Cross-talk between platelets and immunity - implications for host homeostasis and defense | IMMUNOTHROMBOSIS | Project | Results | H2020 | CORDIS

Pubblicazioni

Single platelet and megakaryocyte morpho-dynamics uncovered by multicolor reporter mouse strains in vitro and in vivo.

Autori: Nicolai L, Kaiser R, Escaig R, Hoffknecht ML, Anjum A, Leunig A, Pircher J, Ehrlich A, Lorenz M, Ishikawa-Ankerhold H, Aird WC, Massberg S, Gaertner F.
Pubblicato in: Haematologica, 2021, ISSN 0390-6078
Editore: Ferrata Storti Foundation
DOI: 10.3324/haematol.2021.278896

Thrombocytopenia and splenic platelet-directed immune responses after IV ChAdOx1 nCov-19 administration

Autori: Leo Nicolai, Alexander Leunig, Kami Pekayvaz, Max Esefeld, Afra Anjum, Justina Rath, Eva Riedlinger, Vincent Ehreiser, Magdalena Mader, Luke Eivers, Marie-Louise Hoffknecht, Zhe Zhang, Daniela Kugelmann, Dario Rossaro, Raphael Escaig, Rainer Kaiser, Vivien Polewka, Anna Titova, Tobias Petzold, Karsten Spiekermann, Matteo Iannacone, Thomas Thiele, Andreas Greinacher, Konstantin Stark, Steffen Massb
Pubblicato in: Blood, Numero 00064971, 2022, Pagina/e 478–490, ISSN 0006-4971
Editore: American Society of Hematology
DOI: 10.1182/blood.2021014712

Interplay between inflammation and thrombosis in cardiovascular pathology.

Autori: Konstantin Stark, Steffen Massberg
Pubblicato in: Nature Reviews Cardiology, Numero 18(9), 2021, Pagina/e 666-682, ISSN 1759-5002
Editore: Nature Publishing Group
DOI: 10.1038/s41569-021-00552-1

Immunothrombotic Dysregulation in COVID-19 Pneumonia Is Associated With Respiratory Failure and Coagulopathy

Autori: Leo Nicolai, Alexander Leunig, Sophia Brambs, Rainer Kaiser, Tobias Weinberger, Michael Weigand, Maximilian Muenchhoff, Johannes C. Hellmuth, Stephan Ledderose, Heiko Schulz, Clemens Scherer, Martina Rudelius, Michael Zoller, Dominik Höchter, Oliver Keppler, Daniel Teupser, Bernhard Zwißler, Michael von Bergwelt-Baildon, Stefan Kääb, Steffen Massberg, Kami Pekayvaz, Konstantin Stark
Pubblicato in: Circulation, Numero 142/12, 2020, Pagina/e 1176-1189, ISSN 0009-7322
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circulationaha.120.048488

Vascular surveillance by haptotactic blood platelets in inflammation and infection

Autori: Leo Nicolai, Karin Schiefelbein, Silvia Lipsky, Alexander Leunig, Marie Hoffknecht, Kami Pekayvaz, Ben Raude, Charlotte Marx, Andreas Ehrlich, Joachim Pircher, Zhe Zhang, Inas Saleh, Anna-Kristina Marel, Achim Löf, Tobias Petzold, Michael Lorenz, Konstantin Stark, Robert Pick, Gerhild Rosenberger, Ludwig Weckbach, Bernd Uhl, Sheng Xia, Christoph Andreas Reichel, Barbara Walzog, Christian Schulz,
Pubblicato in: Nature Communications, Numero 11/1, 2020, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-020-19515-0

Self-sustaining IL-8 loops drive a prothrombotic neutrophil phenotype in severe COVID-19

Autori: Rainer Kaiser, Alexander Leunig, Kami Pekayvaz, Oliver Popp, Markus Joppich, Vivien Polewka, Raphael Escaig, Afra Anjum, Marie-Louise Hoffknecht, Christoph Gold, Sophia Brambs, Anouk Engel, Sven Stockhausen, Viktoria Knottenberg, Anna Titova, Mohamed Haji, Clemens Scherer, Maximilian Muenchhoff, Johannes C. Hellmuth, Kathrin Saar, Benjamin Schubert, Anne Hilgendorff, Christian Schulz, Stefan Kää
Pubblicato in: JCI Insight, Numero 6/18, 2021, ISSN 2379-3708
Editore: American Society for Clinical Investigation
DOI: 10.1172/jci.insight.150862

Neutrophil “plucking” on megakaryocytes drives platelet production and boosts cardiovascular disease

Autori: Tobias Petzold, Zhe Zhang, Iván Ballesteros, Inas Saleh, Amin Polzin, Manuela Thienel, Lulu Liu, Qurrat Ul Ain, Vincent Ehreiser, Christian Weber, Badr Kilani, Pontus Mertsch, Jeremias Götschke, Sophie Cremer, Wenwen Fu, Michael Lorenz, Hellen Ishikawa-Ankerhold, Elisabeth Raatz, Shaza El-Nemr, Agnes Görlach, Esther Marhuenda, Konstantin Stark, Joachim Pircher, David Stegner, Christian Gieger,
Pubblicato in: Immunity, Numero 10974180, 2022, Pagina/e 1-15, ISSN 1097-4180
Editore: Cell Press
DOI: 10.1016/j.immuni.2022.10.001

Procoagulant platelet sentinels prevent inflammatory bleeding through GPIIBIIIA and GPVI

Autori: Rainer Kaiser, Raphael Escaig, Jan Kranich, Marie-Louise Hoffknecht, Afra Anjum, Vivien Polewka, Magdalena Mader, Wenbo Hu, Larissa Belz, Christoph Gold, Anna Titova, Michael Lorenz, Kami Pekayvaz, Stefan Kääb, Florian Gaertner, Konstantin Stark, Thomas Brocker, Steffen Massberg, Leo Nicolai
Pubblicato in: Blood, Numero 00064971, 2022, Pagina/e 121-139, ISSN 0006-4971
Editore: American Society of Hematology
DOI: 10.1182/blood.2021014914

Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection

Autori: Kami Pekayvaz, Alexander Leunig, Rainer Kaiser, Markus Joppich, Sophia Brambs, Aleksandar Janjic, Oliver Popp, Daniel Nixdorf, Valeria Fumagalli, Nora Schmidt, Vivien Polewka, Afra Anjum, Viktoria Knottenberg, Luke Eivers, Lucas E. Wange, Christoph Gold, Marieluise Kirchner, Maximilian Muenchhoff, Johannes C. Hellmuth, Clemens Scherer, Raquel Rubio-Acero, Tabea Eser, Flora Deák, Kerstin Puchinger
Pubblicato in: Nature Communications, Numero 13/1, 2022, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-022-28508-0

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Cross-talk between platelets and immunity - implications for host homeostasis and defense

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