Crevel, Christine S. Benn, Mihai G. Netea
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Using BCG vaccine to enhance non-specific protection of health care workers during the COVID-19 pandemic: A structured summary of a study protocol for a randomised controlled trial in Denmark

Auteurs: Anne Marie Rosendahl Madsen, Frederik Schaltz-Buchholzer, Thomas Benfield, Morten Bjerregaard-Andersen, Lars Skov Dalgaard, Christine Dam, Sisse Bolm Ditlev, Gulia Faizi, Isik Somuncu Johansen, Poul-Erik Kofoed, Gitte Schultz Kristensen, Ellen Christine Leth Loekkegaard, Christian Backer Mogensen, Libin Mohamed, Anne Ostenfeld, Emilie Sundhaugen Oedegaard, Marcus Kjaer Soerensen, Christian Wejse,
Publié dans: Trials, Numéro 21/1, 2020, ISSN 1745-6215
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Evidence for the heterologous benefits of prior BCG vaccination on COVISHIELD™ vaccine-induced immune responses in SARS-CoV-2 seronegative young Indian adults

Auteurs: Chetan Kumar N, Dwarkanath P, Shivalingaiah S, Rao S, D'Souza G, Dias M, Maguire TJA, Doores KJ, Zoodsma M, Geckin B, Dasgupta P, Babji S, van Meijgaarden KE, Joosten SA, Ottenhoff THM, Li Y, Netea MG, Stuart KD, De Rosa SC, McElrath MJ, Vyakarnam A.
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Trained Immunity: a Tool for Reducing Susceptibility to and the Severity of SARS-CoV-2 Infection

Auteurs: Mihai G. Netea, Evangelos J. Giamarellos-Bourboulis, Jorge Domínguez-Andrés, Nigel Curtis, Reinout van Crevel, Frank L. van de Veerdonk, Marc Bonten
Publié dans: Cell, Numéro 181/5, 2020, Page(s) 969-977, ISSN 0092-8674
Éditeur: Cell Press
DOI: 10.1016/j.cell.2020.04.042

Single-cell RNA sequencing reveals induction of distinct trained-immunity programs in human monocytes.

Auteurs: Zhang B, Moorlag SJ, Dominguez-Andres J, Bulut Ö, Kilic G, Liu Z, van Crevel R, Xu CJ, Joosten LA, Netea MG, Li Y.
Publié dans: J. Clin. Invest., Numéro 7, 2022, Page(s) 132, ISSN 0021-9738
Éditeur: American Society for Clinical Investigation
DOI: 10.1172/jci147719

Designing the Next Generation of Vaccines: Relevance for Future Pandemics

Auteurs: Jorge Domínguez-Andrés, Reinout van Crevel, Maziar Divangahi, Mihai G. Netea
Publié dans: mBio, Numéro 11/6, 2020, ISSN 2161-2129
Éditeur: American Society for Microbiology
DOI: 10.1128/mbio.02616-20

Trained immunity: Target for prophylaxis and therapy

Auteurs: Ziogas A, Bruno M, van der Meel R, Mulder WJM, Netea MG.
Publié dans: Cell Host & Microbe, Numéro 2023 Nov 8;31(11), 2023, Page(s) 1776-1791, ISSN 1931-3128
Éditeur: Cell Press
DOI: 10.1016/j.chom.2023.10.015

A single-cell view on host immune transcriptional response to in vivo BCG-induced trained immunity

Auteurs: : Li W, Moorlag SJCFM, Koeken VACM, Röring RJ, de Bree LCJ, Mourits VP, Gupta MK, Zhang B, Fu J, Zhang Z, Grondman I, van Meijgaarden KE, Zhou L, Alaswad A, Joosten LAB, van Crevel R, Xu CJ, Netea MG, Li Y.
Publié dans: Cell Reports, Numéro Volume 42, Numéro 5, 30 May 2023,, 2023, Page(s) 112487, ISSN 2211-1247
Éditeur: Cell Press
DOI: 10.1016/j.celrep.2023.112487

The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity

Auteurs: Marcin F Osuchowski, Martin S Winkler, Tomasz Skirecki, Sara Cajander, Manu Shankar-Hari, Gunnar Lachmann, Guillaume Monneret, Fabienne Venet, Michael Bauer, Frank M Brunkhorst, Sebastian Weis, Alberto Garcia-Salido, Matthijs Kox, Jean-Marc Cavaillon, Florian Uhle, Markus A Weigand, Stefanie B Flohé, W Joost Wiersinga, Raquel Almansa, Amanda de la Fuente, Ignacio Martin-Loeches, Christian Meisel,
Publié dans: The Lancet Respiratory Medicine, Numéro 9/6, 2021, Page(s) 622-642, ISSN 2213-2600
Éditeur: Elsevier Limited
DOI: 10.1016/s2213-2600(21)00218-6

An open label trial of anakinra to prevent respiratory failure in COVID-19

Auteurs: Evdoxia Kyriazopoulou, Periklis Panagopoulos, Symeon Metallidis, George N Dalekos, Garyphallia Poulakou, Nikolaos Gatselis, Eleni Karakike, Maria Saridaki, Georgia Loli, Aggelos Stefos, Danai Prasianaki, Sarah Georgiadou, Olga Tsachouridou, Vasileios Petrakis, Konstantinos Tsiakos, Maria Kosmidou, Vassiliki Lygoura, Maria Dareioti, Haralampos Milionis, Ilias C Papanikolaou, Karolina Akinosoglou, D
Publié dans: eLife, Numéro 10, 2021, ISSN 2050-084X
Éditeur: eLife Sciences Publications
DOI: 10.7554/elife.66125

Characterization of sepsis inflammatory endotypes using circulatory proteins in patients with severe infection: a prospective cohort study

Auteurs: Ricaño-Ponce I, Riza AL, de Nooijer AH, Pirvu A, Dorobantu S, Dragos A, Streata I, Roskanovic M, Grondman I, Dumitrescu F, Kumar V, Netea MG, Ioana M.
Publié dans: BMC infectious diseases, Numéro 2022 Oct 8, 2022, Page(s) 22(1):778., ISSN 1471-2334
Éditeur: BioMed Central
DOI: 10.1186/s12879-022-07761-0

Stronger induction of trained immunity by mucosal BCG or MTBVAC vaccination compared to standard intradermal vaccination

Auteurs: Michel P.M. Vierboom, Karin Dijkman, Claudia C. Sombroek, Sam O. Hofman, Charelle Boot, Richard A.W. Vervenne, Krista G. Haanstra, Maarten van der Sande, Liesbeth van Emst, Jorge Domínguez-Andrés, Simone J.C.F.M. Moorlag, Clemens H.M. Kocken, Jelle Thole, Esteban Rodríguez, Eugenia Puentes, Joost H.A. Martens, Reinout van Crevel, Mihai G. Netea, Nacho Aguilo, Carlos Martin, Frank A.W. Verreck
Publié dans: Cell Reports Medicine, Numéro 2/1, 2021, Page(s) 100185, ISSN 2666-3791
Éditeur: Elsevier
DOI: 10.1016/j.xcrm.2020.100185

Data of common and species-specific transcriptional host responses to pathogenic fungi

Auteurs: Mariolina Bruno, Robter Horst, Marina Pekmezovic, Vinod Kumar, Yang Li, Mihai G. Netea, Jean-Paul Latgé, Mark S. Gresnigt, Frank L. van de Veerdonk
Publié dans: Data in Brief, Numéro 35, 2021, Page(s) 106928, ISSN 2352-3409
Éditeur: Elsevier BV
DOI: 10.1016/j.dib.2021.106928

BCG-Induced Trained Immunity in Healthy Individuals: The Effect of Plasma Muramyl Dipeptide Concentrations

Auteurs: Vera P. Mourits, Valerie A. C. M. Koeken, L. Charlotte J. de Bree, Simone J. C. F. M. Moorlag, Wern Cui Chu, Xiaoli Xu, Helga Dijkstra, Heidi Lemmers, Leo A. B. Joosten, Yue Wang, Reinout van Crevel, Mihai G. Netea
Publié dans: Journal of Immunology Research, Numéro 2020, 2020, Page(s) 1-8, ISSN 2314-8861
Éditeur: Hindawi Publishing Corporation
DOI: 10.1155/2020/5812743

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