Trained immunity: improving the next generation of vaccines for the older generation

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

RORα negatively regulates BCG-induced trained immunity

Autores: Kilic G, Matzaraki V, Bulut O, Baydemir I, Ferreira AV, Rabold K, Moorlag SJCFM, Koeken VACM, de Bree LCJ, Mourits VP, Joosten LAB, Domínguez-Andrés J, Netea MG.
Publicado en: Cellular Immunology, Edición 2024 Sep-Oct;, 2024, Página(s) 403-404, ISSN 0008-8749
Editor: Academic Press
DOI: 10.1016/j.cellimm.2024.104862

A modular approach toward producing nanotherapeutics targeting the innate immune system

Autores: Mandy M. T. van Leent, Anu E. Meerwaldt, Alexandre Berchouchi, Yohana C. Toner, Marianne E. Burnett, Emma D. Klein, Anna Vera D. Verschuur, Sheqouia A. Nauta, Jazz Munitz, Geoffrey Prévot, Esther M. van Leeuwen, Farideh Ordikhani, Vera P. Mourits, Claudia Calcagno, Philip M. Robson, George Soultanidis, Thomas Reiner, Rick R. M. Joosten, Heiner Friedrich, Joren C. Madsen, Ewelina Kluza, Roy van de
Publicado en: Science Advances, Edición 7/10, 2021, Página(s) eabe7853, ISSN 2375-2548
Editor: AAAS
DOI: 10.1126/sciadv.abe7853

The impact of BNT162b2 mRNA vaccine on adaptive and innate immune responses

Autores: : Föhse K, Geckin B, Zoodsma M, Kilic G, Liu Z, Röring RJ, Overheul GJ, van de Maat J, Bulut O, Hoogerwerf JJ, Ten Oever J, Simonetti E, Schaal H, Adams O, Müller L, Ostermann PN, van de Veerdonk FL, Joosten LAB, Haagmans BL, van Crevel R, van Rij RP, GeurtsvanKessel C, de Jonge MI, Li Y, Domínguez-Andrés J, Netea MG.
Publicado en: Clinical Immunology, Edición Volume 255, October 2023,, 2023, Página(s) 109762, ISSN 1521-6616
Editor: Academic Press
DOI: 10.1016/j.clim.2023.109762

Defining trained immunity and its role in health and disease

Autores: Mihai G. Netea, Jorge Domínguez-Andrés, Luis B. Barreiro, Triantafyllos Chavakis, Maziar Divangahi, Elaine Fuchs, Leo A. B. Joosten, Jos W. M. van der Meer, Musa M. Mhlanga, Willem J. M. Mulder, Niels P. Riksen, Andreas Schlitzer, Joachim L. Schultze, Christine Stabell Benn, Joseph C. Sun, Ramnik J. Xavier, Eicke Latz
Publicado en: Nature Reviews Immunology, Edición 20/6, 2020, Página(s) 375-388, ISSN 1474-1733
Editor: Nature Publishing Group
DOI: 10.1038/s41577-020-0285-6

β-Glucan Induces Protective Trained Immunity against Mycobacterium tuberculosis Infection: A Key Role for IL-1

Autores: Simone J.C.F.M. Moorlag, Nargis Khan, Boris Novakovic, Eva Kaufmann, Trees Jansen, Reinout van Crevel, Maziar Divangahi, Mihai G. Netea
Publicado en: Cell Reports, Edición 31/7, 2020, Página(s) 107634, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2020.107634

Trained immunity: implications for vaccination

Autores: Büsranur Geckin, Friedrich Konstantin Föhse, Jorge Domínguez-Andrés, Mihai G Netea
Publicado en: Current Opinion in Immunology, Edición 77, 2023, Página(s) 102190, ISSN 0952-7915
Editor: Elsevier BV
DOI: 10.1016/j.coi.2022.102190

A higher BMI is not associated with a different immune response and disease course in critically ill COVID-19 patients

Autores: Emma J. Kooistra, Aline H. de Nooijer, Wout J. Claassen, Inge Grondman, Nico A. F. Janssen, Mihai G. Netea, Frank L. van de Veerdonk, Johannes G. van der Hoeven, Matthijs Kox, Peter Pickkers
Publicado en: International Journal of Obesity, Edición 45/3, 2021, Página(s) 687-694, ISSN 0307-0565
Editor: Nature Publishing Group
DOI: 10.1038/s41366-021-00747-z

Engineering cytokine therapeutics

Autores: : Deckers J, Anbergen T, Hokke AM, de Dreu A, Schrijver DP, de Bruin K, Toner YC, Beldman TJ, Spangler JB, de Greef TFA, Grisoni F, van der Meel R, Joosten LAB, Merkx M, Netea MG, Mulder WJM.
Publicado en: Nature Reviews Bioengineering, Edición 2023, 1, 2023, Página(s) 286–303, ISSN 2731-6092
Editor: Clockss
DOI: 10.1038/s44222-023-00030-y

The role of sirtuin 1 on the induction of trained immunity.

Autores: Mourits VP, Helder LS, Matzaraki V, Koeken VACM, Groh L, de Bree LCJ, Moorlag SJCFM, van der Heijden CDCC, Keating ST, van Puffelen JH, Jaeger M, Joosten LAB, Netea MG.
Publicado en: Cell Immunol., 2021, Página(s) 104393, ISSN 0008-8749
Editor: Academic Press
DOI: 10.1016/j.cellimm.2021.104393

The Set7 Lysine Methyltransferase Regulates Plasticity in Oxidative Phosphorylation Necessary for Trained Immunity Induced by β-Glucan

Autores: Samuel T. Keating, Laszlo Groh, Charlotte D.C.C. van der Heijden, Hanah Rodriguez, Jéssica C. dos Santos, Stephanie Fanucchi, Jun Okabe, Harikrishnan Kaipananickal, Jelmer H. van Puffelen, Leonie Helder, Marlies P. Noz, Vasiliki Matzaraki, Yang Li, L. Charlotte J. de Bree, Valerie A.C.M. Koeken, Simone J.C.F.M. Moorlag, Vera P. Mourits, Jorge Domínguez-Andrés, Marije Oosting, Elianne P. Bulthui
Publicado en: Cell Reports, Edición 31/3, 2020, Página(s) 107548, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2020.107548

Urban living in healthy Tanzanians is associated with an inflammatory status driven by dietary and metabolic changes.

Autores: Temba GS, Kullaya V, Pecht T, Mmbaga BT, Aschenbrenner AC, Ulas T, Kibiki G, Lyamuya F, Boahen CK, Kumar V, Joosten LAB, Schultze JL, van der Ven AJ, Netea MG, de Mast Q.
Publicado en: Nat Immunol., 2021, Página(s) 287-300, ISSN 1529-2908
Editor: Nature Publishing Group
DOI: 10.1038/s41590-021-00867-8

C5a-licensed phagocytes drive sterilizing immunity during systemic fungal infection

Autores: Desai JV, Kumar D, Freiwald T, Chauss D, Johnson MD, Abers MS, Steinbrink JM, Perfect JR, Alexander B, Matzaraki V, Snarr BD, Zarakas MA, Oikonomou V, Silva LM, Shivarathri R, Beltran E, Demontel LN, Wang L, Lim JK, Launder D, Conti HR, Swamydas M, McClain MT, Moutsopoulos NM, Kazemian M, Netea MG, Kumar V, Köhl J, Kemper C, Afzali B, Lionakis MS.
Publicado en: cell, Edición Volume 186, Edición 13, 22 June 2023, 2023, Página(s) 2802-2822.e22, ISSN 0092-8674
Editor: Cell Press
DOI: 10.1016/j.cell.2023.04.031

In vitro induction of trained immunity in adherent human monocytes

Autores: Jorge Domínguez-Andrés, Rob J.W. Arts, Siroon Bekkering, Harsh Bahrar, Bastiaan A. Blok, L. Charlotte J. de Bree, Mariolina Bruno, Özlem Bulut, Priya A. Debisarun, Helga Dijkstra, Jéssica Cristina dos Santos, Anaísa V. Ferreira, Daniela Flores-Gomez, Laszlo A. Groh, Inge Grondman, Leonie Helder, Cor Jacobs, Liesbeth Jacobs, Trees Jansen, Gizem Kilic, Viola Klück, Valerie A.C.M. Koeken, Heidi
Publicado en: STAR Protocols, Edición 2/1, 2021, Página(s) 100365, ISSN 2666-1667
Editor: Cell Press
DOI: 10.1016/j.xpro.2021.100365

Outcomes Associated With Use of a Kinin B2 Receptor Antagonist Among Patients With COVID-19

Autores: Frank L. van de Veerdonk, Ilse J. E. Kouijzer, Aline H. de Nooijer, Hans G. van der Hoeven, Coen Maas, Mihai G. Netea, Roger J. M. Brüggemann
Publicado en: JAMA Network Open, Edición 3/8, 2020, Página(s) e2017708, ISSN 2574-3805
Editor: JAMA network
DOI: 10.1001/jamanetworkopen.2020.17708

Regulation of plasma soluble receptors of TNF and IL-1 in patients with COVID-19 differs from that observed in sepsis

Autores: Aksu MD, van der Ent T, Zhang Z, Riza AL, de Nooijer AH, Ricaño-Ponce I, Janssen N, Engel JJ, Streata I, Dijkstra H, Lemmers H, Grondman I, Koeken VACM, Antoniadou E, Antonakos N, van de Veerdonk FL, Li Y, Giamarellos-Bourboulis EJ, Netea MG, Ziogas A.
Publicado en: Journal of Infection, Edición Volume 89, Edición 6, December 2024,, 2024, Página(s) 106300, ISSN 0163-4453
Editor: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.jinf.2024.106300

Hydroxychloroquine Inhibits the Trained Innate Immune Response to Interferons

Autores: Nils Rother, Cansu Yanginlar, Rik G.H. Lindeboom, Siroon Bekkering, Mandy M.T. van Leent, Baranca Buijsers, Inge Jonkman, Mark de Graaf, Marijke Baltissen, Lieke A. Lamers, Niels P. Riksen, Zahi A. Fayad, Willem J.M. Mulder, Luuk B. Hilbrands, Leo A.B. Joosten, Mihai G. Netea, Michiel Vermeulen, Johan van der Vlag, Raphaël Duivenvoorden
Publicado en: Cell Reports Medicine, Edición 1/9, 2020, Página(s) 100146, ISSN 2666-3791
Editor: elsevier
DOI: 10.1016/j.xcrm.2020.100146

Safety and COVID-19 Symptoms in Individuals Recently Vaccinated with BCG: a Retrospective Cohort Study

Autores: Simone J.C.F.M. Moorlag, Rosanne C. van Deuren, Cornelis H. van Werkhoven, Martin Jaeger, Priya Debisarun, Esther Taks, Vera P. Mourits, Valerie A.C.M. Koeken, L. Charlotte J. de Bree, Thijs ten Doesschate, Maartje C. Cleophas, Sanne Smeekens, Marije Oosting, Frank L. van de Veerdonk, Leo A.B. Joosten, Jaap ten Oever, Jos W.M. van der Meer, Nigel Curtis, Peter Aaby, Christine Stabell-Benn, Evangel
Publicado en: Cell Reports Medicine, Edición 1/5, 2020, Página(s) 100073, ISSN 2666-3791
Editor: Elsevier
DOI: 10.1016/j.xcrm.2020.100073

Trained Immunity-Promoting Nanobiologic Therapy Suppresses Tumor Growth and Potentiates Checkpoint Inhibition.

Autores: Priem B, van Leent MMT, Teunissen AJP, Sofias AM, Mourits VP, Willemsen L, Klein ED, Oosterwijk RS, Meerwaldt AE, Munitz J, Prévot G, Vera Verschuur A, Nauta SA, van Leeuwen EM, Fisher EL, de Jong KAM, Zhao Y, Toner YC, Soultanidis G, Calcagno C, Bomans PHH, Friedrich H, Sommerdijk N, Reiner T, Duivenvoorden R, Zupančič E, Di Martino JS, Kluza E, Rashidian M, Ploegh HL, Dijkhuizen RM, Hak S, P
Publicado en: Cell, 2020, Página(s) 786-801, ISSN 0092-8674
Editor: Cell Press
DOI: 10.1016/j.cell.2020.09.059

Clonal hematopoiesis driven by mutated DNMT3A promotes inflammatory bone loss

Autores: Wang H, Divaris K, Pan B, Li X, Lim JH, Saha G, Barovic M, Giannakou D, Korostoff JM, Bing Y, Sen S, Moss K, Wu D, Beck JD, Ballantyne CM, Natarajan P, North KE, Netea MG, Chavakis T, Hajishengallis G.
Publicado en: Cell, Edición Volume 187, Edición 14, 11 July 2024,, 2024, Página(s) 3690-3711.e19, ISSN 1097-4172
Editor: Cellpress
DOI: 10.1016/j.cell.2024.05.003

Trained immunity as a novel approach against COVID‐19 with a focus on Bacillus Calmette–Guérin vaccine: mechanisms, challenges and perspectives

Autores: Yahya Sohrabi, Jéssica Cristina Dos Santos, Marc Dorenkamp, Hannes Findeisen, Rinesh Godfrey, Mihai G Netea, Leo AB Joosten
Publicado en: Clinical & Translational Immunology, Edición 9/12, 2020, ISSN 2050-0068
Editor: ASI
DOI: 10.1002/cti2.1228

BCG Vaccination Induces Long-Term Functional Reprogramming of Human Neutrophils

Autores: Simone J.C.F.M. Moorlag, Yessica Alina Rodriguez-Rosales, Joshua Gillard, Stephanie Fanucchi, Kate Theunissen, Boris Novakovic, Cynthia M. de Bont, Yutaka Negishi, Ezio T. Fok, Lydia Kalafati, Panayotis Verginis, Vera P. Mourits, Valerie A.C.M. Koeken, L. Charlotte J. de Bree, Ger J.M. Pruijn, Craig Fenwick, Reinout van Crevel, Leo A.B. Joosten, Irma Joosten, Hans Koenen, Musa M. Mhlanga, Dimitri
Publicado en: Cell Reports, Edición 33/7, 2020, Página(s) 108387, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2020.108387

The Role of Cell Metabolism in Innate Immune Memory

Autores: Anaisa Valido Ferreira, Jorge Domiguéz-Andrés, Mihai Gheorghe Netea
Publicado en: Journal of Innate Immunity, 2021, Página(s) 1-9, ISSN 1662-811X
Editor: Karger AG
DOI: 10.1159/000512280

Toward personalized immunotherapy in sepsis: The PROVIDE randomized clinical trial

Autores: : Leventogiannis K, Kyriazopoulou E, Antonakos N, Kotsaki A, Tsangaris I, Markopoulou D, Grondman I, Rovina N, Theodorou V, Antoniadou E, Koutsodimitropoulos I, Dalekos G, Vlachogianni G, Akinosoglou K, Koulouras V, Komnos A, Kontopoulou T, Prekates A, Koutsoukou A, van der Meer JWM, Dimopoulos G, Kyprianou M, Netea MG, Giamarellos-Bourboulis EJ.
Publicado en: Cell Reports Medicine, Edición Volume 3, Edición 11, 15 November 2022,, 2022, Página(s) 100817, ISSN 2666-3791
Editor: Cell Pres Elsevier Inc.
DOI: 10.1016/j.xcrm.2022.100817

Influence of the microbiome, diet and genetics on inter-individual variation in the human plasma metabolome

Autores: Andreu-Sánchez S, Wang D, Augustijn HE, Vich Vila A; Lifelines Cohort Study, Weersma RK, Medema MH, Netea MG, Kuipers F, Wijmenga C, Zhernakova A, Fu J.
Publicado en: Nature medicine, Edición 28 nov 2022, 2022, Página(s) 2322-2343, ISSN 1078-8956
Editor: Nature Publishing Group
DOI: 10.1038/s41591-022-02014-8

Presence of Genetic Variants Among Young Men With Severe COVID-19

Autores: Caspar I. van der Made, Annet Simons, Janneke Schuurs-Hoeijmakers, Guus van den Heuvel, Tuomo Mantere, Simone Kersten, Rosanne C. van Deuren, Marloes Steehouwer, Simon V. van Reijmersdal, Martin Jaeger, Tom Hofste, Galuh Astuti, Jordi Corominas Galbany, Vyne van der Schoot, Hans van der Hoeven, Wanda Hagmolen of ten Have, Eva Klijn, Catrien van den Meer, Jeroen Fiddelaers, Quirijn de Mast, Chantal
Publicado en: JAMA, Edición 324/7, 2020, Página(s) 663, ISSN 0098-7484
Editor: American Medical Association
DOI: 10.1001/jama.2020.13719

Plasma metabolome predicts trained immunity responses after antituberculosis BCG vaccination.

Autores: Koeken VACM, Qi C, Mourits VP, de Bree LCJ, Moorlag SJCFM, Sonawane V, Lemmers H, Dijkstra H, Joosten LAB, van Laarhoven A, Xu CJ, van Crevel R, Netea MG, Li Y.
Publicado en: PLoS Biology, Edición 12 Sept 2022, 20(9), 2022, Página(s) e3001765, ISSN 1544-9173
Editor: Public Library of Science
DOI: 10.1371/journal.pbio.3001765

Deadly COVID-19 among the elderly: Innate immune memory helping those most in need

Autores: Yahya Sohrabi, Holger Reinecke, Leo A.B. Joosten, Mihai G. Netea
Publicado en: Med, Edición 2/4, 2021, Página(s) 378-383, ISSN 2666-6340
Editor: elsevier
DOI: 10.1016/j.medj.2021.02.004

Trained immunity: adaptation within innate immune mechanisms

Autores: Jorge Domínguez-Andrés, Jéssica Cristina dos Santos, Siroon Bekkering, Willem J. M. Mulder, Jos W. M. van der Meer, Niels P. Riksen, Leo A. B. Joosten, Mihai G. Netea
Publicado en: Physiological Reviews, Edición 103, 2022, Página(s) 313-346, ISSN 0031-9333
Editor: American Physiological Society
DOI: 10.1152/physrev.00031.2021

MMR vaccination induces trained immunity via functional and metabolic reprogramming of γδ T cells

Autores: Röring RJ, Debisarun PA, Botey-Bataller J, Suen TK, Bulut Ö, Kilic G, Koeken VA, Sarlea A, Bahrar H, Dijkstra H, Lemmers H, Gössling KL, Rüchel N, Ostermann PN, Müller L, Schaal H, Adams O, Borkhardt A, Ariyurek Y, de Meijer EJ, Kloet SL, Ten Oever J, Placek K, Li Y, Netea MG.
Publicado en: Journal of clinical investigation, Edición Published January 30, 2024, 2024, Página(s) 106851, ISSN 1558-8238
Editor: London Open Access Text
DOI: 10.1172/jci170848

Dysregulated Innate and Adaptive Immune Responses Discriminate Disease Severity in COVID-19

Autores: Nico A F Janssen, Inge Grondman, Aline H de Nooijer, Collins K Boahen, Valerie A C M Koeken, Vasiliki Matzaraki, Vinod Kumar, Xuehui He, Matthijs Kox, Hans J P M Koenen, Ruben L Smeets, Irma Joosten, Roger J M Brüggemann, Ilse J E Kouijzer, Hans G van der Hoeven, Jeroen A Schouten, Tim Frenzel, Monique H E Reijers, Wouter Hoefsloot, Anton S M Dofferhoff, Marjan J van Apeldoorn, Marc J T Blaauw, K
Publicado en: The Journal of Infectious Diseases, Edición 223/8, 2021, Página(s) 1322-1333, ISSN 0022-1899
Editor: University of Chicago Press
DOI: 10.1093/infdis/jiab065

The effect of BCG vaccination in the elderly on infectious and non-infectious immune-mediated diseases

Autores: Dulfer EA, Föhse K, Taks EJM, Moorlag SJCFM, Koekenbier EL, van de Maat JS, Ten Oever J, Hoogerwerf JJ, van Werkhoven CH, Bonten MJM, van Hylckama Vlieg A, Rosendaal FR, Netea MG
Publicado en: Journal of Infection, Edición Volume 89, Edición 6, December 2024, 2024, Página(s) 106344, ISSN 1532-2742
Editor: sassari
DOI: 10.1016/j.jinf.2024.106344

A protein-free vaccine stimulates innate immunity and protects against nosocomial pathogens

Autores: Yan J, Nielsen TB, Lu P, Talyansky Y, Slarve M, Reza H, Novakovic B, Netea MG, Keller AE, Warren T, DiGiandomenico A, Sellman BR, Luna BM, Spellberg B. A
Publicado en: Science translational medicine, Edición 4 Oct 2023 Vol 15, Edición 716, 2023, Página(s) 9556, ISSN 1946-6234
Editor: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.adf9556

Favorable Anakinra Responses in Severe Covid-19 Patients with Secondary Hemophagocytic Lymphohistiocytosis

Autores: George Dimopoulos, Quirijn de Mast, Nikolaos Markou, Maria Theodorakopoulou, Apostolos Komnos, Maria Mouktaroudi, Mihai G. Netea, Themistoklis Spyridopoulos, Rebecca J. Verheggen, Jacobien Hoogerwerf, Alexandra Lachana, Frank L. van de Veerdonk, Evangelos J. Giamarellos-Bourboulis
Publicado en: Cell Host & Microbe, Edición 28/1, 2020, Página(s) 117-123.e1, ISSN 1931-3128
Editor: Cell Press
DOI: 10.1016/j.chom.2020.05.007

Fatty acid desaturation and lipoxygenase pathways support trained immunity

Autores: Ferreira AV, Alarcon-Barrera JC, Domínguez-Andrés J, Bulut Ö, Kilic G, Debisarun PA, Röring RJ, Özhan HN, Terschlüsen E, Ziogas A, Kostidis S, Mohammed Y, Matzaraki V, Renieris G, Giamarellos-Bourboulis EJ, Netea MG, Giera M.
Publicado en: Nature Communications, Edición 2023 Nov 15;14(1), 2023, Página(s) 7385, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-023-43315-x

The Association of TSH and Thyroid Hormones With Lymphopenia in Bacterial Sepsis and COVID-19

Autores: Inge Grondman, Aline H de Nooijer, Nikolaos Antonakos, Nico A F Janssen, Maria Mouktaroudi, Konstantinos Leventogiannis, Marco Medici, Jan W A Smit, Antonius E van Herwaarden, Leo A B Joosten, Frank L van de Veerdonk, Peter Pickkers, Matthijs Kox, Martin Jaeger, Mihai G Netea, Evangelos J Giamarellos-Bourboulis, Romana T Netea-Maier
Publicado en: The Journal of Clinical Endocrinology & Metabolism, 2021, ISSN 0021-972X
Editor: The Endocrine Society
DOI: 10.1210/clinem/dgab148

The anti-inflammatory cytokine interleukin-37 is an inhibitor of trained immunity

Autores: Giulio Cavalli, Isak W. Tengesdal, Mark Gresnigt, Travis Nemkov, Rob J.W. Arts, Jorge Domínguez-Andrés, Raffaella Molteni, Davide Stefanoni, Eleonora Cantoni, Laura Cassina, Silvia Giugliano, Kiki Schraa, Taylor S. Mills, Eric M. Pietras, Elan Z. Eisenmensser, Lorenzo Dagna, Alessandra Boletta, Angelo D’Alessandro, Leo A.B. Joosten, Mihai G. Netea, Charles A. Dinarello
Publicado en: Cell Reports, Edición 35/1, 2021, Página(s) 108955, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2021.108955

BCG vaccination in health care providers and the protection against COVID-19

Autores: Mihai G. Netea, Jos W.M. van der Meer, Reinout van Crevel
Publicado en: Journal of Clinical Investigation, Edición 131/2, 2021, ISSN 0021-9738
Editor: American Society for Clinical Investigation
DOI: 10.1172/jci145545

Seasonal variation in BCG-induced trained immunity

Autores: Kilic G, Debisarun PA, Alaswad A, Baltissen MP, Lamers LA, de Bree LCJ, Benn CS, Aaby P, Dijkstra H, Lemmers H, Martens JHA, Domínguez-Andrés J, van Crevel R, Li Y, Xu CJ, Netea MG.
Publicado en: Vaccine, Edición Volume 42, Edición 24, 24 October 2024, 2024, Página(s) 126109, ISSN 2230-2298
Editor: Dove medical press
DOI: 10.1016/j.vaccine.2024.07.010

Persistent bone marrow hemozoin accumulation confers a survival advantage against bacterial infection via cell-intrinsic Myd88 signaling

Autores: Zhu Y, Gao Q, Zhang J, Cheng Y, Yang S, Xu R, Yuan J, Novakovic B, Netea MG, Cheng SC.
Publicado en: signaling. Cell Rep., Edición 2024 Oct 22;43 (10), 2024, Página(s) 114850, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2024.114850

Sepsis pathogenesis and outcome are shaped by the balance between the transcriptional states of systemic inflammation and antimicrobial response

Autores: Rachel Brandes-Leibovitz, Anca Riza, Gal Yankovitz, Andrei Pirvu, Stefania Dorobantu, Adina Dragos, Ioana Streata, Isis Ricaño-Ponce, Aline de Nooijer, Florentina Dumitrescu, Nikolaos Antonakos, Eleni Antoniadou, George Dimopoulos, Ioannis Koutsodimitropoulos, Theano Kontopoulou, Dimitra Markopoulou, Eleni Aimoniotou, Apostolos Komnos, George N. Dalekos, Mihai Ioana, Evangelos J. Giamarellos-Bour
Publicado en: Cell Reports Medicine, Edición 5, 2024, Página(s) 101829, ISSN 2666-3791
Editor: Cell Pres Elsevier Inc.
DOI: 10.1016/j.xcrm.2024.101829

BCG vaccination alters the epigenetic landscape of progenitor cells in human bone marrow to influence innate immune responses

Autores: Sun SJ, Aguirre-Gamboa R, de Bree LCJ, Sanz J, Dumaine A, van der Velden WJFM, Joosten LAB, Khader S, Divangahi M, Netea MG, Barreiro LB.
Publicado en: Immunity, Edición Volume 57, Edición 9, 10 September 2024, 2024, Página(s) 2095-2107.e8, ISSN 1097-4180
Editor: cellpress
DOI: 10.1016/j.immuni.2024.07.021

Complement Activation in the Disease Course of Coronavirus Disease 2019 and Its Effects on Clinical Outcomes

Autores: Aline H de Nooijer, Inge Grondman, Nico A F Janssen, Mihai G Netea, Loek Willems, Frank L van de Veerdonk, Evangelos J Giamarellos-Bourboulis, Erik J M Toonen, Leo A B Joosten, Martin Jaeger, Helga Dijkstra, Heidi Lemmers, Liesbeth van Emst, Kiki Schraa, Cor Jacobs, Anneke Hijmans, Trees Jansen, Fieke Weren, Liz Fransman, Jelle Gerretsen, Josephine van de Maat, Gerine Nijman, Simone Moorlag, Esthe
Publicado en: The Journal of Infectious Diseases, Edición 223/2, 2020, Página(s) 214-224, ISSN 0022-1899
Editor: University of Chicago Press
DOI: 10.1093/infdis/jiaa646

New live attenuated tuberculosis vaccine MTBVAC induces trained immunity and confers protection against experimental lethal pneumonia

Autores: Raquel Tarancón, Jorge Domínguez-Andrés, Santiago Uranga, Anaísa V. Ferreira, Laszlo A. Groh, Mirian Domenech, Fernando González-Camacho, Niels P. Riksen, Nacho Aguilo, José Yuste, Carlos Martín, Mihai G. Netea
Publicado en: PLOS Pathogens, Edición 16/4, 2020, Página(s) e1008404, ISSN 1553-7374
Editor: PLOS
DOI: 10.1371/journal.ppat.1008404

Anakinra treatment in critically ill COVID-19 patients: a prospective cohort study

Autores: Emma J. Kooistra, Nicole J. B. Waalders, Inge Grondman, Nico A. F. Janssen, Aline H. de Nooijer, Mihai G. Netea, Frank L. van de Veerdonk, Esther Ewalds, Johannes G. van der Hoeven, Matthijs Kox, Peter Pickkers
Publicado en: Critical Care, Edición 24/1, 2020, ISSN 1364-8535
Editor: Springer Nature
DOI: 10.1186/s13054-020-03364-w

Glutathione Metabolism Contributes to the Induction of Trained Immunity

Autores: Anaisa V. Ferreira, Valerie A. C. M. Koeken, Vasiliki Matzaraki, Sarantos Kostidis, Juan Carlos Alarcon-Barrera, L. Charlotte J. de Bree, Simone J. C. F. M. Moorlag, Vera P. Mourits, Boris Novakovic, Martin A. Giera, Mihai G. Netea, Jorge Domínguez-Andrés
Publicado en: Cells, Edición 10/5, 2021, Página(s) 971, ISSN 2073-4409
Editor: MDPI
DOI: 10.3390/cells10050971

BCG vaccination in humans inhibits systemic inflammation in a sex-dependent manner

Autores: Valerie A.C.M. Koeken, L. Charlotte J. de Bree, Vera P. Mourits, Simone J.C.F.M. Moorlag, Jona Walk, Branko Cirovic, Rob J.W. Arts, Martin Jaeger, Helga Dijkstra, Heidi Lemmers, Leo A.B. Joosten, Christine S. Benn, Reinout van Crevel, Mihai G. Netea
Publicado en: Journal of Clinical Investigation, Edición 130/10, 2020, Página(s) 5591-5602, ISSN 0021-9738
Editor: American Society for Clinical Investigation
DOI: 10.1172/jci133935

Immune cells fold and damage fungal hyphae

Autores: Judith M. Bain, M. Fernanda Alonso, Delma S. Childers, Catriona A. Walls, Kevin Mackenzie, Arnab Pradhan, Leanne E. Lewis, Johanna Louw, Gabriela M. Avelar, Daniel E. Larcombe, Mihai G. Netea, Neil A. R. Gow, Gordon D. Brown, Lars P. Erwig, Alistair J. P. Brown
Publicado en: Proceedings of the National Academy of Sciences, Edición 118/15, 2021, Página(s) e2020484118, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.2020484118

A minimal common outcome measure set for COVID-19 clinical research

Autores: John C Marshall, Srinivas Murthy, Janet Diaz, N K Adhikari, Derek C Angus, Yaseen M Arabi, Kenneth Baillie, Michael Bauer, Scott Berry, Bronagh Blackwood, Marc Bonten, Fernando Bozza, Frank Brunkhorst, Allen Cheng, Mike Clarke, Vu Quoc Dat, Menno de Jong, Justin Denholm, Lennie Derde, Jake Dunning, Xiaobin Feng, Tom Fletcher, Nadine Foster, Rob Fowler, Nina Gobat, Charles Gomersall, Anthony Gordon
Publicado en: The Lancet Infectious Diseases, Edición 20/8, 2020, Página(s) e192-e197, ISSN 1473-3099
Editor: The Lancet Publishing Group
DOI: 10.1016/s1473-3099(20)30483-7

Beneficial non-specific effects of live vaccines against COVID-19 and other unrelated infections

Autores: Aaby P, Netea MG, Benn CS.
Publicado en: Lancet Inct. dis., Edición 29 aug 2022, 2022, Página(s) S1473-3099(22)00498-4, ISSN 1473-3099
Editor: The Lancet Publishing Group
DOI: 10.1016/s1473-3099(22)00498-4

Comparative host transcriptome in response to pathogenic fungi identifies common and species-specific transcriptional antifungal host response pathways

Autores: Mariolina Bruno, Intan M.W. Dewi, Vicky Matzaraki, Rob ter Horst, Marina Pekmezovic, Berenice Rösler, Laszlo Groh, Rutger J. Röring, Vinod Kumar, Yang Li, Agostinho Carvalho, Mihai G. Netea, Jean-Paul Latgé, Mark S. Gresnigt, Frank L. van de Veerdonk
Publicado en: Computational and Structural Biotechnology Journal, Edición 19, 2021, Página(s) 647-663, ISSN 2001-0370
Editor: Elsevier
DOI: 10.1016/j.csbj.2020.12.036

BCG-induced non-specific effects on heterologous infectious disease in Ugandan neonates: an investigator-blind randomised controlled trial

Autores: Sarah Prentice, Beatrice Nassanga, Emily L Webb, Florence Akello, Fred Kiwudhu, Hellen Akurut, Alison M Elliott, Rob J W Arts, Mihai G Netea, Hazel M Dockrell, Stephen Cose, Sarah Prentice, Beatrice Nassanga, Hellen Akurut, Florence Akello, Fred Kiwudhu, Stephen Cose, Hazel Dockrell, Emily Webb, Alison Elliott, Irene Nabaweesi, Christopher Zziwa, Milly Namutebi, Benigna Namarra, Florence Akello, E
Publicado en: The Lancet Infectious Diseases, 2021, ISSN 1473-3099
Editor: The Lancet Publishing Group
DOI: 10.1016/s1473-3099(20)30653-8

Complex Immune Dysregulation in COVID-19 Patients with Severe Respiratory Failure

Autores: Evangelos J. Giamarellos-Bourboulis, Mihai G. Netea, Nikoletta Rovina, Karolina Akinosoglou, Anastasia Antoniadou, Nikolaos Antonakos, Georgia Damoraki, Theologia Gkavogianni, Maria-Evangelia Adami, Paraskevi Katsaounou, Maria Ntaganou, Magdalini Kyriakopoulou, George Dimopoulos, Ioannis Koutsodimitropoulos, Dimitrios Velissaris, Panagiotis Koufargyris, Athanassios Karageorgos, Konstantina Katrini
Publicado en: Cell Host & Microbe, Edición 27/6, 2020, Página(s) 992-1000.e3, ISSN 1931-3128
Editor: Cell Press
DOI: 10.1016/j.chom.2020.04.009

Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients

Autores: Anna C. Aschenbrenner, Maria Mouktaroudi, Benjamin Krämer, Marie Oestreich, Nikolaos Antonakos, Melanie Nuesch-Germano, Konstantina Gkizeli, Lorenzo Bonaguro, Nico Reusch, Kevin Baßler, Maria Saridaki, Rainer Knoll, Tal Pecht, Theodore S. Kapellos, Sarandia Doulou, Charlotte Kröger, Miriam Herbert, Lisa Holsten, Arik Horne, Ioanna D. Gemünd, Nikoletta Rovina, Shobhit Agrawal, Kilian Dahm, Mart
Publicado en: Genome Medicine, Edición 13/1, 2021, ISSN 1756-994X
Editor: BioMed Central
DOI: 10.1186/s13073-020-00823-5

Chronic HIV infection induces transcriptional and functional reprogramming of innate immune cells

Autores: Wouter A. van der Heijden, Lisa Van de Wijer, Farid Keramati, Wim Trypsteen, Sofie Rutsaert, Rob ter Horst, Martin Jaeger, Hans J.P.M. Koenen, Hendrik G. Stunnenberg, Irma Joosten, Paul E. Verweij, Jan van Lunzen, Charles A. Dinarello, Leo A.B. Joosten, Linos Vandekerckhove, Mihai G. Netea, André J.A.M. van der Ven, Quirijn de Mast
Publicado en: JCI Insight, Edición 6/7, 2021, ISSN 2379-3708
Editor: ASCI
DOI: 10.1172/jci.insight.145928

Improving the odds of survival: transgenerational effects of infections

Autores: Victoria M Spanou, Theano P Andriopoulou, Evangelos J Giamarellos-Bourboulis, Mihai G Netea
Publicado en: EMBO Molecular Medicine, 2025, ISSN 1757-4684
Editor: Chichester Wiley Europe
DOI: 10.1038/s44321-025-00192-9

Controlled Human Malaria Infection Induces Long-Term Functional Changes in Monocytes

Autores: Jona Walk, Farid Keramati, L. Charlotte J. de Bree, Rob J. W. Arts, Bas Blok, Mihai G. Netea, Hendrik G. Stunnenberg, Robert W. Sauerwein
Publicado en: Frontiers in Molecular Biosciences, Edición 7, 2020, ISSN 2296-889X
Editor: Frontiers in Molecular Biosciences
DOI: 10.3389/fmolb.2020.604553

An integrative genomics approach identifies KDM4 as a modulator of trained immunity.

Autores: Moorlag SJCFM, Matzaraki V, van Puffelen JH, van der Heijden C, Keating S, Groh L, Röring RJ, Bakker OB, Mourits VP, Koeken VACM, de Bree LCJ, Smeekens SP, Oosting M, Gamboa RA, Riksen NP, Xavier RJ, Wijmenga C, Kumar V, van Crevel R, Novakovic B, Joosten LAB, Li Y, Netea MG.
Publicado en: Eur J Immunol., Edición 2022, 2022, Página(s) 431-446, ISSN 0014-2980
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/eji.202149577

Lysine methyltransferase G9a is an important modulator of trained immunity

Autores: Vera P Mourits, Jelmer H Puffelen, Boris Novakovic, Mariolina Bruno, Anaísa V Ferreira, Rob JW Arts, Laszlo Groh, Tania O Crișan, Jelle Zwaag, Elisa Jentho, Matthijs Kox, Peter Pickkers, Frank L Veerdonk, Sebastian Weis, Egbert Oosterwijk, Sita H Vermeulen, Mihai G Netea, Leo AB Joosten
Publicado en: Clinical & Translational Immunology, Edición 10/2, 2021, ISSN 2050-0068
Editor: Wiley & Sons
DOI: 10.1002/cti2.1253

Impaired ketogenesis ties metabolism to T cell dysfunction in COVID-19

Autores: Karagiannis F, Peukert K, Surace L, Michla M, Nikolka F, Fox M, Weiss P, Feuerborn C, Maier P, Schulz S, Al B, Seeliger B, Welte T, David S, Grondman I, de Nooijer AH, Pickkers P, Kleiner JL, Berger MM, Brenner T, Putensen C; Bonn COVIMMUNE Consortium, Kato H, Garbi N, Netea MG, Hiller K, Placek K, Bode C, Wilhelm C.
Publicado en: Nature, Edición july 28 2022, 2022, Página(s) 801-807, ISSN 1476-4687
Editor: Nature Research
DOI: 10.1038/s41586-022-05128-8

An integrative model of cardiometabolic traits identifies two types of metabolic syndrome

Autores: Amit Frishberg, Inge van den Munckhof, Rob ter Horst, Kiki Schraa, Leo AB Joosten, Joost HW Rutten, Adrian C Iancu, Ioana M Dregoesc, Bogdan A Tigu, Mihai G Netea, Niels P Riksen, Irit Gat-Viks
Publicado en: eLife, Edición 10, 2021, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/elife.61710

The influence of the gut microbiome on BCG-induced trained immunity.

Autores: Stražar M, Mourits VP, Koeken VACM, de Bree LCJ, Moorlag SJCFM, Joosten LAB, van Crevel R, Vlamakis H, Netea MG, Xavier RJ
Publicado en: Genome Biology, 2021, Página(s) 275, ISSN 1474-760X
Editor: BMC
DOI: 10.1186/s13059-021-02482-0

Multi-omics analysis of innate and adaptive responses to BCG vaccination reveals epigenetic cell states that predict trained immunity

Autores: Moorlag SJCFM, Folkman L, Ter Horst R, Krausgruber T, Barreca D, Schuster LC, Fife V, Matzaraki V, Li W, Reichl S, Mourits VP, Koeken VACM, de Bree LCJ, Dijkstra H, Lemmers H, van Cranenbroek B, van Rijssen E, Koenen HJPM, Joosten I, Xu CJ, Li Y, Joosten LAB, van Crevel R, Netea MG, Bock C.
Publicado en: Immunity, Edición Volume 57, Edición 1, 9 January 2024,, 2024, Página(s) 171-187.e14, ISSN 1074-7613
Editor: Cell Press
DOI: 10.1016/j.immuni.2023.12.005

Two Randomized Controlled Trials of Bacillus Calmette-Guérin Vaccination to reduce absenteeism among health care workers and hospital admission by elderly persons during the COVID-19 pandemic: A structured summary of the study protocols for two randomised controlled trials

Autores: Thijs ten Doesschate, Simone J. C. F. M. Moorlag, Thomas W. van der Vaart, Esther Taks, Priya Debisarun, Jaap ten Oever, Chantal P. Bleeker-Rovers, Patricia Bruijning Verhagen, Arief Lalmohamed, Rob ter Heine, Reinout van Crevel, Janneke van de Wijgert, Axel B. Janssen, Marc J. Bonten, Cornelis H. van Werkhoven, Mihai G. Netea
Publicado en: Trials, Edición 21/1, 2020, ISSN 1745-6215
Editor: BioMed Central
DOI: 10.1186/s13063-020-04389-w

BCG Vaccination in Humans Elicits Trained Immunity via the Hematopoietic Progenitor Compartment

Autores: Branko Cirovic, L. Charlotte J. de Bree, Laszlo Groh, Bas A. Blok, Joyce Chan, Walter J.F.M. van der Velden, M.E.J. Bremmers, Reinout van Crevel, Kristian Händler, Simone Picelli, Jonas Schulte-Schrepping, Kathrin Klee, Marije Oosting, Valerie A.C.M. Koeken, Jakko van Ingen, Yang Li, Christine S. Benn, Joachim L. Schultze, Leo A.B. Joosten, Nigel Curtis, Mihai G. Netea, Andreas Schlitzer
Publicado en: Cell Host & Microbe, Edición 28/2, 2020, Página(s) 322-334.e5, ISSN 1931-3128
Editor: Cell Press
DOI: 10.1016/j.chom.2020.05.014

VPM1002 as Prophylaxis Against Severe Respiratory Tract Infections Including Coronavirus Disease 2019 in the Elderly: A Phase 3 Randomized, Double-Blind, Placebo-Controlled, Multicenter Clinical Study

Autores: Blossey AM, Brückner S, May M, Parzmair GP, Sharma H, Shaligram U, Grode L, Kaufmann SHE, Netea MG, Schindler C.
Publicado en: Clinical infectious diseases, Edición Volume 76, Edición 7, 1 April 2023,, 2023, Página(s) 1304–1310, ISSN 2684-4559
Editor: Oxfor university press
DOI: 10.1093/cid/ciac881

Conceptualization of population-specific human functional immune-genomics projects to identify factors that contribute to variability in immune and infectious diseases

Autores: Collins K. Boahen, Leo A.B. Joosten, Mihai G. Netea, Vinod Kumar
Publicado en: Heliyon, Edición 7/4, 2021, Página(s) e06755, ISSN 2405-8440
Editor: Cellpress, Elsevier
DOI: 10.1016/j.heliyon.2021.e06755

Innate Immune Training of Human Macrophages by Cathelicidin Analogs

Autores: Dijk A, Anten J, Bakker A, Evers N, Hoekstra AT, Chang JC, Scheenstra MR, Veldhuizen EJA, Netea MG, Berkers CR, Haagsman HP.
Publicado en: Front Immunol ., Edición 26 july 2022, 2022, Página(s) 13:777530, ISSN 1664-3224
Editor: Frontiers Research Foundation
DOI: 10.3389/fimmu.2022.777530

Alendronate modulates cytokine responses in healthy young individuals after BCG vaccination

Autores: Bulut O, Kilic G, Debisarun PA, Röring RJ, Sun S, Kolkman M, van Rijssen E, Ten Oever J, Koenen H, Barreiro L, Domínguez-Andrés J, Netea MG.
Publicado en: Immunology Letters, Edición Volume 267, June 2024,, 2024, Página(s) 106851, ISSN 0165-2478
Editor: Elsevier BV
DOI: 10.1016/j.imlet.2024.106851

The Architecture of Circulating Immune Cells Is Dysregulated in People Living With HIV on Long Term Antiretroviral Treatment and Relates With Markers of the HIV-1 Reservoir, Cytomegalovirus, and Microbial Translocation

Autores: Lisa Van de Wijer, Wouter A. van der Heijden, Rob ter Horst, Martin Jaeger, Wim Trypsteen, Sofie Rutsaert, Bram van Cranenbroek, Esther van Rijssen, Irma Joosten, Leo Joosten, Linos Vandekerckhove, Till Schoofs, Jan van Lunzen, Mihai G. Netea, Hans J.P.M. Koenen, André J.A.M. van der Ven, Quirijn de Mast
Publicado en: Frontiers in Immunology, Edición 12, 2021, ISSN 1664-3224
Editor: Frontiers in Immunology
DOI: 10.3389/fimmu.2021.661990

Systemic administration of β-glucan induces immune training in microglia

Autores: Yang Heng, Xiaoming Zhang, Malte Borggrewe, Hilmar R. J. van Weering, Maaike L. Brummer, Tjalling W. Nijboer, Leo A. B. Joosten, Mihai G. Netea, Erik W. G. M. Boddeke, Jon D. Laman, Bart J. L. Eggen
Publicado en: Journal of Neuroinflammation, Edición 18/1, 2021, ISSN 1742-2094
Editor: BioMed Central
DOI: 10.1186/s12974-021-02103-4

Rare variants increase the risk of severe COVID-19

Autores: Frank L van de Veerdonk, Mihai G Netea
Publicado en: eLife, Edición 10, 2021, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/elife.67860

Postinfectious Epigenetic Immune Modifications — A Double-Edged Sword

Autores: Andrew R. DiNardo, Mihai G. Netea, Daniel M. Musher
Publicado en: New England Journal of Medicine, Edición 384/3, 2021, Página(s) 261-270, ISSN 0028-4793
Editor: Massachusetts Medical Society
DOI: 10.1056/nejmra2028358

Resolving sepsis-induced immunoparalysis via trained immunity by targeting interleukin-4 to myeloid cells

Autores: Schrijver DP, Röring RJ, Deckers J, de Dreu A, Toner YC, Prevot G, Priem B, Munitz J, Nugraha EG, van Elsas Y, Azzun A, Anbergen T, Groh LA, Becker AMD, Pérez-Medina C, Oosterwijk RS, Novakovic B, Moorlag SJCFM, Jansen A, Pickkers P, Kox M, Beldman TJ, Kluza E, van Leent MMT, Teunissen AJP, van der Meel R, Fayad ZA, Joosten LAB, Fisher EA, Merkx M, Netea MG, Mulder WJM.
Publicado en: Nature Biomedical Engineering, Edición 2023, 7, 2023, Página(s) 1097–1112, ISSN 2157-846X
Editor: CLOCKSS
DOI: 10.1038/s41551-023-01050-0

BCG vaccination-induced acquired control of mycobacterial growth differs from growth control preexisting to BCG vaccination

Autores: van Meijgaarden KE, Li W, Moorlag SJCFM, Koeken VACM, Koenen HJPM, Joosten LAB, Vyakarnam A, Ahmed A, Rakshit S, Adiga V, Ottenhoff THM, Li Y, Netea MG, Joosten SA.
Publicado en: nature Communications, Edición 2024 Jan 2;15(1):114, 2024, Página(s) 44252-5, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-023-44252-5

Routine vaccination for influenza and pneumococcal disease and its effect on COVID-19 in a population of Dutch older adults

Autores: Esther J.M. Taks, Konstantin Föhse, Simone J.C.F.M. Moorlag, Jacobien Hoogerwerf, Reinout van Crevel, Cornelis H. van Werkhoven, Mihai G. Netea, Jaap ten Oever
Publicado en: Vaccine: X, Edición 14, 2023, Página(s) 100344, ISSN 2590-1362
Editor: Cell Pres Elsevier Inc.
DOI: 10.1016/j.jvacx.2023.100344

Activate: Randomized Clinical Trial of BCG Vaccination against Infection in the Elderly

Autores: Evangelos J. Giamarellos-Bourboulis, Maria Tsilika, Simone Moorlag, Nikolaos Antonakos, Antigone Kotsaki, Jorge Domínguez-Andrés, Evdoxia Kyriazopoulou, Theologia Gkavogianni, Maria-Evangelia Adami, Georgia Damoraki, Panagiotis Koufargyris, Athanassios Karageorgos, Amalia Bolanou, Hans Koenen, Reinout van Crevel, Dionyssia-Irene Droggiti, George Renieris, Antonios Papadopoulos, Mihai G. Netea
Publicado en: Cell, Edición 183/2, 2020, Página(s) 315-323.e9, ISSN 0092-8674
Editor: Cell Press
DOI: 10.1016/j.cell.2020.08.051

Trained innate immunity: Concept, nomenclature, and future perspectives

Autores: Netea MG, Joosten LAB.
Publicado en: Journal of Allergy and Clinical Immunology, Edición Volume 154, Edición 5, November 2024,, 2024, Página(s) 1079-1084, ISSN 2772-8293
Editor: New York Elsevier, Inc.
DOI: 10.1016/j.jaci.2024.09.005

Bridging animal and clinical research during SARS-CoV-2 pandemic: A new-old challenge

Autores: Martin S. Winkler, Tomasz Skirecki, Frank M. Brunkhorst, Sara Cajander, Jean-Marc Cavaillon, Ricard Ferrer, Stefanie B. Flohé, Alberto García-Salido, Evangelos J. Giamarellos-Bourboulis, Massimo Girardis, Matthijs Kox, Gunnar Lachmann, Ignacio Martin-Loeches, Mihai G. Netea, Thibaud Spinetti, Joerg C. Schefold, Antoni Torres, Florian Uhle, Fabienne Venet, Sebastian Weis, André Scherag, Ignacio
Publicado en: EBioMedicine, Edición 66, 2021, Página(s) 103291, ISSN 2352-3964
Editor: Elsevier BV
DOI: 10.1016/j.ebiom.2021.103291

Neonatal BCG vaccination is associated with a long-term DNA methylation signature in circulating monocytes

Autores: Bannister S, Kim B, Domínguez-Andrés J, Kilic G, Ansell BRE, Neeland MR, Moorlag SJCFM, Matzaraki V, Vlahos A, Shepherd R, Germano S, Bahlo M, Messina NL, Saffery R, Netea MG, Curtis N, Novakovic B.
Publicado en: Sci Adv, Edición 5 aug 2022, 2022, Página(s) 8(31):eabn4002, ISSN 2375-2548
Editor: American Association for the Advancement of Science,
DOI: 10.1126/sciadv.abn4002

Innate Immune Training of Granulopoiesis Promotes Anti-tumor Activity

Autores: Lydia Kalafati, Ioannis Kourtzelis, Jonas Schulte-Schrepping, Xiaofei Li, Aikaterini Hatzioannou, Tatyana Grinenko, Eman Hagag, Anupam Sinha, Canan Has, Sevina Dietz, Antonio Miguel de Jesus Domingues, Marina Nati, Sundary Sormendi, Ales Neuwirth, Antonios Chatzigeorgiou, Athanasios Ziogas, Mathias Lesche, Andreas Dahl, Ian Henry, Pallavi Subramanian, Ben Wielockx, Peter Murray, Peter Mirtschink,
Publicado en: Cell, Edición 183/3, 2020, Página(s) 771-785.e12, ISSN 0092-8674
Editor: Cell Press
DOI: 10.1016/j.cell.2020.09.058

BCG-induced trained immunity: can it offer protection against COVID-19?

Autores: Luke A. J. O’Neill, Mihai G. Netea
Publicado en: Nature Reviews Immunology, Edición 20/6, 2020, Página(s) 335-337, ISSN 1474-1733
Editor: Nature Publishing Group
DOI: 10.1038/s41577-020-0337-y

Thyrotrophin and thyroxine support immune homeostasis in humans

Autores: Martin Jaeger, Yvette J.E Sloot, Rob Ter Horst, Xiaojing Chu, Hans J.P.M. Koenen, Valerie A.C.M. Koeken, Simone J.C.F.M. Moorlag, Charlotte J. Bree, Vera P. Mourits, Heidi Lemmers, Helga Dijkstra, Marco Medici, Antonius E. Herwaarden, Irma Joosten, Leo A.B. Joosten, Yang Li, Johannes W.A. Smit, Mihai G. Netea, Romana T. Netea‐Maier
Publicado en: Immunology, Edición 163/2, 2021, Página(s) 155-168, ISSN 0019-2805
Editor: Blackwell Publishing Inc.
DOI: 10.1111/imm.13306

Transmission of trained immunity and heterologous resistance to infections across generations

Autores: Katzmarski N, Domínguez-Andrés J, Cirovic B, Renieris G, Ciarlo E, Le Roy D, Lepikhov K, Kattler K, Gasparoni G, Händler K, Theis H, Beyer M, van der Meer JWM, Joosten LAB, Walter J, Schultze JL, Roger T, Giamarellos-Bourboulis EJ, Schlitzer A, Netea MG.
Publicado en: Nat Immunol., Edición 11, 2021, Página(s) 1382-1390, ISSN 1529-2908
Editor: Nature Publishing Group
DOI: 10.1038/s41590-021-01052-7

Circadian rhythm influences induction of trained immunity by BCG vaccination

Autores: L. Charlotte J. de Bree, Vera P. Mourits, Valerie A.C.M. Koeken, Simone J.C.F.M. Moorlag, Robine Janssen, Lukas Folkman, Daniele Barreca, Thomas Krausgruber, Victoria Fife-Gernedl, Boris Novakovic, Rob J.W. Arts, Helga Dijkstra, Heidi Lemmers, Christoph Bock, Leo A.B. Joosten, Reinout van Crevel, Christine S. Benn, Mihai G. Netea
Publicado en: Journal of Clinical Investigation, Edición 130/10, 2020, Página(s) 5603-5617, ISSN 0021-9738
Editor: American Society for Clinical Investigation
DOI: 10.1172/jci133934

Using BCG vaccine to enhance non-specific protection of health care workers during the COVID-19 pandemic: A structured summary of a study protocol for a randomised controlled trial in Denmark

Autores: Anne Marie Rosendahl Madsen, Frederik Schaltz-Buchholzer, Thomas Benfield, Morten Bjerregaard-Andersen, Lars Skov Dalgaard, Christine Dam, Sisse Bolm Ditlev, Gulia Faizi, Isik Somuncu Johansen, Poul-Erik Kofoed, Gitte Schultz Kristensen, Ellen Christine Leth Loekkegaard, Christian Backer Mogensen, Libin Mohamed, Anne Ostenfeld, Emilie Sundhaugen Oedegaard, Marcus Kjaer Soerensen, Christian Wejse,
Publicado en: Trials, Edición 21/1, 2020, ISSN 1745-6215
Editor: BioMed Central
DOI: 10.1186/s13063-020-04714-3

Evidence for the heterologous benefits of prior BCG vaccination on COVISHIELD™ vaccine-induced immune responses in SARS-CoV-2 seronegative young Indian adults

Autores: Chetan Kumar N, Dwarkanath P, Shivalingaiah S, Rao S, D'Souza G, Dias M, Maguire TJA, Doores KJ, Zoodsma M, Geckin B, Dasgupta P, Babji S, van Meijgaarden KE, Joosten SA, Ottenhoff THM, Li Y, Netea MG, Stuart KD, De Rosa SC, McElrath MJ, Vyakarnam A.
Publicado en: Front Immunol, Edición 4 Oct 2022, 2022, Página(s) 13:985938, ISSN 1664-3224
Editor: Frontiers Research Foundation
DOI: 10.3389/fimmu.2022.985938

Trained Immunity: a Tool for Reducing Susceptibility to and the Severity of SARS-CoV-2 Infection

Autores: Mihai G. Netea, Evangelos J. Giamarellos-Bourboulis, Jorge Domínguez-Andrés, Nigel Curtis, Reinout van Crevel, Frank L. van de Veerdonk, Marc Bonten
Publicado en: Cell, Edición 181/5, 2020, Página(s) 969-977, ISSN 0092-8674
Editor: Cell Press
DOI: 10.1016/j.cell.2020.04.042

Single-cell RNA sequencing reveals induction of distinct trained-immunity programs in human monocytes.

Autores: Zhang B, Moorlag SJ, Dominguez-Andres J, Bulut Ö, Kilic G, Liu Z, van Crevel R, Xu CJ, Joosten LA, Netea MG, Li Y.
Publicado en: J. Clin. Invest., Edición 7, 2022, Página(s) 132, ISSN 0021-9738
Editor: American Society for Clinical Investigation
DOI: 10.1172/jci147719

Designing the Next Generation of Vaccines: Relevance for Future Pandemics

Autores: Jorge Domínguez-Andrés, Reinout van Crevel, Maziar Divangahi, Mihai G. Netea
Publicado en: mBio, Edición 11/6, 2020, ISSN 2161-2129
Editor: American Society for Microbiology
DOI: 10.1128/mbio.02616-20

Trained immunity: Target for prophylaxis and therapy

Autores: Ziogas A, Bruno M, van der Meel R, Mulder WJM, Netea MG.
Publicado en: Cell Host & Microbe, Edición 2023 Nov 8;31(11), 2023, Página(s) 1776-1791, ISSN 1931-3128
Editor: Cell Press
DOI: 10.1016/j.chom.2023.10.015

A single-cell view on host immune transcriptional response to in vivo BCG-induced trained immunity

Autores: : Li W, Moorlag SJCFM, Koeken VACM, Röring RJ, de Bree LCJ, Mourits VP, Gupta MK, Zhang B, Fu J, Zhang Z, Grondman I, van Meijgaarden KE, Zhou L, Alaswad A, Joosten LAB, van Crevel R, Xu CJ, Netea MG, Li Y.
Publicado en: Cell Reports, Edición Volume 42, Edición 5, 30 May 2023,, 2023, Página(s) 112487, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2023.112487

The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity

Autores: Marcin F Osuchowski, Martin S Winkler, Tomasz Skirecki, Sara Cajander, Manu Shankar-Hari, Gunnar Lachmann, Guillaume Monneret, Fabienne Venet, Michael Bauer, Frank M Brunkhorst, Sebastian Weis, Alberto Garcia-Salido, Matthijs Kox, Jean-Marc Cavaillon, Florian Uhle, Markus A Weigand, Stefanie B Flohé, W Joost Wiersinga, Raquel Almansa, Amanda de la Fuente, Ignacio Martin-Loeches, Christian Meisel,
Publicado en: The Lancet Respiratory Medicine, Edición 9/6, 2021, Página(s) 622-642, ISSN 2213-2600
Editor: Elsevier Limited
DOI: 10.1016/s2213-2600(21)00218-6

An open label trial of anakinra to prevent respiratory failure in COVID-19

Autores: Evdoxia Kyriazopoulou, Periklis Panagopoulos, Symeon Metallidis, George N Dalekos, Garyphallia Poulakou, Nikolaos Gatselis, Eleni Karakike, Maria Saridaki, Georgia Loli, Aggelos Stefos, Danai Prasianaki, Sarah Georgiadou, Olga Tsachouridou, Vasileios Petrakis, Konstantinos Tsiakos, Maria Kosmidou, Vassiliki Lygoura, Maria Dareioti, Haralampos Milionis, Ilias C Papanikolaou, Karolina Akinosoglou, D
Publicado en: eLife, Edición 10, 2021, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/elife.66125

Characterization of sepsis inflammatory endotypes using circulatory proteins in patients with severe infection: a prospective cohort study

Autores: Ricaño-Ponce I, Riza AL, de Nooijer AH, Pirvu A, Dorobantu S, Dragos A, Streata I, Roskanovic M, Grondman I, Dumitrescu F, Kumar V, Netea MG, Ioana M.
Publicado en: BMC infectious diseases, Edición 2022 Oct 8, 2022, Página(s) 22(1):778., ISSN 1471-2334
Editor: BioMed Central
DOI: 10.1186/s12879-022-07761-0

Stronger induction of trained immunity by mucosal BCG or MTBVAC vaccination compared to standard intradermal vaccination

Autores: Michel P.M. Vierboom, Karin Dijkman, Claudia C. Sombroek, Sam O. Hofman, Charelle Boot, Richard A.W. Vervenne, Krista G. Haanstra, Maarten van der Sande, Liesbeth van Emst, Jorge Domínguez-Andrés, Simone J.C.F.M. Moorlag, Clemens H.M. Kocken, Jelle Thole, Esteban Rodríguez, Eugenia Puentes, Joost H.A. Martens, Reinout van Crevel, Mihai G. Netea, Nacho Aguilo, Carlos Martin, Frank A.W. Verreck
Publicado en: Cell Reports Medicine, Edición 2/1, 2021, Página(s) 100185, ISSN 2666-3791
Editor: Elsevier
DOI: 10.1016/j.xcrm.2020.100185

Data of common and species-specific transcriptional host responses to pathogenic fungi

Autores: Mariolina Bruno, Robter Horst, Marina Pekmezovic, Vinod Kumar, Yang Li, Mihai G. Netea, Jean-Paul Latgé, Mark S. Gresnigt, Frank L. van de Veerdonk
Publicado en: Data in Brief, Edición 35, 2021, Página(s) 106928, ISSN 2352-3409
Editor: Elsevier BV
DOI: 10.1016/j.dib.2021.106928

BCG-Induced Trained Immunity in Healthy Individuals: The Effect of Plasma Muramyl Dipeptide Concentrations

Autores: Vera P. Mourits, Valerie A. C. M. Koeken, L. Charlotte J. de Bree, Simone J. C. F. M. Moorlag, Wern Cui Chu, Xiaoli Xu, Helga Dijkstra, Heidi Lemmers, Leo A. B. Joosten, Yue Wang, Reinout van Crevel, Mihai G. Netea
Publicado en: Journal of Immunology Research, Edición 2020, 2020, Página(s) 1-8, ISSN 2314-8861
Editor: Hindawi Publishing Corporation
DOI: 10.1155/2020/5812743

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