Descrizione del progetto
Niente paura: nuove strade da esplorare nel trattamento dei disturbi d’ansia
I disturbi d’ansia e il disturbo post traumatico da stress colpiscono milioni di persone in tutto il mondo. Per trattarli può essere impiegata la terapia psicologica, di cui la terapia espositiva è lo standard di riferimento. Tuttavia, fino al 50 % dei pazienti non trae beneficio dalla terapia a causa di una risposta insufficiente ad essa o di una successiva recidiva. Il progetto ReduceFear, finanziato dall’UE, esaminerà le strategie di riduzione della paura nella terapia espositiva: i processi di apprendimento dell’estinzione e della svalutazione, che riducono entrambi la paura impiegando approcci diversi. I risultati del progetto contribuiranno all’ottimizzazione della terapia.
Obiettivo
My ambition is to become an independent PI and clinical psychologist with a novel research line focusing on treatment optimization and personalization for anxiety disorders and post-traumatic stress disorder (PTSD). The MSCA-IF will provide the essential building blocks for this research line, and provides the opportunity to develop generic skills necessary to transfer from a postdoc position to an Assistant Professor position. Training through research: I will bring my expertise in neuroimaging and clinical psychology to the host, and the host’ PI will train me in experimental task development. The aim of ReduceFear is to examine fear reduction strategies that play a role in exposure therapy, the gold standard therapy for anxiety disorders and PTSD. These disorders are highly common, and up to 50% of patients do not benefit from the therapy. The project will concurrently assess (a) extinction learning, a process that reduces the over-expectation of harm but is highly fragile and dysfunctional in anxiety patients, and (b) threat (US) devaluation, a highly-understudied process that has potential to more robustly reduce excessive fears by reducing the perceived aversiveness of the threat. Overall objective: to examine for the first time (1) the neurobiological mechanisms of US devaluation compared to extinction learning to identify (pre)clinical targets for therapy augmentation, and (2) US devaluation mechanisms in patients with anxiety disorders. If anxiety patients not show any deficits in US devaluation, exposure-based therapies may be adapted to enhance focus on US devaluation. Hands-on training: As identified by a Gap Analysis, I will work on the following competences in order to reach scientific maturity and to successfully lead my own research group in the future: (1) Networking, (2) Time-management / Self-management, (3) Grant Writing, (4) Leadership, (5) Teaching, and (6) Communication/Dissemination.
Campo scientifico
Parole chiave
Programma(i)
Argomento(i)
Meccanismo di finanziamento
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)Coordinatore
3000 Leuven
Belgio