Exploiting the Tumor Proteome Activity Status for Future Cancer Therapies

Información del proyecto

TOPAS

Identificador del acuerdo de subvención: 833710

DOI

10.3030/833710

Proyecto cerrado

Fecha de la firma de la CE 7 Junio 2019

Fecha de inicio 1 Septiembre 2019

Fecha de finalización 31 Agosto 2024

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 2 272 055,00

Aportación de la UE

€ 2 272 055,00

Coordinado por

TECHNISCHE UNIVERSITAET MUENCHEN
Germany

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (17)

Proteome activity landscapes of tumor cell lines determine drug responses

Autores: Martin Frejno, Chen Meng, Benjamin Ruprecht, Thomas Oellerich, Sebastian Scheich, Karin Kleigrewe, Enken Drecoll, Patroklos Samaras, Alexander Hogrebe, Dominic Helm, Julia Mergner, Jana Zecha, Stephanie Heinzlmeir, Mathias Wilhelm, Julia Dorn, Hans-Michael Kvasnicka, Hubert Serve, Wilko Weichert, Bernhard Kuster
Publicado en: Nature Communications, Edición 11/1, 2020, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-020-17336-9

Decrypting the molecular basis of cellular drug phenotypes by dose-resolved expression proteomics

Autores: Stephan Eckert, Nicola Berner, Karl Kramer, Annika Schneider, Julian Müller, Severin Lechner, Sarah Brajkovic, Amirhossein Sakhteman, Christian Graetz, Jonas Fackler, Michael Dudek, Michael W. Pfaffl, Percy Knolle, Stephanie Wilhelm, Bernhard Kuster
Publicado en: Nature Biotechnology, 2024, ISSN 1087-0156
Editor: Nature Publishing Group
DOI: 10.1038/s41587-024-02218-y

Data, Reagents, Assays and Merits of Proteomics for SARS-CoV-2 Research and Testing

Autores: Jana Zecha, Chien-Yun Lee, Florian P. Bayer, Chen Meng, Vincent Grass, Johannes Zerweck, Karsten Schnatbaum, Thomas Michler, Andreas Pichlmair, Christina Ludwig, Bernhard Kuster
Publicado en: Molecular & Cellular Proteomics, Edición 19/9, 2020, Página(s) 1503-1522, ISSN 1535-9476
Editor: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/mcp.ra120.002164

CurveCurator: a recalibrated F-statistic to assess, classify, and explore significance of dose-response curves

Autores: Bayer FP, Gander M, Kuster B, The M
Publicado en: Nature Communications, Edición 14(1), 2023, Página(s) 7902, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-023-43696-z

Evaluation of Disposable Trap Column nanoLC-FAIMS-MS/MS for the Proteomic Analysis of FFPE Tissue

Autores: Stephan Eckert, Yun-Chien Chang, Florian P Bayer, Matthew The, Peer-Hendrik Kuhn, Wilko Weichert, Bernhard Kuster
Publicado en: Journal of Proteome Research, Edición 20(12), 2021, Página(s) 5402-5411, ISSN 1535-3893
Editor: American Chemical Society
DOI: 10.1021/acs.jproteome.1c00695

Robust Microflow LC-MS/MS for Proteome Analysis: 38 000 Runs and Counting

Autores: Bian Y, Bayer FP, Chang YC, Meng C, Hoefer S, Deng N, Zheng R, Boychenko O, Kuster B.
Publicado en: Analytical Chemistry, 2021, ISSN 0003-2700
Editor: American Chemical Society
DOI: 10.1021/acs.analchem.1c00257

Identification of 7 000-9 000 Proteins from Cell Lines and Tissues by Single-Shot Microflow LC-MS/MS.

Autores: Yangyang Bian; Yangyang Bian; Piero Giansanti; Julia Mergner; Runsheng Zheng; Mathias Wilhelm; Alexander Boychenko; Bernhard Kuster
Publicado en: Analytical Chemistry, Edición 93(25), 2021, Página(s) 8687-8692, ISSN 0003-2700
Editor: American Chemical Society
DOI: 10.1021/acs.analchem.1c00738

ProteomicsDB: toward a FAIR open-source resource for life-science research

Autores: Lautenbacher, L., Samaras, P., Muller, J., Grafberger, A., Shraideh, M., Rank, J., Fuchs, S. T., Schmidt, T. K., The, M., Dallago, C., Wittges, H., Rost, B., Krcmar, H., Kuster, B. & Wilhelm, M.
Publicado en: Nucleic Acids Research, 2022, ISSN 0305-1048
Editor: Oxford University Press
DOI: 10.1093/nar/gkab1026

Mass spectrometry-based draft of the mouse proteome

Autores: Piero Giansanti, Patroklos Samaras, Yangyang Bian, Chen Meng, Andrea Coluccio, Martin Frejno, Hannah Jakubowsky, Sophie Dobiasch, Rashmi R Hazarika, Julia Rechenberger, Julia Calzada-Wack, Johannes Krumm, Sebastian Mueller, Chien-Yun Lee, Nicole Wimberger, Ludwig Lautenbacher, Zonera Hassan, Yun-Chien Chang, Chiara Falcomatà, Florian P Bayer, Stefanie Bärthel, Tobias Schmidt, Roland Rad, Stephan
Publicado en: Nature Methods, 2022, ISSN 1548-7091
Editor: Nature Publishing Group
DOI: 10.1038/s41592-022-01526-y

Chemical proteomics reveals the target landscape of 1,000 kinase inhibitors.

Autores: Reinecke M, Brear P, Vornholz L, Berger BT, Seefried F, Wilhelm S, Samaras P, Gyenis L, Litchfield DW, Médard G, Müller S, Ruland J, Hyvönen M, Wilhelm M, Kuster B.
Publicado en: Nature Chemical Biology, 2023, ISSN 1552-4450
Editor: Nature Publishing Group
DOI: 10.1038/s41589-023-01459-3

SIMSI-Transfer: Software-Assisted Reduction of Missing Values in Phosphoproteomic and Proteomic Isobaric Labeling Data Using Tandem Mass Spectrum Clustering

Autores: Firas Hamood, Florian P Bayer, Mathias Wilhelm, Bernhard Kuster, Matthew The
Publicado en: Molecular & Cellular Proteomics, Edición 21(8), 2022, Página(s) 100238, ISSN 1535-9476
Editor: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.mcpro.2022.100238

Decrypting drug actions and protein modifications by dose- and time-resolved proteomics

Autores: Zecha J, Bayer FP, Wiechmann S, Woortman J, Berner N, Müller J, Schneider A, Kramer K, Abril-Gil M, Hopf T, Reichart L, Chen L, Hansen FM, Lechner S, Samaras P, Eckert S, Lautenbacher L, Reinecke M, Hamood F, Prokofeva P, Vornholz L, Falcomatà C, Dorsch M, Schröder A, Venhuizen A, Wilhelm S, Médard G, Stoehr G, Ruland J, Grüner BM, Saur D, Buchner M, Ruprecht B, Hahne H, The M, Wilhelm M, Kus
Publicado en: Science, Edición 380(6640), 2023, Página(s) 93–101, ISSN 0036-8075
Editor: American Association for the Advancement of Science
DOI: 10.1126/science.ade3925

Illuminating phenotypic drug responses of sarcoma cells to kinase inhibitors by phosphoproteomics

Autores: Lee CY, The M, Meng C, Bayer FP, Putzker K, Müller J, Streubel J, Woortman J, Sakhteman A, Resch M, Schneider A, Wilhelm S, Kuster B
Publicado en: Molecular Systems Biology, Edición 20(1), 2023, Página(s) 28-55, ISSN 1744-4292
Editor: Nature Publishing Group
DOI: 10.1038/s44320-023-00004-7

Reanalysis of ProteomicsDB Using an Accurate, Sensitive, and Scalable False Discovery Rate Estimation Approach for Protein Groups

Autores: Matthew The, Patroklos Samaras, Bernhard Kuster, Mathias Wilhelm
Publicado en: Molecular & Cellular Proteomics, Edición 21(12), 2022, Página(s) 100437, ISSN 1535-9476
Editor: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.mcpro.2022.100437

Decrypting lysine deacetylase inhibitor action and protein modifications by dose-resolved proteomics

Autores: Yun-Chien Chang, Christian Gnann, Raphael R. Steimbach, Florian P. Bayer, Severin Lechner, Amirhossein Sakhteman, Miriam Abele, Jana Zecha, Jakob Trendel, Matthew The, Emma Lundberg, Aubry K. Miller, Bernhard Kuster
Publicado en: Cell Reports, Edición 43, 2024, Página(s) 114272, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2024.114272

Linking post-translational modifications and protein turnover by site-resolved protein turnover profiling

Autores: Jana Zecha, Wassim Gabriel, Ria Spalek, Yun-Chien Chang, Julia Mergner, Mathias Wilhelm, Florian Bassermann, Bernhard Kuster
Publicado en: Nature communications, Edición 13(1), 2022, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-021-27639-0

Robust, reproducible and quantitative analysis of thousands of proteomes by micro-flow LC-MS/MS

Autores: Yangyang Bian, Runsheng Zheng, Florian P. Bayer, Cassandra Wong, Yun-Chien Chang, Chen Meng, Daniel P. Zolg, Maria Reinecke,Jana Zecha, Svenja Wiechmann, Stephanie Heinzlmeir, Johannes Scherr, Bernhard Hemmer,Mike Baynham, Anne-Claude Gingras, Oleksandr Boychenko, and Bernhard Kuster
Publicado en: Nature communications, Edición 11(1), 2020, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-019-13973-x