Projektbeschreibung
Den Mechanismen der Immunothrombose auf der Spur
Die Erkennung von Krankheitserregern durch spezialisierte Zellen des Immunsystems wie Monozyten und Neutrophile aktiviert gleichermaßen das Gerinnungssystem. Dieses als Immunothrombose bezeichnete Zusammenwirken führt zum Einschluss von Krankheitserregern, wodurch ihre Ausbreitung im Gefäßkompartiment gehemmt und die Schädigung anderer Organe verhindert wird. Ziel des EU-finanzierten Projekts IMMUNOTHROMBOSIS ist die Aufklärung des diesem Phänomen zugrunde liegenden Mechanismus, um dessen möglichen Einfluss auf Herz-Kreislauf-Erkrankungen zu verstehen. Die Forschenden werden sich auf die Blutplättchen konzentrieren und deren Funktion innerhalb der homöostatischen und pathogenen Synergie von Thrombose und Entzündung an den Tag bringen. Die Ergebnisse werden neuartigen Interventionen gegen die Bildung von Thromben und zur Heilung von Herz-Kreislauf-Erkrankungen den Weg bereiten.
Ziel
The overall aim of the IMMUNOTHROMBOSIS project is to clarify the mechanisms underlying the recently identified synergism between thrombosis and inflammation. Thrombus formation and inflammation are vital host responses that ensure homeostasis, but can also drive cardiovascular disease, including myocardial infarction and stroke, the major causes of death in Europe. My group and others discovered, that thrombosis and inflammation are not to be considered separate processes. They are tightly interrelated and synergize in immune defence, but also in inflammatory and thrombotic diseases in a process we termed immunothrombosis. Targeting this synergism has great potential to identify innovative and unconventional strategies to more specifically prevent undesired activation of thrombotic and inflammatory pathways. However, this requires a deeper mechanistic understanding of immunothrombosis. I recently identified two ground-breaking novel immunothrombotic principles: I discovered that platelets have the ability to migrate autonomously, which assists immune cells in fighting pathogens. Further, I revealed that immune cells play a central role in controlling the production of platelets from their megakaryocyte precursors. The physiological and pathophysiological relevance of both processes is unclear. This is the starting point and focus of the IMMUNOTHROMBOSIS project. My aim is to define how platelets use their ability to migrate to support immune cells in protection of vascular integrity (objective 1) and to identify the contribution of platelet migration to different cardiovascular diseases involving immunothrombotic tissue damage (objective 2). Finally, I will clarify how inflammatory responses feedback to the production of thrombotic effectors and dissect inflammatory mechanisms that control platelet production (objective 3). IMMUNOTHROMBOSIS will identify new options for specific prevention or treatment of thrombotic and inflammatory cardiovascular diseases.
Wissenschaftliches Gebiet
- medical and health sciencesclinical medicineangiologyvascular diseases
- medical and health sciencesbasic medicineimmunology
- medical and health sciencesclinical medicinecardiologycardiovascular diseases
- medical and health sciencesbasic medicineneurologystroke
- medical and health sciencesbasic medicinephysiologyhomeostasis
Programm/Programme
Thema/Themen
Finanzierungsplan
ERC-ADG - Advanced GrantGastgebende Einrichtung
80539 Muenchen
Deutschland